Details for: CL0000575

Cell ID: CL0000575

Cell Name: corneal epithelial cell

Marker Score Threshold: 1105
(Derived using integrated single-cell and genomic data)

Description: An epithelial cell of the cornea.

Synonyms: epithelial cell of cornea

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ACACA (ENSG00000278540)
    Fold Change: 2.59
    Ensembl ID: ENSG00000278540
  • Gene Symbol: CRYBG1 (ENSG00000112297)
    Fold Change: 2.53
    Ensembl ID: ENSG00000112297
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 2.4
    Ensembl ID: ENSG00000085224
  • Gene Symbol: AMPD3 (ENSG00000133805)
    Fold Change: 2.4
    Ensembl ID: ENSG00000133805
  • Gene Symbol: ADK (ENSG00000156110)
    Fold Change: 2.32
    Ensembl ID: ENSG00000156110
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 2.3
    Ensembl ID: ENSG00000182718
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 2.28
    Ensembl ID: ENSG00000142599
  • Gene Symbol: ASPH (ENSG00000198363)
    Fold Change: 2.27
    Ensembl ID: ENSG00000198363
  • Gene Symbol: ABR (ENSG00000159842)
    Fold Change: 2.18
    Ensembl ID: ENSG00000159842
  • Gene Symbol: ACVR2A (ENSG00000121989)
    Fold Change: 2.18
    Ensembl ID: ENSG00000121989
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 2.15
    Ensembl ID: ENSG00000130402
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 2.12
    Ensembl ID: ENSG00000122359
  • Gene Symbol: ADAM10 (ENSG00000137845)
    Fold Change: 2.1
    Ensembl ID: ENSG00000137845
  • Gene Symbol: AGL (ENSG00000162688)
    Fold Change: 1.86
    Ensembl ID: ENSG00000162688
  • Gene Symbol: ACYP2 (ENSG00000170634)
    Fold Change: 1.84
    Ensembl ID: ENSG00000170634
  • Gene Symbol: ADH7 (ENSG00000196344)
    Fold Change: 1.84
    Ensembl ID: ENSG00000196344
  • Gene Symbol: ABAT (ENSG00000183044)
    Fold Change: 1.8
    Ensembl ID: ENSG00000183044
  • Gene Symbol: BCKDHB (ENSG00000083123)
    Fold Change: 1.8
    Ensembl ID: ENSG00000083123
  • Gene Symbol: ARHGAP5 (ENSG00000100852)
    Fold Change: 1.79
    Ensembl ID: ENSG00000100852
  • Gene Symbol: AP1G1 (ENSG00000166747)
    Fold Change: 1.79
    Ensembl ID: ENSG00000166747
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 1.75
    Ensembl ID: ENSG00000184009
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.75
    Ensembl ID: ENSG00000069849
  • Gene Symbol: ATP6V0A1 (ENSG00000033627)
    Fold Change: 1.74
    Ensembl ID: ENSG00000033627
  • Gene Symbol: PARP4 (ENSG00000102699)
    Fold Change: 1.71
    Ensembl ID: ENSG00000102699
  • Gene Symbol: ATP2B4 (ENSG00000058668)
    Fold Change: 1.71
    Ensembl ID: ENSG00000058668
  • Gene Symbol: AUH (ENSG00000148090)
    Fold Change: 1.71
    Ensembl ID: ENSG00000148090
  • Gene Symbol: JAG1 (ENSG00000101384)
    Fold Change: 1.7
    Ensembl ID: ENSG00000101384
  • Gene Symbol: RND3 (ENSG00000115963)
    Fold Change: 1.7
    Ensembl ID: ENSG00000115963
  • Gene Symbol: ALDH3A2 (ENSG00000072210)
    Fold Change: 1.68
    Ensembl ID: ENSG00000072210
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.68
    Ensembl ID: ENSG00000087274
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 1.67
    Ensembl ID: ENSG00000075624
  • Gene Symbol: AP2A2 (ENSG00000183020)
    Fold Change: 1.66
    Ensembl ID: ENSG00000183020
  • Gene Symbol: ATR (ENSG00000175054)
    Fold Change: 1.65
    Ensembl ID: ENSG00000175054
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 1.64
    Ensembl ID: ENSG00000135046
  • Gene Symbol: ALDH1A1 (ENSG00000165092)
    Fold Change: 1.63
    Ensembl ID: ENSG00000165092
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.59
    Ensembl ID: ENSG00000084234
  • Gene Symbol: ZFHX3 (ENSG00000140836)
    Fold Change: 1.58
    Ensembl ID: ENSG00000140836
  • Gene Symbol: ALDH3A1 (ENSG00000108602)
    Fold Change: 1.57
    Ensembl ID: ENSG00000108602
  • Gene Symbol: ATP2A2 (ENSG00000174437)
    Fold Change: 1.56
    Ensembl ID: ENSG00000174437
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 1.55
    Ensembl ID: ENSG00000142192
  • Gene Symbol: ALDH7A1 (ENSG00000164904)
    Fold Change: 1.55
    Ensembl ID: ENSG00000164904
  • Gene Symbol: ABO (ENSG00000175164)
    Fold Change: 1.53
    Ensembl ID: ENSG00000175164
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 1.52
    Ensembl ID: ENSG00000166710
  • Gene Symbol: BAG1 (ENSG00000107262)
    Fold Change: 1.49
    Ensembl ID: ENSG00000107262
  • Gene Symbol: ARNT (ENSG00000143437)
    Fold Change: 1.48
    Ensembl ID: ENSG00000143437
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.44
    Ensembl ID: ENSG00000138279
  • Gene Symbol: ABL1 (ENSG00000097007)
    Fold Change: 1.44
    Ensembl ID: ENSG00000097007
  • Gene Symbol: ALK (ENSG00000171094)
    Fold Change: 1.43
    Ensembl ID: ENSG00000171094
