Details for: RHOB
Gene ID: 388
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: RHOB
Ensembl ID: ENSG00000143878
Description: ras homolog family member B
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 68.6rCSI 53.18%PRS 13.02
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CSI 65.68rCSI 68.8%PRS 12.71
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CSI 65.57rCSI 50.52%PRS 12.4
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CSI 50.75rCSI 44.63%PRS 9.9
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CSI 47.13rCSI 64.12%PRS 20.81
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CSI 40.06rCSI 57.17%PRS 15.4
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CSI 36.09rCSI 86.61%PRS 24.65
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CSI 31.31rCSI 42.8%PRS 15.49
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CSI 30.86rCSI 29.68%PRS 28.16
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CSI 30.12rCSI 27.65%PRS 15.66
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CSI 28.67rCSI 78.78%PRS 22.49
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CSI 28.6rCSI 41.91%PRS 58.96
-
CSI 25.68rCSI 74.35%PRS 15.49
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CSI 25.62rCSI 24.71%PRS 9.49
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CSI 23.32rCSI 23.76%PRS 19.53
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CSI 22.56rCSI 28.93%PRS 15.77
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CSI 21.66rCSI 28.38%PRS 19.12
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CSI 21.35rCSI 56.21%PRS 26.66
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CSI 21.23rCSI 20.43%PRS 14.15
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CSI 21.1rCSI 50.32%PRS 39.73
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CSI 21.01rCSI 74.57%PRS 22.3
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CSI 20.7rCSI 16.82%PRS 14.41
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CSI 19.99rCSI 38.87%PRS 13.94
-
CSI 18.94rCSI 15.87%PRS 16.34
-
CSI 18.92rCSI 29.87%PRS 13.67
-
CSI 16.97rCSI 32.08%PRS 29.5
-
CSI 16.94rCSI 54.34%PRS 19.92
-
CSI 16.76rCSI 88.1%PRS 24.31
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CSI 16.74rCSI 16.53%PRS 50.15
-
CSI 16.67rCSI 38.01%PRS 14.22
-
CSI 14.94rCSI 28.04%PRS 26.88
-
CSI 14.55rCSI 38.39%PRS 16.31
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CSI 14.38rCSI 12.76%PRS 13.65
-
CSI 14rCSI 49.12%PRS 24.62
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CSI 13.72rCSI 74.71%PRS 33.44
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CSI 13.35rCSI 10.03%PRS 14.2
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CSI 13.07rCSI 24.93%PRS 21.77
-
CSI 12.96rCSI 22.2%PRS 18.32
-
CSI 12.64rCSI 17.5%PRS 19.61
-
CSI 12.51rCSI 56.59%PRS 47.42
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CSI 12.18rCSI 22.33%PRS 51.22
-
CSI 12.05rCSI 12.48%PRS 16.03
-
CSI 11.91rCSI 24.72%PRS 13.63
-
CSI 11.82rCSI 38.34%PRS 16.67
-
CSI 11.71rCSI 52.17%PRS 37.05
-
CSI 11.68rCSI 18.65%PRS 14.95
-
CSI 11.63rCSI 17.87%PRS 19.35
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CSI 11.53rCSI 46.08%PRS 29.68
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CSI 11.41rCSI 16.71%PRS 15.91
-
CSI 11.3rCSI 26.36%PRS 32.18
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CSI 11.08rCSI 54.62%PRS 18.52
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CSI 11.04rCSI 51.67%PRS 27.75
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CSI 11.01rCSI 30.84%PRS 21.09
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CSI 10.92rCSI 14.92%PRS 15.12
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CSI 10.86rCSI 16.06%PRS 15.72
-
CSI 10.6rCSI 29.81%PRS 19.37
-
CSI 10.59rCSI 17.44%PRS 15.9
-
CSI 10.53rCSI 22.42%PRS 21.96
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CSI 10.25rCSI 16.43%PRS 40.95
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CSI 10.09rCSI 9.93%PRS 14.84
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CSI 9.97rCSI 14.37%PRS 21.86
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CSI 9.88rCSI 24.76%PRS 39.02
-
CSI 9.8rCSI 9.26%PRS 14.24
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CSI 9.42rCSI 10.92%PRS 20.15
-
CSI 9.27rCSI 74.03%PRS 52.45
-
CSI 9.23rCSI 6.86%PRS 20.21
-
CSI 9.06rCSI 8.37%PRS 24.86
