ALOX5 | ENSG00000012779 | NCBI 240

Details for: ALOX5

Gene ID: 240

Symbol: ALOX5

Ensembl ID: ENSG00000012779

Description: arachidonate 5-lipoxygenase

Associated with

Arachidonate metabolism
(R-HSA-2142753)
Biosynthesis of aspirin-triggered d-series resolvins
(R-HSA-9020265)
Biosynthesis of d-series resolvins
(R-HSA-9018676)
Biosynthesis of dha-derived spms
(R-HSA-9018677)
Biosynthesis of dpa-derived spms
(R-HSA-9018683)
Biosynthesis of dpan-3 spms
(R-HSA-9025094)
Biosynthesis of dpan-3-derived 13-series resolvins
(R-HSA-9026403)
Biosynthesis of dpan-3-derived maresins
(R-HSA-9026290)
Biosynthesis of dpan-3-derived protectins and resolvins
(R-HSA-9026286)
Biosynthesis of e-series 18(r)-resolvins
(R-HSA-9023661)
Biosynthesis of e-series 18(s)-resolvins
(R-HSA-9018896)
Biosynthesis of electrophilic ω-3 pufa oxo-derivatives
(R-HSA-9027604)
Biosynthesis of epa-derived spms
(R-HSA-9018679)
Biosynthesis of lipoxins (lx)
(R-HSA-2142700)
Biosynthesis of maresins
(R-HSA-9018682)
Biosynthesis of specialized proresolving mediators (spms)
(R-HSA-9018678)
Cytokine signaling in immune system
(R-HSA-1280215)
Fatty acid metabolism
(R-HSA-8978868)
Immune system
(R-HSA-168256)
Innate immune system
(R-HSA-168249)
Interleukin-1 family signaling
(R-HSA-446652)
Interleukin-4 and interleukin-13 signaling
(R-HSA-6785807)
Interleukin-18 signaling
(R-HSA-9012546)
Metabolism
(R-HSA-1430728)
Metabolism of lipids
(R-HSA-556833)
Neutrophil degranulation
(R-HSA-6798695)
Signaling by interleukins
(R-HSA-449147)
Synthesis of 5-eicosatetraenoic acids
(R-HSA-2142688)
Synthesis of leukotrienes (lt) and eoxins (ex)
(R-HSA-2142691)
Arachidonate 5-lipoxygenase activity
(GO:0004051)
Arachidonate 8(s)-lipoxygenase activity
(GO:0036403)
Arachidonate 12(s)-lipoxygenase activity
(GO:0004052)
Arachidonate metabolic process
(GO:0019369)
Cytosol
(GO:0005829)
Dendritic cell migration
(GO:0036336)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Ficolin-1-rich granule lumen
(GO:1904813)
Glucose homeostasis
(GO:0042593)
Humoral immune response
(GO:0006959)
Hydrolase activity
(GO:0016787)
Iron ion binding
(GO:0005506)
Leukocyte chemotaxis involved in inflammatory response
(GO:0002232)
Leukocyte migration involved in inflammatory response
(GO:0002523)
Leukotriene a4 biosynthetic process
(GO:1901753)
Leukotriene biosynthetic process
(GO:0019370)
Leukotriene metabolic process
(GO:0006691)
Leukotriene production involved in inflammatory response
(GO:0002540)
Lipid oxidation
(GO:0034440)
Lipoxin biosynthetic process
(GO:2001301)
Lipoxygenase pathway
(GO:0019372)
Long-chain fatty acid biosynthetic process
(GO:0042759)
Negative regulation of angiogenesis
(GO:0016525)
Negative regulation of endothelial cell proliferation
(GO:0001937)
Negative regulation of inflammatory response
(GO:0050728)
Negative regulation of response to endoplasmic reticulum stress
(GO:1903573)
Negative regulation of sprouting angiogenesis
(GO:1903671)
Negative regulation of vascular wound healing
(GO:0061044)
Negative regulation of wound healing
(GO:0061045)
Nuclear envelope
(GO:0005635)
Nuclear envelope lumen
(GO:0005641)
Nuclear matrix
(GO:0016363)
Nuclear membrane
(GO:0031965)
Nucleoplasm
(GO:0005654)
Perinuclear region of cytoplasm
(GO:0048471)
Positive regulation of bone mineralization
(GO:0030501)
Positive regulation of leukocyte adhesion to arterial endothelial cell
(GO:1904999)
Protein binding
(GO:0005515)
Regulation of cellular response to oxidative stress
(GO:1900407)
Regulation of cytokine production involved in inflammatory response
(GO:1900015)
Regulation of fat cell differentiation
(GO:0045598)
Regulation of inflammatory response
(GO:0050727)
Regulation of inflammatory response to wounding
(GO:0106014)
Regulation of insulin secretion
(GO:0050796)
Regulation of reactive oxygen species biosynthetic process
(GO:1903426)
Secretory granule lumen
(GO:0034774)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 87.1129
Cell Significance Index: -13.5500
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 54.8014
Cell Significance Index: -13.9000
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 32.9102
Cell Significance Index: -13.3700
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 29.0444
Cell Significance Index: -14.9400
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 10.9817
Cell Significance Index: -13.5400
Cell Name: tuft cell of small intestine (CL0009080)
Fold Change: 5.8060
Cell Significance Index: 58.5700
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 5.4650
Cell Significance Index: -14.6400
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 3.7087
Cell Significance Index: 705.7900
Cell Name: centroblast (CL0009112)
Fold Change: 3.5361
Cell Significance Index: 8.2500
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 3.0299
Cell Significance Index: 56.0000
Cell Name: colon goblet cell (CL0009039)
Fold Change: 2.5329
Cell Significance Index: 250.5600
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 2.3168
Cell Significance Index: 21.3400
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 2.2486
Cell Significance Index: 34.7900
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 2.1426
Cell Significance Index: 111.3000
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 1.3344
