Details for: TMEM258

Gene ID: 746

Symbol: TMEM258

Ensembl ID: ENSG00000134825

Description: transmembrane protein 258

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 4.05
    Marker Score: 6,236
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 4.03
    Marker Score: 3,430
  • Cell Name: cord blood hematopoietic stem cell (CL2000095)
    Fold Change: 3.67
    Marker Score: 2,768
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 3.55
    Marker Score: 46,846
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 3.4
    Marker Score: 6,198
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 3.32
    Marker Score: 1,223
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 3.26
    Marker Score: 110,846
  • Cell Name: blood cell (CL0000081)
    Fold Change: 3.23
    Marker Score: 37,503
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 3.22
    Marker Score: 31,884
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 3.2
    Marker Score: 2,858
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 3.2
    Marker Score: 110,768
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 3.17
    Marker Score: 1,266
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 3.17
    Marker Score: 3,303
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 3.12
    Marker Score: 1,404
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 3.11
    Marker Score: 8,592
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 3.1
    Marker Score: 19,779
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 3.08
    Marker Score: 987
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 3.07
    Marker Score: 20,010
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 3.07
    Marker Score: 2,053
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 3.07
    Marker Score: 171,460
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 3.03
    Marker Score: 6,883
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 3.03
    Marker Score: 19,715
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 3.03
    Marker Score: 7,396
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 3
    Marker Score: 6,831
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 2.96
    Marker Score: 2,319
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 2.95
    Marker Score: 15,505
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 2.95
    Marker Score: 4,736
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 2.93
    Marker Score: 39,392
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 2.92
    Marker Score: 25,390
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 2.89
    Marker Score: 997
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 2.88
    Marker Score: 3,755
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 2.86
    Marker Score: 1,793
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 2.84
    Marker Score: 16,867
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 2.82
    Marker Score: 3,879
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.79
    Marker Score: 10,765
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.73
    Marker Score: 11,765
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 2.72
    Marker Score: 20,257
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 2.71
    Marker Score: 2,597
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.7
    Marker Score: 30,453
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 2.7
    Marker Score: 4,481
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 2.7
    Marker Score: 7,060
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 2.69
    Marker Score: 5,617
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 2.68
    Marker Score: 5,361
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 2.68
    Marker Score: 5,225
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 2.67
    Marker Score: 3,783
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 2.67
    Marker Score: 1,267
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 2.67
    Marker Score: 8,426
  • Cell Name: theca cell (CL0000503)
    Fold Change: 2.67
    Marker Score: 1,913
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 2.67
    Marker Score: 6,726
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 2.65
    Marker Score: 2,687
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 2.64
    Marker Score: 4,207
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 2.64
    Marker Score: 4,964
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 2.64
    Marker Score: 2,818
  • Cell Name: tracheobronchial serous cell (CL0019001)
    Fold Change: 2.64
    Marker Score: 963
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 2.63
    Marker Score: 961
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 2.62
    Marker Score: 2,537
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.62
    Marker Score: 26,413
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 2.62
    Marker Score: 2,068
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 2.62
    Marker Score: 20,482
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 2.61
    Marker Score: 6,984
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 2.59
    Marker Score: 1,623
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 2.59
    Marker Score: 4,241
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 2.58
    Marker Score: 1,331
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 2.58
    Marker Score: 2,897
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 2.58
    Marker Score: 3,705
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 2.57
    Marker Score: 2,417
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.56
    Marker Score: 612
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 2.56
    Marker Score: 65,494
  • Cell Name: ventricular cardiac muscle cell (CL2000046)
    Fold Change: 2.55
    Marker Score: 1,057
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 2.55
    Marker Score: 807
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 2.55
    Marker Score: 6,930
  • Cell Name: club cell (CL0000158)
    Fold Change: 2.54
    Marker Score: 2,970
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.54
    Marker Score: 16,258
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 2.54
    Marker Score: 4,430
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 2.54
    Marker Score: 1,991
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 2.53
    Marker Score: 4,307
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 2.53
    Marker Score: 2,706
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 2.53
    Marker Score: 4,523
  • Cell Name: epithelial cell of exocrine pancreas (CL1001433)
    Fold Change: 2.52
    Marker Score: 1,419
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 2.5
    Marker Score: 1,336
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 2.5
    Marker Score: 1,248
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.48
    Marker Score: 7,361
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 2.46
    Marker Score: 1,032
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 2.44
    Marker Score: 1,628
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 2.44
    Marker Score: 9,971
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 2.44
    Marker Score: 1,390
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 2.43
    Marker Score: 781
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 2.42
    Marker Score: 839
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 2.42
    Marker Score: 1,141
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 2.41
    Marker Score: 858
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 2.41
    Marker Score: 127,657
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 2.41
    Marker Score: 2,980
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: 2.39
    Marker Score: 1,045
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 2.39
    Marker Score: 1,421
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 2.39
    Marker Score: 4,099
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 2.39
    Marker Score: 11,458
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 2.38
    Marker Score: 2,384
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 2.38
    Marker Score: 2,590
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 2.37
    Marker Score: 735
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 2.37
    Marker Score: 1,969

