Details for: S100A10

Gene ID: 6281

Symbol: S100A10

Ensembl ID: ENSG00000197747

Description: S100 calcium binding protein A10

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 837.3770
    Cell Significance Index: -130.2500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 519.9426
    Cell Significance Index: -131.8800
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 358.1766
    Cell Significance Index: -147.5500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 286.4510
    Cell Significance Index: -135.2400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 272.7333
    Cell Significance Index: -140.2900
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 202.6461
    Cell Significance Index: -135.9800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 105.3890
    Cell Significance Index: -129.9400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 36.5657
    Cell Significance Index: -112.3100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 33.8516
    Cell Significance Index: -133.5800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 28.7921
    Cell Significance Index: -77.1300
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 23.9160
    Cell Significance Index: 205.5100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 20.5703
    Cell Significance Index: -45.0200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 14.4173
    Cell Significance Index: 266.4700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 8.3650
    Cell Significance Index: 95.0300
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 7.4432
    Cell Significance Index: 131.5300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 7.3223
    Cell Significance Index: 344.1400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 6.2849
    Cell Significance Index: 184.5800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 4.5692
    Cell Significance Index: 340.5400
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 4.4570
    Cell Significance Index: 32.0100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 4.3238
    Cell Significance Index: 113.7000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 4.0852
    Cell Significance Index: 2231.0100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 4.0356
    Cell Significance Index: 1784.2500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 3.9781
    Cell Significance Index: 108.2800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 3.7848
    Cell Significance Index: 108.5000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 3.7012
    Cell Significance Index: 478.1700
  • Cell Name: peg cell (CL4033014)
    Fold Change: 3.6202
    Cell Significance Index: 83.6400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 2.7309
    Cell Significance Index: 193.1400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.7285
    Cell Significance Index: 176.0300
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 2.5767
    Cell Significance Index: 38.6100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.4343
    Cell Significance Index: 287.0800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 2.2802
    Cell Significance Index: 280.3700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 2.2323
    Cell Significance Index: 286.1700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2.1759
    Cell Significance Index: 98.6300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 2.1329
    Cell Significance Index: 210.9900
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.9785
    Cell Significance Index: 30.6100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.5762
    Cell Significance Index: 14.5200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 1.4872
    Cell Significance Index: 1125.6700
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 1.1542
    Cell Significance Index: 16.1900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.1437
    Cell Significance Index: 206.1800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.0273
    Cell Significance Index: 27.4300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 1.0186
    Cell Significance Index: 19.8800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.9206
    Cell Significance Index: 175.1900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.7427
    Cell Significance Index: 544.5100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.6875
    Cell Significance Index: 136.4400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: 0.4104
    Cell Significance Index: 32.5000
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 0.3894
    Cell Significance Index: 2.4100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3306
    Cell Significance Index: 298.5100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1847
    Cell Significance Index: 6.4900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1723
    Cell Significance Index: 8.9500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1219
    Cell Significance Index: 16.7400
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 0.0796
    Cell Significance Index: 0.4900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0774
    Cell Significance Index: 3.9100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0426
    Cell Significance Index: 4.3500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0366
    Cell Significance Index: -27.0900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0391
    Cell Significance Index: -72.0900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0396
    Cell Significance Index: -6.7700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0521
    Cell Significance Index: -80.1500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0608
    Cell Significance Index: -114.4900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0820
    Cell Significance Index: -111.4400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1010
    Cell Significance Index: -63.0500
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.1308
    Cell Significance Index: -0.7900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.2057
    Cell Significance Index: -130.6600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.2076
    Cell Significance Index: -117.0600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2211
    Cell Significance Index: -6.1800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2482
    Cell Significance Index: -28.4400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2863
    Cell Significance Index: -9.1700
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.2910
    Cell Significance Index: -4.4200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.3165
    Cell Significance Index: -143.6600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.3231
    Cell Significance Index: -92.9600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.3903
    Cell Significance Index: -139.9800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.4661
    Cell Significance Index: -7.8000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.5187
    Cell Significance Index: -109.2600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.6535
    Cell Significance Index: -76.1600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.6792
    Cell Significance Index: -136.2500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.6896
    Cell Significance Index: -14.9400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.7500
    Cell Significance Index: -30.7300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.9316
    Cell Significance Index: -135.4300
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -1.0082
    Cell Significance Index: -17.3800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -1.0421
    Cell Significance Index: -118.9500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -1.0628
    Cell Significance Index: -14.5000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -1.1271
    Cell Significance Index: -52.5500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -1.2654
    Cell Significance Index: -66.4400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -1.2967
    Cell Significance Index: -135.0200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -1.5443
    Cell Significance Index: -32.8900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -1.6447
    Cell Significance Index: -126.2200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -1.7887
    Cell Significance Index: -37.4400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.9450
    Cell Significance Index: -119.2500
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: -2.0478
    Cell Significance Index: -35.1800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -2.0969
    Cell Significance Index: -132.1600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -2.1145
    Cell Significance Index: -129.9700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -2.1571
    Cell Significance Index: -145.0500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -2.1686
    Cell Significance Index: -54.2100
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -2.1942
    Cell Significance Index: -28.1000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -2.3531
    Cell Significance Index: -69.3100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -2.6123
    Cell Significance Index: -146.5900
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -2.7739
    Cell Significance Index: -28.7200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -2.9339
    Cell Significance Index: -78.4800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -3.2016
    Cell Significance Index: -117.5300
  • Cell Name: germ cell (CL0000586)
    Fold Change: -3.2560
    Cell Significance Index: -24.5900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -3.3920
    Cell Significance Index: -117.8700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** S100A10 is a small, acidic protein with a molecular weight of approximately 10 kDa. It is a calcium-binding protein, which means it can interact with calcium ions to regulate its activity. The protein has a unique ability to bind to various proteins and lipids, including annexin 2 (Anxa2) and phospholipids, which are essential for its function. S100A10 is highly expressed in cells involved in immune responses, such as monocytes, T cells, and dendritic cells, suggesting its role in immune regulation. **Pathways and Functions** S100A10 is involved in various cellular pathways, including: 1. **Calcium-dependent protein binding**: S100A10 binds to calcium ions, which regulates its interactions with other proteins, such as Anxa2, to modulate cell signaling and protein functions. 2. **Hemostasis**: S100A10 is involved in the regulation of fibrinolysis, the process by which the body breaks down blood clots. This protein helps to regulate the activity of plasminogen activators, which are essential for fibrinolysis. 3. **Exocytosis and cell signaling**: S100A10 regulates exocytosis, the process by which cells release molecules, such as neurotransmitters and hormones, into the extracellular space. This protein also modulates cell signaling pathways, including those involved in immune responses and inflammation. 4. **Cell adhesion and migration**: S100A10 interacts with proteins involved in cell adhesion, such as integrins and CD44, to regulate cell migration and tissue repair. **Clinical Significance** S100A10 has been implicated in various diseases, including: 1. **Inflammatory disorders**: S100A10 is overexpressed in inflammatory conditions, such as rheumatoid arthritis and multiple sclerosis, suggesting its role in immune regulation and inflammation. 2. **Cancer**: S100A10 is overexpressed in certain types of cancer, including breast and lung cancer, suggesting its involvement in tumor progression and metastasis. 3. **Cardiovascular diseases**: S100A10 is involved in the regulation of hemostasis and fibrinolysis, making it a potential biomarker for cardiovascular diseases, such as myocardial infarction and stroke. In conclusion, S100A10 is a multifunctional protein that plays a critical role in various cellular processes, including calcium homeostasis, cell signaling, and protein interactions. Its expression in immune cells and epithelial cells suggests its involvement in immune regulation and inflammation. Further research is needed to fully understand the clinical significance of S100A10 and its potential applications in disease diagnosis and treatment. References: * [Insert references to relevant studies and research articles] Note: This article is a hypothetical example and not based on real research data. The information provided is a summary of the characteristics, pathways, and functions of S100A10, as well as its clinical significance, based on the provided description.

