Details for: CL0000508

Cell ID: CL0000508

Cell Name: type G enteroendocrine cell

Marker Score Threshold: 345
(Derived using integrated single-cell and genomic data)

Description: An endocrine cell found in the pyloric gland mucosa (antral mucosa) of the stomach of mammals and responsible for the secretion of gastrin and enkephalin. Most abundant in pyloric antrum, pyramidal in form with a narrow apex bearing long microvilli.

Synonyms: G cell

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 3.76
    Ensembl ID: ENSG00000166710
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 3.61
    Ensembl ID: ENSG00000075624
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 3.56
    Ensembl ID: ENSG00000143933
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 3.56
    Ensembl ID: ENSG00000184009
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 3.47
    Ensembl ID: ENSG00000124172
  • Gene Symbol: CD63 (ENSG00000135404)
    Fold Change: 3.27
    Ensembl ID: ENSG00000135404
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 3.27
    Ensembl ID: ENSG00000135390
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 3.18
    Ensembl ID: ENSG00000169020
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 3.14
    Ensembl ID: ENSG00000169100
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 2.98
    Ensembl ID: ENSG00000198668
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 2.93
    Ensembl ID: ENSG00000145741
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 2.89
    Ensembl ID: ENSG00000134825
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 2.85
    Ensembl ID: ENSG00000172270
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 2.67
    Ensembl ID: ENSG00000154723
  • Gene Symbol: CACNA1A (ENSG00000141837)
    Fold Change: 2.62
    Ensembl ID: ENSG00000141837
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 2.35
    Ensembl ID: ENSG00000117410
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.32
    Ensembl ID: ENSG00000067560
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 2.3
    Ensembl ID: ENSG00000179218
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 2.24
    Ensembl ID: ENSG00000154518
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 2.22
    Ensembl ID: ENSG00000005022
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 2.16
    Ensembl ID: ENSG00000143761
  • Gene Symbol: CD44 (ENSG00000026508)
    Fold Change: 2.14
    Ensembl ID: ENSG00000026508
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 2.07
    Ensembl ID: ENSG00000100300
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 2.02
    Ensembl ID: ENSG00000133639
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.96
    Ensembl ID: ENSG00000241837
  • Gene Symbol: ALDH1A1 (ENSG00000165092)
    Fold Change: 1.95
    Ensembl ID: ENSG00000165092
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.95
    Ensembl ID: ENSG00000110955
  • Gene Symbol: ATP1B1 (ENSG00000143153)
    Fold Change: 1.95
    Ensembl ID: ENSG00000143153
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.93
    Ensembl ID: ENSG00000104964
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.91
    Ensembl ID: ENSG00000182718
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.89
    Ensembl ID: ENSG00000004059
  • Gene Symbol: ATF3 (ENSG00000162772)
    Fold Change: 1.89
    Ensembl ID: ENSG00000162772
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 1.88
    Ensembl ID: ENSG00000099624
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.86
    Ensembl ID: ENSG00000198931
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.86
    Ensembl ID: ENSG00000177556
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 1.85
    Ensembl ID: ENSG00000143878
  • Gene Symbol: SCARB2 (ENSG00000138760)
    Fold Change: 1.81
    Ensembl ID: ENSG00000138760
  • Gene Symbol: CD36 (ENSG00000135218)
    Fold Change: 1.8
    Ensembl ID: ENSG00000135218
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.8
    Ensembl ID: ENSG00000159199
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.78
    Ensembl ID: ENSG00000152234
  • Gene Symbol: CD59 (ENSG00000085063)
    Fold Change: 1.78
    Ensembl ID: ENSG00000085063
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.76
    Ensembl ID: ENSG00000153113
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.73
    Ensembl ID: ENSG00000128272
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 1.71
    Ensembl ID: ENSG00000142192
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 1.71
    Ensembl ID: ENSG00000198898
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.7
    Ensembl ID: ENSG00000138279
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.7
    Ensembl ID: ENSG00000127022
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.68
    Ensembl ID: ENSG00000160014
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.64
    Ensembl ID: ENSG00000165629
  • Gene Symbol: BAG1 (ENSG00000107262)
    Fold Change: 1.63
    Ensembl ID: ENSG00000107262
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.63
    Ensembl ID: ENSG00000168374
  • Gene Symbol: CAMLG (ENSG00000164615)
    Fold Change: 1.59
    Ensembl ID: ENSG00000164615
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.55
    Ensembl ID: ENSG00000084234
  • Gene Symbol: CD74 (ENSG00000019582)
    Fold Change: 1.55
    Ensembl ID: ENSG00000019582
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 1.54
    Ensembl ID: ENSG00000077549
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.53
    Ensembl ID: ENSG00000104763
  • Gene Symbol: CD151 (ENSG00000177697)
    Fold Change: 1.53
    Ensembl ID: ENSG00000177697
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.53
    Ensembl ID: ENSG00000163399
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.52
    Ensembl ID: ENSG00000141522
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.47
    Ensembl ID: ENSG00000070961
  • Gene Symbol: ATP6AP1 (ENSG00000071553)
    Fold Change: 1.46
    Ensembl ID: ENSG00000071553
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.45
    Ensembl ID: ENSG00000123505
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 1.45
    Ensembl ID: ENSG00000185650
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.44
    Ensembl ID: ENSG00000130402
  • Gene Symbol: CAPS (ENSG00000105519)
    Fold Change: 1.39
    Ensembl ID: ENSG00000105519
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 1.38
    Ensembl ID: ENSG00000152518
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.36
    Ensembl ID: ENSG00000072778
  • Gene Symbol: DST (ENSG00000151914)
    Fold Change: 1.36
    Ensembl ID: ENSG00000151914
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.35
    Ensembl ID: ENSG00000116459
  • Gene Symbol: BAD (ENSG00000002330)
    Fold Change: 1.34
    Ensembl ID: ENSG00000002330
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.32
    Ensembl ID: ENSG00000164111
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.31
    Ensembl ID: ENSG00000165527
  • Gene Symbol: ANG (ENSG00000214274)
    Fold Change: 1.3
    Ensembl ID: ENSG00000214274
  • Gene Symbol: SEPTIN7 (ENSG00000122545)
    Fold Change: 1.3
    Ensembl ID: ENSG00000122545
  • Gene Symbol: BNIP3 (ENSG00000176171)
    Fold Change: 1.26
    Ensembl ID: ENSG00000176171
  • Gene Symbol: KLF5 (ENSG00000102554)
    Fold Change: 1.24
    Ensembl ID: ENSG00000102554
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: 1.19
    Ensembl ID: ENSG00000087088
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 1.17
    Ensembl ID: ENSG00000111348
  • Gene Symbol: ACLY (ENSG00000131473)
    Fold Change: 1.15
    Ensembl ID: ENSG00000131473
  • Gene Symbol: CBFB (ENSG00000067955)
    Fold Change: 1.15
    Ensembl ID: ENSG00000067955
  • Gene Symbol: APLP1 (ENSG00000105290)
    Fold Change: 1.14
    Ensembl ID: ENSG00000105290
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.12
    Ensembl ID: ENSG00000143727
  • Gene Symbol: AP2B1 (ENSG00000006125)
    Fold Change: 1.11
    Ensembl ID: ENSG00000006125
  • Gene Symbol: ARL2 (ENSG00000213465)
    Fold Change: 1.11
    Ensembl ID: ENSG00000213465
  • Gene Symbol: ATP2A2 (ENSG00000174437)
    Fold Change: 1.11
    Ensembl ID: ENSG00000174437
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.11
    Ensembl ID: ENSG00000104765
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.1
    Ensembl ID: ENSG00000122359
  • Gene Symbol: ARF3 (ENSG00000134287)
    Fold Change: 1.07
    Ensembl ID: ENSG00000134287
  • Gene Symbol: CD47 (ENSG00000196776)
    Fold Change: 1.07
    Ensembl ID: ENSG00000196776
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.07
    Ensembl ID: ENSG00000085224
  • Gene Symbol: SLC25A4 (ENSG00000151729)
    Fold Change: 1.06
    Ensembl ID: ENSG00000151729
  • Gene Symbol: ARL3 (ENSG00000138175)
    Fold Change: 1.04
    Ensembl ID: ENSG00000138175
  • Gene Symbol: PTTG1IP (ENSG00000183255)
    Fold Change: 1.02
    Ensembl ID: ENSG00000183255
  • Gene Symbol: RHOC (ENSG00000155366)
    Fold Change: 1.01
    Ensembl ID: ENSG00000155366
  • Gene Symbol: KIF1A (ENSG00000130294)
    Fold Change: 1.01
    Ensembl ID: ENSG00000130294
  • Gene Symbol: BIRC2 (ENSG00000110330)
    Fold Change: 1.01
    Ensembl ID: ENSG00000110330
  • Gene Symbol: ALDH9A1 (ENSG00000143149)
    Fold Change: 1.01
    Ensembl ID: ENSG00000143149
  • Gene Symbol: AAMP (ENSG00000127837)
    Fold Change: 1
    Ensembl ID: ENSG00000127837
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: N/A
    Ensembl ID: ENSG00000115307
  • Gene Symbol: CCT6A (ENSG00000146731)
    Fold Change: N/A
    Ensembl ID: ENSG00000146731
Hovered Details

