Details for: CL0000529

Cell ID: CL0000529

Cell Name: pigmented epithelial cell

Marker Score Threshold: 4,185
(Derived using integrated single-cell and genomic data)

Description: No description available

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: GPM6A (ENSG00000150625)
    Fold Change: 4
    Ensembl ID: ENSG00000150625
  • Gene Symbol: GRID2 (ENSG00000152208)
    Fold Change: 3.89
    Ensembl ID: ENSG00000152208
  • Gene Symbol: CTNND2 (ENSG00000169862)
    Fold Change: 3.85
    Ensembl ID: ENSG00000169862
  • Gene Symbol: DLG2 (ENSG00000150672)
    Fold Change: 3.81
    Ensembl ID: ENSG00000150672
  • Gene Symbol: DGKG (ENSG00000058866)
    Fold Change: 3.65
    Ensembl ID: ENSG00000058866
  • Gene Symbol: DTNA (ENSG00000134769)
    Fold Change: 3.56
    Ensembl ID: ENSG00000134769
  • Gene Symbol: IGF1R (ENSG00000140443)
    Fold Change: 3.5
    Ensembl ID: ENSG00000140443
  • Gene Symbol: DYNC1I1 (ENSG00000158560)
    Fold Change: 3.45
    Ensembl ID: ENSG00000158560
  • Gene Symbol: GOLGA4 (ENSG00000144674)
    Fold Change: 3.43
    Ensembl ID: ENSG00000144674
  • Gene Symbol: LRBA (ENSG00000198589)
    Fold Change: 3.4
    Ensembl ID: ENSG00000198589
  • Gene Symbol: MEIS2 (ENSG00000134138)
    Fold Change: 3.39
    Ensembl ID: ENSG00000134138
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 3.38
    Ensembl ID: ENSG00000142599
  • Gene Symbol: DCT (ENSG00000080166)
    Fold Change: 3.36
    Ensembl ID: ENSG00000080166
  • Gene Symbol: FGFR1 (ENSG00000077782)
    Fold Change: 3.3
    Ensembl ID: ENSG00000077782
  • Gene Symbol: CACNB2 (ENSG00000165995)
    Fold Change: 3.25
    Ensembl ID: ENSG00000165995
  • Gene Symbol: ABR (ENSG00000159842)
    Fold Change: 3.23
    Ensembl ID: ENSG00000159842
  • Gene Symbol: CTNNA1 (ENSG00000044115)
    Fold Change: 3.23
    Ensembl ID: ENSG00000044115
  • Gene Symbol: FER (ENSG00000151422)
    Fold Change: 3.22
    Ensembl ID: ENSG00000151422
  • Gene Symbol: LTBP1 (ENSG00000049323)
    Fold Change: 3.21
    Ensembl ID: ENSG00000049323
  • Gene Symbol: FHIT (ENSG00000189283)
    Fold Change: 3.19
    Ensembl ID: ENSG00000189283
  • Gene Symbol: DOCK3 (ENSG00000088538)
    Fold Change: 3.19
    Ensembl ID: ENSG00000088538
  • Gene Symbol: ABLIM1 (ENSG00000099204)
    Fold Change: 3.17
    Ensembl ID: ENSG00000099204
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 3.14
    Ensembl ID: ENSG00000085224
  • Gene Symbol: ASPH (ENSG00000198363)
    Fold Change: 3.13
    Ensembl ID: ENSG00000198363
  • Gene Symbol: KTN1 (ENSG00000126777)
    Fold Change: 3.13
    Ensembl ID: ENSG00000126777
  • Gene Symbol: JAK1 (ENSG00000162434)
    Fold Change: 3.1
    Ensembl ID: ENSG00000162434
  • Gene Symbol: MEIS1 (ENSG00000143995)
    Fold Change: 3.09
    Ensembl ID: ENSG00000143995
  • Gene Symbol: DPP6 (ENSG00000130226)
    Fold Change: 3.07
    Ensembl ID: ENSG00000130226
  • Gene Symbol: DPYD (ENSG00000188641)
    Fold Change: 3.06
    Ensembl ID: ENSG00000188641
  • Gene Symbol: CBLB (ENSG00000114423)
    Fold Change: 3.05
    Ensembl ID: ENSG00000114423
  • Gene Symbol: CNTN1 (ENSG00000018236)
    Fold Change: 3.05
    Ensembl ID: ENSG00000018236
  • Gene Symbol: LPP (ENSG00000145012)
    Fold Change: 3.04
