Details for: TRPM5

Gene ID: 29850

Symbol: TRPM5

Ensembl ID: ENSG00000070985

Description: transient receptor potential cation channel subfamily M member 5

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 4.9168
    Cell Significance Index: 49.6000
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 3.5155
    Cell Significance Index: 29.8800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 3.3009
    Cell Significance Index: 628.1700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 2.2860
    Cell Significance Index: 226.1400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.5410
    Cell Significance Index: 44.4000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.3560
    Cell Significance Index: 36.9100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.2005
    Cell Significance Index: 195.2600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.1627
    Cell Significance Index: 126.4700
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.7271
    Cell Significance Index: 10.3500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.7114
    Cell Significance Index: 49.2000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.6533
    Cell Significance Index: 39.2200
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.5975
    Cell Significance Index: 6.9500
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.5877
    Cell Significance Index: 14.2400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2820
    Cell Significance Index: 12.7800
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.1951
    Cell Significance Index: 2.5200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.1896
    Cell Significance Index: 6.5900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1872
    Cell Significance Index: 9.7300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1851
    Cell Significance Index: 4.0100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1440
    Cell Significance Index: 5.0600
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.1383
    Cell Significance Index: 3.4500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.1147
    Cell Significance Index: 2.3800
  • Cell Name: helper T cell (CL0000912)
    Fold Change: 0.1126
    Cell Significance Index: 1.6000
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.0633
    Cell Significance Index: 0.6700
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.0547
    Cell Significance Index: 0.8200
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.0425
    Cell Significance Index: 0.6400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0319
    Cell Significance Index: 0.6800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0256
    Cell Significance Index: 0.6400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0195
    Cell Significance Index: 3.5100
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.0055
    Cell Significance Index: 0.0500
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.0033
    Cell Significance Index: 0.0300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0021
    Cell Significance Index: 0.0300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.0017
    Cell Significance Index: 0.0500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0007
    Cell Significance Index: -1.3900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0010
    Cell Significance Index: -0.1900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0010
    Cell Significance Index: -0.3700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0016
    Cell Significance Index: -0.9000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0024
    Cell Significance Index: -1.3300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0024
    Cell Significance Index: -3.7500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0028
    Cell Significance Index: -2.0500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0030
    Cell Significance Index: -1.9300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0030
    Cell Significance Index: -2.1900
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0051
    Cell Significance Index: -0.2100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0058
    Cell Significance Index: -0.7100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0063
    Cell Significance Index: -2.8600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0081
    Cell Significance Index: -0.1100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0086
    Cell Significance Index: -0.9900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0092
    Cell Significance Index: -2.6600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0100
    Cell Significance Index: -1.0200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0105
    Cell Significance Index: -2.1100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0114
    Cell Significance Index: -0.5300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0116
    Cell Significance Index: -0.7100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0117
    Cell Significance Index: -1.3600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0124
    Cell Significance Index: -2.1100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0125
    Cell Significance Index: -2.6300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0131
    Cell Significance Index: -1.9000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0133
    Cell Significance Index: -1.8200
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.0144
    Cell Significance Index: -0.1500
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.0160
    Cell Significance Index: -0.1600
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0164
    Cell Significance Index: -0.2800
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.0165
    Cell Significance Index: -0.1600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0210
    Cell Significance Index: -0.4400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0232
    Cell Significance Index: -0.6500
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: -0.0265
    Cell Significance Index: -0.3200
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0285
    Cell Significance Index: -0.4200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0293
    Cell Significance Index: -0.9400
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0305
    Cell Significance Index: -0.4900
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: -0.0318
