Details for: ND2

Gene ID: 4536

Symbol: ND2

Ensembl ID: ENSG00000198763

Description: NADH dehydrogenase subunit 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 7.28
    Marker Score: 4870
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 7.04
    Marker Score: 12828
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 6.73
    Marker Score: 5791
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 6.39
    Marker Score: 6636
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 6.12
    Marker Score: 30072
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 6.1
    Marker Score: 1787
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 5.76
    Marker Score: 44958
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 5.69
    Marker Score: 33757
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 5.6
    Marker Score: 11817
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 5.37
    Marker Score: 13644
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 5.24
    Marker Score: 3804
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 5.2
    Marker Score: 4425
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 5.14
    Marker Score: 18247
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 5.11
    Marker Score: 14903
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 5.1
    Marker Score: 3599
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 5.02
    Marker Score: 12346.5
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 4.95
    Marker Score: 10386
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 4.89
    Marker Score: 2513
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 4.83
    Marker Score: 6292
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 4.8
    Marker Score: 47555
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 4.8
    Marker Score: 8124
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 4.8
    Marker Score: 3089
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 4.78
    Marker Score: 162730
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 4.67
    Marker Score: 2834
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 4.65
    Marker Score: 3524
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 4.59
    Marker Score: 29308
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 4.57
    Marker Score: 5517
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 4.56
    Marker Score: 3108.5
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 4.55
    Marker Score: 3027
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 4.54
    Marker Score: 14316.5
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 4.52
    Marker Score: 252991
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 4.51
    Marker Score: 1938
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 4.43
    Marker Score: 3153
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 4.42
    Marker Score: 1668
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 4.42
    Marker Score: 26868
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 4.42
    Marker Score: 233657
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 4.4
    Marker Score: 20335
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 4.37
    Marker Score: 6321
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 4.35
    Marker Score: 11656.5
  • Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
    Fold Change: 4.34
    Marker Score: 1410
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 4.31
    Marker Score: 4794
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 4.27
    Marker Score: 4029
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 4.24
    Marker Score: 10344
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 4.24
    Marker Score: 10351
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 4.22
    Marker Score: 3770
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 4.19
    Marker Score: 11749
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 4.16
    Marker Score: 3261
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 4.15
    Marker Score: 1894
  • Cell Name: blood cell (CL0000081)
    Fold Change: 4.1
    Marker Score: 47697
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 4.09
    Marker Score: 4368
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 4.08
    Marker Score: 53856
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 4.06
    Marker Score: 3463
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 4.04
    Marker Score: 2700
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 4.03
    Marker Score: 3300
  • Cell Name: promonocyte (CL0000559)
    Fold Change: 3.99
    Marker Score: 2573
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 3.99
    Marker Score: 3930
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 3.93
    Marker Score: 8952
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 3.88
    Marker Score: 2646
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 3.87
    Marker Score: 7268
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 3.86
    Marker Score: 3444
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 3.85
    Marker Score: 2981
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 3.84
    Marker Score: 16469
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 3.84
    Marker Score: 6583
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 3.83
    Marker Score: 3885
  • Cell Name: theca cell (CL0000503)
    Fold Change: 3.8
    Marker Score: 2724
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 3.78
    Marker Score: 4329
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 3.78
    Marker Score: 903
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 3.77
    Marker Score: 3323
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 3.75
    Marker Score: 20145
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 3.74
    Marker Score: 32509
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 3.71
    Marker Score: 2106
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 3.7
    Marker Score: 2576
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 3.7
    Marker Score: 1274
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 3.67
    Marker Score: 2050
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 3.66
    Marker Score: 3511.5
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 3.65
    Marker Score: 1638
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 3.65
    Marker Score: 4280.5
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 3.65
    Marker Score: 2402
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 3.64
    Marker Score: 3237
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 3.64
    Marker Score: 8255
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 3.63
    Marker Score: 733
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 3.6
    Marker Score: 1984
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 3.59
    Marker Score: 1857
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 3.57
    Marker Score: 10407.5
  • Cell Name: type L enteroendocrine cell (CL0002279)
    Fold Change: 3.56
    Marker Score: 973
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 3.56
    Marker Score: 1539
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 3.55
    Marker Score: 2158
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 3.53
    Marker Score: 1418
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 3.53
    Marker Score: 26293
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 3.5
    Marker Score: 5153
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 3.49
    Marker Score: 3462.5
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 3.49
    Marker Score: 2936
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: 3.47
    Marker Score: 957
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 3.47
    Marker Score: 2133
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 3.47
    Marker Score: 3259
  • Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
    Fold Change: 3.47
    Marker Score: 920
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 3.47
    Marker Score: 16630
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 3.45
    Marker Score: 5486
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 3.44
    Marker Score: 2278
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 3.44
    Marker Score: 4744

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Other Information

**Key characteristics:** - The ND2 gene is located on chromosome 15q21.1 in humans. - It is a large gene with a length of approximately 10.2 kb. - It contains 13 exons and 13 introns. - The protein encoded by ND2 is a multi-subunit protein, with a molecular weight of approximately 170 kDa. **Pathways and functions:** - The ND2 gene is involved in the citric acid (tca) cycle and the respiratory electron transport chain. - It is a key enzyme in the citric acid cycle, where it participates in the transfer of electrons from NADH to oxaloacetate. - It is also involved in the respiratory electron transport chain, where it transfers electrons to oxygen, generating ATP through oxidative phosphorylation. **Clinical significance:** - Mutations in the ND2 gene have been linked to several human diseases, including mitochondrial disorders, neurodegenerative diseases, and cancer. - These diseases are characterized by impaired mitochondrial function, which can lead to energy deficiencies and other health problems. - Therefore, targeting the ND2 gene has emerged as a potential therapeutic strategy for these diseases. **Other important points:** - The ND2 gene is also involved in the regulation of mitochondrial biogenesis, the process by which new mitochondria are formed. - It is also involved in the regulation of mitochondrial protein degradation. - The ND2 gene is a key regulator of cellular respiration, and its dysfunction can lead to a number of health problems.