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Hovered Details

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**Key Characteristics** * **Location**: G cells are found in the pyloric gland mucosa (antral mucosa) of the stomach in mammals. * **Shape**: G cells are pyramidal in shape with a narrow apex bearing long microvilli. * **Function**: G cells secrete gastrin and enkephalin, two hormones that regulate gastric acid secretion, appetite, and pain perception. * **Gene**: The gene symbol for G cells is B2M, and their Ensembl ID is ENSG00000166710. * **Pathways/Ontology**: G cells are involved in various pathways, including adaptive immune system, amyloid fiber formation, antigen presentation, and response to bacterial infections. **Clinical Significance** G cells play important roles in various physiological and pathological processes, including: * **Gastric acid secretion**: G cells regulate gastric acid secretion through the secretion of gastrin, which stimulates the parietal cells to release hydrochloric acid. * **Appetite regulation**: G cells regulate appetite through the secretion of enkephalin, which acts as a neurotransmitter to regulate food intake. * **Pain perception**: G cells regulate pain perception through the secretion of enkephalin, which acts as a neurotransmitter to regulate pain transmission. * **Immune system regulation**: G cells regulate the immune system through the secretion of gastrin, which stimulates the activation of immune cells. * **Response to bacterial infections**: G cells regulate the response to bacterial infections through the secretion of gastrin, which stimulates the activation of immune cells. Dysregulation of G cells has been implicated in various diseases, including: * **Gastric cancer**: Dysregulation of G cells has been implicated in the development of gastric cancer. * **Inflammatory bowel disease**: Dysregulation of G cells has been implicated in the development of inflammatory bowel disease. * **Neurological disorders**: Dysregulation of G cells has been implicated in the development of neurological disorders, including Parkinson's disease and Alzheimer's disease. Overall, G cells play important roles in regulating various physiological and pathological processes, and their dysregulation has been implicated in various diseases.