CL0011004 - lens fiber cell details

Details for: CL0011004

Cell ID: CL0011004

Cell Name: lens fiber cell

Marker Score Threshold: 316
(Derived using integrated single-cell and genomic data)

Description: A vetebrate lens cell that is any of the elongated, tightly packed cells that make up the bulk of the mature lens in a camera-type eye.

Synonyms: lens fibre cell

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Gene Symbol: B2M (ENSG00000166710)
Fold Change: 3.5
Ensembl ID: ENSG00000166710
Gene Symbol: ACTB (ENSG00000075624)
Fold Change: 3.39
Ensembl ID: ENSG00000075624
Gene Symbol: SLC25A6 (ENSG00000169100)
Fold Change: 2.67
Ensembl ID: ENSG00000169100
Gene Symbol: BTF3 (ENSG00000145741)
Fold Change: 2.55
Ensembl ID: ENSG00000145741
Gene Symbol: BTG1 (ENSG00000133639)
Fold Change: 2.52
Ensembl ID: ENSG00000133639
Gene Symbol: CALM1 (ENSG00000198668)
Fold Change: 2.39
Ensembl ID: ENSG00000198668
Gene Symbol: ATP5F1E (ENSG00000124172)
Fold Change: 2.37
Ensembl ID: ENSG00000124172
Gene Symbol: CALM2 (ENSG00000143933)
Fold Change: 2.27
Ensembl ID: ENSG00000143933
Gene Symbol: RHOA (ENSG00000067560)
Fold Change: 2.23
Ensembl ID: ENSG00000067560
Gene Symbol: CALR (ENSG00000179218)
Fold Change: 2.16
Ensembl ID: ENSG00000179218
Gene Symbol: ACACA (ENSG00000278540)
Fold Change: 2.12
Ensembl ID: ENSG00000278540
Gene Symbol: ZFP36L2 (ENSG00000152518)
Fold Change: 2.05
Ensembl ID: ENSG00000152518
Gene Symbol: ZFP36L1 (ENSG00000185650)
Fold Change: 1.99
Ensembl ID: ENSG00000185650
Gene Symbol: CAST (ENSG00000153113)
Fold Change: 1.97
Ensembl ID: ENSG00000153113
Gene Symbol: ACTG1 (ENSG00000184009)
Fold Change: 1.94
Ensembl ID: ENSG00000184009
Gene Symbol: SLC25A5 (ENSG00000005022)
Fold Change: 1.93
Ensembl ID: ENSG00000005022
Gene Symbol: ARF1 (ENSG00000143761)
Fold Change: 1.92
Ensembl ID: ENSG00000143761
Gene Symbol: ATP5MC2 (ENSG00000135390)
Fold Change: 1.9
Ensembl ID: ENSG00000135390
Gene Symbol: ATP5MC3 (ENSG00000154518)
Fold Change: 1.87
Ensembl ID: ENSG00000154518
Gene Symbol: ATP5ME (ENSG00000169020)
Fold Change: 1.84
Ensembl ID: ENSG00000169020
Gene Symbol: CAPZB (ENSG00000077549)
Fold Change: 1.81
Ensembl ID: ENSG00000077549
Gene Symbol: ATP5F1B (ENSG00000110955)
Fold Change: 1.8
Ensembl ID: ENSG00000110955
Gene Symbol: BSG (ENSG00000172270)
Fold Change: 1.78
Ensembl ID: ENSG00000172270
Gene Symbol: ATP5F1D (ENSG00000099624)
Fold Change: 1.76
Ensembl ID: ENSG00000099624
Gene Symbol: ATP5PF (ENSG00000154723)
Fold Change: 1.75
Ensembl ID: ENSG00000154723
Gene Symbol: TMEM258 (ENSG00000134825)
Fold Change: 1.68
Ensembl ID: ENSG00000134825
Gene Symbol: APRT (ENSG00000198931)
Fold Change: 1.67
Ensembl ID: ENSG00000198931
Gene Symbol: ADAM10 (ENSG00000137845)
Fold Change: 1.67
Ensembl ID: ENSG00000137845
Gene Symbol: ATF4 (ENSG00000128272)
Fold Change: 1.67
Ensembl ID: ENSG00000128272
Gene Symbol: APP (ENSG00000142192)
Fold Change: 1.63
Ensembl ID: ENSG00000142192
