Details for: CL1000443

Cell ID: CL1000443

Cell Name: ciliary muscle cell

Marker Score Threshold: 2195
(Derived using integrated single-cell and genomic data)

Description: A smooth muscle cell that is part of the ciliary body.

Synonyms: smooth muscle cell of ciliary body

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ADGRB3 (ENSG00000135298)
    Fold Change: 3.83
    Ensembl ID: ENSG00000135298
  • Gene Symbol: ZFHX3 (ENSG00000140836)
    Fold Change: 3.78
    Ensembl ID: ENSG00000140836
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 3.59
    Ensembl ID: ENSG00000075624
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 3.55
    Ensembl ID: ENSG00000142599
  • Gene Symbol: ATP2A2 (ENSG00000174437)
    Fold Change: 3.54
    Ensembl ID: ENSG00000174437
  • Gene Symbol: A2M (ENSG00000175899)
    Fold Change: 3.5
    Ensembl ID: ENSG00000175899
  • Gene Symbol: ACTN1 (ENSG00000072110)
    Fold Change: 3.06
    Ensembl ID: ENSG00000072110
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 2.96
    Ensembl ID: ENSG00000085224
  • Gene Symbol: ADCY5 (ENSG00000173175)
    Fold Change: 2.92
    Ensembl ID: ENSG00000173175
  • Gene Symbol: ACTA2 (ENSG00000107796)
    Fold Change: 2.9
    Ensembl ID: ENSG00000107796
  • Gene Symbol: ACACB (ENSG00000076555)
    Fold Change: 2.78
    Ensembl ID: ENSG00000076555
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 2.71
    Ensembl ID: ENSG00000130402
  • Gene Symbol: APBB2 (ENSG00000163697)
    Fold Change: 2.65
    Ensembl ID: ENSG00000163697
  • Gene Symbol: ANK2 (ENSG00000145362)
    Fold Change: 2.54
    Ensembl ID: ENSG00000145362
  • Gene Symbol: ABL1 (ENSG00000097007)
    Fold Change: 2.52
    Ensembl ID: ENSG00000097007
  • Gene Symbol: ATM (ENSG00000149311)
    Fold Change: 2.52
    Ensembl ID: ENSG00000149311
  • Gene Symbol: ALCAM (ENSG00000170017)
    Fold Change: 2.5
    Ensembl ID: ENSG00000170017
  • Gene Symbol: ARHGAP6 (ENSG00000047648)
    Fold Change: 2.49
    Ensembl ID: ENSG00000047648
  • Gene Symbol: ATP1A2 (ENSG00000018625)
    Fold Change: 2.45
    Ensembl ID: ENSG00000018625
  • Gene Symbol: ACYP2 (ENSG00000170634)
    Fold Change: 2.42
    Ensembl ID: ENSG00000170634
  • Gene Symbol: ATP2B4 (ENSG00000058668)
    Fold Change: 2.34
    Ensembl ID: ENSG00000058668
  • Gene Symbol: ABL2 (ENSG00000143322)
    Fold Change: 2.28
    Ensembl ID: ENSG00000143322
  • Gene Symbol: ABCD2 (ENSG00000173208)
    Fold Change: 2.26
    Ensembl ID: ENSG00000173208
  • Gene Symbol: BCKDHB (ENSG00000083123)
    Fold Change: 2.26
    Ensembl ID: ENSG00000083123
  • Gene Symbol: ARHGAP5 (ENSG00000100852)
    Fold Change: 2.22
    Ensembl ID: ENSG00000100852
  • Gene Symbol: ARNT (ENSG00000143437)
    Fold Change: 2.19
    Ensembl ID: ENSG00000143437
  • Gene Symbol: BIN1 (ENSG00000136717)
    Fold Change: 2.18
    Ensembl ID: ENSG00000136717
  • Gene Symbol: ACTN2 (ENSG00000077522)
    Fold Change: 2.12
    Ensembl ID: ENSG00000077522
  • Gene Symbol: ACACA (ENSG00000278540)
    Fold Change: 2.1
    Ensembl ID: ENSG00000278540
  • Gene Symbol: ADAM10 (ENSG00000137845)
    Fold Change: 2.05
    Ensembl ID: ENSG00000137845
  • Gene Symbol: BDNF (ENSG00000176697)
    Fold Change: 2.03
    Ensembl ID: ENSG00000176697
  • Gene Symbol: AUH (ENSG00000148090)
    Fold Change: 2.03
    Ensembl ID: ENSG00000148090
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.03
    Ensembl ID: ENSG00000184009
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 2.03
    Ensembl ID: ENSG00000104964
  • Gene Symbol: APOD (ENSG00000189058)
    Fold Change: 2.02
    Ensembl ID: ENSG00000189058
  • Gene Symbol: ASPH (ENSG00000198363)
    Fold Change: 2.01
    Ensembl ID: ENSG00000198363
  • Gene Symbol: ABR (ENSG00000159842)
    Fold Change: 2
    Ensembl ID: ENSG00000159842
  • Gene Symbol: ARSB (ENSG00000113273)
    Fold Change: 1.92
    Ensembl ID: ENSG00000113273
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 1.86
    Ensembl ID: ENSG00000166710
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.84
    Ensembl ID: ENSG00000087274
  • Gene Symbol: AP2B1 (ENSG00000006125)
    Fold Change: 1.81
    Ensembl ID: ENSG00000006125
  • Gene Symbol: BCL6 (ENSG00000113916)
    Fold Change: 1.81
    Ensembl ID: ENSG00000113916
  • Gene Symbol: AGL (ENSG00000162688)
    Fold Change: 1.77
    Ensembl ID: ENSG00000162688
  • Gene Symbol: AP1G1 (ENSG00000166747)
    Fold Change: 1.76
    Ensembl ID: ENSG00000166747
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 1.73
    Ensembl ID: ENSG00000067560
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 1.72
    Ensembl ID: ENSG00000142192
  • Gene Symbol: APBA2 (ENSG00000034053)
    Fold Change: 1.72
    Ensembl ID: ENSG00000034053
  • Gene Symbol: ADK (ENSG00000156110)
    Fold Change: 1.71
    Ensembl ID: ENSG00000156110
