Details for: ARHGAP6

Gene ID: 395

Symbol: ARHGAP6

Ensembl ID: ENSG00000047648

Description: Rho GTPase activating protein 6

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 5.58
    Marker Score: 3,105
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 3.61
    Marker Score: 1,954
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 3.28
    Marker Score: 2,525
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 2.85
    Marker Score: 1,873
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 2.81
    Marker Score: 1,479
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 2.64
    Marker Score: 835
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 2.54
    Marker Score: 2,918
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 2.53
    Marker Score: 2,411
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 2.49
    Marker Score: 5,467
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 2.48
    Marker Score: 1,719
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 2.2
    Marker Score: 9,188
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 2.18
    Marker Score: 7,724
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 2.03
    Marker Score: 738
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.99
    Marker Score: 982
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 1.95
    Marker Score: 506
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 1.94
    Marker Score: 965
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.88
    Marker Score: 3,611
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.83
    Marker Score: 1,067
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.81
    Marker Score: 18,736
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 1.63
    Marker Score: 1,445
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.55
    Marker Score: 1,876
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 1.54
    Marker Score: 558
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.53
    Marker Score: 6,330
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.47
    Marker Score: 1,571
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 1.46
    Marker Score: 755
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.42
    Marker Score: 13,448
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.39
    Marker Score: 3,285
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 1.37
    Marker Score: 3,875
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1.35
    Marker Score: 3,381
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.33
    Marker Score: 306
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.32
    Marker Score: 5,122
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 1.28
    Marker Score: 575
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 1.27
    Marker Score: 1,046
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.27
    Marker Score: 10,891
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.22
    Marker Score: 2,475
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.19
    Marker Score: 867
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 1.18
    Marker Score: 375
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 1.17
    Marker Score: 3,846
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.17
    Marker Score: 1,259
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 1.15
    Marker Score: 645
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.15
    Marker Score: 992
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 1.14
    Marker Score: 329
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.14
    Marker Score: 4,780
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.13
    Marker Score: 22,388
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 1.06
    Marker Score: 1,539
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.06
    Marker Score: 1,500
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.06
    Marker Score: 269
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 1.04
    Marker Score: 434
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 1
    Marker Score: 2,550
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1
    Marker Score: 314
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,773
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,998
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.99
    Marker Score: 673
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.98
    Marker Score: 408
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,403
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 499
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.96
    Marker Score: 453
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.96
    Marker Score: 5,739
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.95
    Marker Score: 235
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,409
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.93
    Marker Score: 560
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 0.92
    Marker Score: 698
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.92
    Marker Score: 421
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.92
    Marker Score: 367
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,731
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.89
    Marker Score: 2,385
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 320
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.88
    Marker Score: 5,022
  • Cell Name: mural cell (CL0008034)
    Fold Change: 0.88
    Marker Score: 100,649
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,271
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.87
    Marker Score: 413
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.86
    Marker Score: 31,598
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.85
    Marker Score: 315
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.84
    Marker Score: 13,207
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 0.84
    Marker Score: 901
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.83
    Marker Score: 487
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.82
    Marker Score: 13,166
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.82
    Marker Score: 625
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.81
    Marker Score: 1,009
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.8
    Marker Score: 161
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.79
    Marker Score: 1,064
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.78
    Marker Score: 3,169
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1,254
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.77
    Marker Score: 211
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.75
    Marker Score: 688
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 389
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.71
    Marker Score: 875
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.7
    Marker Score: 868
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.7
    Marker Score: 282
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.69
    Marker Score: 342
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 177
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.68
    Marker Score: 447
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.66
    Marker Score: 965
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.66
    Marker Score: 265
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.65
    Marker Score: 273
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.65
    Marker Score: 168
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.64
    Marker Score: 1,208
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.64
    Marker Score: 312
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.62
    Marker Score: 602
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.62
    Marker Score: 346

