Details for: SET

Gene ID: 6418

Symbol: SET

Ensembl ID: ENSG00000119335

Description: SET nuclear proto-oncogene

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 642.4498
    Cell Significance Index: -99.9300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 355.3808
    Cell Significance Index: -90.1400
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 295.6687
    Cell Significance Index: -121.8000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 246.1013
    Cell Significance Index: -116.1900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 220.1074
    Cell Significance Index: -113.2200
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 173.5412
    Cell Significance Index: -116.4500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 93.2150
    Cell Significance Index: -114.9300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 39.0539
    Cell Significance Index: -104.6200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 30.1010
    Cell Significance Index: -118.7800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 25.8672
    Cell Significance Index: -79.4500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 17.8426
    Cell Significance Index: -39.0500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 6.2419
    Cell Significance Index: 216.9100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 5.4480
    Cell Significance Index: 148.2900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 4.3639
    Cell Significance Index: 599.2800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 4.3622
    Cell Significance Index: 536.3800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 4.0830
    Cell Significance Index: 191.9000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 4.0029
    Cell Significance Index: 258.2500
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 3.8413
    Cell Significance Index: 41.7600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 3.5510
    Cell Significance Index: 640.1400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 3.4417
    Cell Significance Index: 243.4100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 3.1694
    Cell Significance Index: 66.3400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 3.1217
    Cell Significance Index: 1704.8100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 3.0912
    Cell Significance Index: 1366.7200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 3.0903
    Cell Significance Index: 81.2600
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 2.9807
    Cell Significance Index: 22.9800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 2.8810
    Cell Significance Index: 32.7300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 2.5709
    Cell Significance Index: 332.1500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.5206
    Cell Significance Index: 117.5200
  • Cell Name: peg cell (CL4033014)
    Fold Change: 2.4555
    Cell Significance Index: 56.7300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.3037
    Cell Significance Index: 171.6900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.1413
    Cell Significance Index: 252.5300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 2.0057
    Cell Significance Index: 18.4700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.8175
    Cell Significance Index: 52.3700
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 1.7971
    Cell Significance Index: 11.0600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.5869
    Cell Significance Index: 45.4900
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.5254
    Cell Significance Index: 19.5400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.4414
    Cell Significance Index: 184.7800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.4326
    Cell Significance Index: 155.8200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.3692
    Cell Significance Index: 36.5600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.3108
    Cell Significance Index: 68.0900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.1413
    Cell Significance Index: 226.4900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.1213
    Cell Significance Index: 58.8800
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.0333
    Cell Significance Index: 18.2600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9175
    Cell Significance Index: 149.2200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.9050
    Cell Significance Index: 154.5400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.8863
    Cell Significance Index: 177.8000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.8313
    Cell Significance Index: 239.1900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5822
    Cell Significance Index: 57.5900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.4330
    Cell Significance Index: 24.3000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.4093
    Cell Significance Index: 25.1600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3555
    Cell Significance Index: 67.6500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3350
    Cell Significance Index: 120.1500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.3148
    Cell Significance Index: 19.8400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1881
    Cell Significance Index: 6.6100
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 0.1455
    Cell Significance Index: 1.2500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.1431
    Cell Significance Index: 104.9100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.1168
    Cell Significance Index: 88.4100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0714
    Cell Significance Index: 1.2000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0152
    Cell Significance Index: -28.5600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0406
    Cell Significance Index: -30.0600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0531
    Cell Significance Index: -2.4100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0572
    Cell Significance Index: -1.6800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0589
    Cell Significance Index: -6.7200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0592
    Cell Significance Index: -109.1200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0705
    Cell Significance Index: -108.5500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0876
    Cell Significance Index: -54.7100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0883
    Cell Significance Index: -120.0600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0985
    Cell Significance Index: -10.0600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.1144
    Cell Significance Index: -72.6500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1418
    Cell Significance Index: -79.9500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2126
    Cell Significance Index: -44.7800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.2174
    Cell Significance Index: -98.6500
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.2906
    Cell Significance Index: -2.3200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.2970
    Cell Significance Index: -5.4900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.3485
    Cell Significance Index: -9.7400
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.3856
    Cell Significance Index: -2.3300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.4468
    Cell Significance Index: -51.1900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.4511
    Cell Significance Index: -7.7300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.5343
    Cell Significance Index: -7.2900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.5860
    Cell Significance Index: -14.9700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.5942
    Cell Significance Index: -86.3800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.6192
    Cell Significance Index: -72.1700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.7006
    Cell Significance Index: -55.4900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.7399
    Cell Significance Index: -16.0300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.7523
    Cell Significance Index: -24.1000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -1.0318
    Cell Significance Index: -27.6000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -1.0570
    Cell Significance Index: -71.0700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -1.1284
    Cell Significance Index: -117.4900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -1.3601
    Cell Significance Index: -104.3800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -1.5612
    Cell Significance Index: -33.2500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -1.6367
    Cell Significance Index: -113.1900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.8894
    Cell Significance Index: -115.8400
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -2.0355
    Cell Significance Index: -35.0900
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -2.0585
    Cell Significance Index: -21.3100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -2.2394
    Cell Significance Index: -65.9600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -2.3134
    Cell Significance Index: -102.3300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -2.3838
    Cell Significance Index: -57.1700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -2.4544
    Cell Significance Index: -90.1000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -2.5750
    Cell Significance Index: -69.0000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -2.5964
    Cell Significance Index: -53.8600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Cellular localization:** SET is primarily found in the nucleus, where it interacts with histones, chromatin, and other nuclear proteins to regulate chromatin structure and gene expression. 2. **Proto-oncogenic potential:** SET's role as a nuclear proto-oncogene suggests its potential to contribute to tumorigenesis through dysregulated expression or activity. 3. **Histone binding and modification:** SET binds to histones and other chromatin-associated proteins, influencing chromatin condensation, nucleosome assembly, and histone modification. 4. **Regulation of transcription:** SET modulates transcription by interacting with transcription factors, co-repressors, and chromatin remodeling complexes. **Pathways and Functions:** 1. **Cell cycle regulation:** SET influences cell cycle progression by regulating the expression of cyclin-dependent kinases and other cell cycle regulators. 2. **DNA replication and repair:** SET's involvement in DNA replication and repair mechanisms highlights its role in maintaining genomic stability. 3. **Chromatin remodeling and condensation:** SET's interaction with chromatin-associated proteins and histones regulates chromatin structure, influencing gene expression and transcriptional regulation. 4. **Stem cell maintenance:** SET's expression in stem cells, including skeletal muscle satellite stem cells and basal cell of prostate epithelium, underscores its role in maintaining cellular self-renewal and differentiation. **Clinical Significance:** The SET gene's involvement in various cellular processes and its potential role in tumorigenesis make it a promising target for cancer therapy and diagnostics. Studies have shown that SET overexpression is associated with several types of cancer, including prostate, breast, and lung cancer. Furthermore, SET's involvement in immune cell regulation and chronic inflammation highlights its potential as a therapeutic target in autoimmune diseases. Additionally, SET's expression in stem cells and cancer stem cells suggests its role in maintaining cancer cell self-renewal and resistance to therapy. In conclusion, the SET gene's complex role in regulating cellular processes, including cell cycle progression, transcription, and chromatin structure, underscores its significance in maintaining cellular homeostasis and potentially contributing to tumorigenesis. Further research is needed to fully elucidate the mechanisms by which SET influences cellular regulation and to explore its potential as a therapeutic target in cancer and autoimmune diseases.

