Details for: CAPNS1

Gene ID: 826

Symbol: CAPNS1

Ensembl ID: ENSG00000126247

Description: calpain small subunit 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 2.64
    Marker Score: 2206
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.47
    Marker Score: 85519
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.4
    Marker Score: 134461
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 2.4
    Marker Score: 1359
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 2.27
    Marker Score: 5724
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 2.22
    Marker Score: 3685
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 2.2
    Marker Score: 1499.5
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 2.14
    Marker Score: 16708
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.09
    Marker Score: 2197
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 2.07
    Marker Score: 1384
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 2.06
    Marker Score: 17744
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 2.04
    Marker Score: 3612
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 2.02
    Marker Score: 7174
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 2.01
    Marker Score: 5383.5
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.98
    Marker Score: 9522
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.98
    Marker Score: 7334
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.97
    Marker Score: 4903
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 1.97
    Marker Score: 12559
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.96
    Marker Score: 3921
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.95
    Marker Score: 19736
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 1.94
    Marker Score: 3771
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 1.93
    Marker Score: 2321
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 1.93
    Marker Score: 1359
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 1.92
    Marker Score: 1842
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.92
    Marker Score: 2825
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.91
    Marker Score: 1937
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 1.87
    Marker Score: 2140
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.86
    Marker Score: 20937
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 1.81
    Marker Score: 934
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.8
    Marker Score: 2552
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.8
    Marker Score: 5649
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.78
    Marker Score: 45484
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.77
    Marker Score: 512
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 1.77
    Marker Score: 2808
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 1.76
    Marker Score: 6059
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.74
    Marker Score: 1843.5
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 1.73
    Marker Score: 613
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.71
    Marker Score: 3904
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.7
    Marker Score: 1764
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.69
    Marker Score: 3843
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.69
    Marker Score: 1806
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 1.68
    Marker Score: 4049
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 1.68
    Marker Score: 863
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 1.67
    Marker Score: 2691
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 1.66
    Marker Score: 716
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.66
    Marker Score: 1562
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 1.65
    Marker Score: 1479
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 1.65
    Marker Score: 1489
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.65
    Marker Score: 4484
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 1.64
    Marker Score: 986
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.63
    Marker Score: 900
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 1.63
    Marker Score: 1161
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.63
    Marker Score: 1832
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.63
    Marker Score: 7015
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.58
    Marker Score: 15902
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 1.57
    Marker Score: 335
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.57
    Marker Score: 1696
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 1.57
    Marker Score: 504
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.55
    Marker Score: 725
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 1.55
    Marker Score: 1551
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 1.55
    Marker Score: 583
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.55
    Marker Score: 17996
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 1.54
    Marker Score: 2372
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.54
    Marker Score: 11455
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 1.53
    Marker Score: 486
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 1.53
    Marker Score: 753
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 1.52
    Marker Score: 1636
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 1.52
    Marker Score: 524
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.52
    Marker Score: 13177
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.52
    Marker Score: 349
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 1.5
    Marker Score: 2065
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 1.5
    Marker Score: 6239
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.49
    Marker Score: 3548
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 1.48
    Marker Score: 7804
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 1.48
    Marker Score: 1735
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 1.48
    Marker Score: 524
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.48
    Marker Score: 353
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 1.48
    Marker Score: 1382
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 1.47
    Marker Score: 846
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.47
    Marker Score: 855
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.47
    Marker Score: 1559
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 1.47
    Marker Score: 9554
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.45
    Marker Score: 358
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 1.45
    Marker Score: 2100
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 1.44
    Marker Score: 347
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.43
    Marker Score: 1843
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 1.42
    Marker Score: 5896
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.42
    Marker Score: 5568
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 1.42
    Marker Score: 1077
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 1.41
    Marker Score: 1110
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 1.41
    Marker Score: 2674
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 1.4
    Marker Score: 957
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 1.4
    Marker Score: 875
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.39
    Marker Score: 5377
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.39
    Marker Score: 344
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.39
    Marker Score: 5674
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.38
    Marker Score: 1196
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 1.37
    Marker Score: 517
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 1.36
    Marker Score: 704.5
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1.36
    Marker Score: 902.5

