Gene ALOX5 - ENSG00000012779 | NCBI Gene ID: 240

Details for: ALOX5

Gene ID: 240

Symbol: ALOX5

Ensembl ID: ENSG00000012779

Description: arachidonate 5-lipoxygenase

Associated with

Arachidonic acid metabolism
(R-HSA-2142753)
Biosynthesis of aspirin-triggered d-series resolvins
(R-HSA-9020265)
Biosynthesis of d-series resolvins
(R-HSA-9018676)
Biosynthesis of dha-derived spms
(R-HSA-9018677)
Biosynthesis of dpa-derived spms
(R-HSA-9018683)
Biosynthesis of dpan-3 spms
(R-HSA-9025094)
Biosynthesis of dpan-3-derived 13-series resolvins
(R-HSA-9026403)
Biosynthesis of dpan-3-derived maresins
(R-HSA-9026290)
Biosynthesis of dpan-3-derived protectins and resolvins
(R-HSA-9026286)
Biosynthesis of e-series 18(r)-resolvins
(R-HSA-9023661)
Biosynthesis of e-series 18(s)-resolvins
(R-HSA-9018896)
Biosynthesis of electrophilic ω-3 pufa oxo-derivatives
(R-HSA-9027604)
Biosynthesis of epa-derived spms
(R-HSA-9018679)
Biosynthesis of maresins
(R-HSA-9018682)
Biosynthesis of specialized proresolving mediators (spms)
(R-HSA-9018678)
Cytokine signaling in immune system
(R-HSA-1280215)
Fatty acid metabolism
(R-HSA-8978868)
Immune system
(R-HSA-168256)
Innate immune system
(R-HSA-168249)
Interleukin-1 family signaling
(R-HSA-446652)
Interleukin-4 and interleukin-13 signaling
(R-HSA-6785807)
Interleukin-18 signaling
(R-HSA-9012546)
Metabolism
(R-HSA-1430728)
Metabolism of lipids
(R-HSA-556833)
Neutrophil degranulation
(R-HSA-6798695)
Signaling by interleukins
(R-HSA-449147)
Synthesis of 5-eicosatetraenoic acids
(R-HSA-2142688)
Synthesis of leukotrienes (lt) and eoxins (ex)
(R-HSA-2142691)
Synthesis of lipoxins (lx)
(R-HSA-2142700)
Arachidonate 5-lipoxygenase activity
(GO:0004051)
Arachidonate 8(s)-lipoxygenase activity
(GO:0036403)
Arachidonate 12(s)-lipoxygenase activity
(GO:0004052)
Arachidonic acid metabolic process
(GO:0019369)
Cytosol
(GO:0005829)
Dendritic cell migration
(GO:0036336)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Ficolin-1-rich granule lumen
(GO:1904813)
Glucose homeostasis
(GO:0042593)
Hepoxilin biosynthetic process
(GO:0051122)
Humoral immune response
(GO:0006959)
Hydrolase activity
(GO:0016787)
Iron ion binding
(GO:0005506)
Leukocyte chemotaxis involved in inflammatory response
(GO:0002232)
Leukocyte migration involved in inflammatory response
(GO:0002523)
Leukotriene a4 biosynthetic process
(GO:1901753)
Leukotriene biosynthetic process
(GO:0019370)
Leukotriene metabolic process
(GO:0006691)
Leukotriene production involved in inflammatory response
(GO:0002540)
Linoleic acid metabolic process
(GO:0043651)
Lipid oxidation
(GO:0034440)
Lipoxin biosynthetic process
(GO:2001301)
Lipoxygenase pathway
(GO:0019372)
Long-chain fatty acid biosynthetic process
(GO:0042759)
Negative regulation of angiogenesis
(GO:0016525)
Negative regulation of endothelial cell proliferation
(GO:0001937)
Negative regulation of inflammatory response
(GO:0050728)
Negative regulation of response to endoplasmic reticulum stress
(GO:1903573)
Negative regulation of sprouting angiogenesis
(GO:1903671)
Negative regulation of vascular wound healing
(GO:0061044)
Negative regulation of wound healing
(GO:0061045)
Nuclear envelope
(GO:0005635)
Nuclear envelope lumen
(GO:0005641)
Nuclear matrix
(GO:0016363)
Nuclear membrane
(GO:0031965)
Nucleoplasm
(GO:0005654)
Perinuclear region of cytoplasm
(GO:0048471)
Positive regulation of bone mineralization
(GO:0030501)
Positive regulation of leukocyte adhesion to arterial endothelial cell
(GO:1904999)
Protein binding
(GO:0005515)
Regulation of cellular response to oxidative stress
(GO:1900407)
Regulation of cytokine production involved in inflammatory response
(GO:1900015)
Regulation of fat cell differentiation
(GO:0045598)
Regulation of inflammatory response
(GO:0050727)
Regulation of inflammatory response to wounding
(GO:0106014)
Regulation of insulin secretion
(GO:0050796)