Genular Protein ID: 2525809510

Symbol: SET_HUMAN

Name: Protein SET

UniProtKB Accession Codes:

Q01105 A5A5H4 A6NGV1 B4DUE2 Q15541 Q5VXV1 Q5VXV2 Q6FHZ5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 13 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 19 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIR 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 Reactome 2 RefSeq 4 SASBDB 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 2 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1630450

Title: Can, a putative oncogene associated with myeloid leukemogenesis, may be activated by fusion of its 3' half to different genes: characterization of the set gene.

PubMed ID: 1630450

DOI: 10.1128/mcb.12.8.3346-3355.1992

PubMed ID: 8192856

Title: Purification and characterization of two putative HLA class II associated proteins: PHAPI and PHAPII.

PubMed ID: 8192856

DOI: 10.1515/bchm3.1994.375.2.113

PubMed ID: 7753797

Title: Replication factor encoded by a putative oncogene, set, associated with myeloid leukemogenesis.

PubMed ID: 7753797

DOI: 10.1073/pnas.92.10.4279

PubMed ID: 8626647

Title: The myeloid leukemia-associated protein SET is a potent inhibitor of protein phosphatase 2A.

PubMed ID: 8626647

DOI: 10.1074/jbc.271.19.11059

PubMed ID: 15642345

Title: Inhibitors of protein phosphatase-2A from human brain structures, immunocytological localization and activities towards dephosphorylation of the Alzheimer type hyperphosphorylated tau.

PubMed ID: 15642345

DOI: 10.1016/j.febslet.2004.11.097

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8294483

Title: Identification and characterization of SET, a nuclear phosphoprotein encoded by the translocation break point in acute undifferentiated leukemia.

PubMed ID: 8294483

DOI: 10.1016/s0021-9258(17)42162-4

PubMed ID: 9773788

Title: Expression of SET, an inhibitor of protein phosphatase 2A, in renal development and Wilms' tumor.

PubMed ID: 9773788

DOI: 10.1681/asn.v9101873

PubMed ID: 11163245

Title: Regulation of histone acetylation and transcription by INHAT, a human cellular complex containing the Set oncoprotein.

PubMed ID: 11163245

DOI: 10.1016/s0092-8674(01)00196-9

PubMed ID: 11231286

Title: Identification and characterization of SEB, a novel protein that binds to the acute undifferentiated leukemia-associated protein SET.