    Cell Significance Index: -0.3600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0321
    Cell Significance Index: -2.1600
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0329
    Cell Significance Index: -0.4000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0330
    Cell Significance Index: -0.8900
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0332
    Cell Significance Index: -0.4200
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: -0.0340
    Cell Significance Index: -0.3800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0341
    Cell Significance Index: -0.8800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0351
    Cell Significance Index: -2.1600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0365
    Cell Significance Index: -1.9000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0387
    Cell Significance Index: -2.9700
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.0405
    Cell Significance Index: -0.3900
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0433
    Cell Significance Index: -0.7300
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.0442
    Cell Significance Index: -0.4800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0446
    Cell Significance Index: -0.8700
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.0463
    Cell Significance Index: -0.4800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0465
    Cell Significance Index: -2.6100
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: -0.0472
    Cell Significance Index: -0.5000
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.0475
    Cell Significance Index: -0.3100
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: -0.0498
    Cell Significance Index: -0.5400
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: -0.0541
    Cell Significance Index: -0.5600
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.0542
    Cell Significance Index: -0.3600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0551
    Cell Significance Index: -1.4500
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0575
    Cell Significance Index: -0.8400
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.0584
    Cell Significance Index: -0.4500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0596
    Cell Significance Index: -2.8000
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.0600
    Cell Significance Index: -0.5700
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: -0.0616
    Cell Significance Index: -0.5900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0651
    Cell Significance Index: -2.2800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0666
    Cell Significance Index: -1.1200
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: -0.0688
    Cell Significance Index: -0.5500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0696
    Cell Significance Index: -3.0800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0706
    Cell Significance Index: -2.3100
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0707
    Cell Significance Index: -0.7700
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: -0.0714
    Cell Significance Index: -0.3400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TRPM5 is a non-selective cation channel that is activated by a variety of stimuli, including temperature, pH, and ligands such as calcium and magnesium. It is a member of the TRP channel family, which is known for its ability to detect a wide range of sensory stimuli. TRPM5 has a unique structure, consisting of six transmembrane domains and a pore-forming region. This structure allows it to modulate the flow of ions across the cell membrane, leading to changes in cell excitability and signaling pathways. One of the most notable characteristics of TRPM5 is its ability to detect sweet, bitter, and umami tastes. This is achieved through its interaction with specific ligands, such as sugars and amino acids, which bind to the channel and trigger its activation. TRPM5 is also involved in the detection of other sensory stimuli, including temperature and mechanical forces. **Pathways and Functions:** TRPM5 is involved in several key signaling pathways, including calcium-mediated signaling and ligand-gated calcium channel activity. Upon activation, TRPM5 can modulate the flow of calcium ions into the cell, leading to changes in cell excitability and signaling pathways. This can have a range of effects, including the regulation of gene expression, cell proliferation, and differentiation. TRPM5 is also involved in the detection of various stimuli, including temperature, pH, and mechanical forces. This is achieved through its interaction with specific ligands and its ability to modulate the flow of ions across the cell membrane. In addition to its role in taste perception, TRPM5 is also involved in other cellular processes, including immune function and cardiovascular function. For example, TRPM5 has been shown to play a role in the regulation of immune cell function, including the activation of dendritic cells and the production of cytokines. **Clinical Significance:** Dysregulation of TRPM5 has been implicated in a range of clinical disorders, including taste disorders, diabetes, and cardiovascular disease. For example, mutations in the TRPM5 gene have been associated with congenital insensitivity to pain with anhidrosis (CIPA), a rare genetic disorder characterized by impaired pain perception and anhidrosis. TRPM5 has also been shown to play a role in the development of diabetes. For example, studies have shown that TRPM5 is involved in the regulation of glucose metabolism and insulin secretion, and that its dysfunction can contribute to the development of type 2 diabetes. In addition to its role in disease, TRPM5 has also been explored as a potential therapeutic target for various conditions, including pain management and cardiovascular disease. For example, TRPM5 antagonists have been shown to have analgesic and vasodilatory effects, making them potential candidates for the treatment of pain and cardiovascular disease. In conclusion, TRPM5 is a crucial component of the TRP channel family, playing a pivotal role in taste perception, immune function, and cardiovascular function. Its dysregulation has been implicated in a range of clinical disorders, and it has potential as a therapeutic target for various conditions. Further research is needed to fully understand the role of TRPM5 in human health and disease.

