Details for: ARHGAP6

Gene ID: 395

Symbol: ARHGAP6

Ensembl ID: ENSG00000047648

Description: Rho GTPase activating protein 6

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 186.1838
    Cell Significance Index: -28.9600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 114.4915
    Cell Significance Index: -29.0400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 65.8450
    Cell Significance Index: -26.7500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 63.7546
    Cell Significance Index: -30.1000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 58.6234
    Cell Significance Index: -30.1600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 23.4802
    Cell Significance Index: -28.9500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 17.6735
    Cell Significance Index: -38.6800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.3517
    Cell Significance Index: -29.0100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 6.6193
    Cell Significance Index: 129.1900
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 6.3278
    Cell Significance Index: 39.0400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 4.0417
    Cell Significance Index: 103.8900
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 3.2643
    Cell Significance Index: 69.7800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 2.8582
    Cell Significance Index: 91.5500
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 2.8013
    Cell Significance Index: 18.9800
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 2.5663
    Cell Significance Index: 22.7800
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 1.8983
    Cell Significance Index: 15.9500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.7384
    Cell Significance Index: 623.5200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 1.4185
    Cell Significance Index: 71.6900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 1.4033
    Cell Significance Index: 94.3600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 1.2141
    Cell Significance Index: 126.4200
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.0610
    Cell Significance Index: 10.9800
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 1.0474
    Cell Significance Index: 16.9000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.0322
    Cell Significance Index: 468.4700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.6953
    Cell Significance Index: 1309.1700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.6830
    Cell Significance Index: 472.4200
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.6156
    Cell Significance Index: 8.8400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5835
    Cell Significance Index: 111.0500
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.5537
    Cell Significance Index: 5.7400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.5378
    Cell Significance Index: 30.1800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.4559
    Cell Significance Index: 12.4100
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.3252
    Cell Significance Index: 3.4000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3184
    Cell Significance Index: 39.1500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2473
    Cell Significance Index: 49.6100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2404
    Cell Significance Index: 217.0600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.2243
    Cell Significance Index: 3.0600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2180
    Cell Significance Index: 39.2900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1590
    Cell Significance Index: 244.7600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1393
    Cell Significance Index: 13.7800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0851
    Cell Significance Index: 13.8500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0841
    Cell Significance Index: 4.3700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0803
    Cell Significance Index: 15.9300
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.0510
    Cell Significance Index: 0.4600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0496
    Cell Significance Index: 91.5400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0176
    Cell Significance Index: 12.9400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0119
    Cell Significance Index: 7.5400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0066
    Cell Significance Index: 0.9100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.0054
    Cell Significance Index: 0.5900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0031
    Cell Significance Index: -4.1600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0116
    Cell Significance Index: -0.7100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0182
    Cell Significance Index: -0.6400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0264
    Cell Significance Index: -19.5200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0418
    Cell Significance Index: -6.0800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0429
    Cell Significance Index: -24.1900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0434
    Cell Significance Index: -1.2500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0441
    Cell Significance Index: -33.3900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0468
    Cell Significance Index: -1.1700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0470
    Cell Significance Index: -4.8000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0525
    Cell Significance Index: -28.6500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0553
    Cell Significance Index: -34.5500
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0607
    Cell Significance Index: -0.4900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0812
    Cell Significance Index: -23.3600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0970
    Cell Significance Index: -7.4500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1163
    Cell Significance Index: -6.0600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1220
    Cell Significance Index: -20.8400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1242
    Cell Significance Index: -14.4700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.1261
