Details for: CL0019032

Cell ID: CL0019032

Cell Name: intestinal tuft cell

Marker Score Threshold: 316
(Derived using integrated single-cell and genomic data)

Description: Any brush cell that is part of the intestinal epithelium.

Synonyms: intestinal brush cell

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 3.1
    Ensembl ID: ENSG00000075624
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 2.94
    Ensembl ID: ENSG00000166710
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 2.58
    Ensembl ID: ENSG00000169100
  • Gene Symbol: COX4I1 (ENSG00000131143)
    Fold Change: 2.57
    Ensembl ID: ENSG00000131143
  • Gene Symbol: CFL1 (ENSG00000172757)
    Fold Change: 2.56
    Ensembl ID: ENSG00000172757
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.46
    Ensembl ID: ENSG00000184009
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 2.45
    Ensembl ID: ENSG00000145741
  • Gene Symbol: CIRBP (ENSG00000099622)
    Fold Change: 2.44
    Ensembl ID: ENSG00000099622
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 2.43
    Ensembl ID: ENSG00000198668
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 2.24
    Ensembl ID: ENSG00000135390
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 2.22
    Ensembl ID: ENSG00000133639
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.2
    Ensembl ID: ENSG00000067560
  • Gene Symbol: CDC42 (ENSG00000070831)
    Fold Change: 2.18
    Ensembl ID: ENSG00000070831
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 2.11
    Ensembl ID: ENSG00000124172
  • Gene Symbol: KLF6 (ENSG00000067082)
    Fold Change: 2.07
    Ensembl ID: ENSG00000067082
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 1.97
    Ensembl ID: ENSG00000077549
  • Gene Symbol: COX5B (ENSG00000135940)
    Fold Change: 1.94
    Ensembl ID: ENSG00000135940
  • Gene Symbol: SEPTIN7 (ENSG00000122545)
    Fold Change: 1.93
    Ensembl ID: ENSG00000122545
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 1.93
    Ensembl ID: ENSG00000179218
  • Gene Symbol: CD63 (ENSG00000135404)
    Fold Change: 1.92
    Ensembl ID: ENSG00000135404
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.91
    Ensembl ID: ENSG00000143761
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 1.86
    Ensembl ID: ENSG00000143933
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 1.83
    Ensembl ID: ENSG00000185650
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 1.72
    Ensembl ID: ENSG00000154723
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 1.7
    Ensembl ID: ENSG00000005022
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 1.69
    Ensembl ID: ENSG00000134825
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 1.69
    Ensembl ID: ENSG00000154518
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.68
    Ensembl ID: ENSG00000110955
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 1.68
    Ensembl ID: ENSG00000152518
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 1.68
    Ensembl ID: ENSG00000169020
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.66
    Ensembl ID: ENSG00000127022
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.65
    Ensembl ID: ENSG00000172270
  • Gene Symbol: CD74 (ENSG00000019582)
    Fold Change: 1.64
    Ensembl ID: ENSG00000019582
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.63
    Ensembl ID: ENSG00000152234
  • Gene Symbol: CLIC1 (ENSG00000213719)
    Fold Change: 1.61
    Ensembl ID: ENSG00000213719
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 1.59
    Ensembl ID: ENSG00000099624
  • Gene Symbol: CLTA (ENSG00000122705)
    Fold Change: 1.56
    Ensembl ID: ENSG00000122705
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.55
    Ensembl ID: ENSG00000128272
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.55
    Ensembl ID: ENSG00000085224
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.54
    Ensembl ID: ENSG00000153113
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.52
    Ensembl ID: ENSG00000198931
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.5
    Ensembl ID: ENSG00000165629
  • Gene Symbol: CLK1 (ENSG00000013441)
    Fold Change: 1.48
    Ensembl ID: ENSG00000013441
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.45
    Ensembl ID: ENSG00000117410
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.45
    Ensembl ID: ENSG00000116489
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 1.45
    Ensembl ID: ENSG00000198898
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.44
    Ensembl ID: ENSG00000164111
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.42
    Ensembl ID: ENSG00000182718
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.42
    Ensembl ID: ENSG00000241837
  • Gene Symbol: AP2M1 (ENSG00000161203)
    Fold Change: 1.42
    Ensembl ID: ENSG00000161203
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.37
    Ensembl ID: ENSG00000116459
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.36
    Ensembl ID: ENSG00000141522
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.35
    Ensembl ID: ENSG00000168374
  • Gene Symbol: CD47 (ENSG00000196776)
    Fold Change: 1.33
    Ensembl ID: ENSG00000196776
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.3
    Ensembl ID: ENSG00000069849
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.3
    Ensembl ID: ENSG00000160014
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.29
    Ensembl ID: ENSG00000104964
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.28
    Ensembl ID: ENSG00000149925
  • Gene Symbol: CHD2 (ENSG00000173575)
    Fold Change: 1.28
    Ensembl ID: ENSG00000173575
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.27
    Ensembl ID: ENSG00000084234
  • Gene Symbol: CD44 (ENSG00000026508)
    Fold Change: 1.26
    Ensembl ID: ENSG00000026508
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.25
    Ensembl ID: ENSG00000104765
  • Gene Symbol: CD81 (ENSG00000110651)
    Fold Change: 1.25
    Ensembl ID: ENSG00000110651
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.24
    Ensembl ID: ENSG00000130402
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 1.24
    Ensembl ID: ENSG00000111348
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.24
    Ensembl ID: ENSG00000163399
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.23
    Ensembl ID: ENSG00000159199
  • Gene Symbol: AP2S1 (ENSG00000042753)
    Fold Change: 1.23
    Ensembl ID: ENSG00000042753
  • Gene Symbol: FOXN3 (ENSG00000053254)
    Fold Change: 1.21
    Ensembl ID: ENSG00000053254
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 1.21
    Ensembl ID: ENSG00000100300
  • Gene Symbol: CCT6A (ENSG00000146731)
    Fold Change: 1.2
    Ensembl ID: ENSG00000146731
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 1.19
    Ensembl ID: ENSG00000142192
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.19
    Ensembl ID: ENSG00000104763
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.19
    Ensembl ID: ENSG00000108561
  • Gene Symbol: CCND3 (ENSG00000112576)
    Fold Change: 1.19
    Ensembl ID: ENSG00000112576
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.17
    Ensembl ID: ENSG00000122359
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.16
    Ensembl ID: ENSG00000070961
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.16
    Ensembl ID: ENSG00000138279
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.16
    Ensembl ID: ENSG00000165527
  • Gene Symbol: CHD1 (ENSG00000153922)
    Fold Change: 1.16
    Ensembl ID: ENSG00000153922
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.14
    Ensembl ID: ENSG00000123505
  • Gene Symbol: AP3S1 (ENSG00000177879)
    Fold Change: 1.14
    Ensembl ID: ENSG00000177879
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.13
    Ensembl ID: ENSG00000160710
  • Gene Symbol: CLNS1A (ENSG00000074201)
    Fold Change: 1.11
    Ensembl ID: ENSG00000074201
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.1
    Ensembl ID: ENSG00000072778
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.1
    Ensembl ID: ENSG00000100823
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.1
    Ensembl ID: ENSG00000143727
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.1
    Ensembl ID: ENSG00000148700
  • Gene Symbol: CAMLG (ENSG00000164615)
    Fold Change: 1.08
    Ensembl ID: ENSG00000164615
  • Gene Symbol: CLTC (ENSG00000141367)
    Fold Change: 1.08
    Ensembl ID: ENSG00000141367
  • Gene Symbol: COPA (ENSG00000122218)
    Fold Change: 1.07
    Ensembl ID: ENSG00000122218
  • Gene Symbol: TBCB (ENSG00000105254)
    Fold Change: 1.06
    Ensembl ID: ENSG00000105254
  • Gene Symbol: CCNH (ENSG00000134480)
    Fold Change: 1.05
    Ensembl ID: ENSG00000134480
  • Gene Symbol: CD59 (ENSG00000085063)
    Fold Change: 1.05
    Ensembl ID: ENSG00000085063
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.05
    Ensembl ID: ENSG00000115307
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.03
    Ensembl ID: ENSG00000177556
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 1.03
    Ensembl ID: ENSG00000135046
  • Gene Symbol: CLTB (ENSG00000175416)
    Fold Change: 1.01
    Ensembl ID: ENSG00000175416
  • Gene Symbol: ANXA4 (ENSG00000196975)
    Fold Change: 1.01
    Ensembl ID: ENSG00000196975
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: N/A
    Ensembl ID: ENSG00000087088
Hovered Details

