Details for: CAPNS1

Gene ID: 826

Symbol: CAPNS1

Ensembl ID: ENSG00000126247

Description: calpain small subunit 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 334.5651
    Cell Significance Index: -52.0400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 190.3066
    Cell Significance Index: -48.2700
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 137.4447
    Cell Significance Index: -56.6200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 122.4840
    Cell Significance Index: -49.7600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 118.2320
    Cell Significance Index: -55.8200
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 105.2907
    Cell Significance Index: -54.1600
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 83.4101
    Cell Significance Index: -55.9700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 44.4055
    Cell Significance Index: -54.7500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 17.5858
    Cell Significance Index: -47.1100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 14.1230
    Cell Significance Index: -55.7300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 12.1343
    Cell Significance Index: -37.2700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 9.4353
    Cell Significance Index: -20.6500
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 2.3923
    Cell Significance Index: 22.0300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 2.3582
    Cell Significance Index: 26.7900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.1324
    Cell Significance Index: 1164.5800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.9513
    Cell Significance Index: 125.8900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.8799
    Cell Significance Index: 258.1600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.7565
    Cell Significance Index: 316.6400
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.7443
    Cell Significance Index: 40.3000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.6698
    Cell Significance Index: 205.3200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.3238
    Cell Significance Index: 61.7200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.3072
    Cell Significance Index: 24.1600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.2947
    Cell Significance Index: 35.2400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.2690
    Cell Significance Index: 365.1300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.2306
    Cell Significance Index: 26.6600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.1558
    Cell Significance Index: 54.3200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.1015
    Cell Significance Index: 57.2200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.0846
    Cell Significance Index: 979.2900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.8429
    Cell Significance Index: 24.2900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7759
    Cell Significance Index: 126.1900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.6950
    Cell Significance Index: 51.8000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.6662
    Cell Significance Index: 126.7800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.6255
    Cell Significance Index: 80.8200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6028
    Cell Significance Index: 59.6300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.5614
    Cell Significance Index: 71.9700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.5253
    Cell Significance Index: 23.8100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5054
    Cell Significance Index: 101.3900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4964
    Cell Significance Index: 219.4600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3342
    Cell Significance Index: 66.3300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.3091
    Cell Significance Index: 21.8600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.2508
    Cell Significance Index: 5.2500
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.2040
    Cell Significance Index: 3.6100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.1522
    Cell Significance Index: 4.4700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1277
    Cell Significance Index: 21.8100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0819
    Cell Significance Index: 2.2900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0707
    Cell Significance Index: 25.3500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0457
    Cell Significance Index: 34.6000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0312
    Cell Significance Index: 0.8400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0219
    Cell Significance Index: 16.0700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0063
    Cell Significance Index: -11.9400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0190
    Cell Significance Index: -35.0000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0213
    Cell Significance Index: -32.8400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0217
    Cell Significance Index: -0.5800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0236
    Cell Significance Index: -17.5100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0321
    Cell Significance Index: -43.6300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0333
    Cell Significance Index: -20.8100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0421
    Cell Significance Index: -4.9600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0440
    Cell Significance Index: -4.4900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0530
    Cell Significance Index: -33.6500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0587
    Cell Significance Index: -33.1300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0595
    Cell Significance Index: -41.1800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0973
    Cell Significance Index: -44.1700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1316
    Cell Significance Index: -6.9100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1320
    Cell Significance Index: -3.4700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1392
    Cell Significance Index: -15.9500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1449
    Cell Significance Index: -30.5100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1733
    Cell Significance Index: -2.9000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2111
    Cell Significance Index: -2.8800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2699
    Cell Significance Index: -39.2400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2778
    Cell Significance Index: -32.3800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3044
    Cell Significance Index: -9.7500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3108
    Cell Significance Index: -8.9100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.3230
    Cell Significance Index: -4.8400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3274
    Cell Significance Index: -25.1300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3684
    Cell Significance Index: -23.2200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.3920
    Cell Significance Index: -27.1100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.4347
    Cell Significance Index: -49.6200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4418
    Cell Significance Index: -34.9900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.4450
    Cell Significance Index: -29.9300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.4753
    Cell Significance Index: -16.5200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.4960
    Cell Significance Index: -12.6700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.5263
    Cell Significance Index: -54.8000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.5722
    Cell Significance Index: -35.1700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.5790
    Cell Significance Index: -12.3300
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: -0.6060
    Cell Significance Index: -4.0200
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.7718
    Cell Significance Index: -4.7500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.7846
    Cell Significance Index: -44.0300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.7929
    Cell Significance Index: -48.6100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.8402
    Cell Significance Index: -29.5300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.8660
    Cell Significance Index: -45.1100
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.8812
    Cell Significance Index: -9.5800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.8866
    Cell Significance Index: -44.8100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.9149
    Cell Significance Index: -37.4900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.9441
    Cell Significance Index: -23.6000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -1.0173
    Cell Significance Index: -29.0300
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -1.0679
    Cell Significance Index: -8.9700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.0778
    Cell Significance Index: -47.6800
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -1.0787
    Cell Significance Index: -15.1300
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -1.0814
    Cell Significance Index: -11.2000
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -1.1152
    Cell Significance Index: -15.8800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Subunit of Calpain Complex:** CAPNS1 is a subunit of the calpain complex, which is a heterodimeric enzyme composed of a large subunit (CAPNS2) and a small subunit (CAPNS1). 2. **Calcium-Dependent Cysteine-Type Endopeptidase:** CAPNS1 is a calcium-dependent cysteine-type endopeptidase, which means it requires calcium ions to catalyze the cleavage of protein substrates. 3. **Regulation of Proteolysis:** CAPNS1 plays a crucial role in regulating proteolysis, which is essential for maintaining cellular homeostasis and responding to various cellular stresses. 4. **Involvement in Cell Signaling:** CAPNS1 is involved in cell signaling pathways, including the regulation of macroautophagy and the positive regulation of cell population proliferation. **Pathways and Functions:** 1. **Calcium Ion Binding:** CAPNS1 binds to calcium ions, which activates the calpain complex and enables it to cleave protein substrates. 2. **Cytosol and Extracellular Matrix Organization:** CAPNS1 regulates the organization of the cytosol and extracellular matrix, which is essential for maintaining tissue structure and function. 3. **Protein Binding:** CAPNS1 interacts with various proteins, including calpain large subunit (CAPNS2), cdk5, and other proteins involved in cell signaling pathways. 4. **Regulation of Apoptosis:** CAPNS1 plays a role in regulating apoptosis, a process of programmed cell death, which is essential for tissue homeostasis and responding to cellular stresses. **Clinical Significance:** 1. **Neurodegenerative Diseases:** Dysregulation of CAPNS1 has been implicated in neurodegenerative disorders, such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS). 2. **Cancer:** CAPNS1 has been identified as a potential biomarker for various types of cancer, including breast cancer, lung cancer, and colon cancer. 3. **Cardiovascular Disease:** CAPNS1 has been implicated in cardiovascular disease, including atherosclerosis and cardiac hypertrophy. 4. **Regenerative Medicine:** CAPNS1 has the potential to be used as a therapeutic target for regenerative medicine, including tissue engineering and organ transplantation. In conclusion, CAPNS1 is a critical gene involved in various cellular processes, including proteolysis, cell signaling, and programmed cell death. Dysregulation of CAPNS1 has been implicated in several diseases, including neurodegenerative disorders, cancer, and cardiovascular disease. Further research is needed to fully understand the role of CAPNS1 in human health and disease.