Regulation of reactive oxygen species biosynthetic process
(GO:1903426)
Secretory granule lumen
(GO:0034774)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: retina horizontal cell (CL0000745)
Fold Change: 3.42
Marker Score: 3280.5
Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: 2.95
Marker Score: 2082
Cell Name: alveolar macrophage (CL0000583)
Fold Change: 2.43
Marker Score: 62128
Cell Name: mature microglial cell (CL0002629)
Fold Change: 2.39
Marker Score: 865
Cell Name: classical monocyte (CL0000860)
Fold Change: 2.26
Marker Score: 9381
Cell Name: myeloid dendritic cell (CL0000782)
Fold Change: 2.16
Marker Score: 1313
Cell Name: retinal cone cell (CL0000573)
Fold Change: 2.11
Marker Score: 6048
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 1.94
Marker Score: 108215
Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
Fold Change: 1.92
Marker Score: 3748
Cell Name: lung macrophage (CL1001603)
Fold Change: 1.89
Marker Score: 2161
Cell Name: central nervous system macrophage (CL0000878)
Fold Change: 1.84
Marker Score: 913
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.83
Marker Score: 2697
Cell Name: OFF-bipolar cell (CL0000750)
Fold Change: 1.8
Marker Score: 5340
Cell Name: B-1b B cell (CL0000821)
Fold Change: 1.66
Marker Score: 382
Cell Name: small pre-B-II cell (CL0000954)
Fold Change: 1.62
Marker Score: 1946
Cell Name: elicited macrophage (CL0000861)
Fold Change: 1.6
Marker Score: 9720.5
Cell Name: mural cell (CL0008034)
Fold Change: 1.47
Marker Score: 168806
Cell Name: class switched memory B cell (CL0000972)
Fold Change: 1.46
Marker Score: 1370
Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
Fold Change: 1.45
Marker Score: 3748
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: 1.45
Marker Score: 3601.5
Cell Name: late pro-B cell (CL0002048)
Fold Change: 1.38
Marker Score: 1633
Cell Name: mononuclear cell (CL0000842)
Fold Change: 1.37
Marker Score: 441
Cell Name: dendritic cell, human (CL0001056)
Fold Change: 1.34
Marker Score: 1364
Cell Name: blood cell (CL0000081)
Fold Change: 1.22
Marker Score: 14141
Cell Name: centroblast (CL0009112)
Fold Change: 1.21
Marker Score: 598
Cell Name: ON-bipolar cell (CL0000749)
Fold Change: 1.21
Marker Score: 3519
Cell Name: CD38-negative naive B cell (CL0002102)
Fold Change: 1.12
Marker Score: 2350
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 1.11
Marker Score: 3285
Cell Name: myeloid leukocyte (CL0000766)
Fold Change: 1.11
Marker Score: 1335
Cell Name: B-1 B cell (CL0000819)
Fold Change: 1.08
Marker Score: 1887.5
Cell Name: professional antigen presenting cell (CL0000145)
Fold Change: 1.07
Marker Score: 551
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 1.07
Marker Score: 1122
Cell Name: Hofbauer cell (CL3000001)
Fold Change: 1.06
Marker Score: 586
Cell Name: papillary tips cell (CL1000597)
Fold Change: 1.05
Marker Score: 212
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 1.04
Marker Score: 251760.5
Cell Name: non-classical monocyte (CL0000875)
Fold Change: 1.03
Marker Score: 2483
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71779
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48004
Cell Name: transitional stage B cell (CL0000818)
Fold Change: 0.99
Marker Score: 350
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30405
Cell Name: intermediate monocyte (CL0002393)
Fold Change: 0.98
Marker Score: 338
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.96
Marker Score: 496
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.95
Marker Score: 451
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2409
Cell Name: IgG memory B cell (CL0000979)
Fold Change: 0.94
Marker Score: 565.5
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2729
Cell Name: IgG-negative class switched memory B cell (CL0002117)
Fold Change: 0.91
Marker Score: 896
Cell Name: granulocyte (CL0000094)
Fold Change: 0.89
Marker Score: 400