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Hovered Details

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**Key Characteristics** 1. **Location**: Intestinal tuft cells are found in the intestinal epithelium, specifically in the brush border region. 2. **Cellular morphology**: These cells have a unique morphology, characterized by the presence of microvilli and a high number of adherens junctions. 3. **Actin cytoskeleton**: Intestinal tuft cells possess a dynamic actin cytoskeleton that regulates cell motility, cell-cell junction organization, and signaling pathways. 4. **Gap junction formation**: These cells are capable of forming gap junctions, which are essential for maintaining tissue homeostasis. 5. **Immune regulation**: Intestinal tuft cells play a crucial role in regulating immune responses, including the regulation of cytokine signaling and the modulation of immune cell activity. 6. **Cell polarity**: These cells maintain cell polarity through the regulation of actin dynamics and the formation of adherens junctions. 7. **Signaling pathways**: Intestinal tuft cells are involved in various signaling pathways, including the regulation of actin dynamics, cell motility, and immune responses. **Clinical Significance** 1. **Intestinal disorders**: Intestinal tuft cells play a crucial role in maintaining the integrity of the intestinal epithelium, and their dysfunction has been implicated in various intestinal disorders, including inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS). 2. **Immune system regulation**: The regulation of immune responses by intestinal tuft cells has implications for the treatment of autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 3. **Cancer development**: The dysregulation of cell polarity and signaling pathways in intestinal tuft cells has been implicated in the development of colorectal cancer. 4. **Neurological disorders**: The connection between intestinal tuft cells and the nervous system has been explored in the context of neurological disorders, such as Parkinson's disease and multiple sclerosis. 5. **Infectious diseases**: The role of intestinal tuft cells in regulating immune responses has implications for the treatment of infectious diseases, such as tuberculosis and HIV. In summary, intestinal tuft cells are a unique subtype of brush cells that play a crucial role in regulating various cellular processes, including cell motility, cell-cell junction organization, and signaling pathways. Their dysfunction has been implicated in various intestinal disorders, immune system regulation, and cancer development, highlighting the importance of further research into the biology and clinical significance of these cells.