Details for: ALOX5

Gene ID: 240

Symbol: ALOX5

Ensembl ID: ENSG00000012779

Description: arachidonate 5-lipoxygenase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: fibroblast (CL0000057)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: T cell (CL0000084)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: granulocyte (CL0000094)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: mast cell (CL0000097)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: astrocyte (CL0000127)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: club cell (CL0000158)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: platelet (CL0000233)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: macrophage (CL0000235)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: B cell (CL0000236)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: neuron (CL0000540)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: monocyte (CL0000576)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: enterocyte (CL0000584)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: basal cell (CL0000646)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: podocyte (CL0000653)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: pericyte (CL0000669)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: leukocyte (CL0000738)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: neutrophil (CL0000775)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: plasma cell (CL0000786)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: memory B cell (CL0000787)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: naive B cell (CL0000788)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: plasmablast (CL0000980)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: malignant cell (CL0001064)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: N/A
    Cell Significance Index: 0.0000
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: N/A
    Cell Significance Index: 0.0000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** * ALOX5 is a member of the lipoxygenase family of enzymes, which are responsible for the metabolism of arachidonic acid. * The enzyme is highly specific for arachidonic acid, with a high affinity for this substrate. * ALOX5 is a cytosolic enzyme, with a single polypeptide chain that contains the active site. * The enzyme is activated by calcium ions and other signaling molecules, which facilitate its enzymatic activity. * ALOX5 is highly inducible, with its expression increased in response to inflammatory stimuli. **Pathways and Functions:** * ALOX5 plays a central role in the biosynthesis of leukotrienes, which are involved in various inflammatory and immune responses, including: + Allergic reactions and asthma + Cardiovascular diseases, including atherosclerosis and hypertension + Inflammatory responses to injury or infection * The enzyme is also involved in the regulation of other signaling pathways, including: + Cytokine production and signaling + Leukocyte chemotaxis and migration + Angiogenesis and wound healing * ALOX5 has been implicated in various diseases, including: + Asthma and chronic obstructive pulmonary disease (COPD) + Cardiovascular disease and atherosclerosis + Cancer and tumor progression **Clinical Significance:** * ALOX5 is a potential therapeutic target for the treatment of inflammatory and immune-related diseases, including asthma, cardiovascular disease, and cancer. * Inhibitors of ALOX5, such as zileuton, have been developed as therapeutic agents for the treatment of asthma and other inflammatory diseases. * The enzyme's role in the biosynthesis of leukotrienes has also led to the development of leukotriene receptor antagonists and other therapeutic agents for the treatment of asthma and other inflammatory diseases. * Further research is needed to fully understand the mechanisms of ALOX5 and its role in various diseases, and to develop effective therapeutic strategies for the treatment of inflammatory and immune-related disorders. In conclusion, ALOX5 is a critical enzyme in the biosynthesis of leukotrienes, which play a central role in inflammatory and immune responses. The enzyme's role in various diseases has led to the development of therapeutic agents, and further research is needed to fully understand its mechanisms and to develop effective treatments for inflammatory and immune-related disorders.

Genular Protein ID: 4261439502

Symbol: LOX5_HUMAN

Name: Arachidonate 5-lipoxygenase

UniProtKB Accession Codes:

P09917 B7ZLS0 E5FPY5 E5FPY7 E5FPY8 Q5JQ14

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 69 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 28 DrugCentral 1 EC 1 EMBL 12 EMDB 5 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 46 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 9 PDBsum 9 PIR 1 PRINTS 2 PRO 1 PROSITE 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 15 RefSeq 4 Rhea 34 SABIO-RK 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissLipids 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3422434

Title: Cloning of the cDNA for human 5-lipoxygenase.

PubMed ID: 3422434

DOI: 10.1073/pnas.85.2.416

PubMed ID: 2829172

Title: Molecular cloning and amino acid sequence of human 5-lipoxygenase.

PubMed ID: 2829172

DOI: 10.1073/pnas.85.1.26

PubMed ID: 2526519

Title: Molecular cloning and amino acid sequence of human 5-lipoxygenase.

PubMed ID: 2526519

PubMed ID: 21098726

Title: Novel 5-lipoxygenase isoforms affect the biosynthesis of 5-lipoxygenase products.

