Details for: TMEM258
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 611.5263
Cell Significance Index: -95.1200 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 337.6788
Cell Significance Index: -85.6500 - Cell Name: embryonic stem cell (CL0002322)
Fold Change: 281.2979
Cell Significance Index: -115.8800 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 243.7127
Cell Significance Index: -99.0100 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 236.4428
Cell Significance Index: -111.6300 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 210.7564
Cell Significance Index: -108.4100 - Cell Name: ileal goblet cell (CL1000326)
Fold Change: 166.6562
Cell Significance Index: -111.8300 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 104.7926
Cell Significance Index: -100.0500 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 88.6447
Cell Significance Index: -109.3000 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 29.6619
Cell Significance Index: -79.4600 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 28.8745
Cell Significance Index: -113.9400 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 25.1216
Cell Significance Index: -77.1600 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 13.7806
Cell Significance Index: -30.1600 - Cell Name: kidney cell (CL1000497)
Fold Change: 5.9135
Cell Significance Index: 47.2200 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 5.0208
Cell Significance Index: 234.1000 - Cell Name: granulosa cell (CL0000501)
Fold Change: 5.0004
Cell Significance Index: 131.4900 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 4.0997
Cell Significance Index: 563.0100 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 3.8722
Cell Significance Index: 103.5800 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 3.8207
Cell Significance Index: 179.5700 - Cell Name: cell in vitro (CL0001034)
Fold Change: 3.6684
Cell Significance Index: 2003.4000 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 3.4264
Cell Significance Index: 71.7200 - Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
Fold Change: 3.3904
Cell Significance Index: 20.8700 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 2.9005
Cell Significance Index: 522.8800 - Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 2.8773
Cell Significance Index: 31.2800 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 2.8715
Cell Significance Index: 214.0100 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 2.7644
Cell Significance Index: 339.9100 - Cell Name: lactocyte (CL0002325)
Fold Change: 2.6940
Cell Significance Index: 348.0500 - Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 2.6742
Cell Significance Index: 30.3800 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 2.6533
Cell Significance Index: 312.9000 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 2.5961
Cell Significance Index: 76.2500 - Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 2.3367
Cell Significance Index: 29.9300 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 2.3336
Cell Significance Index: 63.5200 - Cell Name: peg cell (CL4033014)
Fold Change: 2.3317
Cell Significance Index: 53.8700 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 2.3167
Cell Significance Index: 66.4100 - Cell Name: odontoblast (CL0000060)
Fold Change: 2.2516
Cell Significance Index: 288.6400 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 2.2429
Cell Significance Index: 382.9900 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 2.1436
Cell Significance Index: 19.7400 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 2.1393
Cell Significance Index: 147.9500 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 1.9565
Cell Significance Index: 865.0200 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 1.8645
Cell Significance Index: 34.4600 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: 1.6522
Cell Significance Index: 116.8500 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 1.1587
Cell Significance Index: 188.4500 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 0.9692
Cell Significance Index: 33.6800 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.8360
Cell Significance Index: 43.4300 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.7316
Cell Significance Index: 47.2000 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.7208
Cell Significance Index: 545.5600 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.6794
Cell Significance Index: 30.8000 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.5524
Cell Significance Index: 15.9200 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.5200
Cell Significance Index: 469.4900 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.4830
Cell Significance Index: 91.9100 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.4693
Cell Significance Index: 12.5300 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.2960
Cell Significance Index: 29.2800 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.2656
Cell Significance Index: 52.7100 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.1300
Cell Significance Index: 2.1800 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 0.0519
Cell Significance Index: 38.0800 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0049
Cell Significance Index: -3.6300 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0278
Cell Significance Index: -52.4300 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0289
Cell Significance Index: -53.2200 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0377
Cell Significance Index: -57.9700 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0421
Cell Significance Index: -4.3000 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0576
Cell Significance Index: -35.9800 - Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: -0.0577
Cell Significance Index: -1.0200 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0954
Cell Significance Index: -129.7000 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0958
Cell Significance Index: -19.2200 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.1175
Cell Significance Index: -6.1700 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.1319
Cell Significance Index: -47.3100 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.1351
Cell Significance Index: -85.8000 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.1362
Cell Significance Index: -76.8200 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1947
Cell Significance Index: -41.0100 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.2078
Cell Significance Index: -94.3100 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.2661
Cell Significance Index: -30.4900 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.2890
Cell Significance Index: -83.1500 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.3068
Cell Significance Index: -15.9800 - Cell Name: germ cell (CL0000586)
Fold Change: -0.3642
Cell Significance Index: -2.7500 - Cell Name: pro-T cell (CL0000827)
Fold Change: -0.5453
Cell Significance Index: -13.9300 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.6235
Cell Significance Index: -39.3000 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.6243
