Details for: RHOB

Gene ID: 388

Symbol: RHOB

Ensembl ID: ENSG00000143878

Description: ras homolog family member B

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 558.4871
    Cell Significance Index: -86.8700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 340.1626
    Cell Significance Index: -86.2800
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 217.7704
    Cell Significance Index: -89.7100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 185.9263
    Cell Significance Index: -87.7800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 167.0927
    Cell Significance Index: -85.9500
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 130.7706
    Cell Significance Index: -87.7500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 70.5865
    Cell Significance Index: -87.0300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 31.2372
    Cell Significance Index: -83.6800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 22.0727
    Cell Significance Index: -87.1000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 20.8533
    Cell Significance Index: -64.0500
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 5.1916
    Cell Significance Index: 31.9500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 4.8384
    Cell Significance Index: 129.6500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 4.3645
    Cell Significance Index: 125.1100
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 3.0694
    Cell Significance Index: 54.2400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.8590
    Cell Significance Index: 392.6200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.6539
    Cell Significance Index: 69.7900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 2.4837
    Cell Significance Index: 447.7400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 2.4812
    Cell Significance Index: 318.0700
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.3695
    Cell Significance Index: 30.3500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.8177
    Cell Significance Index: 223.5000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.5999
    Cell Significance Index: 119.2400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.5314
    Cell Significance Index: 677.0900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.5139
    Cell Significance Index: 71.1500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.4053
    Cell Significance Index: 73.0000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.3978
    Cell Significance Index: 65.1700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.3410
    Cell Significance Index: 86.5200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.2977
    Cell Significance Index: 28.1200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.1525
    Cell Significance Index: 81.5100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.1222
    Cell Significance Index: 612.8400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.0910
    Cell Significance Index: 31.4400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.9464
    Cell Significance Index: 8.7200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.8199
    Cell Significance Index: 37.1700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.7921
    Cell Significance Index: 16.5800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.7809
    Cell Significance Index: 100.8900
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.7085
    Cell Significance Index: 11.9400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.5567
    Cell Significance Index: 10.2900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4780
    Cell Significance Index: 431.5600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4546
    Cell Significance Index: 86.5200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4011
    Cell Significance Index: 79.5900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3666
    Cell Significance Index: 36.2700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.3295
    Cell Significance Index: 8.9700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.3098
    Cell Significance Index: 52.9000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2239
    Cell Significance Index: 36.4100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2042
    Cell Significance Index: 40.9600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1408
    Cell Significance Index: 15.3200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.1329
    Cell Significance Index: 38.2500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0760
    Cell Significance Index: 7.7700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0753
    Cell Significance Index: 27.0000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0484
    Cell Significance Index: 36.6400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0479
    Cell Significance Index: 90.1300
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.0433
    Cell Significance Index: 0.2000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0116
    Cell Significance Index: -15.8200
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0183
    Cell Significance Index: -0.2700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0202
    Cell Significance Index: -9.1500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0247
    Cell Significance Index: -15.6900
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0331
    Cell Significance Index: -0.2000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0335
    Cell Significance Index: -3.9500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0348
    Cell Significance Index: -0.9300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0358
    Cell Significance Index: -22.3500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0536
    Cell Significance Index: -98.7700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0542
    Cell Significance Index: -40.1300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0637
    Cell Significance Index: -46.7000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0645
    Cell Significance Index: -99.3500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1227
    Cell Significance Index: -69.2100
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.1240
    Cell Significance Index: -0.8400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1984
    Cell Significance Index: -3.3200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2721
    Cell Significance Index: -57.3200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2842
    Cell Significance Index: -32.5600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.3058
    Cell Significance Index: -10.7500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.3165
    Cell Significance Index: -21.8900
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.3409
    Cell Significance Index: -7.8700
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.3450
    Cell Significance Index: -5.1700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.4244
    Cell Significance Index: -49.4600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4346
    Cell Significance Index: -22.8200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.4586
    Cell Significance Index: -27.5300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.4829
    Cell Significance Index: -70.2000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.4959
    Cell Significance Index: -56.6100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.6479
    Cell Significance Index: -7.3600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.6770
    Cell Significance Index: -51.9600
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.6945
    Cell Significance Index: -7.5500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.6971
    Cell Significance Index: -72.5800
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.8453
    Cell Significance Index: -7.1000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.8996
    Cell Significance Index: -31.2600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.9823
    Cell Significance Index: -77.8000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.9936
    Cell Significance Index: -66.8100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -1.1298
    Cell Significance Index: -69.4500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -1.1541
    Cell Significance Index: -47.2900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -1.1703
    Cell Significance Index: -59.1500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -1.2170
    Cell Significance Index: -34.0100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.3036
    Cell Significance Index: -79.9200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.3282
    Cell Significance Index: -42.5400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -1.3327
    Cell Significance Index: -26.0100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -1.4020
    Cell Significance Index: -88.3700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -1.4378
    Cell Significance Index: -80.6800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -1.6284
    Cell Significance Index: -43.5600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.7671
    Cell Significance Index: -52.0500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.8064
    Cell Significance Index: -66.3100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -1.8906
    Cell Significance Index: -47.2600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.9409
    Cell Significance Index: -85.8500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -2.1181
    Cell Significance Index: -45.1100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** RHOB is a small GTP-binding protein that belongs to the Rho family of GTPases. It is characterized by its ability to bind and hydrolyze GTP, which regulates its activity and interaction with other proteins. RHOB is highly expressed in various cell types, including those involved in immune responses, such as monocytes and endothelial cells. Its expression is also significant in tissues involved in development and morphogenesis, such as the adrenal gland and lung. **Pathways and Functions:** RHOB is involved in various signaling pathways that regulate cell migration, adhesion, and cytoskeletal organization. Some of the key pathways include: 1. **Rho GTPase cycle:** RHOB interacts with other Rho GTPases to modulate the Rho GTPase cycle, which regulates actin filament organization and cell migration. 2. **G protein-coupled receptor (GPCR) signaling:** RHOB interacts with GPCRs to modulate signaling pathways involved in cell migration and adhesion. 3. **Cytoskeleton organization:** RHOB regulates the organization of the cytoskeleton, including actin filaments, microtubules, and intermediate filaments. 4. **Cell migration and adhesion:** RHOB regulates cell migration and adhesion by modulating the activity of adhesion molecules and the cytoskeleton. 5. **Apoptosis and programmed cell death:** RHOB has been shown to regulate apoptosis and programmed cell death by interacting with pro-apoptotic and anti-apoptotic proteins. **Clinical Significance:** RHOB has been implicated in various diseases and disorders, including: 1. **Cancer:** RHOB is overexpressed in certain types of cancer, including breast, lung, and colon cancer. 2. **Cardiovascular disease:** RHOB is involved in the regulation of blood pressure and cardiovascular disease. 3. **Neurological disorders:** RHOB has been implicated in neurological disorders, including Alzheimer's disease and Parkinson's disease. 4. **Immune responses:** RHOB is involved in the regulation of immune responses, including inflammation and immune cell migration. In conclusion, RHOB is a complex gene that plays a crucial role in regulating various cellular processes, including cell migration, differentiation, and morphogenesis. Its involvement in various diseases and disorders highlights the importance of RHOB in maintaining tissue homeostasis and overall health. Further research is needed to fully understand the functions and clinical significance of RHOB.

