Details for: CL1000443

Cell ID: CL1000443

Cell Name: ciliary muscle cell

Marker Score Threshold: 2,195
(Derived using integrated single-cell and genomic data)

Description: A smooth muscle cell that is part of the ciliary body.

Synonyms: smooth muscle cell of ciliary body

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: DTNA (ENSG00000134769)
    Fold Change: 3.99
    Ensembl ID: ENSG00000134769
  • Gene Symbol: DGKG (ENSG00000058866)
    Fold Change: 3.91
    Ensembl ID: ENSG00000058866
  • Gene Symbol: ADGRB3 (ENSG00000135298)
    Fold Change: 3.83
    Ensembl ID: ENSG00000135298
  • Gene Symbol: DLG2 (ENSG00000150672)
    Fold Change: 3.81
    Ensembl ID: ENSG00000150672
  • Gene Symbol: CHRM3 (ENSG00000133019)
    Fold Change: 3.81
    Ensembl ID: ENSG00000133019
  • Gene Symbol: AFF3 (ENSG00000144218)
    Fold Change: 3.78
    Ensembl ID: ENSG00000144218
  • Gene Symbol: ZFHX3 (ENSG00000140836)
    Fold Change: 3.78
    Ensembl ID: ENSG00000140836
  • Gene Symbol: NRG1 (ENSG00000157168)
    Fold Change: 3.7
    Ensembl ID: ENSG00000157168
  • Gene Symbol: EPS8 (ENSG00000151491)
    Fold Change: 3.62
    Ensembl ID: ENSG00000151491
  • Gene Symbol: GNG7 (ENSG00000176533)
    Fold Change: 3.61
    Ensembl ID: ENSG00000176533
  • Gene Symbol: IGF1R (ENSG00000140443)
    Fold Change: 3.61
    Ensembl ID: ENSG00000140443
  • Gene Symbol: DMD (ENSG00000198947)
    Fold Change: 3.61
    Ensembl ID: ENSG00000198947
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 3.59
    Ensembl ID: ENSG00000075624
  • Gene Symbol: KCNN2 (ENSG00000080709)
    Fold Change: 3.57
    Ensembl ID: ENSG00000080709
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 3.55
    Ensembl ID: ENSG00000142599
  • Gene Symbol: ATP2A2 (ENSG00000174437)
    Fold Change: 3.54
    Ensembl ID: ENSG00000174437
  • Gene Symbol: COL4A2 (ENSG00000134871)
    Fold Change: 3.54
    Ensembl ID: ENSG00000134871
  • Gene Symbol: COL4A5 (ENSG00000188153)
    Fold Change: 3.53
    Ensembl ID: ENSG00000188153
  • Gene Symbol: LPP (ENSG00000145012)
    Fold Change: 3.53
    Ensembl ID: ENSG00000145012
  • Gene Symbol: CDH6 (ENSG00000113361)
    Fold Change: 3.51
    Ensembl ID: ENSG00000113361
  • Gene Symbol: A2M (ENSG00000175899)
    Fold Change: 3.5
    Ensembl ID: ENSG00000175899
  • Gene Symbol: CACNB2 (ENSG00000165995)
    Fold Change: 3.5
    Ensembl ID: ENSG00000165995
  • Gene Symbol: CALD1 (ENSG00000122786)
    Fold Change: 3.49
    Ensembl ID: ENSG00000122786
  • Gene Symbol: KCNJ3 (ENSG00000162989)
    Fold Change: 3.46
    Ensembl ID: ENSG00000162989
  • Gene Symbol: BMPR1A (ENSG00000107779)
    Fold Change: 3.46
    Ensembl ID: ENSG00000107779
  • Gene Symbol: FBN2 (ENSG00000138829)
    Fold Change: 3.46
    Ensembl ID: ENSG00000138829
  • Gene Symbol: ITPR1 (ENSG00000150995)
    Fold Change: 3.44
    Ensembl ID: ENSG00000150995
  • Gene Symbol: HNRNPU (ENSG00000153187)
    Fold Change: 3.42
    Ensembl ID: ENSG00000153187
  • Gene Symbol: ABLIM1 (ENSG00000099204)
    Fold Change: 3.41
    Ensembl ID: ENSG00000099204
  • Gene Symbol: FGF13 (ENSG00000129682)
    Fold Change: 3.39
    Ensembl ID: ENSG00000129682
  • Gene Symbol: IGFBP7 (ENSG00000163453)
    Fold Change: 3.38
    Ensembl ID: ENSG00000163453
