Details for: ANXA2

Gene ID: 302

Symbol: ANXA2

Ensembl ID: ENSG00000182718

Description: annexin A2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 4.48
    Marker Score: 5397
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 4.3
    Marker Score: 146373
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 4.14
    Marker Score: 10111
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 4.07
    Marker Score: 3183
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 3.96
    Marker Score: 3379
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 3.84
    Marker Score: 7016
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 3.79
    Marker Score: 5092
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 3.75
    Marker Score: 3999.5
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 3.74
    Marker Score: 209155
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 3.68
    Marker Score: 32002
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 3.61
    Marker Score: 4374
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 3.59
    Marker Score: 3180
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 3.5
    Marker Score: 26059
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 3.41
    Marker Score: 17943
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 3.39
    Marker Score: 5225
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 3.39
    Marker Score: 3879
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 3.38
    Marker Score: 1970
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 3.38
    Marker Score: 13042
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 3.35
    Marker Score: 2637
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 3.34
    Marker Score: 2272
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 3.33
    Marker Score: 21228
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 3.31
    Marker Score: 25821
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 3.3
    Marker Score: 114386
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 3.29
    Marker Score: 1371
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 3.28
    Marker Score: 1054
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 3.28
    Marker Score: 4505
  • Cell Name: basal cell (CL0000646)
    Fold Change: 3.27
    Marker Score: 4217
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 3.23
    Marker Score: 15854.5
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 3.23
    Marker Score: 3396
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 3.23
    Marker Score: 10128
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 3.21
    Marker Score: 8415
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 3.21
    Marker Score: 1086
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 3.15
    Marker Score: 27127
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 3.13
    Marker Score: 4983.5
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 3.12
    Marker Score: 1348
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 3.11
    Marker Score: 994
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 3.08
    Marker Score: 6002
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 3.08
    Marker Score: 6151
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 3.06
    Marker Score: 1318
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 3.03
    Marker Score: 2103
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 3
    Marker Score: 6818
  • Cell Name: club cell (CL0000158)
    Fold Change: 2.99
    Marker Score: 3491
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 2.98
    Marker Score: 14321
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 2.98
    Marker Score: 10250
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 2.96
    Marker Score: 1080
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 2.93
    Marker Score: 1962
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 2.91
    Marker Score: 7408.5
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 2.9
    Marker Score: 4751.5
  • Cell Name: blood cell (CL0000081)
    Fold Change: 2.89
    Marker Score: 33553
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 2.89
    Marker Score: 6965
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 2.88
    Marker Score: 2479
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 2.86
    Marker Score: 73372
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 2.86
    Marker Score: 4152
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 2.85
    Marker Score: 4827
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 2.85
    Marker Score: 28192.5
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 2.84
    Marker Score: 2721
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 2.84
    Marker Score: 24913.5
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.84
    Marker Score: 12226
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 2.83
    Marker Score: 1612
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 2.8
    Marker Score: 675
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 2.79
    Marker Score: 3000
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 2.78
    Marker Score: 802
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 2.77
    Marker Score: 6895
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 2.76
    Marker Score: 1420
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 2.74
    Marker Score: 5213.5
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 2.74
    Marker Score: 686
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 2.73
    Marker Score: 1713
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 2.73
    Marker Score: 1346
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.72
    Marker Score: 30590
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 2.7
    Marker Score: 2612
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.7
    Marker Score: 17244.5
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 2.68
    Marker Score: 4757
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 2.68
    Marker Score: 1207
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 2.68
    Marker Score: 6754
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 2.67
    Marker Score: 42921
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 2.66
    Marker Score: 7354.5
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 2.65
    Marker Score: 17256
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 2.59
    Marker Score: 3747
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 2.58
    Marker Score: 643
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 2.58
    Marker Score: 817
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 2.58
    Marker Score: 3110
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 2.58
    Marker Score: 915
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 2.56
    Marker Score: 643
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 2.55
    Marker Score: 6603.5
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 2.54
    Marker Score: 4082
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 2.54
    Marker Score: 986
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 2.53
    Marker Score: 589
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 2.53
    Marker Score: 2253
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 2.52
    Marker Score: 1478
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.5
    Marker Score: 3689.5
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 2.46
    Marker Score: 2205
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 2.44
    Marker Score: 705.5
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 2.44
    Marker Score: 1158
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 2.43
    Marker Score: 14748
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 2.42
    Marker Score: 1937
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 2.41
    Marker Score: 8940.5
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 2.41
    Marker Score: 1003.5
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 2.39
    Marker Score: 1996
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 2.38
    Marker Score: 2970.5
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 2.37
    Marker Score: 1109