PubMed ID: 11231286

DOI: 10.1046/j.1432-1327.2001.02000.x

PubMed ID: 11555662

Title: Granzyme A activates an endoplasmic reticulum-associated caspase-independent nuclease to induce single-stranded DNA nicks.

PubMed ID: 11555662

DOI: 10.1074/jbc.m108137200

PubMed ID: 11909973

Title: HMG2 interacts with the nucleosome assembly protein SET and is a target of the cytotoxic T-lymphocyte protease granzyme A.

PubMed ID: 11909973

DOI: 10.1128/mcb.22.8.2810-2820.2002

PubMed ID: 12628186

Title: Tumor suppressor NM23-H1 is a granzyme A-activated DNase during CTL-mediated apoptosis, and the nucleosome assembly protein SET is its inhibitor.

PubMed ID: 12628186

DOI: 10.1016/s0092-8674(03)00150-8

PubMed ID: 12917472

Title: Herpes simplex virus type 1 tegument protein VP22 interacts with TAF-I proteins and inhibits nucleosome assembly but not regulation of histone acetylation by INHAT.

PubMed ID: 12917472

DOI: 10.1099/vir.0.19326-0

PubMed ID: 12524539

Title: Cleaving the oxidative repair protein Ape1 enhances cell death mediated by granzyme A.

PubMed ID: 12524539

DOI: 10.1038/ni885

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16818237

Title: The exonuclease TREX1 is in the SET complex and acts in concert with NM23-H1 to degrade DNA during granzyme A-mediated cell death.

PubMed ID: 16818237

DOI: 10.1016/j.molcel.2006.06.005

PubMed ID: 16541025

Title: Shugoshin collaborates with protein phosphatase 2A to protect cohesin.

PubMed ID: 16541025

DOI: 10.1038/nature04663

PubMed ID: 17924679

Title: Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.

PubMed ID: 17924679

DOI: 10.1021/pr070152u

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19343227

Title: FE65 binds Teashirt, inhibiting expression of the primate-specific caspase-4.

PubMed ID: 19343227

DOI: 10.1371/journal.pone.0005071

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 25356899

Title: De novo mutations in moderate or severe intellectual disability.

PubMed ID: 25356899

DOI: 10.1371/journal.pgen.1004772

PubMed ID: 29688601

Title: De novo mutations in the SET nuclear proto-oncogene, encoding a component of the inhibitor of histone acetyltransferases (INHAT) complex in patients with nonsyndromic intellectual disability.

PubMed ID: 29688601

DOI: 10.1002/humu.23541

PubMed ID: 17360516

Title: Relationship between the structure of SET/TAF-Ibeta/INHAT and its histone chaperone activity.

PubMed ID: 17360516

DOI: 10.1073/pnas.0603762104

Sequence Information:

  • Length: 290
  • Mass: 33489
  • Checksum: F4664118171EF230
  • Sequence:
    • MAPKRQSPLP PQKKKPRPPP ALGPEETSAS AGLPKKGEKE QQEAIEHIDE VQNEIDRLNE 
QASEEILKVE QKYNKLRQPF FQKRSELIAK IPNFWVTTFV NHPQVSALLG EEDEEALHYL 
TRVEVTEFED IKSGYRIDFY FDENPYFENK VLSKEFHLNE SGDPSSKSTE IKWKSGKDLT 
KRSSQTQNKA SRKRQHEEPE SFFTWFTDHS DAGADELGEV IKDDIWPNPL QYYLVPDMDD 
EEGEGEEDDD DDEEEEGLED IDEEGDEDEG EEDEDDDEGE EGEEDEGEDD

Genular Protein ID: 3577460766

Symbol: A0A8J8YYJ1_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A8J8YYJ1

Database IDs:

ARBA 1 CTD 1 DisGeNET 1 EMBL 2 Ensembl 2 GO 2 Gene3D 2 GeneTree 1 HGNC 1 InterPro 2 NCBI Taxonomy 1 PANTHER 2 PeptideAtlas 2 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 RuleBase 1 SAM 2 SMR 1 SUPFAM 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

  • Length: 266
  • Mass: 31124
  • Checksum: A9A076FE734F8EC4
  • Sequence:
    • MMPRSHQPPP PPHEKEQQEA IEHIDEVQNE IDRLNEQASE EILKVEQKYN KLRQPFFQKR 
SELIAKIPNF WVTTFVNHPQ VSALLGEEDE EALHYLTRVE VTEFEDIKSG YRIDFYFDEN 
PYFENKVLSK EFHLNESGDP SSKSTEIKWK SGKDLTKRSS QTQNKASRKR QHEEPESFFT 
WFTDHSDAGA DELGEVIKDD IWPNPLQYYL VPDMDDEEGE GEEDDDDDEE EEGLEDIDEE 
GDEDEGEEDE DDDEGEEGEE DEGEDD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.