Genular Protein ID: 3251887673

Symbol: TRPM5_HUMAN

Name: Transient receptor potential cation channel subfamily M member 5

UniProtKB Accession Codes:

Q9NZQ8 A6NHS0 Q52LU2 Q9NY34

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 12 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 DrugCentral 1 EMBL 5 Ensembl 1 ExpressionAtlas 1 GO 13 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 2 RefSeq 1 Rhea 2 SMR 1 STRING 1 SignaLink 1 TCDB 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 10607831

Title: Identification and characterization of MTR1, a novel gene with homology to melastatin (MLSN1) and the trp gene family located in the BWS-WT2 critical region on chromosome 11p15.5 and showing allele-specific expression.

PubMed ID: 10607831

DOI: 10.1093/hmg/9.2.203

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14634208

Title: TRPM5 is a transient Ca2+-activated cation channel responding to rapid changes in [Ca2+]i.

PubMed ID: 14634208

DOI: 10.1073/pnas.2334624100

PubMed ID: 34168372

Title: Structures of the TRPM5 channel elucidate mechanisms of activation and inhibition.

PubMed ID: 34168372

DOI: 10.1038/s41594-021-00607-4

Sequence Information:

  • Length: 1165
  • Mass: 131451
  • Checksum: C4AD5BAA866BE73B
  • Sequence:
    • MQDVQGPRPG SPGDAEDRRE LGLHRGEVNF GGSGKKRGKF VRVPSGVAPS VLFDLLLAEW 
HLPAPNLVVS LVGEEQPFAM KSWLRDVLRK GLVKAAQSTG AWILTSALRV GLARHVGQAV 
RDHSLASTST KVRVVAVGMA SLGRVLHRRI LEEAQEDFPV HYPEDDGGSQ GPLCSLDSNL 
SHFILVEPGP PGKGDGLTEL RLRLEKHISE QRAGYGGTGS IEIPVLCLLV NGDPNTLERI 
SRAVEQAAPW LILVGSGGIA DVLAALVNQP HLLVPKVAEK QFKEKFPSKH FSWEDIVRWT 
KLLQNITSHQ HLLTVYDFEQ EGSEELDTVI LKALVKACKS HSQEPQDYLD ELKLAVAWDR 
VDIAKSEIFN GDVEWKSCDL EEVMVDALVS NKPEFVRLFV DNGADVADFL TYGRLQELYR 
SVSRKSLLFD LLQRKQEEAR LTLAGLGTQQ AREPPAGPPA FSLHEVSRVL KDFLQDACRG 
FYQDGRPGDR RRAEKGPAKR PTGQKWLLDL NQKSENPWRD LFLWAVLQNR HEMATYFWAM 
GQEGVAAALA ACKILKEMSH LETEAEAARA TREAKYERLA LDLFSECYSN SEARAFALLV 
RRNRCWSKTT CLHLATEADA KAFFAHDGVQ AFLTRIWWGD MAAGTPILRL LGAFLCPALV 
YTNLITFSEE APLRTGLEDL QDLDSLDTEK SPLYGLQSRV EELVEAPRAQ GDRGPRAVFL 
LTRWRKFWGA PVTVFLGNVV MYFAFLFLFT YVLLVDFRPP PQGPSGPEVT LYFWVFTLVL 
EEIRQGFFTD EDTHLVKKFT LYVGDNWNKC DMVAIFLFIV GVTCRMLPSA FEAGRTVLAM 
DFMVFTLRLI HIFAIHKQLG PKIIVVERMM KDVFFFLFFL SVWLVAYGVT TQALLHPHDG 
RLEWIFRRVL YRPYLQIFGQ IPLDEIDEAR VNCSTHPLLL EDSPSCPSLY ANWLVILLLV 
TFLLVTNVLL MNLLIAMFSY TFQVVQGNAD MFWKFQRYNL IVEYHERPAL APPFILLSHL 
SLTLRRVFKK EAEHKREHLE RDLPDPLDQK VVTWETVQKE NFLSKMEKRR RDSEGEVLRK 
TAHRVDFIAK YLGGLREQEK RIKCLESQIN YCSVLVSSVA DVLAQGGGPR SSQHCGEGSQ 
LVAADHRGGL DGWEQPGAGQ PPSDT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.