Genular Protein ID: 2177450017

Symbol: RHOB_HUMAN

Name: Rho-related GTP-binding protein RhoB

UniProtKB Accession Codes:

P62745 B2R692 P01121 Q5U0H6 Q7RTN5 Q7RTR9 Q9CUV7

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 3 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 14 Ensembl 1 EvolutionaryTrace 1 GO 33 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 9 RefSeq 1 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3283705

Title: Coding sequence of human rho cDNAs clone 6 and clone 9.

PubMed ID: 3283705

DOI: 10.1093/nar/16.6.2717

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3888408

Title: A novel ras-related gene family.

PubMed ID: 3888408

DOI: 10.1016/0092-8674(85)90058-3

PubMed ID: 9478917

Title: PRK1 is targeted to endosomes by the small GTPase, RhoB.

PubMed ID: 9478917

DOI: 10.1074/jbc.273.9.4811

PubMed ID: 10508588

Title: Regulation of epidermal growth factor receptor traffic by the small GTPase rhoB.

PubMed ID: 10508588

DOI: 10.1016/s0960-9822(99)80422-9

PubMed ID: 15226397

Title: Farnesyltransferase inhibitors disrupt EGF receptor traffic through modulation of the RhoB GTPase.

PubMed ID: 15226397

DOI: 10.1242/jcs.01193

PubMed ID: 7537292

Title: Ultrastructural localization of ras-related proteins using epitope-tagged plasmids.

PubMed ID: 7537292

DOI: 10.1177/43.5.7537292

PubMed ID: 1400319

Title: Post-translational modifications of p21rho proteins.

PubMed ID: 1400319

DOI: 10.1016/s0021-9258(19)88661-1

PubMed ID: 7713879

Title: CAAX geranylgeranyl transferase transfers farnesyl as efficiently as geranylgeranyl to RhoB.

PubMed ID: 7713879

DOI: 10.1074/jbc.270.14.7864

PubMed ID: 11546812

Title: AKAP-Lbc anchors protein kinase A and nucleates Galpha 12-selective Rho-mediated stress fiber formation.

PubMed ID: 11546812

DOI: 10.1074/jbc.m106629200

PubMed ID: 12221096

Title: XPLN, a guanine nucleotide exchange factor for RhoA and RhoB, but not RhoC.

PubMed ID: 12221096

DOI: 10.1074/jbc.m207401200

PubMed ID: 16236794

Title: Dissecting the role of Rho-mediated signaling in contractile ring formation.

PubMed ID: 16236794

DOI: 10.1091/mbc.e05-06-0569

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21373644

Title: The nuclear guanine nucleotide exchange factors Ect2 and Net1 regulate RhoB-mediated cell death after DNA damage.

PubMed ID: 21373644

DOI: 10.1371/journal.pone.0017108

PubMed ID: 24141704

Title: A bacterial toxin catalyzing tyrosine glycosylation of Rho and deamidation of Gq and Gi proteins.

PubMed ID: 24141704

DOI: 10.1038/nsmb.2688

PubMed ID: 24905543

Title: Haemorrhagic toxin and lethal toxin from Clostridium sordellii strain vpi9048: molecular characterization and comparative analysis of substrate specificity of the large clostridial glucosylating toxins.

PubMed ID: 24905543

DOI: 10.1111/cmi.12321

PubMed ID: 27807006

Title: RHO binding to FAM65A regulates Golgi reorientation during cell migration.

PubMed ID: 27807006

DOI: 10.1242/jcs.198614

Sequence Information:

  • Length: 196
  • Mass: 22123
  • Checksum: CCE6FD53AE00CD83
  • Sequence:
    • MAAIRKKLVV VGDGACGKTC LLIVFSKDEF PEVYVPTVFE NYVADIEVDG KQVELALWDT 
AGQEDYDRLR PLSYPDTDVI LMCFSVDSPD SLENIPEKWV PEVKHFCPNV PIILVANKKD 
LRSDEHVRTE LARMKQEPVR TDDGRAMAVR IQAYDYLECS AKTKEGVREV FETATRAALQ 
KRYGSQNGCI NCCKVL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.