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.89
Marker Score: 5078
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.88
Marker Score: 317
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5273
Cell Name: alternatively activated macrophage (CL0000890)
Fold Change: 0.82
Marker Score: 341
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1261
Cell Name: luminal epithelial cell of mammary gland (CL0002326)
Fold Change: 0.77
Marker Score: 1372
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.77
Marker Score: 590
Cell Name: epithelial cell of prostate (CL0002231)
Fold Change: 0.77
Marker Score: 533
Cell Name: pre-B-I cell (CL0000956)
Fold Change: 0.77
Marker Score: 196
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.76
Marker Score: 305
Cell Name: brush cell (CL0002204)
Fold Change: 0.76
Marker Score: 692
Cell Name: lung goblet cell (CL1000143)
Fold Change: 0.76
Marker Score: 218
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.75
Marker Score: 386
Cell Name: naive B cell (CL0000788)
Fold Change: 0.74
Marker Score: 664
Cell Name: large pre-B-II cell (CL0000957)
Fold Change: 0.74
Marker Score: 2007
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.73
Marker Score: 3082.5
Cell Name: myeloid cell (CL0000763)
Fold Change: 0.72
Marker Score: 1159
Cell Name: memory B cell (CL0000787)
Fold Change: 0.71
Marker Score: 537
Cell Name: mast cell (CL0000097)
Fold Change: 0.7
Marker Score: 408
Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: 0.69
Marker Score: 543
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.68
Marker Score: 175
Cell Name: Kupffer cell (CL0000091)
Fold Change: 0.68
Marker Score: 681
Cell Name: Langerhans cell (CL0000453)
Fold Change: 0.65
Marker Score: 196
Cell Name: eurydendroid cell (CL0000253)
Fold Change: 0.65
Marker Score: 267
Cell Name: neutrophil (CL0000775)
Fold Change: 0.65
Marker Score: 397
Cell Name: unswitched memory B cell (CL0000970)
Fold Change: 0.65
Marker Score: 379
Cell Name: B-1a B cell (CL0000820)
Fold Change: 0.64
Marker Score: 154
Cell Name: macrophage (CL0000235)
Fold Change: 0.63
Marker Score: 699
Cell Name: germinal center B cell (CL0000844)
Fold Change: 0.61
Marker Score: 369
Cell Name: myelocyte (CL0002193)
Fold Change: 0.57
Marker Score: 247
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.56
Marker Score: 360
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.56
Marker Score: 443
Cell Name: T-helper 17 cell (CL0000899)
Fold Change: 0.55
Marker Score: 364
Cell Name: immature B cell (CL0000816)
Fold Change: 0.55
Marker Score: 364
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: 0.54
Marker Score: 536
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.51
Marker Score: 160
Cell Name: conventional dendritic cell (CL0000990)
Fold Change: 0.49
Marker Score: 337
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.47
Marker Score: 124
Cell Name: thymocyte (CL0000893)
Fold Change: 0.47
Marker Score: 487
Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 0.46
Marker Score: 144
Cell Name: B cell (CL0000236)
Fold Change: 0.44
Marker Score: 416
Cell Name: mucus secreting cell (CL0000319)
Fold Change: 0.44
Marker Score: 111
Cell Name: pro-B cell (CL0000826)
Fold Change: 0.43
Marker Score: 413
Cell Name: dendritic cell (CL0000451)
Fold Change: 0.43
Marker Score: 293
Cell Name: monocyte (CL0000576)
Fold Change: 0.42
Marker Score: 548
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.42
Marker Score: 174
Cell Name: epicardial adipocyte (CL1000309)
Fold Change: 0.41
Marker Score: 200.5
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.41
Marker Score: 279
Cell Name: duct epithelial cell (CL0000068)
Fold Change: 0.4
Marker Score: 189
Cell Name: eosinophil (CL0000771)
Fold Change: 0.4
Marker Score: 131
Cell Name: mature B cell (CL0000785)
Fold Change: 0.4
Marker Score: 292
Cell Name: promonocyte (CL0000559)
Fold Change: 0.39
Marker Score: 253