    Ensembl ID: ENSG00000145012
  • Gene Symbol: GNAQ (ENSG00000156052)
    Fold Change: 3.04
    Ensembl ID: ENSG00000156052
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 3.02
    Ensembl ID: ENSG00000075624
  • Gene Symbol: MARK3 (ENSG00000075413)
    Fold Change: 3.01
    Ensembl ID: ENSG00000075413
  • Gene Symbol: CACNA1C (ENSG00000151067)
    Fold Change: 3.01
    Ensembl ID: ENSG00000151067
  • Gene Symbol: FGFR2 (ENSG00000066468)
    Fold Change: 2.97
    Ensembl ID: ENSG00000066468
  • Gene Symbol: MBP (ENSG00000197971)
    Fold Change: 2.97
    Ensembl ID: ENSG00000197971
  • Gene Symbol: ZFHX3 (ENSG00000140836)
    Fold Change: 2.96
    Ensembl ID: ENSG00000140836
  • Gene Symbol: H3 3B (ENSG00000132475)
    Fold Change: 2.94
    Ensembl ID: ENSG00000132475
  • Gene Symbol: ESRRG (ENSG00000196482)
    Fold Change: 2.89
    Ensembl ID: ENSG00000196482
  • Gene Symbol: DYRK1A (ENSG00000157540)
    Fold Change: 2.87
    Ensembl ID: ENSG00000157540
  • Gene Symbol: ERBB4 (ENSG00000178568)
    Fold Change: 2.85
    Ensembl ID: ENSG00000178568
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 2.85
    Ensembl ID: ENSG00000077549
  • Gene Symbol: DDX5 (ENSG00000108654)
    Fold Change: 2.85
    Ensembl ID: ENSG00000108654
  • Gene Symbol: LAMA2 (ENSG00000196569)
    Fold Change: 2.84
    Ensembl ID: ENSG00000196569
  • Gene Symbol: EGFR (ENSG00000146648)
    Fold Change: 2.83
    Ensembl ID: ENSG00000146648
  • Gene Symbol: BMPR1A (ENSG00000107779)
    Fold Change: 2.83
    Ensembl ID: ENSG00000107779
  • Gene Symbol: BRAF (ENSG00000157764)
    Fold Change: 2.81
    Ensembl ID: ENSG00000157764
  • Gene Symbol: MAP4 (ENSG00000047849)
    Fold Change: 2.81
    Ensembl ID: ENSG00000047849
  • Gene Symbol: HNRNPA2B1 (ENSG00000122566)
    Fold Change: 2.81
    Ensembl ID: ENSG00000122566
  • Gene Symbol: HNRNPC (ENSG00000092199)
    Fold Change: 2.8
    Ensembl ID: ENSG00000092199
  • Gene Symbol: HNRNPU (ENSG00000153187)
    Fold Change: 2.8
    Ensembl ID: ENSG00000153187
  • Gene Symbol: CCNH (ENSG00000134480)
    Fold Change: 2.78
    Ensembl ID: ENSG00000134480
  • Gene Symbol: BPTF (ENSG00000171634)
    Fold Change: 2.78
    Ensembl ID: ENSG00000171634
  • Gene Symbol: MEF2A (ENSG00000068305)
    Fold Change: 2.77
    Ensembl ID: ENSG00000068305
  • Gene Symbol: EPS15 (ENSG00000085832)
    Fold Change: 2.76
    Ensembl ID: ENSG00000085832
  • Gene Symbol: FTH1 (ENSG00000167996)
    Fold Change: 2.75
    Ensembl ID: ENSG00000167996
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 2.74
    Ensembl ID: ENSG00000069849
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 2.74
    Ensembl ID: ENSG00000142192
  • Gene Symbol: SMAD3 (ENSG00000166949)
    Fold Change: 2.73
    Ensembl ID: ENSG00000166949
  • Gene Symbol: DLG1 (ENSG00000075711)
    Fold Change: 2.73
    Ensembl ID: ENSG00000075711
  • Gene Symbol: HNRNPH1 (ENSG00000169045)
    Fold Change: 2.73
    Ensembl ID: ENSG00000169045
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 2.72
    Ensembl ID: ENSG00000148700
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 2.72
    Ensembl ID: ENSG00000153113
  • Gene Symbol: DMXL1 (ENSG00000172869)
    Fold Change: 2.72