-
CSI 9rCSI 37.82%PRS 34.56
-
CSI 8.93rCSI 7.06%PRS 9.39
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CSI 8.87rCSI 7.71%PRS 16.86
-
CSI 8.64rCSI 13.4%PRS 20.75
-
CSI 8.46rCSI 7.87%PRS 13.67
-
CSI 8.43rCSI 9.74%PRS 9.99
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CSI 8.26rCSI 47.41%PRS 46.18
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CSI 7.92rCSI 5.99%PRS 18.85
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CSI 7.81rCSI 14.21%PRS 50.65
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CSI 7.69rCSI 23.7%PRS 20.76
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CSI 7.59rCSI 32.79%PRS 25.97
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CSI 7.59rCSI 8.31%PRS 15.59
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CSI 7.54rCSI 5.24%PRS 16.04
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CSI 7.52rCSI 41.94%PRS 38.01
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CSI 7.48rCSI 11.43%PRS 15.63
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CSI 7.44rCSI 14.73%PRS 34.88
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CSI 7.37rCSI 9.8%PRS 14.93
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CSI 7.34rCSI 44.4%PRS 30.25
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CSI 7.31rCSI 13.95%PRS 31.61
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CSI 7.04rCSI 16.82%PRS 21.19
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CSI 6.97rCSI 5.2%PRS 22.97
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CSI 6.81rCSI 8.26%PRS 17.86
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CSI 6.73rCSI 9.64%PRS 18.74
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CSI 6.66rCSI 5.74%PRS 21.95
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CSI 6.51rCSI 6.82%PRS 14.59
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CSI 6.51rCSI 11.82%PRS 20.9
-
CSI 6.48rCSI 63.73%PRS 39.41
-
CSI 6.39rCSI 49.01%PRS 45.78
-
CSI 6.37rCSI 18.82%PRS 16.67
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CSI 6.37rCSI 6.65%PRS 39.86
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CSI 6.19rCSI 42.52%PRS 26.61
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CSI 6.17rCSI 7.68%PRS 19.23
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CSI 6.13rCSI 28.73%PRS 36.07
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CSI -4.7rCSI -5.6%PRS 23.7%
-
CSI -2.8rCSI -2.2%PRS 17.9%
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CSI -2.4rCSI -5.8%PRS 7.8%
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CSI -2.3rCSI -14.1%PRS 10.7%
-
CSI -1.8rCSI -56.0%PRS 86.2%
-
CSI -1.5rCSI -3.8%PRS 18.0%
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CSI -0.7rCSI -4.1%PRS 8.4%
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CSI -0.5rCSI -0.9%PRS 10.1%
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CSI -0.3rCSI -0.7%PRS 19.0%
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CSI -0.3rCSI -0.7%PRS 24.1%
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CSI -0.2rCSI -0.3%PRS 8.4%
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CSI -0.1rCSI -0.2%PRS 12.7%
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CSI -0.1rCSI -0.2%PRS 8.6%
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CSI 0.1rCSI 0.2%PRS 9.8%
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CSI 0.1rCSI 0.5%PRS 17.8%
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CSI 0.2rCSI 0.3%PRS 30.5%
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CSI 0.2rCSI 0.9%PRS 17.2%
-
CSI 0.2rCSI 1.9%PRS 69.5%
-
CSI 0.3rCSI 1.6%PRS 48.4%
-
CSI 0.3rCSI 2.4%PRS 51.2%
-
CSI 0.3rCSI 1.5%PRS 26.7%
-
CSI 0.3rCSI 1.5%PRS 45.1%
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CSI 0.3rCSI 7.9%PRS 57.7%
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CSI 0.3rCSI 1.6%PRS 52.4%
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CSI 0.3rCSI 1.1%PRS 9.2%
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CSI 0.4rCSI 1.3%PRS 7.5%
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CSI 0.4rCSI 0.6%PRS 23.9%
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CSI 0.4rCSI 2.0%PRS 24.0%
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CSI 0.4rCSI 3.0%PRS 25.0%
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CSI 0.4rCSI 1.1%PRS 11.5%
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CSI 0.4rCSI 0.9%PRS 27.4%