  • Gene Symbol: BCL2L1 (ENSG00000171552)
    Fold Change: 1.42
    Ensembl ID: ENSG00000171552
  • Gene Symbol: ABCB7 (ENSG00000131269)
    Fold Change: 1.4
    Ensembl ID: ENSG00000131269
  • Gene Symbol: ADSS2 (ENSG00000035687)
    Fold Change: 1.35
    Ensembl ID: ENSG00000035687
  • Gene Symbol: ATM (ENSG00000149311)
    Fold Change: 1.34
    Ensembl ID: ENSG00000149311
  • Gene Symbol: APC (ENSG00000134982)
    Fold Change: 1.32
    Ensembl ID: ENSG00000134982
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.32
    Ensembl ID: ENSG00000148700
  • Gene Symbol: BMAL1 (ENSG00000133794)
    Fold Change: 1.32
    Ensembl ID: ENSG00000133794
  • Gene Symbol: ANK3 (ENSG00000151150)
    Fold Change: 1.31
    Ensembl ID: ENSG00000151150
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 1.29
    Ensembl ID: ENSG00000067560
  • Gene Symbol: ACVR1B (ENSG00000135503)
    Fold Change: 1.28
    Ensembl ID: ENSG00000135503
  • Gene Symbol: CCND1 (ENSG00000110092)
    Fold Change: 1.28
    Ensembl ID: ENSG00000110092
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.28
    Ensembl ID: ENSG00000104763
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.28
    Ensembl ID: ENSG00000104964
  • Gene Symbol: ACO2 (ENSG00000100412)
    Fold Change: 1.25
    Ensembl ID: ENSG00000100412
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.25
    Ensembl ID: ENSG00000163399
  • Gene Symbol: ARL4D (ENSG00000175906)
    Fold Change: 1.23
    Ensembl ID: ENSG00000175906
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.23
    Ensembl ID: ENSG00000070961
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.23
    Ensembl ID: ENSG00000165629
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 1.23
    Ensembl ID: ENSG00000124172
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 1.23
    Ensembl ID: ENSG00000135390
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 1.21
    Ensembl ID: ENSG00000169020
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.21
    Ensembl ID: ENSG00000168374
  • Gene Symbol: ATP6V1E1 (ENSG00000131100)
    Fold Change: 1.19
    Ensembl ID: ENSG00000131100
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.16
    Ensembl ID: ENSG00000110955
  • Gene Symbol: BACH1 (ENSG00000156273)
    Fold Change: 1.16
    Ensembl ID: ENSG00000156273
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 1.16
    Ensembl ID: ENSG00000099624
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 1.16
    Ensembl ID: ENSG00000154518
  • Gene Symbol: AREG (ENSG00000109321)
    Fold Change: 1.15
    Ensembl ID: ENSG00000109321
  • Gene Symbol: XIAP (ENSG00000101966)
    Fold Change: 1.15
    Ensembl ID: ENSG00000101966
  • Gene Symbol: ADRB2 (ENSG00000169252)
    Fold Change: 1.14
    Ensembl ID: ENSG00000169252
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.12
    Ensembl ID: ENSG00000143761
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.12
    Ensembl ID: ENSG00000152234
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.12
    Ensembl ID: ENSG00000165527
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.11
    Ensembl ID: ENSG00000117410
  • Gene Symbol: ADCY6 (ENSG00000174233)
    Fold Change: 1.11
    Ensembl ID: ENSG00000174233
  • Gene Symbol: ABL2 (ENSG00000143322)
    Fold Change: 1.11
    Ensembl ID: ENSG00000143322
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.1
    Ensembl ID: ENSG00000160710
  • Gene Symbol: APBA1 (ENSG00000107282)
    Fold Change: 1.09
    Ensembl ID: ENSG00000107282
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.09
    Ensembl ID: ENSG00000159199
  • Gene Symbol: AMFR (ENSG00000159461)
    Fold Change: 1.08
    Ensembl ID: ENSG00000159461
  • Gene Symbol: BARD1 (ENSG00000138376)
    Fold Change: 1.08
    Ensembl ID: ENSG00000138376
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 1.08
    Ensembl ID: ENSG00000154723
  • Gene Symbol: ADM (ENSG00000148926)
    Fold Change: 1.07
    Ensembl ID: ENSG00000148926
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.07
    Ensembl ID: ENSG00000123505
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.06
    Ensembl ID: ENSG00000198931
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.03
    Ensembl ID: ENSG00000116459
  • Gene Symbol: ABCF1 (ENSG00000204574)
    Fold Change: 1.03
    Ensembl ID: ENSG00000204574
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 1.02
    Ensembl ID: ENSG00000005022
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.02
    Ensembl ID: ENSG00000072778
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.02
    Ensembl ID: ENSG00000128272
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.02
    Ensembl ID: ENSG00000177556
  • Gene Symbol: ABCA1 (ENSG00000165029)
    Fold Change: 1
    Ensembl ID: ENSG00000165029
Hovered Details

