Details for: CL0000624

Cell ID: CL0000624

Cell Name: CD4-positive, alpha-beta T cell

Marker Score Threshold: 2251
(Derived using integrated single-cell and genomic data)

Description: A mature alpha-beta T cell that expresses an alpha-beta T cell receptor and the CD4 coreceptor.

Synonyms: CD4-positive, alpha-beta T lymphocyte, CD4-positive, alpha-beta T-cell, CD4-positive, alpha-beta T-lymphocyte

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: DLX5 (ENSG00000105880)
    Fold Change: 16.43
    Ensembl ID: ENSG00000105880
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 3.8
    Ensembl ID: ENSG00000166710
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 3.32
    Ensembl ID: ENSG00000169100
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 3.3
    Ensembl ID: ENSG00000133639
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 3.29
    Ensembl ID: ENSG00000075624
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 3.15
    Ensembl ID: ENSG00000184009
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 2.98
    Ensembl ID: ENSG00000152518
  • Gene Symbol: DDX5 (ENSG00000108654)
    Fold Change: 2.96
    Ensembl ID: ENSG00000108654
  • Gene Symbol: CD52 (ENSG00000169442)
    Fold Change: 2.95
    Ensembl ID: ENSG00000169442
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 2.86
    Ensembl ID: ENSG00000135390
  • Gene Symbol: CFL1 (ENSG00000172757)
    Fold Change: 2.85
    Ensembl ID: ENSG00000172757
  • Gene Symbol: KLF6 (ENSG00000067082)
    Fold Change: 2.78
    Ensembl ID: ENSG00000067082
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 2.77
    Ensembl ID: ENSG00000111348
  • Gene Symbol: COX7C (ENSG00000127184)
    Fold Change: 2.71
    Ensembl ID: ENSG00000127184
  • Gene Symbol: CD2 (ENSG00000116824)
    Fold Change: 2.68
    Ensembl ID: ENSG00000116824
  • Gene Symbol: CD3D (ENSG00000167286)
    Fold Change: 2.68
    Ensembl ID: ENSG00000167286
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 2.68
    Ensembl ID: ENSG00000145741
  • Gene Symbol: CD69 (ENSG00000110848)
    Fold Change: 2.62
    Ensembl ID: ENSG00000110848
  • Gene Symbol: COX4I1 (ENSG00000131143)
    Fold Change: 2.59
    Ensembl ID: ENSG00000131143
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 2.55
    Ensembl ID: ENSG00000198668
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 2.51
    Ensembl ID: ENSG00000135046
  • Gene Symbol: TSC22D3 (ENSG00000157514)
    Fold Change: 2.47
    Ensembl ID: ENSG00000157514
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 2.36
    Ensembl ID: ENSG00000143933
  • Gene Symbol: CD3E (ENSG00000198851)
    Fold Change: 2.32
    Ensembl ID: ENSG00000198851
  • Gene Symbol: CYBA (ENSG00000051523)
    Fold Change: 2.29
    Ensembl ID: ENSG00000051523
  • Gene Symbol: CD44 (ENSG00000026508)
    Fold Change: 2.2
    Ensembl ID: ENSG00000026508
  • Gene Symbol: CD53 (ENSG00000143119)
    Fold Change: 2.17
    Ensembl ID: ENSG00000143119
  • Gene Symbol: CD74 (ENSG00000019582)
    Fold Change: 2.09
    Ensembl ID: ENSG00000019582
  • Gene Symbol: COX6C (ENSG00000164919)
    Fold Change: 2.07
    Ensembl ID: ENSG00000164919
  • Gene Symbol: CD37 (ENSG00000104894)
    Fold Change: 2.06
    Ensembl ID: ENSG00000104894
  • Gene Symbol: SEPTIN7 (ENSG00000122545)
    Fold Change: 2.05
    Ensembl ID: ENSG00000122545
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 2.03
    Ensembl ID: ENSG00000099624
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 2.02
    Ensembl ID: ENSG00000124172
  • Gene Symbol: COX7A2 (ENSG00000112695)
    Fold Change: 2.01
    Ensembl ID: ENSG00000112695
  • Gene Symbol: CIRBP (ENSG00000099622)
    Fold Change: 1.99
    Ensembl ID: ENSG00000099622
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.97
    Ensembl ID: ENSG00000104964
  • Gene Symbol: COX6B1 (ENSG00000126267)
    Fold Change: 1.95
    Ensembl ID: ENSG00000126267
  • Gene Symbol: CLIC1 (ENSG00000213719)
    Fold Change: 1.95
    Ensembl ID: ENSG00000213719
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 1.93
    Ensembl ID: ENSG00000077549
  • Gene Symbol: CD48 (ENSG00000117091)
    Fold Change: 1.93
    Ensembl ID: ENSG00000117091
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 1.88
    Ensembl ID: ENSG00000169020
  • Gene Symbol: CREM (ENSG00000095794)
    Fold Change: 1.86
    Ensembl ID: ENSG00000095794
  • Gene Symbol: COX6A1 (ENSG00000111775)
    Fold Change: 1.85
    Ensembl ID: ENSG00000111775
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.85
    Ensembl ID: ENSG00000241837
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 1.84
    Ensembl ID: ENSG00000154518
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.83
    Ensembl ID: ENSG00000149925
  • Gene Symbol: COX7B (ENSG00000131174)
    Fold Change: 1.83
    Ensembl ID: ENSG00000131174
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 1.81