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** ARHGAP6 is a member of the Rho GTPase-activating protein family, which is characterized by its ability to accelerate the GTP hydrolysis of Rho GTPases, thereby regulating their activity and downstream signaling pathways. The protein is composed of three SH3 domains, which mediate its interactions with other proteins, including Rho GTPases and other SH3-containing proteins. ARHGAP6 is highly expressed in various cell types, including epithelial cells, smooth muscle cells, and fibroblasts, and is involved in the regulation of cytoskeleton dynamics, cell migration, and cell signaling. **Pathways and Functions** ARHGAP6 is involved in several signaling pathways, including: 1. **Actin cytoskeleton regulation**: ARHGAP6 regulates the activity of Rho GTPases, which are key regulators of actin cytoskeleton dynamics. By accelerating the GTP hydrolysis of Rho GTPases, ARHGAP6 modulates the formation and disassembly of actin filaments, thereby regulating cell shape and movement. 2. **Focal adhesion assembly**: ARHGAP6 is involved in the regulation of focal adhesion assembly, which is critical for cell migration and tissue remodeling. By modulating the activity of Rho GTPases, ARHGAP6 regulates the formation and disassembly of focal adhesions. 3. **Stress fiber assembly**: ARHGAP6 is also involved in the regulation of stress fiber assembly, which is critical for cell migration and tissue remodeling. 4. **Phospholipase activation**: ARHGAP6 is a phospholipase activator, which is involved in the regulation of phospholipase C activity, a key regulator of cell signaling. 5. **Regulation of small GTPase-mediated signal transduction**: ARHGAP6 is involved in the regulation of small GTPase-mediated signal transduction, which is critical for cell signaling and response to environmental stimuli. **Clinical Significance** Dysregulation of ARHGAP6 has been implicated in various diseases, including: 1. **Cancer**: ARHGAP6 is often downregulated in cancer cells, leading to increased Rho GTPase activity and enhanced cell migration and invasion. 2. **Neurodegenerative diseases**: ARHGAP6 is involved in the regulation of cytoskeleton dynamics and cell signaling, which are critical for maintaining neuronal function and preventing neurodegeneration. 3. **Cardiovascular disease**: ARHGAP6 is involved in the regulation of vascular smooth muscle cell contraction and relaxation, which is critical for maintaining vascular tone and preventing cardiovascular disease. 4. **Muscular dystrophy**: ARHGAP6 is involved in the regulation of muscle cell contraction and relaxation, which is critical for maintaining muscle function and preventing muscular dystrophy. In conclusion, ARHGAP6 is a critical regulator of Rho GTPase activity and downstream signaling pathways, and its dysregulation has been implicated in various diseases. Further research is needed to fully understand the functions of ARHGAP6 and its role in maintaining tissue homeostasis and regulating cellular behavior.

Genular Protein ID: 2971942003

Symbol: RHG06_HUMAN

Name: Rho GTPase-activating protein 6

UniProtKB Accession Codes:

O43182 B2RWQ0 O43437 Q9P1B3 Q9UK81 Q9UK82

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 5 ExpressionAtlas 1 GO 16 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 5 Pumba 1 RNAct 1 Reactome 2 RefSeq 4 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10699171

Title: Functional analysis of ARHGAP6, a novel GTPase-activating protein for RhoA.

PubMed ID: 10699171

DOI: 10.1093/hmg/9.4.477

PubMed ID: 9417914

Title: Cloning and characterization of a novel rho-type GTPase-activating protein gene (ARHGAP6) from the critical region for microphthalmia with linear skin defects.

PubMed ID: 9417914

DOI: 10.1006/geno.1997.5040

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

Sequence Information:

