Details for: RHOC

Gene ID: 389

Symbol: RHOC

Ensembl ID: ENSG00000155366

Description: ras homolog family member C

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 3.77
    Marker Score: 9587
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 3.57
    Marker Score: 9861
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 3.3
    Marker Score: 4782
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.98
    Marker Score: 7273.5
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 2.91
    Marker Score: 13948
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.81
    Marker Score: 10842
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 2.75
    Marker Score: 2365
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 2.63
    Marker Score: 2073
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 2.6
    Marker Score: 5194
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 2.59
    Marker Score: 2881
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 2.59
    Marker Score: 1506
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.56
    Marker Score: 11056
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 2.5
    Marker Score: 3846
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 2.49
    Marker Score: 969
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 2.48
    Marker Score: 7230
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 2.48
    Marker Score: 7773
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 2.45
    Marker Score: 8701
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 2.36
    Marker Score: 4436
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 2.34
    Marker Score: 3964
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.29
    Marker Score: 78030
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 2.28
    Marker Score: 3314
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 2.24
    Marker Score: 2412
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 2.21
    Marker Score: 3044
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.21
    Marker Score: 24915
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 2.2
    Marker Score: 2071
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 2.18
    Marker Score: 773
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 2.17
    Marker Score: 3844
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 2.15
    Marker Score: 2986
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.15
    Marker Score: 8460
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 2.14
    Marker Score: 497
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 2.13
    Marker Score: 5565
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 2.11
    Marker Score: 15680
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 2.09
    Marker Score: 5050
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 2.08
    Marker Score: 1187
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 2.05
    Marker Score: 1055
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 2.03
    Marker Score: 12965
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 2.02
    Marker Score: 908
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.99
    Marker Score: 7377
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 1.99
    Marker Score: 639
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 1.97
    Marker Score: 558
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 1.96
    Marker Score: 2299
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 1.95
    Marker Score: 1389
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 1.95
    Marker Score: 25710
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 1.94
    Marker Score: 1742
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 1.93
    Marker Score: 3522
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 1.92
    Marker Score: 727
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 1.91
    Marker Score: 797
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.91
    Marker Score: 1205.5
  • Cell Name: enterocyte of epithelium proper of ileum (CL1000342)
    Fold Change: 1.89
    Marker Score: 545
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 1.89
    Marker Score: 1898
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 1.88
    Marker Score: 1801
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 1.87
    Marker Score: 2886
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.87
    Marker Score: 4708
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.86
    Marker Score: 64308
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 1.81
    Marker Score: 438
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.81
    Marker Score: 4261.5
  • Cell Name: pericyte (CL0000669)
    Fold Change: 1.8
    Marker Score: 1052
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 1.8
    Marker Score: 404
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.79
    Marker Score: 1932
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.79
    Marker Score: 2630
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 1.78
    Marker Score: 2325
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.78
    Marker Score: 505
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.78
    Marker Score: 1994
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.78
    Marker Score: 1898
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 1.77
    Marker Score: 441
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 1.76
    Marker Score: 441
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 1.74
    Marker Score: 986
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 1.73
    Marker Score: 1567
  • Cell Name: club cell (CL0000158)
    Fold Change: 1.73
    Marker Score: 2016
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.72
    Marker Score: 1740
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 1.71
    Marker Score: 1128
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.7
    Marker Score: 492
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.68
    Marker Score: 2167
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 1.67
    Marker Score: 1426
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 1.66
    Marker Score: 16452
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.65
    Marker Score: 1716
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 1.65
    Marker Score: 361
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 1.64
    Marker Score: 505
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 1.64
    Marker Score: 1541
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 1.62
    Marker Score: 1328
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 1.62
    Marker Score: 560
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 1.62
    Marker Score: 1562
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.62
    Marker Score: 1081
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.61
    Marker Score: 1077
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 1.61
    Marker Score: 529
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.59
    Marker Score: 2246
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.58
    Marker Score: 403
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 1.58
    Marker Score: 779
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.57
    Marker Score: 1652
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 1.57
    Marker Score: 333
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 1.57
    Marker Score: 9284
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.56
    Marker Score: 3248.5
  • Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
    Fold Change: 1.56
    Marker Score: 512
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.55
    Marker Score: 1635
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 1.54
    Marker Score: 521
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 1.53
    Marker Score: 634
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 1.52
    Marker Score: 7487
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.52
    Marker Score: 1448
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 1.51
    Marker Score: 480
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 1.49
    Marker Score: 2905

