Details for: CL0000796

Cell ID: CL0000796

Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell

Marker Score Threshold: 308
(Derived using integrated single-cell and genomic data)

Description: A alpha-beta intraepithelial T cell found in the columnar epithelium of the gastrointestinal tract. Intraepithelial T cells often have distinct developmental pathways and activation requirements.

Synonyms: IEL, intraepithelial lymphocyte, CD8-positive, alpha-beta intraepithelial T lymphocyte, CD8-positive, alpha-beta intraepithelial T-cell, CD8-positive, alpha-beta intraepithelial T-lymphocyte

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 3.3
    Ensembl ID: ENSG00000075624
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 3.27
    Ensembl ID: ENSG00000166710
  • Gene Symbol: CFL1 (ENSG00000172757)
    Fold Change: 3.1
    Ensembl ID: ENSG00000172757
  • Gene Symbol: CD52 (ENSG00000169442)
    Fold Change: 3.09
    Ensembl ID: ENSG00000169442
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 3.06
    Ensembl ID: ENSG00000184009
  • Gene Symbol: CD7 (ENSG00000173762)
    Fold Change: 3.01
    Ensembl ID: ENSG00000173762
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 3
    Ensembl ID: ENSG00000111348
  • Gene Symbol: CD3D (ENSG00000167286)
    Fold Change: 2.97
    Ensembl ID: ENSG00000167286
  • Gene Symbol: CD63 (ENSG00000135404)
    Fold Change: 2.69
    Ensembl ID: ENSG00000135404
  • Gene Symbol: CLIC1 (ENSG00000213719)
    Fold Change: 2.68
    Ensembl ID: ENSG00000213719
  • Gene Symbol: CD3E (ENSG00000198851)
    Fold Change: 2.63
    Ensembl ID: ENSG00000198851
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 2.61
    Ensembl ID: ENSG00000124172
  • Gene Symbol: COX4I1 (ENSG00000131143)
    Fold Change: 2.6
    Ensembl ID: ENSG00000131143
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 2.46
    Ensembl ID: ENSG00000145741
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 2.41
    Ensembl ID: ENSG00000133639
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 2.32
    Ensembl ID: ENSG00000169100
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 2.3
    Ensembl ID: ENSG00000135390
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 2.24
    Ensembl ID: ENSG00000198668
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 2.11
    Ensembl ID: ENSG00000149925
  • Gene Symbol: ALOX5AP (ENSG00000132965)
    Fold Change: 2.02
    Ensembl ID: ENSG00000132965
  • Gene Symbol: CD69 (ENSG00000110848)
    Fold Change: 2.01
    Ensembl ID: ENSG00000110848
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 1.9
    Ensembl ID: ENSG00000143933
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 1.86
    Ensembl ID: ENSG00000152518
  • Gene Symbol: CD2 (ENSG00000116824)
    Fold Change: 1.84
    Ensembl ID: ENSG00000116824
  • Gene Symbol: COX6B1 (ENSG00000126267)
    Fold Change: 1.82
    Ensembl ID: ENSG00000126267
  • Gene Symbol: CIRBP (ENSG00000099622)
    Fold Change: 1.79
    Ensembl ID: ENSG00000099622
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 1.77
    Ensembl ID: ENSG00000099624
  • Gene Symbol: CDC42 (ENSG00000070831)
    Fold Change: 1.72
    Ensembl ID: ENSG00000070831
  • Gene Symbol: COX6C (ENSG00000164919)
    Fold Change: 1.71
    Ensembl ID: ENSG00000164919
  • Gene Symbol: CAPG (ENSG00000042493)
    Fold Change: 1.7
    Ensembl ID: ENSG00000042493
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 1.68
    Ensembl ID: ENSG00000077549
  • Gene Symbol: COX6A1 (ENSG00000111775)
    Fold Change: 1.66
    Ensembl ID: ENSG00000111775
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.66
    Ensembl ID: ENSG00000198931
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.65
    Ensembl ID: ENSG00000085224
  • Gene Symbol: COX5B (ENSG00000135940)
    Fold Change: 1.65
    Ensembl ID: ENSG00000135940
  • Gene Symbol: RHOC (ENSG00000155366)
    Fold Change: 1.64
    Ensembl ID: ENSG00000155366
  • Gene Symbol: CD74 (ENSG00000019582)
    Fold Change: 1.64
    Ensembl ID: ENSG00000019582
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.6
    Ensembl ID: ENSG00000127022
  • Gene Symbol: CD37 (ENSG00000104894)
    Fold Change: 1.6
    Ensembl ID: ENSG00000104894
  • Gene Symbol: CD53 (ENSG00000143119)
    Fold Change: 1.6
    Ensembl ID: ENSG00000143119
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.54
    Ensembl ID: ENSG00000153113
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.53
    Ensembl ID: ENSG00000110955
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 1.44
    Ensembl ID: ENSG00000005022
  • Gene Symbol: CD3G (ENSG00000160654)
    Fold Change: 1.43
    Ensembl ID: ENSG00000160654
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 1.41
    Ensembl ID: ENSG00000067560
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.41
    Ensembl ID: ENSG00000152234
  • Gene Symbol: CD48 (ENSG00000117091)
    Fold Change: 1.4
