Details for: RHOB

Gene ID: 388

Symbol: RHOB

Ensembl ID: ENSG00000143878

Description: ras homolog family member B

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 4.33
    Marker Score: 5635
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 3.93
    Marker Score: 5685
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 3.77
    Marker Score: 9587
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 3.57
    Marker Score: 63427
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 3.26
    Marker Score: 2810
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 3.23
    Marker Score: 6068
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 3.16
    Marker Score: 3377.5
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 3.13
    Marker Score: 106513.5
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 2.99
    Marker Score: 19103
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 2.77
    Marker Score: 6687
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.71
    Marker Score: 11670
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 2.69
    Marker Score: 1457
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 2.56
    Marker Score: 4198
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 2.52
    Marker Score: 1658
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 2.52
    Marker Score: 1789
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 2.51
    Marker Score: 3640
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 2.49
    Marker Score: 2495
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 2.49
    Marker Score: 5644
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 2.48
    Marker Score: 8815
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 2.45
    Marker Score: 12877
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 2.43
    Marker Score: 4731
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 2.43
    Marker Score: 564
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 2.42
    Marker Score: 2774
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.41
    Marker Score: 15693
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 2.4
    Marker Score: 3322
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 2.39
    Marker Score: 61252
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 2.38
    Marker Score: 2563
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 2.37
    Marker Score: 7432
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 2.34
    Marker Score: 2917
  • Cell Name: pericyte (CL0000669)
    Fold Change: 2.34
    Marker Score: 1365
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 2.32
    Marker Score: 2183
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.3
    Marker Score: 3392
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 2.26
    Marker Score: 1205
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 2.26
    Marker Score: 575
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 2.25
    Marker Score: 2148
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 2.25
    Marker Score: 852
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 2.22
    Marker Score: 1150.5
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 2.19
    Marker Score: 2223
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 2.18
    Marker Score: 2091
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 2.18
    Marker Score: 889
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 2.17
    Marker Score: 627
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 2.15
    Marker Score: 1412
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 2.14
    Marker Score: 3399
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 2.12
    Marker Score: 4225
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 2.1
    Marker Score: 1397
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 2.1
    Marker Score: 595
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 2.1
    Marker Score: 5788
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 2.09
    Marker Score: 5479
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.06
    Marker Score: 4695
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.04
    Marker Score: 22978
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 2.03
    Marker Score: 851
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 2.03
    Marker Score: 1820
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 2.03
    Marker Score: 1692
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 2.02
    Marker Score: 1265.5
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 2
    Marker Score: 1935
  • Cell Name: neural cell (CL0002319)
    Fold Change: 2
    Marker Score: 963
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.99
    Marker Score: 7371
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 1.99
    Marker Score: 741
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 1.98
    Marker Score: 9745
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 1.98
    Marker Score: 1936
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.96
    Marker Score: 1957
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 1.95
    Marker Score: 12696
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.95
    Marker Score: 483
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 1.94
    Marker Score: 11496
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.92
    Marker Score: 3246.5
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.91
    Marker Score: 1652
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.89
    Marker Score: 7274
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.88
    Marker Score: 465
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.88
    Marker Score: 5108
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 1.88
    Marker Score: 966
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 1.87
    Marker Score: 921
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 1.85
    Marker Score: 450
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 1.85
    Marker Score: 637
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 1.84
    Marker Score: 761
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.83
    Marker Score: 1009
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.81
    Marker Score: 1948.5
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 1.8
    Marker Score: 528
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 1.8
    Marker Score: 2222
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 1.8
    Marker Score: 931
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.79
    Marker Score: 1021.5
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.79
    Marker Score: 1913
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 1.78
    Marker Score: 1216
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.77
    Marker Score: 829
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 1.77
    Marker Score: 560
  • Cell Name: glomerular endothelial cell (CL0002188)
    Fold Change: 1.77
    Marker Score: 448
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 1.76
    Marker Score: 1034
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 1.76
    Marker Score: 10720.5
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 1.76
    Marker Score: 2059
  • Cell Name: theca cell (CL0000503)
    Fold Change: 1.76
    Marker Score: 1259
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.76
    Marker Score: 505
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 1.75
    Marker Score: 1096
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.74
    Marker Score: 1187
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.74
    Marker Score: 2004
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.73
    Marker Score: 17378
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 1.72
    Marker Score: 1134
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 1.72
    Marker Score: 7157
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.72
    Marker Score: 396
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.72
    Marker Score: 945
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 1.71
    Marker Score: 1549
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.71
    Marker Score: 1916