  • Gene Symbol: INPP4A (ENSG00000040933)
    Fold Change: 3.38
    Ensembl ID: ENSG00000040933
  • Gene Symbol: FER (ENSG00000151422)
    Fold Change: 3.38
    Ensembl ID: ENSG00000151422
  • Gene Symbol: FGFR2 (ENSG00000066468)
    Fold Change: 3.37
    Ensembl ID: ENSG00000066468
  • Gene Symbol: CNTN1 (ENSG00000018236)
    Fold Change: 3.37
    Ensembl ID: ENSG00000018236
  • Gene Symbol: ETV6 (ENSG00000139083)
    Fold Change: 3.34
    Ensembl ID: ENSG00000139083
  • Gene Symbol: FLNB (ENSG00000136068)
    Fold Change: 3.32
    Ensembl ID: ENSG00000136068
  • Gene Symbol: GUCY1A1 (ENSG00000164116)
    Fold Change: 3.28
    Ensembl ID: ENSG00000164116
  • Gene Symbol: EFNA5 (ENSG00000184349)
    Fold Change: 3.27
    Ensembl ID: ENSG00000184349
  • Gene Symbol: ITPKB (ENSG00000143772)
    Fold Change: 3.26
    Ensembl ID: ENSG00000143772
  • Gene Symbol: GOLGA4 (ENSG00000144674)
    Fold Change: 3.25
    Ensembl ID: ENSG00000144674
  • Gene Symbol: CBLB (ENSG00000114423)
    Fold Change: 3.22
    Ensembl ID: ENSG00000114423
  • Gene Symbol: DLG1 (ENSG00000075711)
    Fold Change: 3.22
    Ensembl ID: ENSG00000075711
  • Gene Symbol: DOCK3 (ENSG00000088538)
    Fold Change: 3.2
    Ensembl ID: ENSG00000088538
  • Gene Symbol: ELF2 (ENSG00000109381)
    Fold Change: 3.12
    Ensembl ID: ENSG00000109381
  • Gene Symbol: CACNA2D1 (ENSG00000153956)
    Fold Change: 3.11
    Ensembl ID: ENSG00000153956
  • Gene Symbol: FKBP5 (ENSG00000096060)
    Fold Change: 3.1
    Ensembl ID: ENSG00000096060
  • Gene Symbol: DYRK1A (ENSG00000157540)
    Fold Change: 3.09
    Ensembl ID: ENSG00000157540
  • Gene Symbol: JAK1 (ENSG00000162434)
    Fold Change: 3.07
    Ensembl ID: ENSG00000162434
  • Gene Symbol: ACTN1 (ENSG00000072110)
    Fold Change: 3.06
    Ensembl ID: ENSG00000072110
  • Gene Symbol: FOXN3 (ENSG00000053254)
    Fold Change: 3.05
    Ensembl ID: ENSG00000053254
  • Gene Symbol: GLS (ENSG00000115419)
    Fold Change: 3.05
    Ensembl ID: ENSG00000115419
  • Gene Symbol: CUX1 (ENSG00000257923)
    Fold Change: 3.04
    Ensembl ID: ENSG00000257923
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 3.03
    Ensembl ID: ENSG00000077549
  • Gene Symbol: DDX5 (ENSG00000108654)
    Fold Change: 3.02
    Ensembl ID: ENSG00000108654
  • Gene Symbol: RUNX1T1 (ENSG00000079102)
    Fold Change: 3.01
    Ensembl ID: ENSG00000079102
  • Gene Symbol: GCNT1 (ENSG00000187210)
    Fold Change: 3
    Ensembl ID: ENSG00000187210
  • Gene Symbol: DYNC1I1 (ENSG00000158560)
    Fold Change: 3
    Ensembl ID: ENSG00000158560
  • Gene Symbol: FHIT (ENSG00000189283)
    Fold Change: 2.96
    Ensembl ID: ENSG00000189283
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 2.96
    Ensembl ID: ENSG00000085224
  • Gene Symbol: ADCY5 (ENSG00000173175)
    Fold Change: 2.92
    Ensembl ID: ENSG00000173175
  • Gene Symbol: HNRNPC (ENSG00000092199)
    Fold Change: 2.91
    Ensembl ID: ENSG00000092199
  • Gene Symbol: ACTA2 (ENSG00000107796)
    Fold Change: 2.9
    Ensembl ID: ENSG00000107796
  • Gene Symbol: FLNA (ENSG00000196924)
    Fold Change: 2.89
    Ensembl ID: ENSG00000196924
  • Gene Symbol: HIF1A (ENSG00000100644)
    Fold Change: 2.89
    Ensembl ID: ENSG00000100644
  • Gene Symbol: LDLRAD4 (ENSG00000168675)
    Fold Change: 2.89