Genular Protein ID: 1866749175

Symbol: CPNS1_HUMAN

Name: Calpain small subunit 1

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 3016651

Title: Nucleotide sequence of a cDNA coding for the small subunit of human calcium-dependent protease.

PubMed ID: 3016651

PubMed ID: 3024120

Title: Gene organization of the small subunit of human calcium-activated neutral protease.

PubMed ID: 3024120

DOI: 10.1093/nar/14.22.8805

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 10639123

Title: The crystal structure of calcium-free human m-calpain suggests an electrostatic switch mechanism for activation by calcium.

PubMed ID: 10639123

DOI: 10.1073/pnas.97.2.588

PubMed ID: 38230350

Title: Biallelic variants in the calpain regulatory subunit CAPNS1 cause pulmonary arterial hypertension.

PubMed ID: 38230350

DOI: 10.1016/j.gimo.2023.100811

Sequence Information:

  • Length: 268
  • Mass: 28316
  • Checksum: 17B87A8E47A90632
  • Sequence:
  • MFLVNSFLKG GGGGGGGGGG LGGGLGNVLG GLISGAGGGG GGGGGGGGGG GGGGGGTAMR 
    ILGGVISAIS EAAAQYNPEP PPPRTHYSNI EANESEEVRQ FRRLFAQLAG DDMEVSATEL 
    MNILNKVVTR HPDLKTDGFG IDTCRSMVAV MDSDTTGKLG FEEFKYLWNN IKRWQAIYKQ 
    FDTDRSGTIC SSELPGAFEA AGFHLNEHLY NMIIRRYSDE SGNMDFDNFI SCLVRLDAMF 
    RAFKSLDKDG TGQIQVNIQE WLQLTMYS

Genular Protein ID: 3622624744

Symbol: A0A0C4DGQ5_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.M111.015131

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

Sequence Information:

  • Length: 322
  • Mass: 33786
  • Checksum: 52002C65AB6E1123
  • Sequence:
  • MFLVNSFLKG GGGGGGGGGG LGGGLGNVLG GLISGAGGGG GGGGGGGGGG GGGGGGTAMR 
    ILGGVISAIS EAAAQYNPEP PPPRTHYSNI EANESEEVRQ FRRLFAQLAG DDMEVSATEL 
    MNILNKVVTR HPDLKTDGFG IDTCRSMVAV MDSDTTGKLG FEEFKYLWNN IKRWQAIYKQ 
    FDTDRSGTIC SSELPGAFEA AGFHLNEHLY NMIIRRYSDE SGNMDFDNFI SCLVRLDAMF 
    RAFKSLDKDG TGQIQVNIQE VRTPILGYGC LGGPHPSALH TSSELQSPSS YFASRPWVRA 
    KGLVLLGFPV LTLHPPLPSG CS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.