Cell Significance Index: 217.0300
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 1.2184
Cell Significance Index: 132.5200
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 1.0390
Cell Significance Index: 122.5400
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 1.0217
Cell Significance Index: 184.1800
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.9767
Cell Significance Index: 26.1300
Cell Name: epithelial cell of prostate (CL0002231)
Fold Change: 0.6601
Cell Significance Index: 4.0700
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.6300
Cell Significance Index: 77.4700
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.6138
Cell Significance Index: 42.4500
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.5937
Cell Significance Index: 35.6500
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.1503
Cell Significance Index: 11.2000
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.1044
Cell Significance Index: 2.6100
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 0.0730
Cell Significance Index: 8.5100
Cell Name: myeloid leukocyte (CL0000766)
Fold Change: 0.0549
Cell Significance Index: 0.4500
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.0385
Cell Significance Index: 1.8100
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.0382
Cell Significance Index: 1.1000
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.0343
Cell Significance Index: 23.7500
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.0271
Cell Significance Index: 5.4400
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.0146
Cell Significance Index: 2.4900
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0022
Cell Significance Index: 4.0900
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.0018
Cell Significance Index: 0.0400
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0016
Cell Significance Index: -2.1800
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0022
Cell Significance Index: -3.4000
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0023
Cell Significance Index: -4.1900
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.0026
Cell Significance Index: -0.0900
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.0035
Cell Significance Index: -0.0600
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0070
Cell Significance Index: -4.3700
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0083
Cell Significance Index: -6.1500
Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0094
Cell Significance Index: -5.1500
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0117
Cell Significance Index: -6.6000
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0129
Cell Significance Index: -8.2100
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0145
Cell Significance Index: -10.9800
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0163
Cell Significance Index: -1.6700
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.0163
Cell Significance Index: -0.7400
Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.0168
Cell Significance Index: -3.3300
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0170
Cell Significance Index: -2.4700
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0176
Cell Significance Index: -6.3100
Cell Name: lactocyte (CL0002325)
Fold Change: -0.0245
Cell Significance Index: -3.1600
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0256
Cell Significance Index: -11.6100
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0358
Cell Significance Index: -7.5400
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0381
Cell Significance Index: -4.3700
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0502
Cell Significance Index: -14.4500
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.0587
Cell Significance Index: -1.2500
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.0751
Cell Significance Index: -3.5000
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.0756
Cell Significance Index: -8.6300
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0820
Cell Significance Index: -11.2600
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.1077
Cell Significance Index: -1.4700
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.1095
Cell Significance Index: -3.0600
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.1132
Cell Significance Index: -8.6900
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.1151
Cell Significance Index: -5.8200
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.1245
Cell Significance Index: -12.9600
Cell Name: odontoblast (CL0000060)
Fold Change: -0.1268
Cell Significance Index: -16.2500
Cell Name: mature microglial cell (CL0002629)
Fold Change: -0.1305
Cell Significance Index: -1.4300
Cell Name: granulosa cell (CL0000501)
Fold Change: -0.1460
Cell Significance Index: -3.8400
Cell Name: central nervous system macrophage (CL0000878)
Fold Change: -0.1474
Cell Significance Index: -1.7700
Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.1587
Cell Significance Index: -6.9000
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.1639
Cell Significance Index: -5.2500
Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: -0.1739
Cell Significance Index: -2.6200