    Ensembl ID: ENSG00000168675
  • Gene Symbol: DIAPH2 (ENSG00000147202)
    Fold Change: 2.88
    Ensembl ID: ENSG00000147202
  • Gene Symbol: LAMC1 (ENSG00000135862)
    Fold Change: 2.87
    Ensembl ID: ENSG00000135862
  • Gene Symbol: CSRP2 (ENSG00000175183)
    Fold Change: 2.85
    Ensembl ID: ENSG00000175183
  • Gene Symbol: KTN1 (ENSG00000126777)
    Fold Change: 2.85
    Ensembl ID: ENSG00000126777
  • Gene Symbol: HNRNPA2B1 (ENSG00000122566)
    Fold Change: 2.81
    Ensembl ID: ENSG00000122566
  • Gene Symbol: DPYSL3 (ENSG00000113657)
    Fold Change: 2.81
    Ensembl ID: ENSG00000113657
  • Gene Symbol: HSPG2 (ENSG00000142798)
    Fold Change: 2.8
    Ensembl ID: ENSG00000142798
  • Gene Symbol: DST (ENSG00000151914)
    Fold Change: 2.8
    Ensembl ID: ENSG00000151914
  • Gene Symbol: BPTF (ENSG00000171634)
    Fold Change: 2.79
    Ensembl ID: ENSG00000171634
  • Gene Symbol: GSN (ENSG00000148180)
    Fold Change: 2.78
    Ensembl ID: ENSG00000148180
  • Gene Symbol: ACACB (ENSG00000076555)
    Fold Change: 2.78
    Ensembl ID: ENSG00000076555
  • Gene Symbol: GRB10 (ENSG00000106070)
    Fold Change: 2.77
    Ensembl ID: ENSG00000106070
  • Gene Symbol: GABRB1 (ENSG00000163288)
    Fold Change: 2.71
    Ensembl ID: ENSG00000163288
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 2.71
    Ensembl ID: ENSG00000130402
  • Gene Symbol: CHN1 (ENSG00000128656)
    Fold Change: 2.71
    Ensembl ID: ENSG00000128656
  • Gene Symbol: BMPR2 (ENSG00000204217)
    Fold Change: 2.69
    Ensembl ID: ENSG00000204217
  • Gene Symbol: ERBB4 (ENSG00000178568)
    Fold Change: 2.67
    Ensembl ID: ENSG00000178568
  • Gene Symbol: COL4A6 (ENSG00000197565)
    Fold Change: 2.66
    Ensembl ID: ENSG00000197565
  • Gene Symbol: GSK3B (ENSG00000082701)
    Fold Change: 2.66
    Ensembl ID: ENSG00000082701
  • Gene Symbol: APBB2 (ENSG00000163697)
    Fold Change: 2.65
    Ensembl ID: ENSG00000163697
  • Gene Symbol: CAMK2D (ENSG00000145349)
    Fold Change: 2.64
    Ensembl ID: ENSG00000145349
  • Gene Symbol: DPYD (ENSG00000188641)
    Fold Change: 2.64
    Ensembl ID: ENSG00000188641
  • Gene Symbol: CKB (ENSG00000166165)
    Fold Change: 2.62
    Ensembl ID: ENSG00000166165
  • Gene Symbol: INPP5A (ENSG00000068383)
    Fold Change: 2.61
    Ensembl ID: ENSG00000068383
  • Gene Symbol: BRAF (ENSG00000157764)
    Fold Change: 2.59
    Ensembl ID: ENSG00000157764
  • Gene Symbol: UBE2K (ENSG00000078140)
    Fold Change: 2.59
    Ensembl ID: ENSG00000078140
  • Gene Symbol: LAMA3 (ENSG00000053747)
    Fold Change: 2.58
    Ensembl ID: ENSG00000053747
  • Gene Symbol: ITGB1 (ENSG00000150093)
    Fold Change: 2.58
    Ensembl ID: ENSG00000150093
  • Gene Symbol: EPS15 (ENSG00000085832)
    Fold Change: 2.57
    Ensembl ID: ENSG00000085832
  • Gene Symbol: LRBA (ENSG00000198589)
    Fold Change: 2.55
    Ensembl ID: ENSG00000198589
  • Gene Symbol: COL4A3 (ENSG00000169031)
    Fold Change: 2.55
    Ensembl ID: ENSG00000169031
  • Gene Symbol: GAPDH (ENSG00000111640)
    Fold Change: 2.55
    Ensembl ID: ENSG00000111640
  • Gene Symbol: CCNH (ENSG00000134480)
    Fold Change: 2.54
    Ensembl ID: ENSG00000134480
  • Gene Symbol: ANK2 (ENSG00000145362)
    Fold Change: 2.54
    Ensembl ID: ENSG00000145362