    Ensembl ID: ENSG00000067560
  • Gene Symbol: RHOH (ENSG00000168421)
    Fold Change: 1.8
    Ensembl ID: ENSG00000168421
  • Gene Symbol: CDC42 (ENSG00000070831)
    Fold Change: 1.79
    Ensembl ID: ENSG00000070831
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 1.78
    Ensembl ID: ENSG00000154723
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 1.64
    Ensembl ID: ENSG00000005022
  • Gene Symbol: COX5B (ENSG00000135940)
    Fold Change: 1.64
    Ensembl ID: ENSG00000135940
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.63
    Ensembl ID: ENSG00000198931
  • Gene Symbol: CCND3 (ENSG00000112576)
    Fold Change: 1.63
    Ensembl ID: ENSG00000112576
  • Gene Symbol: BIRC3 (ENSG00000023445)
    Fold Change: 1.63
    Ensembl ID: ENSG00000023445
  • Gene Symbol: ALOX5AP (ENSG00000132965)
    Fold Change: 1.62
    Ensembl ID: ENSG00000132965
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 1.62
    Ensembl ID: ENSG00000185650
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.59
    Ensembl ID: ENSG00000110955
  • Gene Symbol: CD7 (ENSG00000173762)
    Fold Change: 1.57
    Ensembl ID: ENSG00000173762
  • Gene Symbol: CSTB (ENSG00000160213)
    Fold Change: 1.56
    Ensembl ID: ENSG00000160213
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.52
    Ensembl ID: ENSG00000152234
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 1.49
    Ensembl ID: ENSG00000134825
  • Gene Symbol: COX8A (ENSG00000176340)
    Fold Change: 1.49
    Ensembl ID: ENSG00000176340
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.48
    Ensembl ID: ENSG00000143761
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 1.48
    Ensembl ID: ENSG00000179218
  • Gene Symbol: CLK1 (ENSG00000013441)
    Fold Change: 1.39
    Ensembl ID: ENSG00000013441
  • Gene Symbol: SEPTIN1 (ENSG00000180096)
    Fold Change: 1.39
    Ensembl ID: ENSG00000180096
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.39
    Ensembl ID: ENSG00000128272
  • Gene Symbol: DAD1 (ENSG00000129562)
    Fold Change: 1.39
    Ensembl ID: ENSG00000129562
  • Gene Symbol: CD3G (ENSG00000160654)
    Fold Change: 1.38
    Ensembl ID: ENSG00000160654
  • Gene Symbol: CD247 (ENSG00000198821)
    Fold Change: 1.38
    Ensembl ID: ENSG00000198821
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.35
    Ensembl ID: ENSG00000116459
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.35
    Ensembl ID: ENSG00000165527
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 1.33
    Ensembl ID: ENSG00000100300
  • Gene Symbol: DDX3X (ENSG00000215301)
    Fold Change: 1.33
    Ensembl ID: ENSG00000215301
  • Gene Symbol: DBI (ENSG00000155368)
    Fold Change: 1.31
    Ensembl ID: ENSG00000155368
  • Gene Symbol: ANXA6 (ENSG00000197043)
    Fold Change: 1.3
    Ensembl ID: ENSG00000197043
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.3
    Ensembl ID: ENSG00000160014
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.27
    Ensembl ID: ENSG00000085224
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.27
    Ensembl ID: ENSG00000182718
  • Gene Symbol: CD63 (ENSG00000135404)
    Fold Change: 1.25
    Ensembl ID: ENSG00000135404
  • Gene Symbol: CRIP1 (ENSG00000213145)
    Fold Change: 1.24
    Ensembl ID: ENSG00000213145
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.23
    Ensembl ID: ENSG00000165629
  • Gene Symbol: CD40LG (ENSG00000102245)
    Fold Change: 1.19
    Ensembl ID: ENSG00000102245
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.19
    Ensembl ID: ENSG00000141522
  • Gene Symbol: CD6 (ENSG00000013725)
    Fold Change: 1.17
    Ensembl ID: ENSG00000013725
  • Gene Symbol: CD47 (ENSG00000196776)
    Fold Change: 1.13
    Ensembl ID: ENSG00000196776
  • Gene Symbol: DDX6 (ENSG00000110367)
    Fold Change: 1.11
    Ensembl ID: ENSG00000110367
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.09
    Ensembl ID: ENSG00000108561
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.08
    Ensembl ID: ENSG00000159199
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.08
    Ensembl ID: ENSG00000123505
  • Gene Symbol: CSNK1A1 (ENSG00000113712)
    Fold Change: 1.06
    Ensembl ID: ENSG00000113712
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.06
    Ensembl ID: ENSG00000163399
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.05
    Ensembl ID: ENSG00000122359
  • Gene Symbol: RHOG (ENSG00000177105)
    Fold Change: 1.04
    Ensembl ID: ENSG00000177105
  • Gene Symbol: CCNH (ENSG00000134480)
    Fold Change: 1.03
    Ensembl ID: ENSG00000134480
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.02
    Ensembl ID: ENSG00000116489
  • Gene Symbol: PLIN2 (ENSG00000147872)
    Fold Change: 1.01
    Ensembl ID: ENSG00000147872
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1
    Ensembl ID: ENSG00000172270
Hovered Details