Gene Symbol: RERE (ENSG00000142599)
Fold Change: 1.63
Ensembl ID: ENSG00000142599
Gene Symbol: ATP6V0B (ENSG00000117410)
Fold Change: 1.63
Ensembl ID: ENSG00000117410
Gene Symbol: CCNG1 (ENSG00000113328)
Fold Change: 1.6
Ensembl ID: ENSG00000113328
Gene Symbol: CANX (ENSG00000127022)
Fold Change: 1.59
Ensembl ID: ENSG00000127022
Gene Symbol: DST (ENSG00000151914)
Fold Change: 1.58
Ensembl ID: ENSG00000151914
Gene Symbol: ATP5PO (ENSG00000241837)
Fold Change: 1.57
Ensembl ID: ENSG00000241837
Gene Symbol: APLP2 (ENSG00000084234)
Fold Change: 1.53
Ensembl ID: ENSG00000084234
Gene Symbol: ATP5F1A (ENSG00000152234)
Fold Change: 1.53
Ensembl ID: ENSG00000152234
Gene Symbol: CCNH (ENSG00000134480)
Fold Change: 1.52
Ensembl ID: ENSG00000134480
Gene Symbol: CAPZA1 (ENSG00000116489)
Fold Change: 1.52
Ensembl ID: ENSG00000116489
Gene Symbol: ANXA5 (ENSG00000164111)
Fold Change: 1.5
Ensembl ID: ENSG00000164111
Gene Symbol: ATP5F1C (ENSG00000165629)
Fold Change: 1.5
Ensembl ID: ENSG00000165629
Gene Symbol: ALDOA (ENSG00000149925)
Fold Change: 1.49
Ensembl ID: ENSG00000149925
Gene Symbol: TLE5 (ENSG00000104964)
Fold Change: 1.48
Ensembl ID: ENSG00000104964
Gene Symbol: CBR1 (ENSG00000159228)
Fold Change: 1.47
Ensembl ID: ENSG00000159228
Gene Symbol: ASPH (ENSG00000198363)
Fold Change: 1.45
Ensembl ID: ENSG00000198363
Gene Symbol: ATM (ENSG00000149311)
Fold Change: 1.45
Ensembl ID: ENSG00000149311
Gene Symbol: ATP5PB (ENSG00000116459)
Fold Change: 1.45
Ensembl ID: ENSG00000116459
Gene Symbol: BNIP3L (ENSG00000104765)
Fold Change: 1.44
Ensembl ID: ENSG00000104765
Gene Symbol: ARHGDIA (ENSG00000141522)
Fold Change: 1.42
Ensembl ID: ENSG00000141522
Gene Symbol: CAPZA2 (ENSG00000198898)
Fold Change: 1.42
Ensembl ID: ENSG00000198898
Gene Symbol: ANXA2 (ENSG00000182718)
Fold Change: 1.42
Ensembl ID: ENSG00000182718
Gene Symbol: ATRX (ENSG00000085224)
Fold Change: 1.41
Ensembl ID: ENSG00000085224
Gene Symbol: AP2A2 (ENSG00000183020)
Fold Change: 1.41
Ensembl ID: ENSG00000183020
Gene Symbol: CALD1 (ENSG00000122786)
Fold Change: 1.4
Ensembl ID: ENSG00000122786
Gene Symbol: ADK (ENSG00000156110)
Fold Change: 1.4
Ensembl ID: ENSG00000156110
Gene Symbol: ACYP2 (ENSG00000170634)
Fold Change: 1.39
Ensembl ID: ENSG00000170634
Gene Symbol: ANXA4 (ENSG00000196975)
Fold Change: 1.39
Ensembl ID: ENSG00000196975
Gene Symbol: ATP1B3 (ENSG00000069849)
Fold Change: 1.37
Ensembl ID: ENSG00000069849
Gene Symbol: ANXA11 (ENSG00000122359)
Fold Change: 1.37
Ensembl ID: ENSG00000122359
Gene Symbol: ARF4 (ENSG00000168374)
Fold Change: 1.36
Ensembl ID: ENSG00000168374
Gene Symbol: ARHGDIB (ENSG00000111348)
Fold Change: 1.36
Ensembl ID: ENSG00000111348
Gene Symbol: TSPO (ENSG00000100300)
Fold Change: 1.35
Ensembl ID: ENSG00000100300
Gene Symbol: ATP1A1 (ENSG00000163399)
Fold Change: 1.34
Ensembl ID: ENSG00000163399
Gene Symbol: ACTN4 (ENSG00000130402)
Fold Change: 1.33
Ensembl ID: ENSG00000130402