Cell Name: alveolar macrophage (CL0000583)
Fold Change: -0.1748
Cell Significance Index: -1.5400
Cell Name: myeloid cell (CL0000763)
Fold Change: -0.1799
Cell Significance Index: -2.3900
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.2006
Cell Significance Index: -12.3000
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.2069
Cell Significance Index: -9.1500
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.2082
Cell Significance Index: -5.5600
Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.2227
Cell Significance Index: -14.3700
Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.2311
Cell Significance Index: -12.0400
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: -0.2312
Cell Significance Index: -4.5200
Cell Name: hematopoietic cell (CL0000988)
Fold Change: -0.2386
Cell Significance Index: -3.4900
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.2393
Cell Significance Index: -13.4300
Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.2428
Cell Significance Index: -9.9500
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: -0.2547
Cell Significance Index: -3.1500
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.2615
Cell Significance Index: -9.1600
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.2646
Cell Significance Index: -10.0200
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -0.2651
Cell Significance Index: -7.7900
Cell Name: Purkinje cell (CL0000121)
Fold Change: -0.2688
Cell Significance Index: -5.8900
Cell Name: microglial cell (CL0000129)
Fold Change: -0.2696
Cell Significance Index: -3.1700
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.2762
Cell Significance Index: -17.4100
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.2813
Cell Significance Index: -14.7700
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.2884
Cell Significance Index: -7.8500
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.3199
Cell Significance Index: -11.7500
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.3246
Cell Significance Index: -9.5600
Cell Name: leukocyte (CL0000738)
Fold Change: -0.3265
Cell Significance Index: -5.5500
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: -0.3371
Cell Significance Index: -6.8600
Cell Name: mononuclear phagocyte (CL0000113)
Fold Change: -0.3431
Cell Significance Index: -2.9000
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.3448
Cell Significance Index: -11.2900
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.3473
Cell Significance Index: -11.0600
Cell Name: lens fiber cell (CL0011004)
Fold Change: -0.3554
Cell Significance Index: -11.2400
Cell Name: macrophage (CL0000235)
Fold Change: -0.3771
Cell Significance Index: -3.8500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics:** * ALOX5 is a member of the lipoxygenase family of enzymes, which are responsible for the metabolism of arachidonic acid. * The enzyme is highly specific for arachidonic acid, with a high affinity for this substrate. * ALOX5 is a cytosolic enzyme, with a single polypeptide chain that contains the active site. * The enzyme is activated by calcium ions and other signaling molecules, which facilitate its enzymatic activity. * ALOX5 is highly inducible, with its expression increased in response to inflammatory stimuli. **Pathways and Functions:** * ALOX5 plays a central role in the biosynthesis of leukotrienes, which are involved in various inflammatory and immune responses, including: + Allergic reactions and asthma + Cardiovascular diseases, including atherosclerosis and hypertension + Inflammatory responses to injury or infection * The enzyme is also involved in the regulation of other signaling pathways, including: + Cytokine production and signaling + Leukocyte chemotaxis and migration + Angiogenesis and wound healing * ALOX5 has been implicated in various diseases, including: + Asthma and chronic obstructive pulmonary disease (COPD) + Cardiovascular disease and atherosclerosis + Cancer and tumor progression **Clinical Significance:** * ALOX5 is a potential therapeutic target for the treatment of inflammatory and immune-related diseases, including asthma, cardiovascular disease, and cancer. * Inhibitors of ALOX5, such as zileuton, have been developed as therapeutic agents for the treatment of asthma and other inflammatory diseases. * The enzyme's role in the biosynthesis of leukotrienes has also led to the development of leukotriene receptor antagonists and other therapeutic agents for the treatment of asthma and other inflammatory diseases. * Further research is needed to fully understand the mechanisms of ALOX5 and its role in various diseases, and to develop effective therapeutic strategies for the treatment of inflammatory and immune-related disorders. In conclusion, ALOX5 is a critical enzyme in the biosynthesis of leukotrienes, which play a central role in inflammatory and immune responses. The enzyme's role in various diseases has led to the development of therapeutic agents, and further research is needed to fully understand its mechanisms and to develop effective treatments for inflammatory and immune-related disorders.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Arachidonate 5-lipoxygenase