Gene ID: A unique numerical identifier for this specific gene.
Symbol: Shortened abbreviation or name that represents this gene.
Ensembl Gene ID: A unique identifier assigned by Ensembl for genomic data mapping.
Fold Change: Indicates the ratio of the gene's expression level in ciliary muscle cell cell compared to a baseline. A fold change greater than 1 suggests significant gene expression.

Gene ID: A unique numerical identifier for this specific gene.
Symbol: Shortened abbreviation or name that represents this gene.
Ensembl Gene ID: A unique identifier assigned by Ensembl for genomic data mapping.
Fold Change: Indicates the ratio of the gene's expression level in ciliary muscle cell cell compared to a baseline. A fold change greater than 1 suggests significant gene expression.
**Key Characteristics** * Cell type: Ciliary muscle cell * Location: Ciliary body * Gene symbols: DTNA, DGKG, ADGRB3, DLG2, CHRM3, AFF3, ZFHX3, NRG1 * Gene functions: + DTNA: involved in axon guidance + DGKG: involved in diacylglycerol metabolic process + ADGRB3: involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway + DLG2: involved in activation of NMDA receptors and postsynaptic events + CHRM3: involved in acetylcholine receptor signaling pathway + AFF3: involved in DNA-binding transcription factor activity + ZFHX3: involved in chromatin and circadian regulation of gene expression + NRG1: involved in activation of NMDA receptors and postsynaptic events, as well as cell communication and differentiation * Signaling pathways: + Axon guidance + Cell adhesion + Neurotransmission + Synaptic transmission * Expression in the nervous system: + Regulates synaptic transmission and cell differentiation + Involved in axon guidance and cell adhesion **Clinical Significance** * The ciliary muscle cell plays a crucial role in regulating pupil size and accommodation for near vision, making it an important target for the treatment of eye disorders such as cataracts and glaucoma. * The genes associated with this cell, including DTNA, DGKG, ADGRB3, DLG2, CHRM3, AFF3, ZFHX3, and NRG1, are involved in various signaling pathways that are relevant to the nervous system and eye health. * Understanding the function and regulation of this cell can provide insights into the development and treatment of eye disorders, as well as other neurological conditions. * The cell's role in regulating synaptic transmission and cell differentiation makes it an important subject for study in the context of neurodegenerative diseases such as Alzheimer's and Parkinson's. **Research Directions** * Further study of the gene functions and signaling pathways associated with this cell can provide insights into the regulation of pupil size and accommodation for near vision. * Investigation of the cell's role in regulating synaptic transmission and cell differentiation can provide insights into the development and treatment of eye disorders and neurodegenerative diseases. * Development of therapeutic strategies targeting the genes and signaling pathways associated with this cell can provide new treatments for eye disorders and neurological conditions. **Conclusion** The ciliary muscle cell is a unique and important cell type that plays a crucial role in regulating pupil size and accommodation for near vision. The genes associated with this cell are involved in various signaling pathways that are relevant to the nervous system and eye health. Further study of the gene functions and signaling pathways associated with this cell can provide insights into the regulation of pupil size and accommodation for near vision, as well as the development and treatment of eye disorders and neurodegenerative diseases.