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.63
    Ensembl ID: ENSG00000165629
  • Gene Symbol: AK4 (ENSG00000162433)
    Fold Change: 1.62
    Ensembl ID: ENSG00000162433
  • Gene Symbol: ATR (ENSG00000175054)
    Fold Change: 1.62
    Ensembl ID: ENSG00000175054
  • Gene Symbol: ACO2 (ENSG00000100412)
    Fold Change: 1.62
    Ensembl ID: ENSG00000100412
  • Gene Symbol: ATP6V0A1 (ENSG00000033627)
    Fold Change: 1.6
    Ensembl ID: ENSG00000033627
  • Gene Symbol: SLC25A4 (ENSG00000151729)
    Fold Change: 1.58
    Ensembl ID: ENSG00000151729
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.53
    Ensembl ID: ENSG00000110955
  • Gene Symbol: BACH1 (ENSG00000156273)
    Fold Change: 1.53
    Ensembl ID: ENSG00000156273
  • Gene Symbol: ANXA6 (ENSG00000197043)
    Fold Change: 1.52
    Ensembl ID: ENSG00000197043
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 1.52
    Ensembl ID: ENSG00000143878
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.47
    Ensembl ID: ENSG00000152234
  • Gene Symbol: ATP1B1 (ENSG00000143153)
    Fold Change: 1.46
    Ensembl ID: ENSG00000143153
  • Gene Symbol: APC (ENSG00000134982)
    Fold Change: 1.41
    Ensembl ID: ENSG00000134982
  • Gene Symbol: ADCY2 (ENSG00000078295)
    Fold Change: 1.35
    Ensembl ID: ENSG00000078295
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.35
    Ensembl ID: ENSG00000182718
  • Gene Symbol: ACADM (ENSG00000117054)
    Fold Change: 1.35
    Ensembl ID: ENSG00000117054
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.34
    Ensembl ID: ENSG00000163399
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.34
    Ensembl ID: ENSG00000084234
  • Gene Symbol: ADCY9 (ENSG00000162104)
    Fold Change: 1.33
    Ensembl ID: ENSG00000162104
  • Gene Symbol: ABCB7 (ENSG00000131269)
    Fold Change: 1.32
    Ensembl ID: ENSG00000131269
  • Gene Symbol: ANK1 (ENSG00000029534)
    Fold Change: 1.32
    Ensembl ID: ENSG00000029534
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.3
    Ensembl ID: ENSG00000138279
  • Gene Symbol: ACVR1 (ENSG00000115170)
    Fold Change: 1.29
    Ensembl ID: ENSG00000115170
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 1.29
    Ensembl ID: ENSG00000124172
  • Gene Symbol: AP2A2 (ENSG00000183020)
    Fold Change: 1.29
    Ensembl ID: ENSG00000183020
  • Gene Symbol: XIAP (ENSG00000101966)
    Fold Change: 1.27
    Ensembl ID: ENSG00000101966
  • Gene Symbol: APBA1 (ENSG00000107282)
    Fold Change: 1.26
    Ensembl ID: ENSG00000107282
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.23
    Ensembl ID: ENSG00000069849
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.2
    Ensembl ID: ENSG00000160710
  • Gene Symbol: ANXA4 (ENSG00000196975)
    Fold Change: 1.2
    Ensembl ID: ENSG00000196975
  • Gene Symbol: ACTG2 (ENSG00000163017)
    Fold Change: 1.18
    Ensembl ID: ENSG00000163017
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 1.18
    Ensembl ID: ENSG00000154723
  • Gene Symbol: PARP1 (ENSG00000143799)
    Fold Change: 1.15
    Ensembl ID: ENSG00000143799
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 1.14
    Ensembl ID: ENSG00000154518
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 1.14
    Ensembl ID: ENSG00000169020
  • Gene Symbol: BBS4 (ENSG00000140463)
    Fold Change: 1.13
    Ensembl ID: ENSG00000140463
  • Gene Symbol: BARD1 (ENSG00000138376)
    Fold Change: 1.12
    Ensembl ID: ENSG00000138376
  • Gene Symbol: AK2 (ENSG00000004455)
    Fold Change: 1.1
    Ensembl ID: ENSG00000004455
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.1
    Ensembl ID: ENSG00000164111
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.1
    Ensembl ID: ENSG00000122359
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 1.1
    Ensembl ID: ENSG00000135390
  • Gene Symbol: ACAT1 (ENSG00000075239)
    Fold Change: 1.09
    Ensembl ID: ENSG00000075239
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 1.09
    Ensembl ID: ENSG00000169100
  • Gene Symbol: PARP4 (ENSG00000102699)
    Fold Change: 1.09
    Ensembl ID: ENSG00000102699
  • Gene Symbol: ALDH7A1 (ENSG00000164904)
    Fold Change: 1.08
    Ensembl ID: ENSG00000164904
  • Gene Symbol: AMFR (ENSG00000159461)
    Fold Change: 1.07
    Ensembl ID: ENSG00000159461
  • Gene Symbol: ATP6V1A (ENSG00000114573)
    Fold Change: 1.06
    Ensembl ID: ENSG00000114573
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.04
    Ensembl ID: ENSG00000070961
  • Gene Symbol: ANGPT1 (ENSG00000154188)
    Fold Change: 1.03
    Ensembl ID: ENSG00000154188
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.03
    Ensembl ID: ENSG00000168374
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 1.03
    Ensembl ID: ENSG00000099624
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.02
    Ensembl ID: ENSG00000104763
Hovered Details

