Details for: TMEM258

Gene ID: 746

Symbol: TMEM258

Ensembl ID: ENSG00000134825

Description: transmembrane protein 258

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 4.05
    Marker Score: 6235.5
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 4.03
    Marker Score: 3430
  • Cell Name: cord blood hematopoietic stem cell (CL2000095)
    Fold Change: 3.67
    Marker Score: 2767.5
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 3.55
    Marker Score: 46846
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 3.4
    Marker Score: 6197.5
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 3.32
    Marker Score: 1223
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 3.26
    Marker Score: 110846
  • Cell Name: blood cell (CL0000081)
    Fold Change: 3.23
    Marker Score: 37503
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 3.22
    Marker Score: 31884
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 3.2
    Marker Score: 2858
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 3.2
    Marker Score: 110768
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 3.17
    Marker Score: 1266
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 3.17
    Marker Score: 3303
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 3.12
    Marker Score: 1404
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 3.11
    Marker Score: 8592
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 3.1
    Marker Score: 19779
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 3.08
    Marker Score: 986.5
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 3.07
    Marker Score: 20010
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 3.07
    Marker Score: 2053
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 3.07
    Marker Score: 171460
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 3.03
    Marker Score: 6883
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 3.03
    Marker Score: 19715
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 3.03
    Marker Score: 7396
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 3
    Marker Score: 6831
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 2.96
    Marker Score: 2319
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 2.95
    Marker Score: 15505
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 2.95
    Marker Score: 4736
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 2.93
    Marker Score: 39391.5
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 2.92
    Marker Score: 25390
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 2.89
    Marker Score: 997
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 2.88
    Marker Score: 3755
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 2.86
    Marker Score: 1793
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 2.84
    Marker Score: 16867
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 2.82
    Marker Score: 3879
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.79
    Marker Score: 10765
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.73
    Marker Score: 11765
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 2.72
    Marker Score: 20256.5
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 2.71
    Marker Score: 2597
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.7
    Marker Score: 30452.5
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 2.7
    Marker Score: 4481
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 2.7
    Marker Score: 7060
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 2.69
    Marker Score: 5617
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 2.68
    Marker Score: 5361
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 2.68
    Marker Score: 5225
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 2.67
    Marker Score: 3783
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 2.67
    Marker Score: 1267
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 2.67
    Marker Score: 8426
  • Cell Name: theca cell (CL0000503)
    Fold Change: 2.67
    Marker Score: 1913
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 2.67
    Marker Score: 6726
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 2.65
    Marker Score: 2687
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 2.64
    Marker Score: 4207
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 2.64
    Marker Score: 4964
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 2.64
    Marker Score: 2818
  • Cell Name: tracheobronchial serous cell (CL0019001)
    Fold Change: 2.64
    Marker Score: 963
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 2.63
    Marker Score: 961
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 2.62
    Marker Score: 2537
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.62
    Marker Score: 26413
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 2.62
    Marker Score: 2068
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 2.62
    Marker Score: 20482
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 2.61
    Marker Score: 6984
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 2.59
    Marker Score: 1623
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 2.59
    Marker Score: 4241
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 2.58
    Marker Score: 1331
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 2.58
    Marker Score: 2897
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 2.58
    Marker Score: 3705
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 2.57
    Marker Score: 2417
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.56
    Marker Score: 612
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 2.56
    Marker Score: 65494
  • Cell Name: ventricular cardiac muscle cell (CL2000046)
    Fold Change: 2.55
    Marker Score: 1057
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 2.55
    Marker Score: 807
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 2.55
    Marker Score: 6930
  • Cell Name: club cell (CL0000158)
    Fold Change: 2.54
    Marker Score: 2970
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.54
    Marker Score: 16258
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 2.54
    Marker Score: 4429.5
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 2.54
    Marker Score: 1991
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 2.53
    Marker Score: 4307
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 2.53
    Marker Score: 2706
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 2.53
    Marker Score: 4523
  • Cell Name: epithelial cell of exocrine pancreas (CL1001433)
    Fold Change: 2.52
    Marker Score: 1419
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 2.5
    Marker Score: 1335.5
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 2.5
    Marker Score: 1248
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.48
    Marker Score: 7361
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 2.46
    Marker Score: 1032
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 2.44
    Marker Score: 1628
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 2.44
    Marker Score: 9970.5
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 2.44
    Marker Score: 1389.5
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 2.43
    Marker Score: 781
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 2.42
    Marker Score: 839
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 2.42
    Marker Score: 1141
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 2.41
    Marker Score: 858
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 2.41
    Marker Score: 127657
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 2.41
    Marker Score: 2980
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: 2.39
    Marker Score: 1045
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 2.39
    Marker Score: 1421
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 2.39
    Marker Score: 4099
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 2.39
    Marker Score: 11458
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 2.38
    Marker Score: 2384
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 2.38
    Marker Score: 2590
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 2.37
    Marker Score: 735
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 2.37
    Marker Score: 1969

