Details for: CL1000432

Cell ID: CL1000432

Cell Name: conjunctival epithelial cell

Marker Score Threshold: 1053
(Derived using integrated single-cell and genomic data)

Description: An epithelial cell that is part of the conjunctiva.

Synonyms: epithelial cell of conjunctiva

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 3.23
    Ensembl ID: ENSG00000182718
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 3.12
    Ensembl ID: ENSG00000135046
  • Gene Symbol: ASPH (ENSG00000198363)
    Fold Change: 3.1
    Ensembl ID: ENSG00000198363
  • Gene Symbol: AQP3 (ENSG00000165272)
    Fold Change: 3.04
    Ensembl ID: ENSG00000165272
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.99
    Ensembl ID: ENSG00000184009
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 2.93
    Ensembl ID: ENSG00000075624
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 2.89
    Ensembl ID: ENSG00000130402
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 2.89
    Ensembl ID: ENSG00000163399
  • Gene Symbol: ALDH3A1 (ENSG00000108602)
    Fold Change: 2.72
    Ensembl ID: ENSG00000108602
  • Gene Symbol: ALDH1A1 (ENSG00000165092)
    Fold Change: 2.6
    Ensembl ID: ENSG00000165092
  • Gene Symbol: ARHGAP5 (ENSG00000100852)
    Fold Change: 2.6
    Ensembl ID: ENSG00000100852
  • Gene Symbol: AREG (ENSG00000109321)
    Fold Change: 2.56
    Ensembl ID: ENSG00000109321
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 2.55
    Ensembl ID: ENSG00000104964
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 2.53
    Ensembl ID: ENSG00000122359
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 2.5
    Ensembl ID: ENSG00000142192
  • Gene Symbol: AQP5 (ENSG00000161798)
    Fold Change: 2.4
    Ensembl ID: ENSG00000161798
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 2.38
    Ensembl ID: ENSG00000005022
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 2.35
    Ensembl ID: ENSG00000084234
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 2.3
    Ensembl ID: ENSG00000069849
  • Gene Symbol: JAG1 (ENSG00000101384)
    Fold Change: 2.28
    Ensembl ID: ENSG00000101384
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.24
    Ensembl ID: ENSG00000067560
  • Gene Symbol: ATP2A2 (ENSG00000174437)
    Fold Change: 2.23
    Ensembl ID: ENSG00000174437
  • Gene Symbol: ALDH3A2 (ENSG00000072210)
    Fold Change: 2.23
    Ensembl ID: ENSG00000072210
  • Gene Symbol: RND3 (ENSG00000115963)
    Fold Change: 2.22
    Ensembl ID: ENSG00000115963
  • Gene Symbol: CRYBG1 (ENSG00000112297)
    Fold Change: 2.08
    Ensembl ID: ENSG00000112297
  • Gene Symbol: ATP1B1 (ENSG00000143153)
    Fold Change: 2.07
    Ensembl ID: ENSG00000143153
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 2.05
    Ensembl ID: ENSG00000110955
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 2.03
    Ensembl ID: ENSG00000168374
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.97
    Ensembl ID: ENSG00000143761
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.97
    Ensembl ID: ENSG00000164111
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.96
    Ensembl ID: ENSG00000198931
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.93
    Ensembl ID: ENSG00000128272
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.92
    Ensembl ID: ENSG00000148700
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.91
    Ensembl ID: ENSG00000104763
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.9
    Ensembl ID: ENSG00000138279
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.89
    Ensembl ID: ENSG00000152234
  • Gene Symbol: ALCAM (ENSG00000170017)
    Fold Change: 1.88
    Ensembl ID: ENSG00000170017
  • Gene Symbol: ADSS2 (ENSG00000035687)
    Fold Change: 1.83
    Ensembl ID: ENSG00000035687
  • Gene Symbol: ATF3 (ENSG00000162772)
    Fold Change: 1.83
    Ensembl ID: ENSG00000162772
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.83
    Ensembl ID: ENSG00000165527
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.79
    Ensembl ID: ENSG00000123505
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 1.78
    Ensembl ID: ENSG00000142599
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.78
    Ensembl ID: ENSG00000070961
  • Gene Symbol: ADAM10 (ENSG00000137845)
    Fold Change: 1.78
    Ensembl ID: ENSG00000137845
  • Gene Symbol: AP1G1 (ENSG00000166747)
    Fold Change: 1.76
    Ensembl ID: ENSG00000166747
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.73
    Ensembl ID: ENSG00000165629
  • Gene Symbol: ARL3 (ENSG00000138175)
    Fold Change: 1.71
    Ensembl ID: ENSG00000138175
  • Gene Symbol: ANK3 (ENSG00000151150)
    Fold Change: 1.69
    Ensembl ID: ENSG00000151150
  • Gene Symbol: ADK (ENSG00000156110)
    Fold Change: 1.68
    Ensembl ID: ENSG00000156110