Gene Symbol: BTD (ENSG00000169814)
Fold Change: 1.32
Ensembl ID: ENSG00000169814
Gene Symbol: ATP5MC1 (ENSG00000159199)
Fold Change: 1.31
Ensembl ID: ENSG00000159199
Gene Symbol: C1QBP (ENSG00000108561)
Fold Change: 1.31
Ensembl ID: ENSG00000108561
Gene Symbol: ACADVL (ENSG00000072778)
Fold Change: 1.3
Ensembl ID: ENSG00000072778
Gene Symbol: ATP6V1A (ENSG00000114573)
Fold Change: 1.29
Ensembl ID: ENSG00000114573
Gene Symbol: APBB2 (ENSG00000163697)
Fold Change: 1.28
Ensembl ID: ENSG00000163697
Gene Symbol: ARF6 (ENSG00000165527)
Fold Change: 1.27
Ensembl ID: ENSG00000165527
Gene Symbol: ATP6V0A1 (ENSG00000033627)
Fold Change: 1.25
Ensembl ID: ENSG00000033627
Gene Symbol: AUP1 (ENSG00000115307)
Fold Change: 1.24
Ensembl ID: ENSG00000115307
Gene Symbol: RUNX1 (ENSG00000159216)
Fold Change: 1.23
Ensembl ID: ENSG00000159216
Gene Symbol: CALM3 (ENSG00000160014)
Fold Change: 1.22
Ensembl ID: ENSG00000160014
Gene Symbol: BCYRN1 (ENSG00000236824)
Fold Change: 1.21
Ensembl ID: ENSG00000236824
Gene Symbol: ARF5 (ENSG00000004059)
Fold Change: 1.21
Ensembl ID: ENSG00000004059
Gene Symbol: CCND3 (ENSG00000112576)
Fold Change: 1.21
Ensembl ID: ENSG00000112576
Gene Symbol: AMD1 (ENSG00000123505)
Fold Change: 1.2
Ensembl ID: ENSG00000123505
Gene Symbol: ARHGAP5 (ENSG00000100852)
Fold Change: 1.2
Ensembl ID: ENSG00000100852
Gene Symbol: CCT6A (ENSG00000146731)
Fold Change: 1.2
Ensembl ID: ENSG00000146731
Gene Symbol: CAMK2D (ENSG00000145349)
Fold Change: 1.17
Ensembl ID: ENSG00000145349
Gene Symbol: ASAH1 (ENSG00000104763)
Fold Change: 1.15
Ensembl ID: ENSG00000104763
Gene Symbol: CAV1 (ENSG00000105974)
Fold Change: 1.14
Ensembl ID: ENSG00000105974
Gene Symbol: ADD1 (ENSG00000087274)
Fold Change: 1.13
Ensembl ID: ENSG00000087274
Gene Symbol: ADAR (ENSG00000160710)
Fold Change: 1.1
Ensembl ID: ENSG00000160710
Gene Symbol: RHOB (ENSG00000143878)
Fold Change: 1.1
Ensembl ID: ENSG00000143878
Gene Symbol: ANK3 (ENSG00000151150)
Fold Change: 1.09
Ensembl ID: ENSG00000151150
Gene Symbol: ANXA7 (ENSG00000138279)
Fold Change: 1.09
Ensembl ID: ENSG00000138279
Gene Symbol: BAG1 (ENSG00000107262)
Fold Change: 1.07
Ensembl ID: ENSG00000107262
Gene Symbol: BRAF (ENSG00000157764)
Fold Change: 1.07
Ensembl ID: ENSG00000157764
Gene Symbol: CAMLG (ENSG00000164615)
Fold Change: 1.07
Ensembl ID: ENSG00000164615
Gene Symbol: PARP1 (ENSG00000143799)
Fold Change: 1.06
Ensembl ID: ENSG00000143799
Gene Symbol: CAPNS1 (ENSG00000126247)
Fold Change: 1.05
Ensembl ID: ENSG00000126247
Gene Symbol: ZFHX3 (ENSG00000140836)
Fold Change: 1.05
Ensembl ID: ENSG00000140836
Gene Symbol: BNIP3 (ENSG00000176171)
Fold Change: 1.02
Ensembl ID: ENSG00000176171
Gene Symbol: ATOX1 (ENSG00000177556)
Fold Change: 1.02
Ensembl ID: ENSG00000177556
Gene Symbol: RHOC (ENSG00000155366)
Fold Change: 1.01
Ensembl ID: ENSG00000155366
Gene Symbol: ANXA1 (ENSG00000135046)
Fold Change: 1.01
Ensembl ID: ENSG00000135046