    Ensembl ID: ENSG00000117091
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.39
    Ensembl ID: ENSG00000143761
  • Gene Symbol: CD247 (ENSG00000198821)
    Fold Change: 1.38
    Ensembl ID: ENSG00000198821
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.38
    Ensembl ID: ENSG00000084234
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 1.37
    Ensembl ID: ENSG00000179218
  • Gene Symbol: CD81 (ENSG00000110651)
    Fold Change: 1.37
    Ensembl ID: ENSG00000110651
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 1.36
    Ensembl ID: ENSG00000169020
  • Gene Symbol: CHD2 (ENSG00000173575)
    Fold Change: 1.35
    Ensembl ID: ENSG00000173575
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.35
    Ensembl ID: ENSG00000128272
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 1.34
    Ensembl ID: ENSG00000154723
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.34
    Ensembl ID: ENSG00000116489
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.32
    Ensembl ID: ENSG00000123505
  • Gene Symbol: KLF6 (ENSG00000067082)
    Fold Change: 1.32
    Ensembl ID: ENSG00000067082
  • Gene Symbol: FOXN3 (ENSG00000053254)
    Fold Change: 1.31
    Ensembl ID: ENSG00000053254
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 1.28
    Ensembl ID: ENSG00000135046
  • Gene Symbol: CHD1 (ENSG00000153922)
    Fold Change: 1.27
    Ensembl ID: ENSG00000153922
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 1.26
    Ensembl ID: ENSG00000142192
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.26
    Ensembl ID: ENSG00000241837
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 1.25
    Ensembl ID: ENSG00000154518
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.24
    Ensembl ID: ENSG00000070961
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.23
    Ensembl ID: ENSG00000182718
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.23
    Ensembl ID: ENSG00000172270
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.22
    Ensembl ID: ENSG00000168374
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 1.22
    Ensembl ID: ENSG00000198898
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 1.21
    Ensembl ID: ENSG00000142599
  • Gene Symbol: CLTC (ENSG00000141367)
    Fold Change: 1.2
    Ensembl ID: ENSG00000141367
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.18
    Ensembl ID: ENSG00000148700
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.18
    Ensembl ID: ENSG00000160014
  • Gene Symbol: COPA (ENSG00000122218)
    Fold Change: 1.16
    Ensembl ID: ENSG00000122218
  • Gene Symbol: CLK1 (ENSG00000013441)
    Fold Change: 1.15
    Ensembl ID: ENSG00000013441
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 1.14
    Ensembl ID: ENSG00000185650
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.13
    Ensembl ID: ENSG00000104765
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.13
    Ensembl ID: ENSG00000130402
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.12
    Ensembl ID: ENSG00000104763
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.12
    Ensembl ID: ENSG00000160710
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.12
    Ensembl ID: ENSG00000163399
  • Gene Symbol: CD47 (ENSG00000196776)
    Fold Change: 1.11
    Ensembl ID: ENSG00000196776
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.1
    Ensembl ID: ENSG00000069849
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 1.09
    Ensembl ID: ENSG00000134825
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.09
    Ensembl ID: ENSG00000141522
  • Gene Symbol: TBCB (ENSG00000105254)
    Fold Change: 1.09
    Ensembl ID: ENSG00000105254
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 1.09
    Ensembl ID: ENSG00000143878
  • Gene Symbol: BST2 (ENSG00000130303)
    Fold Change: 1.08
    Ensembl ID: ENSG00000130303
  • Gene Symbol: CLTA (ENSG00000122705)
    Fold Change: 1.07
    Ensembl ID: ENSG00000122705
  • Gene Symbol: PTTG1IP (ENSG00000183255)
    Fold Change: 1.06
    Ensembl ID: ENSG00000183255
  • Gene Symbol: CTSC (ENSG00000109861)
    Fold Change: 1.06
    Ensembl ID: ENSG00000109861
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.06
    Ensembl ID: ENSG00000177556
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.04
    Ensembl ID: ENSG00000165629
  • Gene Symbol: AP2M1 (ENSG00000161203)
    Fold Change: 1.03
    Ensembl ID: ENSG00000161203
  • Gene Symbol: ATM (ENSG00000149311)
    Fold Change: 1.03
    Ensembl ID: ENSG00000149311
  • Gene Symbol: CD8A (ENSG00000153563)
    Fold Change: 1.01
    Ensembl ID: ENSG00000153563
  • Gene Symbol: ADAM10 (ENSG00000137845)
    Fold Change: 1
    Ensembl ID: ENSG00000137845
  • Gene Symbol: AP2B1 (ENSG00000006125)
    Fold Change: N/A
    Ensembl ID: ENSG00000006125
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: N/A
    Ensembl ID: ENSG00000116459
Hovered Details