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Other Information

**Key characteristics:** - CAPNS1 is a large protein (125 kDa) that is expressed in the cytoplasm of cells. - It is a cysteine-type endopeptidase, which means that it cleaves peptide bonds between cysteine residues in proteins. - CAPNS1 is a highly conserved protein, with similar sequences found in organisms from yeast to humans. **Pathways and functions:** - CAPNS1 is involved in a variety of cellular processes, including cell migration, differentiation, and apoptosis. - It is a key regulator of keratinization, the process by which epithelial cells form the cornified envelope of skin and hair. - CAPNS1 also plays a role in the regulation of angiogenesis, cell migration, and tissue remodeling. - It is involved in the degradation of the extracellular matrix and the regulation of cell population proliferation. - CAPNS1 has been implicated in a number of diseases, including Alzheimer's disease, cancer, and cardiovascular disease. **Clinical significance:** - Mutations in the CAPNS1 gene have been linked to a number of diseases, including Alzheimer's disease, cancer, and cardiovascular disease. - Targeting CAPNS1 has been explored as a therapeutic strategy for these diseases. - However, the development of CAPNS1 inhibitors has been challenging due to the protein's important role in both physiological and pathological processes.

Genular Protein ID: 1866749175

Symbol: CPNS1_HUMAN

Name: Calpain small subunit 1

UniProtKB Accession Codes:

P04632 A8K0P1 Q8WTX3 Q96EW0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 2 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CPTAC 2 CTD 1 ChEBI 16 ChEMBL 1 ChiTaRS 1 ComplexPortal 2 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 24 EPD 1 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 10 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 11 PDBsum 9 PIR 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 3 RefSeq 6 SMR 1 STRING 1 SUPFAM 1 SWISS-2DPAGE 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3016651

Title: Nucleotide sequence of a cDNA coding for the small subunit of human calcium-dependent protease.

PubMed ID: 3016651

PubMed ID: 3024120

Title: Gene organization of the small subunit of human calcium-activated neutral protease.

PubMed ID: 3024120

DOI: 10.1093/nar/14.22.8805

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 10639123

Title: The crystal structure of calcium-free human m-calpain suggests an electrostatic switch mechanism for activation by calcium.

PubMed ID: 10639123

DOI: 10.1073/pnas.97.2.588

Sequence Information:

  • Length: 268
  • Mass: 28316
  • Checksum: 17B87A8E47A90632
  • Sequence:
    • MFLVNSFLKG GGGGGGGGGG LGGGLGNVLG GLISGAGGGG GGGGGGGGGG GGGGGGTAMR 
ILGGVISAIS EAAAQYNPEP PPPRTHYSNI EANESEEVRQ FRRLFAQLAG DDMEVSATEL 
MNILNKVVTR HPDLKTDGFG IDTCRSMVAV MDSDTTGKLG FEEFKYLWNN IKRWQAIYKQ 
FDTDRSGTIC SSELPGAFEA AGFHLNEHLY NMIIRRYSDE SGNMDFDNFI SCLVRLDAMF 
RAFKSLDKDG TGQIQVNIQE WLQLTMYS

Genular Protein ID: 3622624744

Symbol: A0A0C4DGQ5_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0C4DGQ5

Database IDs:

ARBA 3 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 3 EPD 1 Ensembl 2 GO 1 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 InterPro 3 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 3 Proteomes 2 RefSeq 2 SUPFAM 1 VEuPathDB 1

Citations:

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.M111.015131

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

Sequence Information:

  • Length: 322
  • Mass: 33786
  • Checksum: 52002C65AB6E1123
  • Sequence:
    • MFLVNSFLKG GGGGGGGGGG LGGGLGNVLG GLISGAGGGG GGGGGGGGGG GGGGGGTAMR 
ILGGVISAIS EAAAQYNPEP PPPRTHYSNI EANESEEVRQ FRRLFAQLAG DDMEVSATEL 
MNILNKVVTR HPDLKTDGFG IDTCRSMVAV MDSDTTGKLG FEEFKYLWNN IKRWQAIYKQ 
FDTDRSGTIC SSELPGAFEA AGFHLNEHLY NMIIRRYSDE SGNMDFDNFI SCLVRLDAMF 
RAFKSLDKDG TGQIQVNIQE VRTPILGYGC LGGPHPSALH TSSELQSPSS YFASRPWVRA 
KGLVLLGFPV LTLHPPLPSG CS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.