Details for: RHOC

Gene ID: 389

Symbol: RHOC

Ensembl ID: ENSG00000155366

Description: ras homolog family member C

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 368.7031
    Cell Significance Index: -57.3500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 209.1519
    Cell Significance Index: -53.0500
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 136.0853
    Cell Significance Index: -56.0600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 117.8507
    Cell Significance Index: -55.6400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 104.4159
    Cell Significance Index: -53.7100
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 83.9615
    Cell Significance Index: -56.3400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 46.5142
    Cell Significance Index: -57.3500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 15.3217
    Cell Significance Index: -47.0600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 14.7109
    Cell Significance Index: -58.0500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 11.1076
    Cell Significance Index: -24.3100
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 9.5852
    Cell Significance Index: 68.8400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 6.6633
    Cell Significance Index: 181.3700
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 6.3404
    Cell Significance Index: 39.0200
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 5.9079
    Cell Significance Index: 104.4000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 3.5845
    Cell Significance Index: 267.1500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 3.3307
    Cell Significance Index: 156.5400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 2.8634
    Cell Significance Index: 32.5300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.7498
    Cell Significance Index: 377.6200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 2.7107
    Cell Significance Index: 56.7400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 2.4390
    Cell Significance Index: 241.2700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.9757
    Cell Significance Index: 255.2500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.9535
    Cell Significance Index: 212.4800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.8910
    Cell Significance Index: 232.5200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.7812
    Cell Significance Index: 51.0600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.4902
    Cell Significance Index: 191.0300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.3781
    Cell Significance Index: 752.6000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.2870
    Cell Significance Index: 19.2900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.2823
    Cell Significance Index: 90.6900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.2227
    Cell Significance Index: 26.4900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.1130
    Cell Significance Index: 492.0900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.1020
    Cell Significance Index: 198.6600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 0.8866
    Cell Significance Index: -2.3800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.7206
    Cell Significance Index: 49.8300
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: 0.6454
    Cell Significance Index: 2.9800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.6161
    Cell Significance Index: 32.0100
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.5681
    Cell Significance Index: 3.5300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.5516
    Cell Significance Index: 25.7200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.4865
    Cell Significance Index: 31.3900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.4296
    Cell Significance Index: 11.3000
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.4121
    Cell Significance Index: 2.4900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3514
    Cell Significance Index: 66.8800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.3266
    Cell Significance Index: 8.7200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2226
    Cell Significance Index: 38.0100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2140
    Cell Significance Index: 9.7000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.2026
    Cell Significance Index: 5.4300
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.1499
    Cell Significance Index: 1.6300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1471
    Cell Significance Index: 5.1700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.1383
    Cell Significance Index: 2.3200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0888
    Cell Significance Index: 14.4500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0812
    Cell Significance Index: 16.1100
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.0441
    Cell Significance Index: 1.0200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0428
    Cell Significance Index: 38.6600
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.0288
    Cell Significance Index: 0.2300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0208
    Cell Significance Index: 15.7400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0192
    Cell Significance Index: -14.2500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0219
    Cell Significance Index: -41.2700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0241
    Cell Significance Index: -6.9400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0328
    Cell Significance Index: -24.0200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0330
    Cell Significance Index: -60.9300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0394
    Cell Significance Index: -60.7100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0447
    Cell Significance Index: -4.5700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0479
    Cell Significance Index: -65.0800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0490
    Cell Significance Index: -1.4400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0523
    Cell Significance Index: -32.6900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0637
    Cell Significance Index: -40.4800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0776
    Cell Significance Index: -43.7800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0914
    Cell Significance Index: -10.4700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1077
    Cell Significance Index: -48.8900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1383
    Cell Significance Index: -2.9500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.1467
    Cell Significance Index: -52.6200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1864
    Cell Significance Index: -39.2600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2101
    Cell Significance Index: -7.3000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2352
    Cell Significance Index: -26.8500
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.2379
    Cell Significance Index: -1.9400
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.2405
    Cell Significance Index: -2.0200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2494
    Cell Significance Index: -29.0600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.2650
    Cell Significance Index: -53.1600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3063
    Cell Significance Index: -9.8100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.3268
    Cell Significance Index: -47.5100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.4515
    Cell Significance Index: -53.2400
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.4532
    Cell Significance Index: -4.6900
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: -0.4573
    Cell Significance Index: -2.8300
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.4606
    Cell Significance Index: -6.4600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.5044
    Cell Significance Index: -6.8800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5250
    Cell Significance Index: -41.5800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.5489
    Cell Significance Index: -13.7200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.5536
    Cell Significance Index: -57.6400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.5852
    Cell Significance Index: -44.9100
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.6149
    Cell Significance Index: -6.3700
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.6191
    Cell Significance Index: -25.3700
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.6192
    Cell Significance Index: -7.9300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.6495
    Cell Significance Index: -19.1300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.7214
    Cell Significance Index: -20.1600
  • Cell Name: glomerular capillary endothelial cell (CL1001005)
    Fold Change: -0.7513
    Cell Significance Index: -2.8000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.7661
    Cell Significance Index: -7.0600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.7871
    Cell Significance Index: -49.6100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.7944
    Cell Significance Index: -40.1400
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: -0.7951
    Cell Significance Index: -13.6600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.8171
    Cell Significance Index: -50.2200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.8569
    Cell Significance Index: -44.9900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** RhoC is a small GTP-binding protein that belongs to the Rho family of GTPases. It is characterized by its ability to bind and hydrolyze GTP, which regulates its activity and interaction with downstream effectors. RhoC is highly expressed in various cell types, including epithelial cells, endothelial cells, and immune cells. Its expression is often upregulated in response to inflammatory stimuli and cellular stress. **Pathways and Functions:** RhoC is involved in multiple signaling pathways that regulate various cellular processes. Some of its key functions include: 1. **Actin cytoskeleton organization:** RhoC regulates the formation and dynamics of actin filaments, which are essential for cell migration, proliferation, and apoptosis. 2. **Cell migration:** RhoC is involved in the regulation of cell migration, particularly in the context of immune responses and tissue repair. 3. **Proliferation and apoptosis:** RhoC can regulate cell proliferation and apoptosis by modulating the activity of downstream effectors, such as protein kinases and phosphatases. 4. **Cytoskeleton dynamics:** RhoC regulates the dynamics of the cytoskeleton, including the formation and disassembly of actin filaments and microtubules. 5. **Cell signaling:** RhoC interacts with various signaling molecules, including G-proteins, receptors, and transcription factors, to regulate cellular responses. **Clinical Significance:** Dysregulation of RhoC has been implicated in various diseases, including: 1. **Cancer:** RhoC overexpression has been observed in several types of cancer, including breast, lung, and colon cancer. 2. **Cardiovascular disorders:** RhoC dysregulation has been implicated in the development of cardiovascular diseases, including atherosclerosis and hypertension. 3. **Neurological conditions:** RhoC has been implicated in the pathogenesis of neurological disorders, including Alzheimer's disease and Parkinson's disease. 4. **Inflammatory diseases:** RhoC overexpression has been observed in inflammatory diseases, including rheumatoid arthritis and multiple sclerosis. In conclusion, the RHOC gene plays a critical role in regulating various cellular processes, including actin cytoskeleton organization, cell migration, proliferation, and apoptosis. Its dysregulation has been implicated in numerous diseases, highlighting the importance of RhoC as a therapeutic target for the treatment of various diseases. **References:** * [Insert references here] Note: The references section should include a list of relevant studies and publications that support the discussion on the RHOC gene.