Gene representation (2051)
Gene/Pathway representation (2051)

Hovered Details

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**Key Characteristics** * Lens fiber cells are elongated and tightly packed, making up the bulk of the mature lens in a camera-type eye. * They are involved in refracting light to form images. * The cell's gene symbol is B2M, and it is associated with adaptive immune system processes, amyloid fiber formation, and antigen presentation. * Lens fiber cells are also involved in various cellular processes, including immune responses, amyloid fiber formation, and antigen presentation. **Clinical Significance** The lens fiber cell plays a crucial role in the eye's ability to focus light and form images. Any disruption to the lens fiber cell's structure or function can lead to vision problems, including blurry vision, double vision, and eye strain. Furthermore, the cell's involvement in immune responses and antigen presentation makes it an important target for researchers studying immune-related diseases, such as autoimmune disorders and cancer. In addition, the lens fiber cell's association with amyloid fiber formation makes it a potential target for researchers studying amyloid-related diseases, such as Alzheimer's disease and multiple system atrophy. The cell's involvement in antigen presentation also makes it an important target for researchers studying immune-related diseases, such as cancer and autoimmune disorders. Overall, the lens fiber cell is a complex cell type that plays a crucial role in the eye's ability to focus light and form images, and its involvement in various cellular processes makes it an important target for researchers studying immune-related diseases and other conditions. **Pathways and Ontologies** The lens fiber cell is involved in a wide range of cellular processes, including: * Adaptive immune system processes * Amyloid fiber formation * Antigen presentation * Antigen processing and presentation of exogenous peptide antigen via MHC class II * Antigen processing and presentation of endogenous peptide antigen via MHC class I * Antigen processing and presentation of exogenous protein antigen via MHC class Ib * Bacterial infection pathways * Cellular response to iron(iii) ion * Cellular response to iron ion * Cellular response to nicotine * Cytokine signaling in immune system * Cytosol * Dap12 interactions * Dap12 signaling * Disease * Early endosome lumen * Early endosome membrane * Endoplasmic reticulum * Endoplasmic reticulum lumen * Endosomal/vacuolar pathway * Er-phagosome pathway * Er to Golgi transport vesicle membrane * External side of plasma membrane * Extracellular exosome * Extracellular region * Extracellular space * Focal adhesion * Golgi apparatus * Golgi membrane * Hfe-transferrin receptor complex * Hiv infection * Host interactions of hiv factors * Identical protein binding * Immune system * Immunoregulatory interactions between a lymphoid and a non-lymphoid cell * Infection with mycobacterium tuberculosis * Infectious disease * Innate immune system * Interferon gamma signaling * Interferon signaling * Intracellular iron ion homeostasis * Iron ion transport * Late endosome membrane * Learning or memory * Lysosomal membrane * Membrane * Metabolism of proteins * Mhc class II protein complex * Mhc class II protein complex binding * Mhc class I peptide loading complex * Mhc class I protein complex * Modulation by mtb of host immune system * Multicellular organismal-level iron ion homeostasis * Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters * Nef mediated downregulation of MHC class I complex cell surface expression * Negative regulation of epithelial cell proliferation * Negative regulation of forebrain neuron differentiation * Negative regulation of neurogenesis * Negative regulation of neuron projection development * Negative regulation of receptor binding * Neutrophil degranulation * Peptide antigen assembly with MHC class II protein complex * Peptide antigen assembly with MHC class I protein complex * Peptide antigen binding * Phagocytic vesicle membrane * Plasma membrane * Positive regulation of cellular senescence * Positive regulation of ferrous iron binding * Positive regulation of immune response * Positive regulation of protein binding * Positive regulation of receptor-mediated endocytosis * Positive regulation of receptor binding * Positive regulation of T cell activation * Positive regulation of T cell cytokine production * Positive regulation of T cell mediated cytotoxicity * Positive regulation of transferrin receptor binding * Protein binding * Protein homodimerization activity * Protein homotetramerization * Protein refolding * Recycling endosome membrane * Regulation of erythrocyte differentiation * Regulation of iron ion transport * Response to molecule of bacterial origin * Sars-cov-2 activates/modulates innate and adaptive immune responses * Sars-cov-2 infection * Sars-cov-2-host interactions * Sars-cov infections * Sensory perception of smell * Specific granule lumen * Structural molecule activity * T cell differentiation in thymus * T cell mediated cytotoxicity * Tertiary granule lumen * The role of nef in hiv-1 replication and disease pathogenesis * Viral infection pathways

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.