Hover over a box to see details here...

**Key characteristics:** * LOX5 is a multi-functional enzyme that can act as an enzyme in the biosynthesis of different lipid molecules, including arachidonic acid, DHA-derived spms, DPA-derived spms, ω-3 PUFA-derived spms, EPA-derived spms, and specialized proresolving mediators (spms). * It is involved in the regulation of inflammation and immune responses. * Mutations in the ALOX5 gene have been linked to the pathogenesis of several diseases, including age-related macular degeneration (AMD), rheumatoid arthritis, and inflammatory bowel disease. **Pathways and functions:** * LOX5 is involved in the biosynthesis of spms, which are lipid mediators that play a role in inflammation and immune responses. * It is primarily expressed in immune cells, including monocytes, macrophages, and dendritic cells. * LOX5 activity is regulated by various factors, including cytokines, hormones, and metabolites. * Its expression is increased in response to inflammatory stimuli, indicating its role in inflammation resolution. **Clinical significance:** * LOX5 gene mutations have been linked to the pathogenesis of several diseases, highlighting its importance in human health. * Understanding the role of LOX5 in inflammation and immunology could lead to the development of novel therapeutic strategies for diseases such as AMD, rheumatoid arthritis, and inflammatory bowel disease. * LOX5 inhibitors are currently being investigated as potential therapeutic agents for these diseases.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Arachidonate 5-lipoxygenase

Genular Protein ID: 4261439502

Symbol: LOX5_HUMAN

Name: Arachidonate 5-lipoxygenase

UniProtKB Accession Codes:

P09917 B7ZLS0 E5FPY5 E5FPY7 E5FPY8 Q5JQ14

Database IDs:

Citations:

PubMed ID: 3422434

Title: Cloning of the cDNA for human 5-lipoxygenase.

PubMed ID: 3422434

DOI: 10.1073/pnas.85.2.416

PubMed ID: 2829172

Title: Molecular cloning and amino acid sequence of human 5-lipoxygenase.

PubMed ID: 2829172

DOI: 10.1073/pnas.85.1.26

PubMed ID: 2526519

Title: Molecular cloning and amino acid sequence of human 5-lipoxygenase.

PubMed ID: 2526519

PubMed ID: 21098726

Title: Novel 5-lipoxygenase isoforms affect the biosynthesis of 5-lipoxygenase products.

PubMed ID: 21098726

DOI: 10.1096/fj.10-173856

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2565035

Title: Characterization of the human 5-lipoxygenase gene.

PubMed ID: 2565035

DOI: 10.1073/pnas.86.8.2587

PubMed ID: 2251250

Title: Characterization of the human 5-lipoxygenase gene promoter.

PubMed ID: 2251250

DOI: 10.1073/pnas.87.23.9073

PubMed ID: 3118366

Title: Reversible, calcium-dependent membrane association of human leukocyte 5-lipoxygenase.

PubMed ID: 3118366

DOI: 10.1073/pnas.84.21.7393

PubMed ID: 1939225

Title: Evaluation of the role of conserved His and Met residues among lipoxygenases by site-directed mutagenesis of recombinant human 5-lipoxygenase.