Genular Protein ID: 4261439502

Symbol: LOX5_HUMAN

Name: Arachidonate 5-lipoxygenase

UniProtKB Accession Codes:

P09917 B7ZLS0 E5FPY5 E5FPY7 E5FPY8 Q5JQ14

Database IDs:

Citations:

PubMed ID: 3422434

Title: Cloning of the cDNA for human 5-lipoxygenase.

PubMed ID: 3422434

DOI: 10.1073/pnas.85.2.416

PubMed ID: 2829172

Title: Molecular cloning and amino acid sequence of human 5-lipoxygenase.

PubMed ID: 2829172

DOI: 10.1073/pnas.85.1.26

PubMed ID: 2526519

Title: Molecular cloning and amino acid sequence of human 5-lipoxygenase.

PubMed ID: 2526519

PubMed ID: 21098726

Title: Novel 5-lipoxygenase isoforms affect the biosynthesis of 5-lipoxygenase products.

PubMed ID: 21098726

DOI: 10.1096/fj.10-173856

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2565035

Title: Characterization of the human 5-lipoxygenase gene.

PubMed ID: 2565035

DOI: 10.1073/pnas.86.8.2587

PubMed ID: 2251250

Title: Characterization of the human 5-lipoxygenase gene promoter.

PubMed ID: 2251250

DOI: 10.1073/pnas.87.23.9073

PubMed ID: 3118366

Title: Reversible, calcium-dependent membrane association of human leukocyte 5-lipoxygenase.

PubMed ID: 3118366

DOI: 10.1073/pnas.84.21.7393

PubMed ID: 1939225

Title: Evaluation of the role of conserved His and Met residues among lipoxygenases by site-directed mutagenesis of recombinant human 5-lipoxygenase.

PubMed ID: 1939225

DOI: 10.1016/s0021-9258(18)54744-x

PubMed ID: 1540191

Title: Mutagenesis studies on the amino acid residues involved in the iron-binding and the activity of human 5-lipoxygenase.

PubMed ID: 1540191

DOI: 10.1016/0006-291x(92)91901-2

PubMed ID: 8245774

Title: 5-lipoxygenase and 5-lipoxygenase-activating protein are localized in the nuclear envelope of activated human leukocytes.