    Cell Significance Index: -8.7200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1306
    Cell Significance Index: -5.9200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1311
    Cell Significance Index: -2.8400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1452
    Cell Significance Index: -30.5900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1513
    Cell Significance Index: -19.4000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.1543
    Cell Significance Index: -9.2700
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.1679
    Cell Significance Index: -5.3100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1740
    Cell Significance Index: -3.6100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1907
    Cell Significance Index: -11.7200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2387
    Cell Significance Index: -30.8400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2507
    Cell Significance Index: -3.5900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2741
    Cell Significance Index: -32.3300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2805
    Cell Significance Index: -22.2100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2867
    Cell Significance Index: -32.8500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3036
    Cell Significance Index: -13.4300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.3373
    Cell Significance Index: -5.7800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3520
    Cell Significance Index: -7.4700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3839
    Cell Significance Index: -28.6100
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.4119
    Cell Significance Index: -6.5400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.4190
    Cell Significance Index: -12.0100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4317
    Cell Significance Index: -13.7500
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.4354
    Cell Significance Index: -8.6100
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.4448
    Cell Significance Index: -3.4000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.4537
    Cell Significance Index: -17.1800
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -0.4591
    Cell Significance Index: -2.1200
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.4623
    Cell Significance Index: -11.2800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4740
    Cell Significance Index: -15.5200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.4822
    Cell Significance Index: -31.1100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4897
    Cell Significance Index: -25.7100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.5100
    Cell Significance Index: -23.9700
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.5208
    Cell Significance Index: -7.4900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.5276
    Cell Significance Index: -33.2600
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: -0.5424
    Cell Significance Index: -5.7400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.5533
    Cell Significance Index: -13.2700
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.5561
    Cell Significance Index: -6.7700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** ARHGAP6 is a member of the Rho GTPase-activating protein family, which is characterized by its ability to accelerate the GTP hydrolysis of Rho GTPases, thereby regulating their activity and downstream signaling pathways. The protein is composed of three SH3 domains, which mediate its interactions with other proteins, including Rho GTPases and other SH3-containing proteins. ARHGAP6 is highly expressed in various cell types, including epithelial cells, smooth muscle cells, and fibroblasts, and is involved in the regulation of cytoskeleton dynamics, cell migration, and cell signaling. **Pathways and Functions** ARHGAP6 is involved in several signaling pathways, including: 1. **Actin cytoskeleton regulation**: ARHGAP6 regulates the activity of Rho GTPases, which are key regulators of actin cytoskeleton dynamics. By accelerating the GTP hydrolysis of Rho GTPases, ARHGAP6 modulates the formation and disassembly of actin filaments, thereby regulating cell shape and movement. 2. **Focal adhesion assembly**: ARHGAP6 is involved in the regulation of focal adhesion assembly, which is critical for cell migration and tissue remodeling. By modulating the activity of Rho GTPases, ARHGAP6 regulates the formation and disassembly of focal adhesions. 3. **Stress fiber assembly**: ARHGAP6 is also involved in the regulation of stress fiber assembly, which is critical for cell migration and tissue remodeling. 4. **Phospholipase activation**: ARHGAP6 is a phospholipase activator, which is involved in the regulation of phospholipase C activity, a key regulator of cell signaling. 5. **Regulation of small GTPase-mediated signal transduction**: ARHGAP6 is involved in the regulation of small GTPase-mediated signal transduction, which is critical for cell signaling and response to environmental stimuli. **Clinical Significance** Dysregulation of ARHGAP6 has been implicated in various diseases, including: 1. **Cancer**: ARHGAP6 is often downregulated in cancer cells, leading to increased Rho GTPase activity and enhanced cell migration and invasion. 2. **Neurodegenerative diseases**: ARHGAP6 is involved in the regulation of cytoskeleton dynamics and cell signaling, which are critical for maintaining neuronal function and preventing neurodegeneration. 3. **Cardiovascular disease**: ARHGAP6 is involved in the regulation of vascular smooth muscle cell contraction and relaxation, which is critical for maintaining vascular tone and preventing cardiovascular disease. 4. **Muscular dystrophy**: ARHGAP6 is involved in the regulation of muscle cell contraction and relaxation, which is critical for maintaining muscle function and preventing muscular dystrophy. In conclusion, ARHGAP6 is a critical regulator of Rho GTPase activity and downstream signaling pathways, and its dysregulation has been implicated in various diseases. Further research is needed to fully understand the functions of ARHGAP6 and its role in maintaining tissue homeostasis and regulating cellular behavior.