Cell Significance Index: -72.7600 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.6500
Cell Significance Index: -94.4800 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.6728
Cell Significance Index: -21.5500 - Cell Name: paneth cell of colon (CL0009009)
Fold Change: -0.7341
Cell Significance Index: -11.0000 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.7736
Cell Significance Index: -21.6200 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.7763
Cell Significance Index: -88.6100 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -1.0283
Cell Significance Index: -81.4400 - Cell Name: theca cell (CL0000503)
Fold Change: -1.0655
Cell Significance Index: -6.2600 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -1.0900
Cell Significance Index: -113.4900 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -1.2401
Cell Significance Index: -69.5900 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -1.3483
Cell Significance Index: -82.8700 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -1.4012
Cell Significance Index: -107.5300 - Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -1.5095
Cell Significance Index: -9.1200 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -1.6117
Cell Significance Index: -21.9900 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -1.6545
Cell Significance Index: -111.2500 - Cell Name: extravillous trophoblast (CL0008036)
Fold Change: -1.6561
Cell Significance Index: -10.2900 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -1.8038
Cell Significance Index: -110.5900 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -1.9824
Cell Significance Index: -58.3900 - Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: -2.0390
Cell Significance Index: -35.1500 - Cell Name: melanocyte of skin (CL1000458)
Fold Change: -2.0875
Cell Significance Index: -29.2600 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -2.3284
Cell Significance Index: -50.4500 - Cell Name: neuron associated cell (CL0000095)
Fold Change: -2.3315
Cell Significance Index: -95.5400 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -2.3547
Cell Significance Index: -63.1000 - Cell Name: seromucus secreting cell (CL0000159)
Fold Change: -2.4324
Cell Significance Index: -50.7300
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Key Characteristics:
TMEM258 is a transmembrane protein, meaning it spans the cell membrane and is embedded in the plasma membrane. It belongs to the TMEM family of proteins, which are known to play roles in various cellular processes, including cell signaling, cell adhesion, and protein transport. TMEM258 is specifically expressed in various cell types, including mesenchymal stem cells, IgA plasma cells, cord blood hematopoietic stem cells, and mature T cells. Its expression is also observed in secretory cells, such as those found in the lung and mammary gland.
Pathways and Functions:
TMEM258 is involved in several cellular pathways, including:
- Endoplasmic Reticulum Stress Response: TMEM258 is part of the oligosaccharyltransferase complex, which is responsible for protein N-linked glycosylation. This process is crucial for protein folding and stability, and TMEM258 plays a role in regulating ER stress response.
- Inflammatory Response: TMEM258 is involved in the inflammatory response, particularly in the context of immune cells, such as T cells and plasma cells.
- Protein Binding: TMEM258 interacts with various proteins, including those involved in protein transport, signaling, and cell adhesion.
- Oligosaccharyltransferase Complex Binding: TMEM258 binds to the oligosaccharyltransferase complex, which is essential for protein N-linked glycosylation.
Clinical Significance:
TMEM258 has been implicated in various diseases, including:
- Autoimmune Disorders: TMEM258 has been shown to play a role in autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis, where immune cells are dysregulated.
- Cancer: TMEM258 has been found to be overexpressed in certain types of cancer, including lung cancer and breast cancer, suggesting its potential role in tumorigenesis.
- Neurological Disorders: TMEM258 has been implicated in neurological disorders, such as Alzheimer’s disease and Parkinson’s disease, where ER stress response and immune regulation are disrupted.
In conclusion, TMEM258 is a multifunctional protein that plays a critical role in endoplasmic reticulum stress response, inflammatory response, and protein binding. Its dysregulation has been implicated in various diseases, highlighting its potential as a therapeutic target for autoimmune disorders, cancer, and neurological disorders.
Recommendations:
Further research is needed to fully elucidate the function and significance of TMEM258. Studies should focus on:
- Functional Analysis: Investigating the functional consequences of TMEM258 expression in different cell types and disease models.
- Pathway Analysis: Elucidating the protein-protein interactions and signaling pathways involved in TMEM258 function.
- Clinical Studies: Conducting clinical studies to explore the association between TMEM258 expression and disease outcomes in patients with autoimmune disorders, cancer, and neurological disorders.
By further understanding the role of TMEM258 in cellular processes and disease, we can identify potential therapeutic targets for the treatment of various diseases.
Genular Protein ID: 3263708872
Symbol: TM258_HUMAN
Name: Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit TMEM258
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11042152
Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.
PubMed ID: 11042152
DOI: 10.1101/gr.140200
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16554811
Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.
PubMed ID: 16554811
DOI: 10.1038/nature04632
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 12665801
Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.
PubMed ID: 12665801
DOI: 10.1038/nbt810
PubMed ID: 12427278
Title: Two overlapping divergent transcription units in the human genome: the FEN1/C11orf10 locus.
PubMed ID: 12427278
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 22223895
Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.
PubMed ID: 22223895
PubMed ID: 22814378
Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
PubMed ID: 22814378
PubMed ID: 26472760
Title: Gene essentiality and synthetic lethality in haploid human cells.
PubMed ID: 26472760
PubMed ID: 27974209
Title: TMEM258 is a component of the oligosaccharyltransferase complex controlling ER stress and intestinal inflammation.
PubMed ID: 27974209
PubMed ID: 28716842
Title: Outer nuclear membrane protein Kuduk modulates the LINC complex and nuclear envelope architecture.
PubMed ID: 28716842
PubMed ID: 31831667
Title: Cryo-electron microscopy structures of human oligosaccharyltransferase complexes OST-A and OST-B.
PubMed ID: 31831667
Sequence Information:
- Length: 79
- Mass: 9079
- Checksum: 8105E40132994646
- Sequence:
MELEAMSRYT SPVNPAVFPH LTVVLLAIGM FFTAWFFVYE VTSTKYTRDI YKELLISLVA SLFMGFGVLF LLLWVGIYV
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.