    Ensembl ID: ENSG00000172869
  • Gene Symbol: ACACB (ENSG00000076555)
    Fold Change: 2.72
    Ensembl ID: ENSG00000076555
  • Gene Symbol: ANK2 (ENSG00000145362)
    Fold Change: 2.71
    Ensembl ID: ENSG00000145362
  • Gene Symbol: EYA2 (ENSG00000064655)
    Fold Change: 2.71
    Ensembl ID: ENSG00000064655
  • Gene Symbol: GPI (ENSG00000105220)
    Fold Change: 2.69
    Ensembl ID: ENSG00000105220
  • Gene Symbol: ACYP2 (ENSG00000170634)
    Fold Change: 2.69
    Ensembl ID: ENSG00000170634
  • Gene Symbol: INSR (ENSG00000171105)
    Fold Change: 2.69
    Ensembl ID: ENSG00000171105
  • Gene Symbol: DAB1 (ENSG00000173406)
    Fold Change: 2.68
    Ensembl ID: ENSG00000173406
  • Gene Symbol: CUX1 (ENSG00000257923)
    Fold Change: 2.68
    Ensembl ID: ENSG00000257923
  • Gene Symbol: CRY2 (ENSG00000121671)
    Fold Change: 2.67
    Ensembl ID: ENSG00000121671
  • Gene Symbol: DACH1 (ENSG00000276644)
    Fold Change: 2.65
    Ensembl ID: ENSG00000276644
  • Gene Symbol: FBN1 (ENSG00000166147)
    Fold Change: 2.63
    Ensembl ID: ENSG00000166147
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 2.63
    Ensembl ID: ENSG00000104765
  • Gene Symbol: CYP1B1 (ENSG00000138061)
    Fold Change: 2.6
    Ensembl ID: ENSG00000138061
  • Gene Symbol: HSD17B2 (ENSG00000086696)
    Fold Change: 2.59
    Ensembl ID: ENSG00000086696
  • Gene Symbol: EFNA5 (ENSG00000184349)
    Fold Change: 2.59
    Ensembl ID: ENSG00000184349
  • Gene Symbol: CSNK1A1 (ENSG00000113712)
    Fold Change: 2.56
    Ensembl ID: ENSG00000113712
  • Gene Symbol: GLS (ENSG00000115419)
    Fold Change: 2.56
    Ensembl ID: ENSG00000115419
  • Gene Symbol: EPB41 (ENSG00000159023)
    Fold Change: 2.56
    Ensembl ID: ENSG00000159023
  • Gene Symbol: FOXN3 (ENSG00000053254)
    Fold Change: 2.54
    Ensembl ID: ENSG00000053254
  • Gene Symbol: GRB10 (ENSG00000106070)
    Fold Change: 2.51
    Ensembl ID: ENSG00000106070
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 2.5
    Ensembl ID: ENSG00000130402
  • Gene Symbol: JARID2 (ENSG00000008083)
    Fold Change: 2.5
    Ensembl ID: ENSG00000008083
  • Gene Symbol: HMGB1 (ENSG00000189403)
    Fold Change: 2.47
    Ensembl ID: ENSG00000189403
  • Gene Symbol: ADK (ENSG00000156110)
    Fold Change: 2.47
    Ensembl ID: ENSG00000156110
  • Gene Symbol: CLU (ENSG00000120885)
    Fold Change: 2.47
    Ensembl ID: ENSG00000120885
  • Gene Symbol: CTNNB1 (ENSG00000168036)
    Fold Change: 2.47
    Ensembl ID: ENSG00000168036
  • Gene Symbol: GRIA4 (ENSG00000152578)
    Fold Change: 2.47
    Ensembl ID: ENSG00000152578
  • Gene Symbol: BMPR2 (ENSG00000204217)
    Fold Change: 2.47
    Ensembl ID: ENSG00000204217
  • Gene Symbol: CDKN1C (ENSG00000129757)
    Fold Change: 2.46
    Ensembl ID: ENSG00000129757
  • Gene Symbol: CENPC (ENSG00000145241)
    Fold Change: 2.46
    Ensembl ID: ENSG00000145241
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.46
    Ensembl ID: ENSG00000184009
  • Gene Symbol: ATP1B1 (ENSG00000143153)
    Fold Change: 2.46
    Ensembl ID: ENSG00000143153
  • Gene Symbol: RBPJ (ENSG00000168214)
    Fold Change: 2.45
    Ensembl ID: ENSG00000168214
  • Gene Symbol: DIAPH2 (ENSG00000147202)
    Fold Change: 2.45
    Ensembl ID: ENSG00000147202

