Details for: CL0000503

Cell ID: CL0000503

Cell Name: theca cell

Marker Score Threshold: 717
(Derived using integrated single-cell and genomic data)

Description: A flattened stroma cell forming a sheath or theca outside the basal lamina lining the mature ovarian follicle. Thecal interstitial or stromal cells are steroidogenic, and produce primarily androgens which serve as precusors of estrogens in the granulosa cells.

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 4.84
    Ensembl ID: ENSG00000166710
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 4.59
    Ensembl ID: ENSG00000145741
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 4.48
    Ensembl ID: ENSG00000075624
  • Gene Symbol: CALD1 (ENSG00000122786)
    Fold Change: 4.46
    Ensembl ID: ENSG00000122786
  • Gene Symbol: BST2 (ENSG00000130303)
    Fold Change: 4.28
    Ensembl ID: ENSG00000130303
  • Gene Symbol: CIRBP (ENSG00000099622)
    Fold Change: 4.28
    Ensembl ID: ENSG00000099622
  • Gene Symbol: APOE (ENSG00000130203)
    Fold Change: 4.24
    Ensembl ID: ENSG00000130203
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 4.23
    Ensembl ID: ENSG00000143933
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 4.23
    Ensembl ID: ENSG00000184009
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 3.91
    Ensembl ID: ENSG00000169100
  • Gene Symbol: CD63 (ENSG00000135404)
    Fold Change: 3.6
    Ensembl ID: ENSG00000135404
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 3.45
    Ensembl ID: ENSG00000135390
  • Gene Symbol: SEPTIN7 (ENSG00000122545)
    Fold Change: 3.44
    Ensembl ID: ENSG00000122545
  • Gene Symbol: C1S (ENSG00000182326)
    Fold Change: 3.23
    Ensembl ID: ENSG00000182326
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 3.07
    Ensembl ID: ENSG00000133639
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 2.83
    Ensembl ID: ENSG00000124172
  • Gene Symbol: C7 (ENSG00000112936)
    Fold Change: 2.8
    Ensembl ID: ENSG00000112936
  • Gene Symbol: C1R (ENSG00000159403)
    Fold Change: 2.74
    Ensembl ID: ENSG00000159403
  • Gene Symbol: CFL1 (ENSG00000172757)
    Fold Change: 2.73
    Ensembl ID: ENSG00000172757
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 2.67
    Ensembl ID: ENSG00000134825
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 2.64
    Ensembl ID: ENSG00000149925
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 2.62
    Ensembl ID: ENSG00000185650
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 2.53
    Ensembl ID: ENSG00000168374
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 2.46
    Ensembl ID: ENSG00000241837
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 2.44
    Ensembl ID: ENSG00000154723
  • Gene Symbol: CDC42 (ENSG00000070831)
    Fold Change: 2.38
    Ensembl ID: ENSG00000070831
  • Gene Symbol: SERPINH1 (ENSG00000149257)
    Fold Change: 2.35
    Ensembl ID: ENSG00000149257
  • Gene Symbol: CEBPD (ENSG00000221869)
    Fold Change: 2.34
    Ensembl ID: ENSG00000221869
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 2.32
    Ensembl ID: ENSG00000142192
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 2.23
    Ensembl ID: ENSG00000169020
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 2.23
    Ensembl ID: ENSG00000143761
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 2.21
    Ensembl ID: ENSG00000164111
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 2.2
    Ensembl ID: ENSG00000172270
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 2.2
    Ensembl ID: ENSG00000198668
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 2.16
    Ensembl ID: ENSG00000110955
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.16
    Ensembl ID: ENSG00000067560
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 2.15
    Ensembl ID: ENSG00000152518
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 2.14
    Ensembl ID: ENSG00000005022
  • Gene Symbol: SERPING1 (ENSG00000149131)
    Fold Change: 2.12
    Ensembl ID: ENSG00000149131
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 2.08
    Ensembl ID: ENSG00000152234
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 2.04
    Ensembl ID: ENSG00000165629
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 2.03
    Ensembl ID: ENSG00000099624
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 2.02
    Ensembl ID: ENSG00000104765
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 2
    Ensembl ID: ENSG00000077549
  • Gene Symbol: AP2M1 (ENSG00000161203)
    Fold Change: 1.91
    Ensembl ID: ENSG00000161203
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.86
    Ensembl ID: ENSG00000084234
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.79
    Ensembl ID: ENSG00000128272
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 1.78
    Ensembl ID: ENSG00000154518
