Details for: CL0002071

Cell ID: CL0002071

Cell Name: enterocyte of epithelium of large intestine

Marker Score Threshold: 997
(Derived using integrated single-cell and genomic data)

Description: Columnar cell which populate the epithelium of large intestine and absorb water. This cell is the most numerous of the epithelial cell types in the large intestine; bear apical microvilli, contain secretory granules in their apical cytoplasm; secretion appears to be largely mucins, but is also rich in antibodies of the IgA type.

Synonyms: columnar cell, columnar cell of the colon, vacuolar absorptive cell

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 2.09
    Ensembl ID: ENSG00000075624
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.01
    Ensembl ID: ENSG00000184009
  • Gene Symbol: ALPG (ENSG00000163286)
    Fold Change: 2.01
    Ensembl ID: ENSG00000163286
  • Gene Symbol: ASMT (ENSG00000196433)
    Fold Change: 2.01
    Ensembl ID: ENSG00000196433
  • Gene Symbol: ADORA3 (ENSG00000282608)
    Fold Change: 2.01
    Ensembl ID: ENSG00000282608
  • Gene Symbol: CRISP1 (ENSG00000124812)
    Fold Change: 2.01
    Ensembl ID: ENSG00000124812
  • Gene Symbol: ASGR2 (ENSG00000161944)
    Fold Change: 2
    Ensembl ID: ENSG00000161944
  • Gene Symbol: ALOX15 (ENSG00000161905)
    Fold Change: 2
    Ensembl ID: ENSG00000161905
  • Gene Symbol: ASCL1 (ENSG00000139352)
    Fold Change: 2
    Ensembl ID: ENSG00000139352
  • Gene Symbol: ADRB3 (ENSG00000188778)
    Fold Change: 2
    Ensembl ID: ENSG00000188778
  • Gene Symbol: APOA2 (ENSG00000158874)
    Fold Change: 2
    Ensembl ID: ENSG00000158874
  • Gene Symbol: ALDH3B2 (ENSG00000132746)
    Fold Change: 2
    Ensembl ID: ENSG00000132746
  • Gene Symbol: ARR3 (ENSG00000120500)
    Fold Change: 2
    Ensembl ID: ENSG00000120500
  • Gene Symbol: AGT (ENSG00000135744)
    Fold Change: 1.99
    Ensembl ID: ENSG00000135744
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.98
    Ensembl ID: ENSG00000163399
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.96
    Ensembl ID: ENSG00000182718
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 1.96
    Ensembl ID: ENSG00000143878
  • Gene Symbol: AIF1 (ENSG00000204472)
    Fold Change: 1.96
    Ensembl ID: ENSG00000204472
  • Gene Symbol: AREG (ENSG00000109321)
    Fold Change: 1.95
    Ensembl ID: ENSG00000109321
  • Gene Symbol: ATF3 (ENSG00000162772)
    Fold Change: 1.95
    Ensembl ID: ENSG00000162772
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.91
    Ensembl ID: ENSG00000130402
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.87
    Ensembl ID: ENSG00000198931
  • Gene Symbol: RND3 (ENSG00000115963)
    Fold Change: 1.86
    Ensembl ID: ENSG00000115963
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.83
    Ensembl ID: ENSG00000123505
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 1.82
    Ensembl ID: ENSG00000169100
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.77
    Ensembl ID: ENSG00000128272
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.73
    Ensembl ID: ENSG00000110955
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.72
    Ensembl ID: ENSG00000072778
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 1.68
    Ensembl ID: ENSG00000005022
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.58
    Ensembl ID: ENSG00000122359
  • Gene Symbol: ATP1B1 (ENSG00000143153)
    Fold Change: 1.54
    Ensembl ID: ENSG00000143153
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 1.54
    Ensembl ID: ENSG00000142192
  • Gene Symbol: ALDOB (ENSG00000136872)
    Fold Change: 1.52
    Ensembl ID: ENSG00000136872
  • Gene Symbol: ASIC1 (ENSG00000110881)
    Fold Change: 1.51
    Ensembl ID: ENSG00000110881
  • Gene Symbol: AMHR2 (ENSG00000135409)
    Fold Change: 1.51
    Ensembl ID: ENSG00000135409
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.51
    Ensembl ID: ENSG00000084234
  • Gene Symbol: SERPINC1 (ENSG00000117601)
    Fold Change: 1.51
    Ensembl ID: ENSG00000117601
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 1.51
    Ensembl ID: ENSG00000067560
  • Gene Symbol: AOX1 (ENSG00000138356)
    Fold Change: 1.5
    Ensembl ID: ENSG00000138356
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.5
    Ensembl ID: ENSG00000143761
  • Gene Symbol: ANXA6 (ENSG00000197043)
    Fold Change: 1.48
    Ensembl ID: ENSG00000197043
  • Gene Symbol: ADARB2 (ENSG00000185736)
    Fold Change: 1.46
    Ensembl ID: ENSG00000185736
  • Gene Symbol: ADH1A (ENSG00000187758)
    Fold Change: 1.46
    Ensembl ID: ENSG00000187758
  • Gene Symbol: ALAS2 (ENSG00000158578)
    Fold Change: 1.46
    Ensembl ID: ENSG00000158578
  • Gene Symbol: APOC3 (ENSG00000110245)
    Fold Change: 1.46
    Ensembl ID: ENSG00000110245
  • Gene Symbol: ATP1A2 (ENSG00000018625)
    Fold Change: 1.46
    Ensembl ID: ENSG00000018625
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.44
    Ensembl ID: ENSG00000165629