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CSI 0.4rCSI 0.7%PRS 26.9%
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CSI 0.4rCSI 0.9%PRS 14.6%
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CSI 0.5rCSI 1.2%PRS 12.8%
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CSI 0.5rCSI 5.8%PRS 43.5%
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CSI 0.5rCSI 0.9%PRS 8.0%
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CSI 0.6rCSI 3.0%PRS 25.4%
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CSI 0.6rCSI 3.8%PRS 66.1%
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CSI 0.6rCSI 4.1%PRS 41.0%
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CSI 0.6rCSI 1.2%PRS 22.6%
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CSI 0.6rCSI 1.9%PRS 14.5%
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CSI 0.6rCSI 0.9%PRS 20.2%
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CSI 0.6rCSI 1.0%PRS 10.5%
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CSI 0.6rCSI 1.2%PRS 17.0%
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CSI 0.7rCSI 1.8%PRS 10.4%
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CSI 0.7rCSI 1.2%PRS 10.4%
-
CSI 0.7rCSI 0.9%PRS 12.0%
-
CSI 0.7rCSI 0.9%PRS 14.4%
-
CSI 0.7rCSI 7.2%PRS 38.1%
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CSI 0.7rCSI 5.7%PRS 29.2%
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CSI 0.7rCSI 0.8%PRS 21.9%
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CSI 0.8rCSI 0.7%PRS 21.5%
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CSI 0.8rCSI 10.1%PRS 43.1%
-
CSI 0.8rCSI 6.8%PRS 23.8%
-
CSI 0.8rCSI 3.1%PRS 28.1%
-
CSI 0.8rCSI 1.2%PRS 14.4%
-
CSI 0.8rCSI 8.9%PRS 18.7%
-
CSI 0.9rCSI 21.9%PRS 59.3%
-
CSI 0.9rCSI 1.2%PRS 22.1%
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CSI 0.9rCSI 1.7%PRS 11.1%
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CSI 1.0rCSI 1.2%PRS 13.5%
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CSI 1.0rCSI 1.5%PRS 12.8%
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CSI 1.0rCSI 4.6%PRS 32.2%
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CSI 1.0rCSI 23.8%PRS 45.1%
-
CSI 1.0rCSI 2.2%PRS 8.4%
-
CSI 1.0rCSI 23.4%PRS 24.7%
-
CSI 1.0rCSI 18.5%PRS 39.1%
-
CSI 1.0rCSI 23.7%PRS 74.2%
-
CSI 1.0rCSI 6.0%PRS 20.5%
-
CSI 1.0rCSI 3.8%PRS 48.5%
-
CSI 1.1rCSI 1.3%PRS 17.2%
-
CSI 1.1rCSI 1.9%PRS 8.0%
-
CSI 1.1rCSI 6.7%PRS 50.6%
-
CSI 1.1rCSI 1.6%PRS 12.7%
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CSI 1.1rCSI 4.8%PRS 24.4%
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CSI 1.1rCSI 1.7%PRS 16.0%
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CSI 1.2rCSI 2.1%PRS 23.1%
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CSI 1.2rCSI 6.3%PRS 48.6%
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CSI 1.2rCSI 1.4%PRS 16.0%
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CSI 1.2rCSI 3.3%PRS 12.7%
-
CSI 1.2rCSI 1.1%PRS 15.4%
-
CSI 1.2rCSI 19.9%PRS 64.3%
-
CSI 1.2rCSI 7.8%PRS 39.3%
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CSI 1.3rCSI 11.6%PRS 38.4%
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CSI 1.3rCSI 5.0%PRS 24.0%
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CSI 1.3rCSI 3.7%PRS 30.2%
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CSI 1.3rCSI 3.3%PRS 13.9%
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CSI 1.3rCSI 3.0%PRS 12.0%
-
CSI 1.4rCSI 3.4%PRS 12.6%
-
CSI 1.4rCSI 24.6%PRS 51.7%
-
CSI 1.5rCSI 7.8%PRS 24.5%
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CSI 1.5rCSI 1.3%PRS 20.6%
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CSI 1.5rCSI 3.9%PRS 22.4%
-
CSI 1.5rCSI 2.0%PRS 18.1%
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CSI 1.6rCSI 17.0%PRS 24.6%
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CSI 1.6rCSI 2.1%PRS 26.1%
-
CSI 1.6rCSI 2.3%PRS 21.5%
-
CSI 1.6rCSI 8.8%PRS 23.0%
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CSI 1.7rCSI 2.1%PRS 15.9%
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CSI 1.7rCSI 5.0%PRS 10.8%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 2177450017
Symbol: RHOB_HUMAN
Name: Rho-related GTP-binding protein RhoB
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 3283705
Title: Coding sequence of human rho cDNAs clone 6 and clone 9.