PubMed ID: 21098726

DOI: 10.1096/fj.10-173856

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2565035

Title: Characterization of the human 5-lipoxygenase gene.

PubMed ID: 2565035

DOI: 10.1073/pnas.86.8.2587

PubMed ID: 2251250

Title: Characterization of the human 5-lipoxygenase gene promoter.

PubMed ID: 2251250

DOI: 10.1073/pnas.87.23.9073

PubMed ID: 3118366

Title: Reversible, calcium-dependent membrane association of human leukocyte 5-lipoxygenase.

PubMed ID: 3118366

DOI: 10.1073/pnas.84.21.7393

PubMed ID: 1939225

Title: Evaluation of the role of conserved His and Met residues among lipoxygenases by site-directed mutagenesis of recombinant human 5-lipoxygenase.

PubMed ID: 1939225

DOI: 10.1016/s0021-9258(18)54744-x

PubMed ID: 1540191

Title: Mutagenesis studies on the amino acid residues involved in the iron-binding and the activity of human 5-lipoxygenase.

PubMed ID: 1540191

DOI: 10.1016/0006-291x(92)91901-2

PubMed ID: 8245774

Title: 5-lipoxygenase and 5-lipoxygenase-activating protein are localized in the nuclear envelope of activated human leukocytes.

PubMed ID: 8245774

DOI: 10.1084/jem.178.6.1935

PubMed ID: 7929073

Title: 5-Lipoxygenase contains a functional Src homology 3-binding motif that interacts with the Src homology 3 domain of Grb2 and cytoskeletal proteins.

PubMed ID: 7929073

DOI: 10.1016/s0021-9258(19)51063-8

PubMed ID: 8615788

Title: The suppression of 5-lipoxygenation of arachidonic acid in human polymorphonuclear leucocytes by the 15-lipoxygenase product (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoic acid: structure-activity relationship and mechanism of action.

PubMed ID: 8615788

DOI: 10.1042/bj3140911

PubMed ID: 8631361

Title: Oxidative inactivation of human 5-lipoxygenase in phosphatidylcholine vesicles.

PubMed ID: 8631361

DOI: 10.1111/j.1432-1033.1996.00416.x

PubMed ID: 11844797

Title: Arachidonic acid promotes phosphorylation of 5-lipoxygenase at Ser-271 by MAPK-activated protein kinase 2 (MK2).

PubMed ID: 11844797

DOI: 10.1074/jbc.m111945200

PubMed ID: 15280375

Title: Protein kinase A inhibits leukotriene synthesis by phosphorylation of 5-lipoxygenase on serine 523.

PubMed ID: 15280375

DOI: 10.1074/jbc.m312568200

PubMed ID: 17114001

Title: Resolvin E2: identification and anti-inflammatory actions: pivotal role of human 5-lipoxygenase in resolvin E series biosynthesis.

PubMed ID: 17114001

DOI: 10.1016/j.chembiol.2006.09.011

PubMed ID: 16275640

Title: Arachidonic acid regulates the translocation of 5-lipoxygenase to the nuclear membranes in human neutrophils.

PubMed ID: 16275640

DOI: 10.1074/jbc.m506513200

PubMed ID: 19022417

Title: Human Dicer C-terminus functions as a 5-lipoxygenase binding domain.

PubMed ID: 19022417

DOI: 10.1016/j.bbagrm.2008.10.002

PubMed ID: 19233132

Title: Distinct parts of leukotriene C(4) synthase interact with 5-lipoxygenase and 5-lipoxygenase activating protein.

PubMed ID: 19233132

DOI: 10.1016/j.bbrc.2009.02.074

PubMed ID: 18978352

Title: Phosphorylation of serine 271 on 5-lipoxygenase and its role in nuclear export.

PubMed ID: 18978352

DOI: 10.1074/jbc.m805593200

PubMed ID: 19807693

Title: Coactosin-like protein functions as a stabilizing chaperone for 5-lipoxygenase: role of tryptophan 102.

PubMed ID: 19807693

DOI: 10.1042/bj20090856

PubMed ID: 21200133

Title: Ligation of CD40 receptor in human B lymphocytes triggers the 5-lipoxygenase pathway to produce reactive oxygen species and activate p38 MAPK.