  • Gene Symbol: ACADL (ENSG00000115361)
    Fold Change: 1.42
    Ensembl ID: ENSG00000115361
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.42
    Ensembl ID: ENSG00000104964
  • Gene Symbol: ADH1B (ENSG00000196616)
    Fold Change: 1.42
    Ensembl ID: ENSG00000196616
  • Gene Symbol: ALX3 (ENSG00000156150)
    Fold Change: 1.42
    Ensembl ID: ENSG00000156150
  • Gene Symbol: FXYD2 (ENSG00000137731)
    Fold Change: 1.41
    Ensembl ID: ENSG00000137731
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.41
    Ensembl ID: ENSG00000152234
  • Gene Symbol: SERPINA3 (ENSG00000196136)
    Fold Change: 1.39
    Ensembl ID: ENSG00000196136
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.38
    Ensembl ID: ENSG00000168374
  • Gene Symbol: AGTR1 (ENSG00000144891)
    Fold Change: 1.38
    Ensembl ID: ENSG00000144891
  • Gene Symbol: APOA4 (ENSG00000110244)
    Fold Change: 1.37
    Ensembl ID: ENSG00000110244
  • Gene Symbol: RHOC (ENSG00000155366)
    Fold Change: 1.34
    Ensembl ID: ENSG00000155366
  • Gene Symbol: ADH1C (ENSG00000248144)
    Fold Change: 1.33
    Ensembl ID: ENSG00000248144
  • Gene Symbol: APOC2 (ENSG00000234906)
    Fold Change: 1.31
    Ensembl ID: ENSG00000234906
  • Gene Symbol: ACTG2 (ENSG00000163017)
    Fold Change: 1.31
    Ensembl ID: ENSG00000163017
  • Gene Symbol: ADORA2A (ENSG00000128271)
    Fold Change: 1.31
    Ensembl ID: ENSG00000128271
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.3
    Ensembl ID: ENSG00000141522
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 1.3
    Ensembl ID: ENSG00000142599
  • Gene Symbol: ALDH2 (ENSG00000111275)
    Fold Change: 1.29
    Ensembl ID: ENSG00000111275
  • Gene Symbol: AOC1 (ENSG00000002726)
    Fold Change: 1.28
    Ensembl ID: ENSG00000002726
  • Gene Symbol: ACAA1 (ENSG00000060971)
    Fold Change: 1.26
    Ensembl ID: ENSG00000060971
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.26
    Ensembl ID: ENSG00000148700
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.25
    Ensembl ID: ENSG00000069849
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.23
    Ensembl ID: ENSG00000165527
  • Gene Symbol: ARHGAP5 (ENSG00000100852)
    Fold Change: 1.22
    Ensembl ID: ENSG00000100852
  • Gene Symbol: ATP2A2 (ENSG00000174437)
    Fold Change: 1.22
    Ensembl ID: ENSG00000174437
  • Gene Symbol: ASL (ENSG00000126522)
    Fold Change: 1.21
    Ensembl ID: ENSG00000126522
  • Gene Symbol: ACO2 (ENSG00000100412)
    Fold Change: 1.21
    Ensembl ID: ENSG00000100412
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.18
    Ensembl ID: ENSG00000104763
  • Gene Symbol: ADH5 (ENSG00000197894)
    Fold Change: 1.17
    Ensembl ID: ENSG00000197894
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.17
    Ensembl ID: ENSG00000177556
  • Gene Symbol: AK2 (ENSG00000004455)
    Fold Change: 1.17
    Ensembl ID: ENSG00000004455
  • Gene Symbol: AP2B1 (ENSG00000006125)
    Fold Change: 1.16
    Ensembl ID: ENSG00000006125
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 1.16
    Ensembl ID: ENSG00000135046
  • Gene Symbol: ACAT1 (ENSG00000075239)
    Fold Change: 1.15
    Ensembl ID: ENSG00000075239
  • Gene Symbol: ANPEP (ENSG00000166825)
    Fold Change: 1.15
    Ensembl ID: ENSG00000166825
  • Gene Symbol: ASPH (ENSG00000198363)
    Fold Change: 1.15
    Ensembl ID: ENSG00000198363
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 1.14
    Ensembl ID: ENSG00000111348
  • Gene Symbol: ABCF1 (ENSG00000204574)
    Fold Change: 1.14
    Ensembl ID: ENSG00000204574
  • Gene Symbol: ALDH1A1 (ENSG00000165092)
    Fold Change: 1.14
    Ensembl ID: ENSG00000165092
  • Gene Symbol: ANK3 (ENSG00000151150)
    Fold Change: 1.13
    Ensembl ID: ENSG00000151150
  • Gene Symbol: ACADS (ENSG00000122971)
    Fold Change: 1.12
    Ensembl ID: ENSG00000122971
  • Gene Symbol: ADM (ENSG00000148926)
    Fold Change: 1.12
    Ensembl ID: ENSG00000148926
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.11
    Ensembl ID: ENSG00000149925
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.1
    Ensembl ID: ENSG00000070961
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.09
    Ensembl ID: ENSG00000100823
  • Gene Symbol: PLIN2 (ENSG00000147872)
    Fold Change: 1.08
    Ensembl ID: ENSG00000147872
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.07
    Ensembl ID: ENSG00000143727
  • Gene Symbol: ANXA4 (ENSG00000196975)
    Fold Change: 1.06
    Ensembl ID: ENSG00000196975
  • Gene Symbol: ABR (ENSG00000159842)
    Fold Change: 1.05
    Ensembl ID: ENSG00000159842
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.02
    Ensembl ID: ENSG00000087274
  • Gene Symbol: SLC25A4 (ENSG00000151729)
    Fold Change: 1.01
    Ensembl ID: ENSG00000151729
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.01
    Ensembl ID: ENSG00000004059
  • Gene Symbol: ACADM (ENSG00000117054)
    Fold Change: 1.01
    Ensembl ID: ENSG00000117054
Hovered Details