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.65
    Ensembl ID: ENSG00000072778
  • Gene Symbol: XIAP (ENSG00000101966)
    Fold Change: 1.64
    Ensembl ID: ENSG00000101966
  • Gene Symbol: ARL4D (ENSG00000175906)
    Fold Change: 1.63
    Ensembl ID: ENSG00000175906
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.62
    Ensembl ID: ENSG00000100823
  • Gene Symbol: PLIN2 (ENSG00000147872)
    Fold Change: 1.6
    Ensembl ID: ENSG00000147872
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.59
    Ensembl ID: ENSG00000177556
  • Gene Symbol: RHOC (ENSG00000155366)
    Fold Change: 1.57
    Ensembl ID: ENSG00000155366
  • Gene Symbol: ADRB2 (ENSG00000169252)
    Fold Change: 1.52
    Ensembl ID: ENSG00000169252
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.5
    Ensembl ID: ENSG00000141522
  • Gene Symbol: ANXA4 (ENSG00000196975)
    Fold Change: 1.5
    Ensembl ID: ENSG00000196975
  • Gene Symbol: ALDH1A3 (ENSG00000184254)
    Fold Change: 1.48
    Ensembl ID: ENSG00000184254
  • Gene Symbol: ATP2B4 (ENSG00000058668)
    Fold Change: 1.48
    Ensembl ID: ENSG00000058668
  • Gene Symbol: AHR (ENSG00000106546)
    Fold Change: 1.45
    Ensembl ID: ENSG00000106546
  • Gene Symbol: ABCF1 (ENSG00000204574)
    Fold Change: 1.45
    Ensembl ID: ENSG00000204574
  • Gene Symbol: ADH7 (ENSG00000196344)
    Fold Change: 1.44
    Ensembl ID: ENSG00000196344
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.44
    Ensembl ID: ENSG00000149925
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.41
    Ensembl ID: ENSG00000160710
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.39
    Ensembl ID: ENSG00000087274
  • Gene Symbol: ADM (ENSG00000148926)
    Fold Change: 1.38
    Ensembl ID: ENSG00000148926
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 1.38
    Ensembl ID: ENSG00000111348
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.33
    Ensembl ID: ENSG00000004059
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.32
    Ensembl ID: ENSG00000143727
  • Gene Symbol: ALDH7A1 (ENSG00000164904)
    Fold Change: 1.31
    Ensembl ID: ENSG00000164904
  • Gene Symbol: BIRC2 (ENSG00000110330)
    Fold Change: 1.29
    Ensembl ID: ENSG00000110330
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 1.28
    Ensembl ID: ENSG00000169100
  • Gene Symbol: ALDH2 (ENSG00000111275)
    Fold Change: 1.24
    Ensembl ID: ENSG00000111275
  • Gene Symbol: ACO2 (ENSG00000100412)
    Fold Change: 1.23
    Ensembl ID: ENSG00000100412
  • Gene Symbol: AK2 (ENSG00000004455)
    Fold Change: 1.22
    Ensembl ID: ENSG00000004455
  • Gene Symbol: ZFHX3 (ENSG00000140836)
    Fold Change: 1.2
    Ensembl ID: ENSG00000140836
  • Gene Symbol: ARL2 (ENSG00000213465)
    Fold Change: 1.18
    Ensembl ID: ENSG00000213465
  • Gene Symbol: ARF3 (ENSG00000134287)
    Fold Change: 1.18
    Ensembl ID: ENSG00000134287
  • Gene Symbol: PARP4 (ENSG00000102699)
    Fold Change: 1.16
    Ensembl ID: ENSG00000102699
  • Gene Symbol: ASS1 (ENSG00000130707)
    Fold Change: 1.16
    Ensembl ID: ENSG00000130707
  • Gene Symbol: ARCN1 (ENSG00000095139)
    Fold Change: 1.15
    Ensembl ID: ENSG00000095139
  • Gene Symbol: ACYP2 (ENSG00000170634)
    Fold Change: 1.14
    Ensembl ID: ENSG00000170634
  • Gene Symbol: AP2A2 (ENSG00000183020)
    Fold Change: 1.14
    Ensembl ID: ENSG00000183020
  • Gene Symbol: ADH5 (ENSG00000197894)
    Fold Change: 1.13
    Ensembl ID: ENSG00000197894
  • Gene Symbol: AGL (ENSG00000162688)
    Fold Change: 1.1
    Ensembl ID: ENSG00000162688
  • Gene Symbol: ARL1 (ENSG00000120805)
    Fold Change: 1.1
    Ensembl ID: ENSG00000120805
  • Gene Symbol: PARP1 (ENSG00000143799)
    Fold Change: 1.08
    Ensembl ID: ENSG00000143799
  • Gene Symbol: AP1B1 (ENSG00000100280)
    Fold Change: 1.08
    Ensembl ID: ENSG00000100280
  • Gene Symbol: ATF1 (ENSG00000123268)
    Fold Change: 1.07
    Ensembl ID: ENSG00000123268
  • Gene Symbol: ALOX5 (ENSG00000012779)
    Fold Change: 1.07
    Ensembl ID: ENSG00000012779
  • Gene Symbol: ACACA (ENSG00000278540)
    Fold Change: 1.06
    Ensembl ID: ENSG00000278540
  • Gene Symbol: ACAA1 (ENSG00000060971)
    Fold Change: 1.06
    Ensembl ID: ENSG00000060971
  • Gene Symbol: AMFR (ENSG00000159461)
    Fold Change: 1.05
    Ensembl ID: ENSG00000159461
  • Gene Symbol: AMPD3 (ENSG00000133805)
    Fold Change: 1.05
    Ensembl ID: ENSG00000133805
  • Gene Symbol: AAMP (ENSG00000127837)
    Fold Change: 1.04
    Ensembl ID: ENSG00000127837
  • Gene Symbol: SLC25A4 (ENSG00000151729)
    Fold Change: 1.01
    Ensembl ID: ENSG00000151729
  • Gene Symbol: ACVR2A (ENSG00000121989)
    Fold Change: 1.01
    Ensembl ID: ENSG00000121989
  • Gene Symbol: ALDH9A1 (ENSG00000143149)
    Fold Change: 1
    Ensembl ID: ENSG00000143149
Hovered Details