PubMed ID: 1939225

DOI: 10.1016/s0021-9258(18)54744-x

PubMed ID: 1540191

Title: Mutagenesis studies on the amino acid residues involved in the iron-binding and the activity of human 5-lipoxygenase.

PubMed ID: 1540191

DOI: 10.1016/0006-291x(92)91901-2

PubMed ID: 8245774

Title: 5-lipoxygenase and 5-lipoxygenase-activating protein are localized in the nuclear envelope of activated human leukocytes.

PubMed ID: 8245774

DOI: 10.1084/jem.178.6.1935

PubMed ID: 7929073

Title: 5-Lipoxygenase contains a functional Src homology 3-binding motif that interacts with the Src homology 3 domain of Grb2 and cytoskeletal proteins.

PubMed ID: 7929073

DOI: 10.1016/s0021-9258(19)51063-8

PubMed ID: 8615788

Title: The suppression of 5-lipoxygenation of arachidonic acid in human polymorphonuclear leucocytes by the 15-lipoxygenase product (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoic acid: structure-activity relationship and mechanism of action.

PubMed ID: 8615788

DOI: 10.1042/bj3140911

PubMed ID: 8631361

Title: Oxidative inactivation of human 5-lipoxygenase in phosphatidylcholine vesicles.

PubMed ID: 8631361

DOI: 10.1111/j.1432-1033.1996.00416.x

PubMed ID: 11844797

Title: Arachidonic acid promotes phosphorylation of 5-lipoxygenase at Ser-271 by MAPK-activated protein kinase 2 (MK2).

PubMed ID: 11844797

DOI: 10.1074/jbc.m111945200

PubMed ID: 15280375

Title: Protein kinase A inhibits leukotriene synthesis by phosphorylation of 5-lipoxygenase on serine 523.

PubMed ID: 15280375

DOI: 10.1074/jbc.m312568200

PubMed ID: 17114001

Title: Resolvin E2: identification and anti-inflammatory actions: pivotal role of human 5-lipoxygenase in resolvin E series biosynthesis.

PubMed ID: 17114001

DOI: 10.1016/j.chembiol.2006.09.011

PubMed ID: 16275640

Title: Arachidonic acid regulates the translocation of 5-lipoxygenase to the nuclear membranes in human neutrophils.

PubMed ID: 16275640

DOI: 10.1074/jbc.m506513200

PubMed ID: 19022417

Title: Human Dicer C-terminus functions as a 5-lipoxygenase binding domain.

PubMed ID: 19022417

DOI: 10.1016/j.bbagrm.2008.10.002

PubMed ID: 19233132

Title: Distinct parts of leukotriene C(4) synthase interact with 5-lipoxygenase and 5-lipoxygenase activating protein.

PubMed ID: 19233132

DOI: 10.1016/j.bbrc.2009.02.074

PubMed ID: 18978352

Title: Phosphorylation of serine 271 on 5-lipoxygenase and its role in nuclear export.

PubMed ID: 18978352

DOI: 10.1074/jbc.m805593200

PubMed ID: 19807693

Title: Coactosin-like protein functions as a stabilizing chaperone for 5-lipoxygenase: role of tryptophan 102.

PubMed ID: 19807693

DOI: 10.1042/bj20090856

PubMed ID: 21200133

Title: Ligation of CD40 receptor in human B lymphocytes triggers the 5-lipoxygenase pathway to produce reactive oxygen species and activate p38 MAPK.

PubMed ID: 21200133

DOI: 10.3858/emm.2011.43.2.012

PubMed ID: 21206090

Title: Pro-resolving actions and stereoselective biosynthesis of 18S E-series resolvins in human leukocytes and murine inflammation.

PubMed ID: 21206090

DOI: 10.1172/jci42545

PubMed ID: 23246375

Title: Conversion of pro-inflammatory murine Alox5 into an anti-inflammatory 15S-lipoxygenating enzyme by multiple mutations of sequence determinants.

PubMed ID: 23246375

DOI: 10.1016/j.abb.2012.11.015

PubMed ID: 24282679

Title: Functional characterization of genetic enzyme variations in human lipoxygenases.