  • Length: 974
  • Mass: 105947
  • Checksum: BEE22EB54F019E30
  • Sequence:
    • MSAQSLLHSV FSCSSPASSS AASAKGFSKR KLRQTRSLDP ALIGGCGSDE AGAEGSARGA 
TAGRLYSPSL PAESLGPRLA SSSRGPPPRA TRLPPPGPLC SSFSTPSTPQ EKSPSGSFHF 
DYEVPLGRGG LKKSMAWDLP SVLAGPASSR SASSILCSSG GGPNGIFASP RRWLQQRKFQ 
SPPDSRGHPY VVWKSEGDFT WNSMSGRSVR LRSVPIQSLS ELERARLQEV AFYQLQQDCD 
LSCQITIPKD GQKRKKSLRK KLDSLGKEKN KDKEFIPQAF GMPLSQVIAN DRAYKLKQDL 
QRDEQKDASD FVASLLPFGN KRQNKELSSS NSSLSSTSET PNESTSPNTP EPAPRARRRG 
AMSVDSITDL DDNQSRLLEA LQLSLPAEAQ SKKEKARDKK LSLNPIYRQV PRLVDSCCQH 
LEKHGLQTVG IFRVGSSKKR VRQLREEFDR GIDVSLEEEH SVHDVAALLK EFLRDMPDPL 
LTRELYTAFI NTLLLEPEEQ LGTLQLLIYL LPPCNCDTLH RLLQFLSIVA RHADDNISKD 
GQEVTGNKMT SLNLATIFGP NLLHKQKSSD KEFSVQSSAR AEESTAIIAV VQKMIENYEA 
LFMVPPDLQN EVLISLLETD PDVVDYLLRR KASQSSSPDM LQSEVSFSVG GRHSSTDSNK 
ASSGDISPYD NNSPVLSERS LLAMQEDAAP GGSEKLYRVP GQFMLVGHLS SSKSRESSPG 
PRLGKDLSEE PFDIWGTWHS TLKSGSKDPG MTGSSGDIFE SSSLRAGPCS LSQGNLSPNW 
PRWQGSPAEL DSDTQGARRT QAAAPATEGR AHPAVSRACS TPHVQVAGKA ERPTARSEQY 
LTLSGAHDLS ESELDVAGLQ SRATPQCQRP HGSGRDDKRP PPPYPGPGKP AAAAAWIQGP 
PEGVETPTDQ GGQAAEREQQ VTQKKLSSAN SLPAGEQDSP RLGDAGWLDW QRERWQIWEL 
LSTDNPDALP ETLV

Genular Protein ID: 3613590312

Symbol: Q59HG6_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q59HG6

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 EMBL 2 GO 1 Gene3D 1 Genevisible 1 GenomeRNAi 1 InterPro 4 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 2 SAM 1 SMART 1 SUPFAM 1

Sequence Information:

  • Length: 729
  • Mass: 79761
  • Checksum: 7E3F4CAA158408B2
  • Sequence:
    • KAGDGSAAPA AAGALGAHRR RVSWALLSTA LGKPRASPAW HLCLSPFRFP TQSHQRPGRE 
EEVVLRCSPA EMSAQSLLHS VFSCSSPASS SAASAKGFSK RKLRQTRSLD PALIGGCGSD 
EAGAEGSARG ATAGRLYSPS LPAESLGPRL ASSSRGPPPR ATRLPPPGPL CSSFSTPSTP 
QEKSPSGSFH FDYEVPLGRG GLKKSMAWDL PSVLAGPASS RSASSILCSS GGGPNGIFAS 
PRRWLQQRKF QSPPDSRGHP YVVWKSEGDF TWNSMSGRSV RLRSVPIQSL SELERARLQE 
VAFYQLQQDC DLSCQITIPK DGQKRKKSLR KKLDSLGKEK NKDKEFIPQA FGMPLSQVIA 
NDRAYKLKQD LQRDEQKDAS DFVASLLPFG NKRQNKELSS SNSSLSSTSE TPNESTSPNT 
PEPAPRARRR GAMSVDSITD LDDNQSRLLE ALQLSLPAEA QSKKEKARDK KLSLNPIYRQ 
VPRLVDSCCQ HLEKHGLQTV GIFRVGSSKK RVRQLREEFD RGIDVSLEEE HSVHDVAALL 
KEFLRDMPDP LLTRELYTAF INTLLLEPEE QLGTLQLLIY LLPPCNCDTL HRLLQFLSIV 
ARHADDNISK DGQEVTGNKM TSLNLATIFG PNLLHKQKSS DKEFSVQSSA RAEESTAIIA 
VVQKMIENYE ALFMVPPDLQ NEVLISLLET DPDVVDYLLR RKASQSSTSS VLPAAVQACP 
QYPASMFTP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.