Genular Protein ID: 3250978326

Symbol: S10AA_HUMAN

Name: Protein S100-A10

UniProtKB Accession Codes:

P60903 A8K4V8 P08206 Q5T1C5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 ComplexPortal 3 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 7 Ensembl 2 EvolutionaryTrace 1 GO 28 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 7 PDBsum 7 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1831433

Title: Primary structure of human, chicken, and Xenopus laevis p11, a cellular ligand of the Src-kinase substrate, annexin II.

PubMed ID: 1831433

DOI: 10.1016/0378-1119(91)90086-q

PubMed ID: 1533380

Title: Cloning and characterization of the human gene encoding p11: structural similarity to other members of the S-100 gene family.

PubMed ID: 1533380

DOI: 10.1016/0378-1119(92)90406-f

PubMed ID: 1386341

Title: cDNA sequence of human p11 calpactin I light chain.

PubMed ID: 1386341

DOI: 10.1016/0888-7543(92)90171-n

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 9886297

Title: The crystal structure of a complex of p11 with the annexin II N-terminal peptide.

PubMed ID: 9886297

DOI: 10.1038/4965

Sequence Information:

  • Length: 97
  • Mass: 11203
  • Checksum: 3E8E03A6E7DD7A8D
  • Sequence:
    • MPSQMEHAME TMMFTFHKFA GDKGYLTKED LRVLMEKEFP GFLENQKDPL AVDKIMKDLD 
QCRDGKVGFQ SFFSLIAGLT IACNDYFVVH MKQKGKK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.