PubMed ID: 24282679

DOI: 10.1016/j.redox.2013.11.001

PubMed ID: 24893149

Title: ATP allosterically activates the human 5-lipoxygenase molecular mechanism of arachidonic acid and 5(S)-hydroperoxy-6(E),8(Z),11(Z),14(Z)-eicosatetraenoic acid.

PubMed ID: 24893149

DOI: 10.1021/bi401621d

PubMed ID: 26210919

Title: Phosphorylation of serine 523 on 5-lipoxygenase in human B lymphocytes.

PubMed ID: 26210919

DOI: 10.1016/j.plefa.2015.06.003

PubMed ID: 31664810

Title: Mutations of Triad Determinants Changes the Substrate Alignment at the Catalytic Center of Human ALOX5.

PubMed ID: 31664810

DOI: 10.1021/acschembio.9b00674

PubMed ID: 21233389

Title: The structure of human 5-lipoxygenase.

PubMed ID: 21233389

DOI: 10.1126/science.1197203

PubMed ID: 22516296

Title: Conversion of human 5-lipoxygenase to a 15-lipoxygenase by a point mutation to mimic phosphorylation at Serine-663.

PubMed ID: 22516296

DOI: 10.1096/fj.12-205286

PubMed ID: 32404334

Title: 15-Lipoxygenase-1 biosynthesis of 7S,14S-diHDHA implicates 15-lipoxygenase-2 in biosynthesis of resolvin D5.

PubMed ID: 32404334

DOI: 10.1194/jlr.ra120000777

PubMed ID: 15308583

Title: Arachidonate lipoxygenase (ALOX) and cyclooxygenase (COX) polymorphisms and colon cancer risk.

PubMed ID: 15308583

DOI: 10.1093/carcin/bgh260

Sequence Information:

Length: 674
Mass: 77983
Checksum: 36F38C0A9E86BB21
Sequence:

MPSYTVTVAT GSQWFAGTDD YIYLSLVGSA GCSEKHLLDK PFYNDFERGA VDSYDVTVDE 
ELGEIQLVRI EKRKYWLNDD WYLKYITLKT PHGDYIEFPC YRWITGDVEV VLRDGRAKLA 
RDDQIHILKQ HRRKELETRQ KQYRWMEWNP GFPLSIDAKC HKDLPRDIQF DSEKGVDFVL 
NYSKAMENLF INRFMHMFQS SWNDFADFEK IFVKISNTIS ERVMNHWQED LMFGYQFLNG 
CNPVLIRRCT ELPEKLPVTT EMVECSLERQ LSLEQEVQQG NIFIVDFELL DGIDANKTDP 
CTLQFLAAPI CLLYKNLANK IVPIAIQLNQ IPGDENPIFL PSDAKYDWLL AKIWVRSSDF 
HVHQTITHLL RTHLVSEVFG IAMYRQLPAV HPIFKLLVAH VRFTIAINTK AREQLICECG 
LFDKANATGG GGHVQMVQRA MKDLTYASLC FPEAIKARGM ESKEDIPYYF YRDDGLLVWE 
AIRTFTAEVV DIYYEGDQVV EEDPELQDFV NDVYVYGMRG RKSSGFPKSV KSREQLSEYL 
TVVIFTASAQ HAAVNFGQYD WCSWIPNAPP TMRAPPPTAK GVVTIEQIVD TLPDRGRSCW 
HLGAVWALSQ FQENELFLGM YPEEHFIEKP VKEAMARFRK NLEAIVSVIA ERNKKKQLPY 
YYLSPDRIPN SVAI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: ALOX5

Associated with

Cells (max top 100)

Other Information

Cloning of the cDNA for human 5-lipoxygenase. PubMed ID: 3422434

Molecular cloning and amino acid sequence of human 5-lipoxygenase. PubMed ID: 2829172

Molecular cloning and amino acid sequence of human 5-lipoxygenase. PubMed ID: 2526519

Novel 5-lipoxygenase isoforms affect the biosynthesis of 5-lipoxygenase products. PubMed ID: 21098726

The DNA sequence and comparative analysis of human chromosome 10. PubMed ID: 15164054