PubMed ID: 8245774

DOI: 10.1084/jem.178.6.1935

PubMed ID: 7929073

Title: 5-Lipoxygenase contains a functional Src homology 3-binding motif that interacts with the Src homology 3 domain of Grb2 and cytoskeletal proteins.

PubMed ID: 7929073

DOI: 10.1016/s0021-9258(19)51063-8

PubMed ID: 8615788

Title: The suppression of 5-lipoxygenation of arachidonic acid in human polymorphonuclear leucocytes by the 15-lipoxygenase product (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoic acid: structure-activity relationship and mechanism of action.

PubMed ID: 8615788

DOI: 10.1042/bj3140911

PubMed ID: 8631361

Title: Oxidative inactivation of human 5-lipoxygenase in phosphatidylcholine vesicles.

PubMed ID: 8631361

DOI: 10.1111/j.1432-1033.1996.00416.x

PubMed ID: 11844797

Title: Arachidonic acid promotes phosphorylation of 5-lipoxygenase at Ser-271 by MAPK-activated protein kinase 2 (MK2).

PubMed ID: 11844797

DOI: 10.1074/jbc.m111945200

PubMed ID: 15280375

Title: Protein kinase A inhibits leukotriene synthesis by phosphorylation of 5-lipoxygenase on serine 523.

PubMed ID: 15280375

DOI: 10.1074/jbc.m312568200

PubMed ID: 17114001

Title: Resolvin E2: identification and anti-inflammatory actions: pivotal role of human 5-lipoxygenase in resolvin E series biosynthesis.

PubMed ID: 17114001

DOI: 10.1016/j.chembiol.2006.09.011

PubMed ID: 16275640

Title: Arachidonic acid regulates the translocation of 5-lipoxygenase to the nuclear membranes in human neutrophils.

PubMed ID: 16275640

DOI: 10.1074/jbc.m506513200

PubMed ID: 19022417

Title: Human Dicer C-terminus functions as a 5-lipoxygenase binding domain.

PubMed ID: 19022417

DOI: 10.1016/j.bbagrm.2008.10.002

PubMed ID: 19233132

Title: Distinct parts of leukotriene C(4) synthase interact with 5-lipoxygenase and 5-lipoxygenase activating protein.

PubMed ID: 19233132

DOI: 10.1016/j.bbrc.2009.02.074

PubMed ID: 18978352

Title: Phosphorylation of serine 271 on 5-lipoxygenase and its role in nuclear export.

PubMed ID: 18978352

DOI: 10.1074/jbc.m805593200

PubMed ID: 19807693

Title: Coactosin-like protein functions as a stabilizing chaperone for 5-lipoxygenase: role of tryptophan 102.

PubMed ID: 19807693

DOI: 10.1042/bj20090856

PubMed ID: 21200133

Title: Ligation of CD40 receptor in human B lymphocytes triggers the 5-lipoxygenase pathway to produce reactive oxygen species and activate p38 MAPK.

PubMed ID: 21200133

DOI: 10.3858/emm.2011.43.2.012

PubMed ID: 21206090

Title: Pro-resolving actions and stereoselective biosynthesis of 18S E-series resolvins in human leukocytes and murine inflammation.

PubMed ID: 21206090

DOI: 10.1172/jci42545

PubMed ID: 23246375

Title: Conversion of pro-inflammatory murine Alox5 into an anti-inflammatory 15S-lipoxygenating enzyme by multiple mutations of sequence determinants.

PubMed ID: 23246375

DOI: 10.1016/j.abb.2012.11.015

PubMed ID: 24282679

Title: Functional characterization of genetic enzyme variations in human lipoxygenases.

PubMed ID: 24282679

DOI: 10.1016/j.redox.2013.11.001

PubMed ID: 24893149

Title: ATP allosterically activates the human 5-lipoxygenase molecular mechanism of arachidonic acid and 5(S)-hydroperoxy-6(E),8(Z),11(Z),14(Z)-eicosatetraenoic acid.