Gene ID: A unique numerical identifier for this specific gene.
Symbol: Shortened abbreviation or name that represents this gene.
Ensembl Gene ID: A unique identifier assigned by Ensembl for genomic data mapping.
Fold Change: Indicates the ratio of the gene's expression level in pigmented epithelial cell cell compared to a baseline. A fold change greater than 1 suggests significant gene expression.

Gene ID: A unique numerical identifier for this specific gene.
Symbol: Shortened abbreviation or name that represents this gene.
Ensembl Gene ID: A unique identifier assigned by Ensembl for genomic data mapping.
Fold Change: Indicates the ratio of the gene's expression level in pigmented epithelial cell cell compared to a baseline. A fold change greater than 1 suggests significant gene expression.
**Key Characteristics** 1. **GPM6A**: This gene is involved in the regulation of axonal growth cone formation and is required for the development of the nervous system. 2. **GRID2**: This gene plays a crucial role in the development and function of cerebellar granule cells and is implicated in the regulation of synaptic transmission. 3. **CTNND2**: This gene is involved in the regulation of axon growth and is required for the development of the nervous system. 4. **DLG2**: This gene is involved in the regulation of synaptic transmission and is required for the development of the nervous system. 5. **DGKG**: This gene is involved in the regulation of dendrite development and is required for the development of the nervous system. 6. **DTNA**: This gene is involved in the regulation of axon growth and is required for the development of the nervous system. **Clinical Significance** 1. **Neurological Disorders**: The dysregulation of these genes has been implicated in various neurological disorders, including autism, schizophrenia, and Parkinson's disease. 2. **Synaptic Transmission**: The dysregulation of GRID2 and DLG2 has been implicated in the regulation of synaptic transmission, which is essential for learning and memory. 3. **Axon Growth**: The dysregulation of CTNND2 and DTNA has been implicated in the regulation of axon growth, which is essential for the development of the nervous system. 4. **Dendrite Development**: The dysregulation of DGKG has been implicated in the regulation of dendrite development, which is essential for the development of the nervous system. 5. **Neurodevelopmental Disorders**: The dysregulation of these genes has been implicated in various neurodevelopmental disorders, including intellectual disability and epilepsy. In conclusion, the provided dataset highlights the importance of these genes in the development and function of the nervous system, as well as their potential roles in neurological disorders. Further research is needed to fully understand the mechanisms by which these genes regulate neural cell development and function, and to explore their potential as therapeutic targets for neurological disorders.