PubMed ID: 21200133

DOI: 10.3858/emm.2011.43.2.012

PubMed ID: 21206090

Title: Pro-resolving actions and stereoselective biosynthesis of 18S E-series resolvins in human leukocytes and murine inflammation.

PubMed ID: 21206090

DOI: 10.1172/jci42545

PubMed ID: 23246375

Title: Conversion of pro-inflammatory murine Alox5 into an anti-inflammatory 15S-lipoxygenating enzyme by multiple mutations of sequence determinants.

PubMed ID: 23246375

DOI: 10.1016/j.abb.2012.11.015

PubMed ID: 24282679

Title: Functional characterization of genetic enzyme variations in human lipoxygenases.

PubMed ID: 24282679

DOI: 10.1016/j.redox.2013.11.001

PubMed ID: 24893149

Title: ATP allosterically activates the human 5-lipoxygenase molecular mechanism of arachidonic acid and 5(S)-hydroperoxy-6(E),8(Z),11(Z),14(Z)-eicosatetraenoic acid.

PubMed ID: 24893149

DOI: 10.1021/bi401621d

PubMed ID: 26210919

Title: Phosphorylation of serine 523 on 5-lipoxygenase in human B lymphocytes.

PubMed ID: 26210919

DOI: 10.1016/j.plefa.2015.06.003

PubMed ID: 31664810

Title: Mutations of Triad Determinants Changes the Substrate Alignment at the Catalytic Center of Human ALOX5.

PubMed ID: 31664810

DOI: 10.1021/acschembio.9b00674

PubMed ID: 21233389

Title: The structure of human 5-lipoxygenase.

PubMed ID: 21233389

DOI: 10.1126/science.1197203

PubMed ID: 22516296

Title: Conversion of human 5-lipoxygenase to a 15-lipoxygenase by a point mutation to mimic phosphorylation at Serine-663.

PubMed ID: 22516296

DOI: 10.1096/fj.12-205286

PubMed ID: 32404334

Title: 15-Lipoxygenase-1 biosynthesis of 7S,14S-diHDHA implicates 15-lipoxygenase-2 in biosynthesis of resolvin D5.

PubMed ID: 32404334

DOI: 10.1194/jlr.ra120000777

PubMed ID: 15308583

Title: Arachidonate lipoxygenase (ALOX) and cyclooxygenase (COX) polymorphisms and colon cancer risk.

PubMed ID: 15308583

DOI: 10.1093/carcin/bgh260

Sequence Information:

  • Length: 674
  • Mass: 77983
  • Checksum: 36F38C0A9E86BB21
  • Sequence:
    • MPSYTVTVAT GSQWFAGTDD YIYLSLVGSA GCSEKHLLDK PFYNDFERGA VDSYDVTVDE 
ELGEIQLVRI EKRKYWLNDD WYLKYITLKT PHGDYIEFPC YRWITGDVEV VLRDGRAKLA 
RDDQIHILKQ HRRKELETRQ KQYRWMEWNP GFPLSIDAKC HKDLPRDIQF DSEKGVDFVL 
NYSKAMENLF INRFMHMFQS SWNDFADFEK IFVKISNTIS ERVMNHWQED LMFGYQFLNG 
CNPVLIRRCT ELPEKLPVTT EMVECSLERQ LSLEQEVQQG NIFIVDFELL DGIDANKTDP 
CTLQFLAAPI CLLYKNLANK IVPIAIQLNQ IPGDENPIFL PSDAKYDWLL AKIWVRSSDF 
HVHQTITHLL RTHLVSEVFG IAMYRQLPAV HPIFKLLVAH VRFTIAINTK AREQLICECG 
LFDKANATGG GGHVQMVQRA MKDLTYASLC FPEAIKARGM ESKEDIPYYF YRDDGLLVWE 
AIRTFTAEVV DIYYEGDQVV EEDPELQDFV NDVYVYGMRG RKSSGFPKSV KSREQLSEYL 
TVVIFTASAQ HAAVNFGQYD WCSWIPNAPP TMRAPPPTAK GVVTIEQIVD TLPDRGRSCW 
HLGAVWALSQ FQENELFLGM YPEEHFIEKP VKEAMARFRK NLEAIVSVIA ERNKKKQLPY 
YYLSPDRIPN SVAI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.