Genular Protein ID: 2971942003

Symbol: RHG06_HUMAN

Name: Rho GTPase-activating protein 6

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 10699171

Title: Functional analysis of ARHGAP6, a novel GTPase-activating protein for RhoA.

PubMed ID: 10699171

DOI: 10.1093/hmg/9.4.477

PubMed ID: 9417914

Title: Cloning and characterization of a novel rho-type GTPase-activating protein gene (ARHGAP6) from the critical region for microphthalmia with linear skin defects.

PubMed ID: 9417914

DOI: 10.1006/geno.1997.5040

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

Sequence Information:

  • Length: 974
  • Mass: 105947
  • Checksum: BEE22EB54F019E30
  • Sequence:
  • MSAQSLLHSV FSCSSPASSS AASAKGFSKR KLRQTRSLDP ALIGGCGSDE AGAEGSARGA 
    TAGRLYSPSL PAESLGPRLA SSSRGPPPRA TRLPPPGPLC SSFSTPSTPQ EKSPSGSFHF 
    DYEVPLGRGG LKKSMAWDLP SVLAGPASSR SASSILCSSG GGPNGIFASP RRWLQQRKFQ 
    SPPDSRGHPY VVWKSEGDFT WNSMSGRSVR LRSVPIQSLS ELERARLQEV AFYQLQQDCD 
    LSCQITIPKD GQKRKKSLRK KLDSLGKEKN KDKEFIPQAF GMPLSQVIAN DRAYKLKQDL 
    QRDEQKDASD FVASLLPFGN KRQNKELSSS NSSLSSTSET PNESTSPNTP EPAPRARRRG 
    AMSVDSITDL DDNQSRLLEA LQLSLPAEAQ SKKEKARDKK LSLNPIYRQV PRLVDSCCQH 
    LEKHGLQTVG IFRVGSSKKR VRQLREEFDR GIDVSLEEEH SVHDVAALLK EFLRDMPDPL 
    LTRELYTAFI NTLLLEPEEQ LGTLQLLIYL LPPCNCDTLH RLLQFLSIVA RHADDNISKD 
    GQEVTGNKMT SLNLATIFGP NLLHKQKSSD KEFSVQSSAR AEESTAIIAV VQKMIENYEA 
    LFMVPPDLQN EVLISLLETD PDVVDYLLRR KASQSSSPDM LQSEVSFSVG GRHSSTDSNK 
    ASSGDISPYD NNSPVLSERS LLAMQEDAAP GGSEKLYRVP GQFMLVGHLS SSKSRESSPG 
    PRLGKDLSEE PFDIWGTWHS TLKSGSKDPG MTGSSGDIFE SSSLRAGPCS LSQGNLSPNW 
    PRWQGSPAEL DSDTQGARRT QAAAPATEGR AHPAVSRACS TPHVQVAGKA ERPTARSEQY 
    LTLSGAHDLS ESELDVAGLQ SRATPQCQRP HGSGRDDKRP PPPYPGPGKP AAAAAWIQGP 
    PEGVETPTDQ GGQAAEREQQ VTQKKLSSAN SLPAGEQDSP RLGDAGWLDW QRERWQIWEL 
    LSTDNPDALP ETLV

Genular Protein ID: 3613590312

Symbol: Q59HG6_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 729
  • Mass: 79761
  • Checksum: 7E3F4CAA158408B2
  • Sequence:
  • KAGDGSAAPA AAGALGAHRR RVSWALLSTA LGKPRASPAW HLCLSPFRFP TQSHQRPGRE 
    EEVVLRCSPA EMSAQSLLHS VFSCSSPASS SAASAKGFSK RKLRQTRSLD PALIGGCGSD 
    EAGAEGSARG ATAGRLYSPS LPAESLGPRL ASSSRGPPPR ATRLPPPGPL CSSFSTPSTP 
    QEKSPSGSFH FDYEVPLGRG GLKKSMAWDL PSVLAGPASS RSASSILCSS GGGPNGIFAS 
    PRRWLQQRKF QSPPDSRGHP YVVWKSEGDF TWNSMSGRSV RLRSVPIQSL SELERARLQE 
    VAFYQLQQDC DLSCQITIPK DGQKRKKSLR KKLDSLGKEK NKDKEFIPQA FGMPLSQVIA 
    NDRAYKLKQD LQRDEQKDAS DFVASLLPFG NKRQNKELSS SNSSLSSTSE TPNESTSPNT 
    PEPAPRARRR GAMSVDSITD LDDNQSRLLE ALQLSLPAEA QSKKEKARDK KLSLNPIYRQ 
    VPRLVDSCCQ HLEKHGLQTV GIFRVGSSKK RVRQLREEFD RGIDVSLEEE HSVHDVAALL 
    KEFLRDMPDP LLTRELYTAF INTLLLEPEE QLGTLQLLIY LLPPCNCDTL HRLLQFLSIV 
    ARHADDNISK DGQEVTGNKM TSLNLATIFG PNLLHKQKSS DKEFSVQSSA RAEESTAIIA 
    VVQKMIENYE ALFMVPPDLQ NEVLISLLET DPDVVDYLLR RKASQSSTSS VLPAAVQACP 
    QYPASMFTP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.