PubMed ID: 24893149

DOI: 10.1021/bi401621d

PubMed ID: 26210919

Title: Phosphorylation of serine 523 on 5-lipoxygenase in human B lymphocytes.

PubMed ID: 26210919

DOI: 10.1016/j.plefa.2015.06.003

PubMed ID: 31664810

Title: Mutations of Triad Determinants Changes the Substrate Alignment at the Catalytic Center of Human ALOX5.

PubMed ID: 31664810

DOI: 10.1021/acschembio.9b00674

PubMed ID: 21233389

Title: The structure of human 5-lipoxygenase.

PubMed ID: 21233389

DOI: 10.1126/science.1197203

PubMed ID: 22516296

Title: Conversion of human 5-lipoxygenase to a 15-lipoxygenase by a point mutation to mimic phosphorylation at Serine-663.

PubMed ID: 22516296

DOI: 10.1096/fj.12-205286

PubMed ID: 32404334

Title: 15-Lipoxygenase-1 biosynthesis of 7S,14S-diHDHA implicates 15-lipoxygenase-2 in biosynthesis of resolvin D5.

PubMed ID: 32404334

DOI: 10.1194/jlr.ra120000777

PubMed ID: 15308583

Title: Arachidonate lipoxygenase (ALOX) and cyclooxygenase (COX) polymorphisms and colon cancer risk.

PubMed ID: 15308583

DOI: 10.1093/carcin/bgh260

Sequence Information:

Length: 674
Mass: 77983
Checksum: 36F38C0A9E86BB21
Sequence:

MPSYTVTVAT GSQWFAGTDD YIYLSLVGSA GCSEKHLLDK PFYNDFERGA VDSYDVTVDE 
ELGEIQLVRI EKRKYWLNDD WYLKYITLKT PHGDYIEFPC YRWITGDVEV VLRDGRAKLA 
RDDQIHILKQ HRRKELETRQ KQYRWMEWNP GFPLSIDAKC HKDLPRDIQF DSEKGVDFVL 
NYSKAMENLF INRFMHMFQS SWNDFADFEK IFVKISNTIS ERVMNHWQED LMFGYQFLNG 
CNPVLIRRCT ELPEKLPVTT EMVECSLERQ LSLEQEVQQG NIFIVDFELL DGIDANKTDP 
CTLQFLAAPI CLLYKNLANK IVPIAIQLNQ IPGDENPIFL PSDAKYDWLL AKIWVRSSDF 
HVHQTITHLL RTHLVSEVFG IAMYRQLPAV HPIFKLLVAH VRFTIAINTK AREQLICECG 
LFDKANATGG GGHVQMVQRA MKDLTYASLC FPEAIKARGM ESKEDIPYYF YRDDGLLVWE 
AIRTFTAEVV DIYYEGDQVV EEDPELQDFV NDVYVYGMRG RKSSGFPKSV KSREQLSEYL 
TVVIFTASAQ HAAVNFGQYD WCSWIPNAPP TMRAPPPTAK GVVTIEQIVD TLPDRGRSCW 
HLGAVWALSQ FQENELFLGM YPEEHFIEKP VKEAMARFRK NLEAIVSVIA ERNKKKQLPY 
YYLSPDRIPN SVAI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: ALOX5

Associated with

Cells (max top 100)

Other Information

Cloning of the cDNA for human 5-lipoxygenase. PubMed ID: 3422434

Molecular cloning and amino acid sequence of human 5-lipoxygenase. PubMed ID: 2829172

Molecular cloning and amino acid sequence of human 5-lipoxygenase. PubMed ID: 2526519

Novel 5-lipoxygenase isoforms affect the biosynthesis of 5-lipoxygenase products. PubMed ID: 21098726

The DNA sequence and comparative analysis of human chromosome 10. PubMed ID: 15164054

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Characterization of the human 5-lipoxygenase gene. PubMed ID: 2565035