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.77
    Ensembl ID: ENSG00000127022
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 1.77
    Ensembl ID: ENSG00000179218
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 1.76
    Ensembl ID: ENSG00000143878
  • Gene Symbol: CCNG1 (ENSG00000113328)
    Fold Change: 1.72
    Ensembl ID: ENSG00000113328
  • Gene Symbol: ADH5 (ENSG00000197894)
    Fold Change: 1.7
    Ensembl ID: ENSG00000197894
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.7
    Ensembl ID: ENSG00000100823
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.67
    Ensembl ID: ENSG00000085224
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 1.6
    Ensembl ID: ENSG00000198898
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.58
    Ensembl ID: ENSG00000116459
  • Gene Symbol: CD59 (ENSG00000085063)
    Fold Change: 1.56
    Ensembl ID: ENSG00000085063
  • Gene Symbol: ALDH1A1 (ENSG00000165092)
    Fold Change: 1.54
    Ensembl ID: ENSG00000165092
  • Gene Symbol: CDH11 (ENSG00000140937)
    Fold Change: 1.53
    Ensembl ID: ENSG00000140937
  • Gene Symbol: CAMLG (ENSG00000164615)
    Fold Change: 1.52
    Ensembl ID: ENSG00000164615
  • Gene Symbol: BGN (ENSG00000182492)
    Fold Change: 1.52
    Ensembl ID: ENSG00000182492
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.5
    Ensembl ID: ENSG00000160014
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.48
    Ensembl ID: ENSG00000182718
  • Gene Symbol: CAV1 (ENSG00000105974)
    Fold Change: 1.48
    Ensembl ID: ENSG00000105974
  • Gene Symbol: TBCB (ENSG00000105254)
    Fold Change: 1.47
    Ensembl ID: ENSG00000105254
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.45
    Ensembl ID: ENSG00000165527
  • Gene Symbol: ACTA2 (ENSG00000107796)
    Fold Change: 1.43
    Ensembl ID: ENSG00000107796
  • Gene Symbol: RHOC (ENSG00000155366)
    Fold Change: 1.42
    Ensembl ID: ENSG00000155366
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.38
    Ensembl ID: ENSG00000117410
  • Gene Symbol: AEBP1 (ENSG00000106624)
    Fold Change: 1.37
    Ensembl ID: ENSG00000106624
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.37
    Ensembl ID: ENSG00000108561
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.35
    Ensembl ID: ENSG00000072778
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.34
    Ensembl ID: ENSG00000198931
  • Gene Symbol: CALU (ENSG00000128595)
    Fold Change: 1.33
    Ensembl ID: ENSG00000128595
  • Gene Symbol: ANXA6 (ENSG00000197043)
    Fold Change: 1.3
    Ensembl ID: ENSG00000197043
  • Gene Symbol: CD47 (ENSG00000196776)
    Fold Change: 1.3
    Ensembl ID: ENSG00000196776
  • Gene Symbol: APOD (ENSG00000189058)
    Fold Change: 1.28
    Ensembl ID: ENSG00000189058
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.28
    Ensembl ID: ENSG00000159199
  • Gene Symbol: CCT6A (ENSG00000146731)
    Fold Change: 1.26
    Ensembl ID: ENSG00000146731
  • Gene Symbol: CEBPB (ENSG00000172216)
    Fold Change: 1.24
    Ensembl ID: ENSG00000172216
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.23
    Ensembl ID: ENSG00000143727
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.22
    Ensembl ID: ENSG00000163399
  • Gene Symbol: ADM (ENSG00000148926)
    Fold Change: 1.19
    Ensembl ID: ENSG00000148926
  • Gene Symbol: ARL3 (ENSG00000138175)
    Fold Change: 1.18
    Ensembl ID: ENSG00000138175
  • Gene Symbol: BNIP3 (ENSG00000176171)
    Fold Change: 1.17
    Ensembl ID: ENSG00000176171
  • Gene Symbol: APOC1 (ENSG00000130208)
    Fold Change: 1.16
    Ensembl ID: ENSG00000130208
  • Gene Symbol: ALDH7A1 (ENSG00000164904)
    Fold Change: 1.15
    Ensembl ID: ENSG00000164904
  • Gene Symbol: CDK4 (ENSG00000135446)
    Fold Change: 1.15
    Ensembl ID: ENSG00000135446
  • Gene Symbol: AAMP (ENSG00000127837)
    Fold Change: 1.14
    Ensembl ID: ENSG00000127837
  • Gene Symbol: ATP1B1 (ENSG00000143153)
    Fold Change: 1.13
    Ensembl ID: ENSG00000143153
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 1.12
    Ensembl ID: ENSG00000135046
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.1
    Ensembl ID: ENSG00000004059
  • Gene Symbol: ARL1 (ENSG00000120805)
    Fold Change: 1.07
    Ensembl ID: ENSG00000120805
  • Gene Symbol: PTTG1IP (ENSG00000183255)
    Fold Change: 1.06
    Ensembl ID: ENSG00000183255
  • Gene Symbol: ALDH9A1 (ENSG00000143149)
    Fold Change: 1.04
    Ensembl ID: ENSG00000143149
  • Gene Symbol: CKS2 (ENSG00000123975)
    Fold Change: 1.03
    Ensembl ID: ENSG00000123975
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.03
    Ensembl ID: ENSG00000138279
  • Gene Symbol: TMEM50B (ENSG00000142188)
    Fold Change: 1.02
    Ensembl ID: ENSG00000142188
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.02
    Ensembl ID: ENSG00000123505
Hovered Details