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Other Information

**Key characteristics:** * TMEM258 is a transmembrane protein with a molecular weight of approximately 130 kDa. * It is a glycoprotein that is expressed on the cell surface and in the cytoplasm. * It is involved in the regulation of cell death and inflammation. **Pathways and functions:** * TMEM258 is involved in the cytoplasm, endoplasmic reticulum, and epithelial cell apoptotic processes. * It is a key regulator of the endoplasmic reticulum (ER) stress response. * It is involved in the regulation of inflammation by interacting with the ER stress sensor PERK2. * It is involved in the regulation of cell migration and differentiation. **Clinical significance:** TMEM258 is a potential therapeutic target for a variety of diseases, including cancer, inflammation, and neurodegenerative disorders. By targeting TMEM258, it is possible to inhibit the progression of these diseases. **Additional information:** * TMEM258 is a member of the TMEM family of proteins, which are involved in the regulation of cell surface signaling. * It is a highly conserved protein that is found in organisms from yeast to humans. * It is a ubiquitin-dependent protein that is degraded by the proteasome.

Genular Protein ID: 3263708872

Symbol: TM258_HUMAN

Name: Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit TMEM258

UniProtKB Accession Codes:

P61165 A8K6L8 Q9D953 Q9Y2Q7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 ComplexPortal 2 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 EMDB 3 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 13 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 2 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 7 PDBsum 3 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TCDB 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniPathway 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11042152

Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.

PubMed ID: 11042152

DOI: 10.1101/gr.140200

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12665801

Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.

PubMed ID: 12665801

DOI: 10.1038/nbt810

PubMed ID: 12427278

Title: Two overlapping divergent transcription units in the human genome: the FEN1/C11orf10 locus.

PubMed ID: 12427278

DOI: 10.1089/15362310260256927

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 26472760

Title: Gene essentiality and synthetic lethality in haploid human cells.

PubMed ID: 26472760

DOI: 10.1126/science.aac7557

PubMed ID: 27974209

Title: TMEM258 is a component of the oligosaccharyltransferase complex controlling ER stress and intestinal inflammation.

PubMed ID: 27974209

DOI: 10.1016/j.celrep.2016.11.042

PubMed ID: 28716842

Title: Outer nuclear membrane protein Kuduk modulates the LINC complex and nuclear envelope architecture.

PubMed ID: 28716842

DOI: 10.1083/jcb.201606043

PubMed ID: 31831667

Title: Cryo-electron microscopy structures of human oligosaccharyltransferase complexes OST-A and OST-B.

PubMed ID: 31831667

DOI: 10.1126/science.aaz3505

Sequence Information:

  • Length: 79
  • Mass: 9079
  • Checksum: 8105E40132994646
  • Sequence:
    • MELEAMSRYT SPVNPAVFPH LTVVLLAIGM FFTAWFFVYE VTSTKYTRDI YKELLISLVA 
SLFMGFGVLF LLLWVGIYV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.