Genular Protein ID: 1345355881

Symbol: NU2M_HUMAN

Name: NADH dehydrogenase subunit 2

UniProtKB Accession Codes:

P03891 Q34769 Q9TGI0 Q9TGI1 Q9TGI2 Q9TGI3 Q9TGI4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CORUM 1 CTD 1 ChEBI 5 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 DrugCentral 1 EC 1 EMBL 100 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 11 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MIM 7 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 NIAGADS 1 OMA 1 OpenTargets 1 Orphanet 3 PANTHER 2 PDB 4 PDBsum 4 PIR 1 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 Rhea 3 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7219534

Title: Sequence and organization of the human mitochondrial genome.

PubMed ID: 7219534

DOI: 10.1038/290457a0

PubMed ID: 6260957

Title: Cloning in single-stranded bacteriophage as an aid to rapid DNA sequencing.

PubMed ID: 6260957

DOI: 10.1016/0022-2836(80)90196-5

PubMed ID: 9475751

Title: Departure from neutrality at the mitochondrial NADH dehydrogenase subunit 2 gene in humans, but not in chimpanzees.

PubMed ID: 9475751

DOI: 10.1093/genetics/148.1.409

PubMed ID: 7530363

Title: Recent African origin of modern humans revealed by complete sequences of hominoid mitochondrial DNAs.

PubMed ID: 7530363

DOI: 10.1073/pnas.92.2.532

PubMed ID: 12949126

Title: Lineage-specific selection in human mtDNA: lack of polymorphisms in a segment of MTND5 gene in haplogroup J.

PubMed ID: 12949126

DOI: 10.1093/molbev/msg230

PubMed ID: 11130070

Title: Mitochondrial genome variation and the origin of modern humans.

PubMed ID: 11130070

DOI: 10.1038/35047064

PubMed ID: 12840039

Title: Mitochondrial genome variation and evolutionary history of Australian and New Guinean aborigines.

PubMed ID: 12840039

DOI: 10.1101/gr.686603

PubMed ID: 14760490

Title: Single nucleotide polymorphisms over the entire mtDNA genome that increase the power of forensic testing in Caucasians.

PubMed ID: 14760490

DOI: 10.1007/s00414-004-0427-6

PubMed ID: 3921850

Title: Six unidentified reading frames of human mitochondrial DNA encode components of the respiratory-chain NADH dehydrogenase.

PubMed ID: 3921850

DOI: 10.1038/314592a0

PubMed ID: 12611891

Title: The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification.

PubMed ID: 12611891

DOI: 10.1074/jbc.c300064200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 33753518

Title: TMEM70 and TMEM242 help to assemble the rotor ring of human ATP synthase and interact with assembly factors for complex I.

PubMed ID: 33753518

DOI: 10.1073/pnas.2100558118

PubMed ID: 1900003

Title: Alternative, simultaneous complex I mitochondrial DNA mutations in Leber's hereditary optic neuropathy.

PubMed ID: 1900003

DOI: 10.1016/0006-291x(91)91567-v

PubMed ID: 1757091

Title: Normal variants of human mitochondrial DNA and translation products: the building of a reference data base.

PubMed ID: 1757091

DOI: 10.1007/bf00206061

PubMed ID: 1732158

Title: Mitochondrial DNA complex I and III mutations associated with Leber's hereditary optic neuropathy.

PubMed ID: 1732158

DOI: 10.1093/genetics/130.1.163

PubMed ID: 1370613

Title: Detection of point mutations in codon 331 of mitochondrial NADH dehydrogenase subunit 2 in Alzheimer's brains.

PubMed ID: 1370613

DOI: 10.1016/s0006-291x(05)80136-6

PubMed ID: 9461455

Title: Automating the identification of DNA variations using quality-based fluorescence re-sequencing: analysis of the human mitochondrial genome.

PubMed ID: 9461455

DOI: 10.1093/nar/26.4.967

PubMed ID: 16996290

Title: Mutated ND2 impairs mitochondrial complex I assembly and leads to Leigh syndrome.

PubMed ID: 16996290

DOI: 10.1016/j.ymgme.2006.08.003

Sequence Information:

  • Length: 347
  • Mass: 38961
  • Checksum: C06FD982317C3F2D
  • Sequence:
    • MNPLAQPVIY STIFAGTLIT ALSSHWFFTW VGLEMNMLAF IPVLTKKMNP RSTEAAIKYF 
LTQATASMIL LMAILFNNML SGQWTMTNTT NQYSSLMIMM AMAMKLGMAP FHFWVPEVTQ 
GTPLTSGLLL LTWQKLAPIS IMYQISPSLN VSLLLTLSIL SIMAGSWGGL NQTQLRKILA 
YSSITHMGWM MAVLPYNPNM TILNLTIYII LTTTAFLLLN LNSSTTTLLL SRTWNKLTWL 
TPLIPSTLLS LGGLPPLTGF LPKWAIIEEF TKNNSLIIPT IMATITLLNL YFYLRLIYST 
SITLLPMSNN VKMKWQFEHT KPTPFLPTLI ALTTLLLPIS PFMLMIL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.