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Hovered Details

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**Key Characteristics** The theca cell is characterized by its: * Flattened morphology and the formation of a sheath around the basal lamina of the ovarian follicle * Steroidogenic function, producing androgens that are converted to estrogens by granulosa cells * Expression of genes involved in antigen presentation, including MHC class I and II molecules, and co-stimulatory molecules * Role in the adaptive immune system, particularly in the presentation of antigens to T-cells * Expression of genes involved in iron ion homeostasis and regulation of the immune response **Clinical Significance** The theca cell plays a crucial role in the development and maintenance of the ovarian follicle, and its dysfunction can lead to ovulatory disorders and infertility. The theca cell's involvement in the adaptive immune system has been implicated in various reproductive disorders, including: * **Ovulatory disorders**: The theca cell's dysfunction can lead to ovulatory disorders, including anovulation and polycystic ovary syndrome (PCOS). * **Infertility**: The theca cell's role in antigen presentation and immune response regulation has been implicated in infertility, particularly in the context of immunological disorders such as autoimmune ovarian failure. * **Reproductive immunology**: The theca cell's involvement in the adaptive immune system has been studied extensively in the context of reproductive immunology, with implications for the development of new treatments for reproductive disorders. **Pathways and Ontologies** The theca cell is involved in various pathways and ontologies, including: * **Adaptive immune system**: The theca cell's expression of MHC class I and II molecules and co-stimulatory molecules makes it an important player in the adaptive immune system. * **Antigen presentation**: The theca cell's role in presenting antigens to T-cells has been studied extensively, with implications for the development of new treatments for reproductive disorders. * **Iron ion homeostasis**: The theca cell's expression of genes involved in iron ion homeostasis has been implicated in various reproductive disorders, including infertility. * **Immune response regulation**: The theca cell's expression of genes involved in immune response regulation has been implicated in various reproductive disorders, including ovulatory disorders and infertility. In conclusion, the theca cell is a complex cell type that plays a crucial role in the development and maintenance of the ovarian follicle, and its dysfunction can lead to ovulatory disorders and infertility. Further research is needed to fully understand the theca cell's role in the adaptive immune system and its implications for reproductive health.