Hover over a box to see details here...

Hovered Details

Hover over a box to see details here...

**Key Characteristics** * Corneal epithelial cells (CL0000575): + Epithelial cells of the cornea + Involved in maintaining the integrity of the cornea + Regulate the expression of genes involved in cell growth and differentiation * ATRX: + Protein involved in the regulation of telomere length and maintenance + Associated with several diseases, including cancer and neurological disorders + Involved in the regulation of gene expression and chromatin remodeling * AMPD3: + Enzyme involved in the metabolism of adenosine and other nucleotides + Involved in the regulation of immune responses and inflammation + Associated with several diseases, including cancer and cardiovascular disease **Clinical Significance** * Corneal epithelial cells (CL0000575): + Impaired function of corneal epithelial cells can lead to corneal diseases, such as corneal ulcers and dry eye syndrome + Corneal epithelial cells play a crucial role in maintaining the integrity of the cornea and preventing infection * ATRX: + Mutations in the ATRX gene are associated with several diseases, including cancer and neurological disorders + ATRX is a potential therapeutic target for the treatment of these diseases * AMPD3: + AMPD3 is involved in the regulation of immune responses and inflammation + Impaired function of AMPD3 has been associated with several diseases, including cancer and cardiovascular disease + AMPD3 is a potential therapeutic target for the treatment of these diseases **Diseases Associated with Each Cell Type** * Corneal epithelial cells (CL0000575): + Corneal ulcers + Dry eye syndrome + Corneal dystrophies * ATRX: + Cancer + Neurological disorders, such as ataxia-telangiectasia and intellectual disability + Epigenetic disorders, such as X-linked silencing of tumor suppressor genes * AMPD3: + Cancer + Cardiovascular disease + Neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease **Future Directions** * Further research is needed to understand the role of corneal epithelial cells in maintaining the integrity of the cornea and preventing infection * The development of new therapeutic strategies for the treatment of ATRX-associated diseases is an area of active research * The study of AMPD3 and its role in immune responses and inflammation may lead to the development of new treatments for diseases associated with AMPD3 dysfunction.