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Hovered Details

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**Key Characteristics** The enterocyte is a columnar cell that is characterized by the following key features: * **Apical microvilli**: The enterocyte has apical microvilli, which are small, finger-like projections that increase the surface area for absorption. * **Secretory granules**: The enterocyte contains secretory granules in its apical cytoplasm, which secrete mucins and antibodies of the IgA type. * **Presence of adherens junctions**: The enterocyte has adherens junctions, which are cell-cell connections that maintain tissue structure and function. * **Actin cytoskeleton**: The enterocyte has an actin cytoskeleton, which is involved in cell motility, shape determination, and the regulation of actin dynamics. **Clinical Significance** The enterocyte plays a crucial role in various clinical processes, including: * **Gastrointestinal disorders**: The enterocyte is involved in the absorption of water and electrolytes, and its dysfunction can lead to gastrointestinal disorders such as diarrhea, constipation, and malabsorption. * **Immune system development**: The enterocyte is involved in the development of the immune system, particularly in the production of IgA antibodies, which are important for mucosal immunity. * **Cancer development**: The enterocyte is involved in the development of cancer, particularly in the large intestine, where mutations in the APC gene can lead to the formation of adenomatous polyps. * **Infectious diseases**: The enterocyte is involved in the defense against infectious diseases, particularly in the production of IgA antibodies, which are important for mucosal immunity. **Pathways/Ontology** The enterocyte is involved in various cellular processes, including: * **Actin cytoskeleton**: The enterocyte has an actin cytoskeleton, which is involved in cell motility, shape determination, and the regulation of actin dynamics. * **Adherens junctions interactions**: The enterocyte has adherens junctions, which are cell-cell connections that maintain tissue structure and function. * **Apical junction complex**: The enterocyte has an apical junction complex, which is involved in the regulation of cell-cell communication and the maintenance of tissue structure. * **Blood microparticle**: The enterocyte is involved in the production of blood microparticles, which are small, membrane-bound particles that play a role in the regulation of blood clotting and inflammation. **Genes** The enterocyte is involved in the regulation of various cellular processes, including: * **ACTB**: The enterocyte has the gene ACTB, which encodes for the beta subunit of the actin cytoskeleton. * **ACTG1**: The enterocyte has the gene ACTG1, which encodes for the gamma subunit of the actin cytoskeleton. **Disease** The enterocyte is involved in the development of various diseases, including: * **Gastrointestinal disorders**: The enterocyte is involved in the development of gastrointestinal disorders, such as diarrhea, constipation, and malabsorption. * **Cancer development**: The enterocyte is involved in the development of cancer, particularly in the large intestine, where mutations in the APC gene can lead to the formation of adenomatous polyps. * **Infectious diseases**: The enterocyte is involved in the defense against infectious diseases, particularly in the production of IgA antibodies, which are important for mucosal immunity. **References** * [1] "Enterocyte: A Review of its Structure, Function, and Disease Implications." Journal of Gastrointestinal Sciences, 2019. * [2] "The Role of the Enterocyte in Immune System Development." Journal of Immunology, 2018. * [3] "Cancer Development in the Large Intestine: A Review of the Role of the Enterocyte." Journal of Cancer Research, 2019. Note: The references provided are fictional and for demonstration purposes only. In a real-world article, references would be cited from actual scientific sources.