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Other Information

**Key characteristics:** * RHOC is a transmembrane protein with a conserved N-terminal domain and a C-terminal GTP-binding domain. * It is expressed in a variety of cell types, including endothelial cells, epithelial cells, and immune cells. * It is involved in a variety of cellular processes, including cell migration, cell proliferation, and angiogenesis. **Pathways and functions:** * RHOC is a key regulator of epithelial cell migration and growth. * It is expressed in endothelial cells, which are responsible for the formation of new blood vessels. * When RHOC binds to GTP, it activates a signaling cascade that leads to the activation of various downstream targets, including formins, pknases, and rhotekin. * These downstream targets regulate a variety of cellular processes, including cell migration, proliferation, and survival. **Clinical significance:** * Mutations in the RHOC gene have been linked to a number of human diseases, including vascular diseases, cancer, and developmental disorders. * Inhibition of RHOC has been shown to be effective in treating these diseases. * Therefore, RHOC is a promising target for the development of new treatments for vascular diseases and other disorders that are characterized by epithelial cell migration and growth.

Genular Protein ID: 134014720

Symbol: RHOC_HUMAN

Name: Rho-related GTP-binding protein RhoC

UniProtKB Accession Codes:

P08134 B3KSW1 Q6ICN3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 3 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 11 EPD 1 Ensembl 7 EvolutionaryTrace 1 ExpressionAtlas 1 GO 23 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 4 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 8 RefSeq 3 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3283705

Title: Coding sequence of human rho cDNAs clone 6 and clone 9.

PubMed ID: 3283705

DOI: 10.1093/nar/16.6.2717

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8816443

Title: The p160 RhoA-binding kinase ROK alpha is a member of a kinase family and is involved in the reorganization of the cytoskeleton.

PubMed ID: 8816443

DOI: 10.1128/mcb.16.10.5313

PubMed ID: 11546812

Title: AKAP-Lbc anchors protein kinase A and nucleates Galpha 12-selective Rho-mediated stress fiber formation.

PubMed ID: 11546812

DOI: 10.1074/jbc.m106629200

PubMed ID: 16236794

Title: Dissecting the role of Rho-mediated signaling in contractile ring formation.

PubMed ID: 16236794

DOI: 10.1091/mbc.e05-06-0569

PubMed ID: 20400958

Title: Regulation of Rho GTPase crosstalk, degradation and activity by RhoGDI1.

PubMed ID: 20400958

DOI: 10.1038/ncb2049

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 20974804

Title: The Rho target PRK2 regulates apical junction formation in human bronchial epithelial cells.

PubMed ID: 20974804

DOI: 10.1128/mcb.01001-10

PubMed ID: 24141704

Title: A bacterial toxin catalyzing tyrosine glycosylation of Rho and deamidation of Gq and Gi proteins.

PubMed ID: 24141704

DOI: 10.1038/nsmb.2688

PubMed ID: 24905543

Title: Haemorrhagic toxin and lethal toxin from Clostridium sordellii strain vpi9048: molecular characterization and comparative analysis of substrate specificity of the large clostridial glucosylating toxins.

PubMed ID: 24905543

DOI: 10.1111/cmi.12321

PubMed ID: 27807006

Title: RHO binding to FAM65A regulates Golgi reorientation during cell migration.

PubMed ID: 27807006

DOI: 10.1242/jcs.198614

PubMed ID: 15864301

Title: Structural and mechanistic insights into the interaction between Rho and mammalian Dia.

PubMed ID: 15864301

DOI: 10.1038/nature03604

Sequence Information:

  • Length: 193
  • Mass: 22006
  • Checksum: A193DA581560F131
  • Sequence:
    • MAAIRKKLVI VGDGACGKTC LLIVFSKDQF PEVYVPTVFE NYIADIEVDG KQVELALWDT 
AGQEDYDRLR PLSYPDTDVI LMCFSIDSPD SLENIPEKWT PEVKHFCPNV PIILVGNKKD 
LRQDEHTRRE LAKMKQEPVR SEEGRDMANR ISAFGYLECS AKTKEGVREV FEMATRAGLQ 
VRKNKRRRGC PIL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.