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Characterization of the human 5-lipoxygenase gene. PubMed ID: 2565035

Characterization of the human 5-lipoxygenase gene promoter. PubMed ID: 2251250

Reversible, calcium-dependent membrane association of human leukocyte 5-lipoxygenase. PubMed ID: 3118366

Evaluation of the role of conserved His and Met residues among lipoxygenases by site-directed mutagenesis of recombinant human 5-lipoxygenase. PubMed ID: 1939225

Mutagenesis studies on the amino acid residues involved in the iron-binding and the activity of human 5-lipoxygenase. PubMed ID: 1540191

5-lipoxygenase and 5-lipoxygenase-activating protein are localized in the nuclear envelope of activated human leukocytes. PubMed ID: 8245774

5-Lipoxygenase contains a functional Src homology 3-binding motif that interacts with the Src homology 3 domain of Grb2 and cytoskeletal proteins. PubMed ID: 7929073

The suppression of 5-lipoxygenation of arachidonic acid in human polymorphonuclear leucocytes by the 15-lipoxygenase product (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoic acid: structure-activity relationship and mechanism of action. PubMed ID: 8615788

Oxidative inactivation of human 5-lipoxygenase in phosphatidylcholine vesicles. PubMed ID: 8631361

Arachidonic acid promotes phosphorylation of 5-lipoxygenase at Ser-271 by MAPK-activated protein kinase 2 (MK2). PubMed ID: 11844797

Protein kinase A inhibits leukotriene synthesis by phosphorylation of 5-lipoxygenase on serine 523. PubMed ID: 15280375

Resolvin E2: identification and anti-inflammatory actions: pivotal role of human 5-lipoxygenase in resolvin E series biosynthesis. PubMed ID: 17114001

Arachidonic acid regulates the translocation of 5-lipoxygenase to the nuclear membranes in human neutrophils. PubMed ID: 16275640

Human Dicer C-terminus functions as a 5-lipoxygenase binding domain. PubMed ID: 19022417

Distinct parts of leukotriene C(4) synthase interact with 5-lipoxygenase and 5-lipoxygenase activating protein. PubMed ID: 19233132

Phosphorylation of serine 271 on 5-lipoxygenase and its role in nuclear export. PubMed ID: 18978352

Coactosin-like protein functions as a stabilizing chaperone for 5-lipoxygenase: role of tryptophan 102. PubMed ID: 19807693

Ligation of CD40 receptor in human B lymphocytes triggers the 5-lipoxygenase pathway to produce reactive oxygen species and activate p38 MAPK. PubMed ID: 21200133

Pro-resolving actions and stereoselective biosynthesis of 18S E-series resolvins in human leukocytes and murine inflammation. PubMed ID: 21206090

Conversion of pro-inflammatory murine Alox5 into an anti-inflammatory 15S-lipoxygenating enzyme by multiple mutations of sequence determinants. PubMed ID: 23246375

Functional characterization of genetic enzyme variations in human lipoxygenases. PubMed ID: 24282679

ATP allosterically activates the human 5-lipoxygenase molecular mechanism of arachidonic acid and 5(S)-hydroperoxy-6(E),8(Z),11(Z),14(Z)-eicosatetraenoic acid. PubMed ID: 24893149

Phosphorylation of serine 523 on 5-lipoxygenase in human B lymphocytes. PubMed ID: 26210919

Mutations of Triad Determinants Changes the Substrate Alignment at the Catalytic Center of Human ALOX5. PubMed ID: 31664810

The structure of human 5-lipoxygenase. PubMed ID: 21233389

Conversion of human 5-lipoxygenase to a 15-lipoxygenase by a point mutation to mimic phosphorylation at Serine-663. PubMed ID: 22516296

15-Lipoxygenase-1 biosynthesis of 7S,14S-diHDHA implicates 15-lipoxygenase-2 in biosynthesis of resolvin D5. PubMed ID: 32404334

Arachidonate lipoxygenase (ALOX) and cyclooxygenase (COX) polymorphisms and colon cancer risk. PubMed ID: 15308583