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Hovered Details

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**Key Characteristics** The ciliary muscle cell has several key characteristics that distinguish it from other cells: * Smooth muscle cell: The ciliary muscle cell is a type of smooth muscle cell that is part of the ciliary body. * Adrenergic receptor beta-3 (ADGRB3) expression: The cell expresses the adrenergic receptor beta-3 protein, which is involved in the regulation of the eye's focus and accommodation. * Zinc finger homeobox 3 (ZFHX3) expression: The cell expresses the zinc finger homeobox 3 protein, which is involved in the regulation of the eye's development and function. * Beta-actin (ACTB) expression: The cell expresses the beta-actin protein, which is involved in the regulation of the cell's cytoskeleton. * Involvement in signaling pathways: The cell is involved in various signaling pathways, including adenylate cyclase-activating g protein-coupled receptor signaling pathway, cell surface receptor signaling pathway, and cerebellar climbing fiber to purkinje cell synapse. * Regulation of synaptic cleft and postsynaptic density membrane: The cell regulates the synaptic cleft and postsynaptic density membrane, which are involved in the transmission of signals between neurons. **Clinical Significance** The ciliary muscle cell plays a crucial role in the regulation of the eye's focus and accommodation, and its dysfunction can lead to various eye disorders, including: * Myopia (nearsightedness): The ciliary muscle cell is responsible for the regulation of the eye's focus, and its dysfunction can lead to myopia. * Hyperopia (farsightedness): The ciliary muscle cell is also involved in the regulation of the eye's focus, and its dysfunction can lead to hyperopia. * Accommodation disorders: The ciliary muscle cell is responsible for the regulation of the eye's accommodation, and its dysfunction can lead to accommodation disorders. * Ciliary body tumors: The ciliary muscle cell can develop tumors, which can lead to various eye disorders, including cataracts and glaucoma. In addition to its clinical significance, the ciliary muscle cell is also an important model for studying various cellular and molecular mechanisms, including: * Cell signaling pathways: The cell is involved in various signaling pathways, including adenylate cyclase-activating g protein-coupled receptor signaling pathway, cell surface receptor signaling pathway, and cerebellar climbing fiber to purkinje cell synapse. * Cytoskeleton regulation: The cell regulates its cytoskeleton, which is involved in various cellular processes, including cell migration and division. * Synaptic transmission: The cell regulates the synaptic cleft and postsynaptic density membrane, which are involved in the transmission of signals between neurons. Overall, the ciliary muscle cell is an important cell type that plays a crucial role in the regulation of the eye's focus and accommodation, and its dysfunction can lead to various eye disorders.