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TMEM258 is a transmembrane protein, meaning it spans the cell membrane and is embedded in the plasma membrane. It belongs to the TMEM family of proteins, which are known to play roles in various cellular processes, including cell signaling, cell adhesion, and protein transport. TMEM258 is specifically expressed in various cell types, including mesenchymal stem cells, IgA plasma cells, cord blood hematopoietic stem cells, and mature T cells. Its expression is also observed in secretory cells, such as those found in the lung and mammary gland. **Pathways and Functions:** TMEM258 is involved in several cellular pathways, including: 1. **Endoplasmic Reticulum Stress Response:** TMEM258 is part of the oligosaccharyltransferase complex, which is responsible for protein N-linked glycosylation. This process is crucial for protein folding and stability, and TMEM258 plays a role in regulating ER stress response. 2. **Inflammatory Response:** TMEM258 is involved in the inflammatory response, particularly in the context of immune cells, such as T cells and plasma cells. 3. **Protein Binding:** TMEM258 interacts with various proteins, including those involved in protein transport, signaling, and cell adhesion. 4. **Oligosaccharyltransferase Complex Binding:** TMEM258 binds to the oligosaccharyltransferase complex, which is essential for protein N-linked glycosylation. **Clinical Significance:** TMEM258 has been implicated in various diseases, including: 1. **Autoimmune Disorders:** TMEM258 has been shown to play a role in autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis, where immune cells are dysregulated. 2. **Cancer:** TMEM258 has been found to be overexpressed in certain types of cancer, including lung cancer and breast cancer, suggesting its potential role in tumorigenesis. 3. **Neurological Disorders:** TMEM258 has been implicated in neurological disorders, such as Alzheimer's disease and Parkinson's disease, where ER stress response and immune regulation are disrupted. In conclusion, TMEM258 is a multifunctional protein that plays a critical role in endoplasmic reticulum stress response, inflammatory response, and protein binding. Its dysregulation has been implicated in various diseases, highlighting its potential as a therapeutic target for autoimmune disorders, cancer, and neurological disorders. **Recommendations:** Further research is needed to fully elucidate the function and significance of TMEM258. Studies should focus on: 1. **Functional Analysis:** Investigating the functional consequences of TMEM258 expression in different cell types and disease models. 2. **Pathway Analysis:** Elucidating the protein-protein interactions and signaling pathways involved in TMEM258 function. 3. **Clinical Studies:** Conducting clinical studies to explore the association between TMEM258 expression and disease outcomes in patients with autoimmune disorders, cancer, and neurological disorders. By further understanding the role of TMEM258 in cellular processes and disease, we can identify potential therapeutic targets for the treatment of various diseases.

Genular Protein ID: 3263708872

Symbol: TM258_HUMAN

Name: Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit TMEM258

UniProtKB Accession Codes:

P61165 A8K6L8 Q9D953 Q9Y2Q7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 ComplexPortal 2 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 EMDB 3 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 13 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 2 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 7 PDBsum 3 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TCDB 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniPathway 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11042152

Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.

PubMed ID: 11042152

DOI: 10.1101/gr.140200

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12665801

Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.

PubMed ID: 12665801

DOI: 10.1038/nbt810

PubMed ID: 12427278

Title: Two overlapping divergent transcription units in the human genome: the FEN1/C11orf10 locus.

PubMed ID: 12427278

DOI: 10.1089/15362310260256927

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 26472760

Title: Gene essentiality and synthetic lethality in haploid human cells.

PubMed ID: 26472760

DOI: 10.1126/science.aac7557

PubMed ID: 27974209

Title: TMEM258 is a component of the oligosaccharyltransferase complex controlling ER stress and intestinal inflammation.

PubMed ID: 27974209

DOI: 10.1016/j.celrep.2016.11.042

PubMed ID: 28716842

Title: Outer nuclear membrane protein Kuduk modulates the LINC complex and nuclear envelope architecture.

PubMed ID: 28716842

DOI: 10.1083/jcb.201606043

PubMed ID: 31831667

Title: Cryo-electron microscopy structures of human oligosaccharyltransferase complexes OST-A and OST-B.

PubMed ID: 31831667

DOI: 10.1126/science.aaz3505

Sequence Information:

  • Length: 79
  • Mass: 9079
  • Checksum: 8105E40132994646
  • Sequence:
    • MELEAMSRYT SPVNPAVFPH LTVVLLAIGM FFTAWFFVYE VTSTKYTRDI YKELLISLVA 
SLFMGFGVLF LLLWVGIYV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.