Characterization of the human 5-lipoxygenase gene promoter. PubMed ID: 2251250

Reversible, calcium-dependent membrane association of human leukocyte 5-lipoxygenase. PubMed ID: 3118366

Evaluation of the role of conserved His and Met residues among lipoxygenases by site-directed mutagenesis of recombinant human 5-lipoxygenase. PubMed ID: 1939225

Mutagenesis studies on the amino acid residues involved in the iron-binding and the activity of human 5-lipoxygenase. PubMed ID: 1540191

5-lipoxygenase and 5-lipoxygenase-activating protein are localized in the nuclear envelope of activated human leukocytes. PubMed ID: 8245774

5-Lipoxygenase contains a functional Src homology 3-binding motif that interacts with the Src homology 3 domain of Grb2 and cytoskeletal proteins. PubMed ID: 7929073

The suppression of 5-lipoxygenation of arachidonic acid in human polymorphonuclear leucocytes by the 15-lipoxygenase product (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoic acid: structure-activity relationship and mechanism of action. PubMed ID: 8615788

Oxidative inactivation of human 5-lipoxygenase in phosphatidylcholine vesicles. PubMed ID: 8631361

Arachidonic acid promotes phosphorylation of 5-lipoxygenase at Ser-271 by MAPK-activated protein kinase 2 (MK2). PubMed ID: 11844797

Protein kinase A inhibits leukotriene synthesis by phosphorylation of 5-lipoxygenase on serine 523. PubMed ID: 15280375

Resolvin E2: identification and anti-inflammatory actions: pivotal role of human 5-lipoxygenase in resolvin E series biosynthesis. PubMed ID: 17114001

Arachidonic acid regulates the translocation of 5-lipoxygenase to the nuclear membranes in human neutrophils. PubMed ID: 16275640

Human Dicer C-terminus functions as a 5-lipoxygenase binding domain. PubMed ID: 19022417

Distinct parts of leukotriene C(4) synthase interact with 5-lipoxygenase and 5-lipoxygenase activating protein. PubMed ID: 19233132

Phosphorylation of serine 271 on 5-lipoxygenase and its role in nuclear export. PubMed ID: 18978352

Coactosin-like protein functions as a stabilizing chaperone for 5-lipoxygenase: role of tryptophan 102. PubMed ID: 19807693

Ligation of CD40 receptor in human B lymphocytes triggers the 5-lipoxygenase pathway to produce reactive oxygen species and activate p38 MAPK. PubMed ID: 21200133

Pro-resolving actions and stereoselective biosynthesis of 18S E-series resolvins in human leukocytes and murine inflammation. PubMed ID: 21206090

Conversion of pro-inflammatory murine Alox5 into an anti-inflammatory 15S-lipoxygenating enzyme by multiple mutations of sequence determinants. PubMed ID: 23246375

Functional characterization of genetic enzyme variations in human lipoxygenases. PubMed ID: 24282679

ATP allosterically activates the human 5-lipoxygenase molecular mechanism of arachidonic acid and 5(S)-hydroperoxy-6(E),8(Z),11(Z),14(Z)-eicosatetraenoic acid. PubMed ID: 24893149

Phosphorylation of serine 523 on 5-lipoxygenase in human B lymphocytes. PubMed ID: 26210919

Mutations of Triad Determinants Changes the Substrate Alignment at the Catalytic Center of Human ALOX5. PubMed ID: 31664810

The structure of human 5-lipoxygenase. PubMed ID: 21233389

Conversion of human 5-lipoxygenase to a 15-lipoxygenase by a point mutation to mimic phosphorylation at Serine-663. PubMed ID: 22516296

15-Lipoxygenase-1 biosynthesis of 7S,14S-diHDHA implicates 15-lipoxygenase-2 in biosynthesis of resolvin D5. PubMed ID: 32404334

Arachidonate lipoxygenase (ALOX) and cyclooxygenase (COX) polymorphisms and colon cancer risk. PubMed ID: 15308583