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Other Information

**Key characteristics:** - RHOB is a GTPase that is highly expressed in the cardiovascular, pulmonary, and immune systems. - It is a key regulator of cell migration, proliferation, and differentiation. - RHOB is involved in the regulation of cell cycle progression, apoptosis, and inflammation. - It is also involved in the regulation of platelet activation and aggregation. **Pathways and functions:** - RHOB is a key regulator of axon guidance by binding to specific receptors and signaling through the G alpha (12/13) pathway. - It is also involved in the regulation of developmental biology, Gpcr downstream signalling, Gpvi-mediated activation cascade, Hemostasis, Nervous system development, Platelet activation, signaling and aggregation, Rho gtpase cycle, Rho gtpase effectors, Rho gtpases activate cit, Rho gtpases activate formins, Rho gtpases activate pkns, Rho gtpases activate rocks, Sema4d in semaphorin signaling, Semaphorin interactions, Signaling by gpcr, Signaling by rho gtpases, Signaling by rho gtpases, miro gtpases and rhobtb3. **Clinical significance:** - Mutations in RHOB have been linked to several human diseases, including autism, cardiovascular disease, and cancer. - RHOB inhibitors are being investigated as potential therapeutic agents for these diseases.

Genular Protein ID: 2177450017

Symbol: RHOB_HUMAN

Name: Rho-related GTP-binding protein RhoB

UniProtKB Accession Codes:

P62745 B2R692 P01121 Q5U0H6 Q7RTN5 Q7RTR9 Q9CUV7

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 3 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 14 EPD 1 Ensembl 1 EvolutionaryTrace 1 GO 33 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 3 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 9 RefSeq 1 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3283705

Title: Coding sequence of human rho cDNAs clone 6 and clone 9.

PubMed ID: 3283705

DOI: 10.1093/nar/16.6.2717

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3888408

Title: A novel ras-related gene family.

PubMed ID: 3888408

DOI: 10.1016/0092-8674(85)90058-3

PubMed ID: 9478917

Title: PRK1 is targeted to endosomes by the small GTPase, RhoB.

PubMed ID: 9478917

DOI: 10.1074/jbc.273.9.4811

PubMed ID: 10508588

Title: Regulation of epidermal growth factor receptor traffic by the small GTPase rhoB.

PubMed ID: 10508588

DOI: 10.1016/s0960-9822(99)80422-9

PubMed ID: 15226397

Title: Farnesyltransferase inhibitors disrupt EGF receptor traffic through modulation of the RhoB GTPase.

PubMed ID: 15226397

DOI: 10.1242/jcs.01193

PubMed ID: 7537292

Title: Ultrastructural localization of ras-related proteins using epitope-tagged plasmids.

PubMed ID: 7537292

DOI: 10.1177/43.5.7537292

PubMed ID: 1400319

Title: Post-translational modifications of p21rho proteins.

PubMed ID: 1400319

DOI: 10.1016/s0021-9258(19)88661-1

PubMed ID: 7713879

Title: CAAX geranylgeranyl transferase transfers farnesyl as efficiently as geranylgeranyl to RhoB.

PubMed ID: 7713879

DOI: 10.1074/jbc.270.14.7864

PubMed ID: 11546812

Title: AKAP-Lbc anchors protein kinase A and nucleates Galpha 12-selective Rho-mediated stress fiber formation.

PubMed ID: 11546812

DOI: 10.1074/jbc.m106629200

PubMed ID: 12221096

Title: XPLN, a guanine nucleotide exchange factor for RhoA and RhoB, but not RhoC.

PubMed ID: 12221096

DOI: 10.1074/jbc.m207401200

PubMed ID: 16236794

Title: Dissecting the role of Rho-mediated signaling in contractile ring formation.

PubMed ID: 16236794

DOI: 10.1091/mbc.e05-06-0569

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21373644

Title: The nuclear guanine nucleotide exchange factors Ect2 and Net1 regulate RhoB-mediated cell death after DNA damage.

PubMed ID: 21373644

DOI: 10.1371/journal.pone.0017108

PubMed ID: 24141704

Title: A bacterial toxin catalyzing tyrosine glycosylation of Rho and deamidation of Gq and Gi proteins.

PubMed ID: 24141704

DOI: 10.1038/nsmb.2688

PubMed ID: 24905543

Title: Haemorrhagic toxin and lethal toxin from Clostridium sordellii strain vpi9048: molecular characterization and comparative analysis of substrate specificity of the large clostridial glucosylating toxins.

PubMed ID: 24905543

DOI: 10.1111/cmi.12321

PubMed ID: 27807006

Title: RHO binding to FAM65A regulates Golgi reorientation during cell migration.

PubMed ID: 27807006

DOI: 10.1242/jcs.198614

Sequence Information:

  • Length: 196
  • Mass: 22123
  • Checksum: CCE6FD53AE00CD83
  • Sequence:
    • MAAIRKKLVV VGDGACGKTC LLIVFSKDEF PEVYVPTVFE NYVADIEVDG KQVELALWDT 
AGQEDYDRLR PLSYPDTDVI LMCFSVDSPD SLENIPEKWV PEVKHFCPNV PIILVANKKD 
LRSDEHVRTE LARMKQEPVR TDDGRAMAVR IQAYDYLECS AKTKEGVREV FETATRAALQ 
KRYGSQNGCI NCCKVL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.