Genular Protein ID: 134014720

Symbol: RHOC_HUMAN

Name: Rho-related GTP-binding protein RhoC

UniProtKB Accession Codes:

P08134 B3KSW1 Q6ICN3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 3 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 11 Ensembl 7 EvolutionaryTrace 1 ExpressionAtlas 1 GO 23 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 8 RefSeq 3 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3283705

Title: Coding sequence of human rho cDNAs clone 6 and clone 9.

PubMed ID: 3283705

DOI: 10.1093/nar/16.6.2717

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8816443

Title: The p160 RhoA-binding kinase ROK alpha is a member of a kinase family and is involved in the reorganization of the cytoskeleton.

PubMed ID: 8816443

DOI: 10.1128/mcb.16.10.5313

PubMed ID: 11546812

Title: AKAP-Lbc anchors protein kinase A and nucleates Galpha 12-selective Rho-mediated stress fiber formation.

PubMed ID: 11546812

DOI: 10.1074/jbc.m106629200

PubMed ID: 16236794

Title: Dissecting the role of Rho-mediated signaling in contractile ring formation.

PubMed ID: 16236794

DOI: 10.1091/mbc.e05-06-0569

PubMed ID: 20400958

Title: Regulation of Rho GTPase crosstalk, degradation and activity by RhoGDI1.

PubMed ID: 20400958

DOI: 10.1038/ncb2049

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 20974804

Title: The Rho target PRK2 regulates apical junction formation in human bronchial epithelial cells.

PubMed ID: 20974804

DOI: 10.1128/mcb.01001-10

PubMed ID: 24141704

Title: A bacterial toxin catalyzing tyrosine glycosylation of Rho and deamidation of Gq and Gi proteins.

PubMed ID: 24141704

DOI: 10.1038/nsmb.2688

PubMed ID: 24905543

Title: Haemorrhagic toxin and lethal toxin from Clostridium sordellii strain vpi9048: molecular characterization and comparative analysis of substrate specificity of the large clostridial glucosylating toxins.

PubMed ID: 24905543

DOI: 10.1111/cmi.12321

PubMed ID: 27807006

Title: RHO binding to FAM65A regulates Golgi reorientation during cell migration.

PubMed ID: 27807006

DOI: 10.1242/jcs.198614

PubMed ID: 15864301

Title: Structural and mechanistic insights into the interaction between Rho and mammalian Dia.

PubMed ID: 15864301

DOI: 10.1038/nature03604

Sequence Information:

  • Length: 193
  • Mass: 22006
  • Checksum: A193DA581560F131
  • Sequence:
    • MAAIRKKLVI VGDGACGKTC LLIVFSKDQF PEVYVPTVFE NYIADIEVDG KQVELALWDT 
AGQEDYDRLR PLSYPDTDVI LMCFSIDSPD SLENIPEKWT PEVKHFCPNV PIILVGNKKD 
LRQDEHTRRE LAKMKQEPVR SEEGRDMANR ISAFGYLECS AKTKEGVREV FEMATRAGLQ 
VRKNKRRRGC PIL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.