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Hovered Details

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**Key Characteristics** Conjunctival epithelial cells are characterized by their ability to: 1. **Form tight junctions**: These cells are connected by tight junctions, which prevent the passage of solutes and ions between the cells, maintaining the integrity of the epithelial barrier. 2. **Express ANXA2**: Conjunctival epithelial cells express the annexin A2 (ANXA2) protein, which is involved in various cellular processes, including cell signaling, adhesion, and membrane trafficking. 3. **Participate in immune responses**: These cells are involved in the innate immune response, producing cytokines and chemokines that recruit immune cells to the site of infection or inflammation. 4. **Regulate epithelial homeostasis**: Conjunctival epithelial cells help maintain the health and function of the conjunctiva by regulating the expression of genes involved in cell proliferation, differentiation, and survival. **Clinical Significance** Dysregulation of conjunctival epithelial cells has been implicated in various ocular diseases, including: 1. **Dry eye syndrome**: Conjunctival epithelial cell dysfunction can lead to dry eye syndrome, characterized by reduced tear production and increased evaporation of tears. 2. **Conjunctivitis**: Inflammation of the conjunctiva, often caused by infection or allergic reactions, can be triggered by altered conjunctival epithelial cell function. 3. **Epithelial dysplasia**: Abnormalities in conjunctival epithelial cell function can lead to epithelial dysplasia, a precursor to squamous cell carcinoma. 4. **Blepharitis**: Conjunctival epithelial cell dysfunction can contribute to blepharitis, an inflammatory condition affecting the eyelids. **Pathways Involved** Conjunctival epithelial cells are involved in various signaling pathways, including: 1. **ANXA2-p11 complex**: The ANXA2-p11 complex regulates cell signaling, adhesion, and membrane trafficking. 2. **Adherens junctions**: Conjunctival epithelial cells form adherens junctions, which are critical for maintaining the integrity of the epithelial barrier. 3. **Angiogenesis**: These cells are involved in angiogenesis, the formation of new blood vessels, which is essential for wound healing and tissue repair. 4. **Cytokine signaling**: Conjunctival epithelial cells produce cytokines and chemokines that recruit immune cells to the site of infection or inflammation. In conclusion, conjunctival epithelial cells play a critical role in maintaining the health and function of the eye, and their dysregulation has been implicated in various ocular diseases. Understanding the key characteristics, clinical significance, and pathways involved in the function of these cells is essential for the development of novel therapeutic strategies for ocular diseases.