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Hovered Details

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**Key Characteristics** The CD8-alpha-beta-positive, alpha-beta intraepithelial T cell is characterized by the following key features: 1. **Alpha-beta T cell receptor expression**: These cells express alpha-beta T cell receptors, which are essential for recognizing and binding to antigens. 2. **Intraepithelial localization**: These cells reside within the epithelial layer of the gastrointestinal tract, where they can interact with other cells and tissues. 3. **Distinct developmental pathways**: The development of intraepithelial T cells is thought to be distinct from that of peripheral T cells, with unique signaling pathways and gene expression profiles. 4. **Activation requirements**: Intraepithelial T cells require specific activation signals to function effectively, which can be influenced by the presence of antigen-presenting cells and other immune cells. 5. **Apoptosis regulation**: These cells play a crucial role in regulating apoptosis (programmed cell death) within the epithelial layer, which is essential for maintaining tissue homeostasis. **Clinical Significance** The CD8-alpha-beta-positive, alpha-beta intraepithelial T cell plays a crucial role in maintaining the integrity of the epithelial barrier, particularly in the gastrointestinal tract. Dysregulation of these cells has been implicated in various diseases, including: 1. **Inflammatory bowel disease**: Abnormalities in intraepithelial T cell function have been linked to the development of inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis. 2. **Cancer**: Intraepithelial T cells have been shown to play a role in the development and progression of cancer, particularly in the gastrointestinal tract. 3. **Immune system disorders**: Abnormalities in intraepithelial T cell function have been implicated in various immune system disorders, including autoimmune diseases and immunodeficiency syndromes. In summary, the CD8-alpha-beta-positive, alpha-beta intraepithelial T cell is a unique and essential component of the immune system, playing a crucial role in maintaining tissue homeostasis and preventing disease. Further research is needed to fully understand the function and regulation of these cells, particularly in the context of disease.