PubMed ID: 3283705
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15815621
Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
PubMed ID: 15815621
DOI: 10.1038/nature03466
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 3888408
PubMed ID: 9478917
Title: PRK1 is targeted to endosomes by the small GTPase, RhoB.
PubMed ID: 9478917
PubMed ID: 10508588
Title: Regulation of epidermal growth factor receptor traffic by the small GTPase rhoB.
PubMed ID: 10508588
PubMed ID: 15226397
Title: Farnesyltransferase inhibitors disrupt EGF receptor traffic through modulation of the RhoB GTPase.
PubMed ID: 15226397
DOI: 10.1242/jcs.01193
PubMed ID: 7537292
Title: Ultrastructural localization of ras-related proteins using epitope-tagged plasmids.
PubMed ID: 7537292
DOI: 10.1177/43.5.7537292
PubMed ID: 1400319
Title: Post-translational modifications of p21rho proteins.
PubMed ID: 1400319
PubMed ID: 7713879
Title: CAAX geranylgeranyl transferase transfers farnesyl as efficiently as geranylgeranyl to RhoB.
PubMed ID: 7713879
PubMed ID: 11546812
Title: AKAP-Lbc anchors protein kinase A and nucleates Galpha 12-selective Rho-mediated stress fiber formation.
PubMed ID: 11546812
PubMed ID: 12221096
Title: XPLN, a guanine nucleotide exchange factor for RhoA and RhoB, but not RhoC.
PubMed ID: 12221096
PubMed ID: 16236794
Title: Dissecting the role of Rho-mediated signaling in contractile ring formation.
PubMed ID: 16236794
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21373644
Title: The nuclear guanine nucleotide exchange factors Ect2 and Net1 regulate RhoB-mediated cell death after DNA damage.
PubMed ID: 21373644
PubMed ID: 24141704
Title: A bacterial toxin catalyzing tyrosine glycosylation of Rho and deamidation of Gq and Gi proteins.
PubMed ID: 24141704
DOI: 10.1038/nsmb.2688
PubMed ID: 24905543
Title: Haemorrhagic toxin and lethal toxin from Clostridium sordellii strain vpi9048: molecular characterization and comparative analysis of substrate specificity of the large clostridial glucosylating toxins.
PubMed ID: 24905543
DOI: 10.1111/cmi.12321
PubMed ID: 27807006
Title: RHO binding to FAM65A regulates Golgi reorientation during cell migration.
PubMed ID: 27807006
DOI: 10.1242/jcs.198614
Sequence Information:
- Length: 196
- Mass: 22123
- Checksum: CCE6FD53AE00CD83
- Sequence:
MAAIRKKLVV VGDGACGKTC LLIVFSKDEF PEVYVPTVFE NYVADIEVDG KQVELALWDT AGQEDYDRLR PLSYPDTDVI LMCFSVDSPD SLENIPEKWV PEVKHFCPNV PIILVANKKD LRSDEHVRTE LARMKQEPVR TDDGRAMAVR IQAYDYLECS AKTKEGVREV FETATRAALQ KRYGSQNGCI NCCKVL