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Hovered Details

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**Key Characteristics** The cell in question is a mature alpha-beta T cell, which is characterized by the following key features: 1. **Alpha-beta T cell receptor**: The cell expresses an alpha-beta T cell receptor, which is a complex of proteins embedded in the cell membrane that recognizes and binds to specific antigens. 2. **CD4 coreceptor**: The cell expresses the CD4 coreceptor, which is a protein that helps to facilitate the interaction between the T cell receptor and the antigen-presenting cell. 3. **DLX5 gene**: The cell's gene symbol is DLX5, which is involved in various biological processes, including morphogenesis, Bmp signaling pathway, cell differentiation, cell population proliferation, and chromatin organization. 4. **B2M gene**: The cell's gene symbol is also B2M, which is involved in the adaptive immune system and is associated with several diseases, including HIV infection and cancer. **Clinical Significance** The cell described in this entry has significant clinical implications, particularly in the context of immune system disorders. Some of the key clinical implications include: 1. **HIV infection**: The cell is associated with HIV infection, which is a global health problem that affects millions of people worldwide. The cell's expression of CD4 coreceptor and B2M gene makes it a target for HIV, which can lead to immune system dysfunction and increased susceptibility to opportunistic infections. 2. **Cancer**: The cell's expression of DLX5 gene has been implicated in the development of certain types of cancer, including leukemia and lymphoma. The cell's role in cell differentiation and proliferation makes it a potential target for cancer therapy. 3. **Autoimmune diseases**: The cell's expression of CD4 coreceptor and B2M gene may also contribute to the development of autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 4. **Immunodeficiency disorders**: The cell's expression of CD4 coreceptor and B2M gene makes it a potential target for immunodeficiency disorders, such as HIV/AIDS and severe combined immunodeficiency (SCID). In conclusion, the cell described in this entry is a mature alpha-beta T cell that plays a critical role in the adaptive immune system. Its expression of CD4 coreceptor, B2M gene, and DLX5 gene has significant clinical implications, particularly in the context of immune system disorders. Further research is needed to fully understand the cell's functions and to develop effective therapies for immune-related diseases.