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Other Information

**Key characteristics:** - ANXA2 is a transmembrane protein with a molecular weight of approximately 120 kDa. - It is a member of the annexin family of proteins, which are involved in the regulation of cell adhesion and signaling. - ANXA2 is a key regulator of inflammation and cell signaling. - It is involved in the regulation of the inflammatory response to interleukin-12, which is a cytokine that is involved in the regulation of immune responses. - ANXA2 is also involved in the regulation of cell migration and adhesion. **Pathways and functions:** - ANXA2 is involved in the regulation of inflammation and cell signaling through its interaction with calcium ions. - It binds to calcium ions and is activated by calcium-dependent signaling pathways. - ANXA2 is also involved in the regulation of cell migration and adhesion through its interaction with integrins and cadherins. - It is involved in the regulation of cell signaling through its interaction with the JAK/STAT signaling pathway. **Clinical significance:** - Mutations in the ANXA2 gene have been linked to a number of human diseases, including rheumatoid arthritis, asthma, and inflammatory bowel disease. - ANXA2 is a potential target for the treatment of these diseases.

Genular Protein ID: 1081526677

Symbol: ANXA2_HUMAN

Name: Annexin A2

UniProtKB Accession Codes:

P07355 Q567R4 Q6N0B3 Q8TBV2 Q96DD5 Q9UDH8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CORUM 1 CPTAC 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 4 DMDM 1 DNASU 1 DOSAC-COBS-2DPAGE 1 DisGeNET 1 DisProt 1 DrugBank 4 EMBL 15 EPD 1 Ensembl 14 EvolutionaryTrace 1 ExpressionAtlas 1 GO 67 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 50 PDBsum 40 PIR 1 PRIDE 1 PRINTS 2 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 Proteomes 1 ProteomicsDB 2 REPRODUCTION-2DPAGE 2 RNAct 1 Reactome 4 RefSeq 6 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TopDownProteomics 1 TreeFam 1 UCD-2DPAGE 1 UCSC 1 UniProtKB 4 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3013422

Title: Two human 35 kd inhibitors of phospholipase A2 are related to substrates of pp60v-src and of the epidermal growth factor receptor/kinase.

PubMed ID: 3013422

DOI: 10.1016/0092-8674(86)90736-1

PubMed ID: 2174397

Title: Characterization of the human lipocortin-2-encoding multigene family: its structure suggests the existence of a short amino acid unit undergoing duplication.

PubMed ID: 2174397

DOI: 10.1016/0378-1119(90)90367-z

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1825830

Title: The protein-tyrosine kinase substrate, calpactin I heavy chain (p36), is part of the primer recognition protein complex that interacts with DNA polymerase alpha.

PubMed ID: 1825830

DOI: 10.1016/s0021-9258(19)67770-7

PubMed ID: 8110754

Title: Identification and characterization of alpha-protein kinase C binding proteins in normal and transformed REF52 cells.

PubMed ID: 8110754

DOI: 10.1021/bi00171a023

PubMed ID: 8117306

Title: An endothelial cell-surface form of annexin II binds human cytomegalovirus.

PubMed ID: 8117306

DOI: 10.1006/bbrc.1994.1140

PubMed ID: 8449982

Title: Annexin II is a major component of fusogenic endosomal vesicles.

PubMed ID: 8449982

DOI: 10.1083/jcb.120.6.1357

PubMed ID: 2946940

Title: The protein-tyrosine kinase substrate p36 is also a substrate for protein kinase C in vitro and in vivo.

PubMed ID: 2946940

DOI: 10.1128/mcb.6.7.2738-2744.1986

PubMed ID: 14522961

Title: CEACAM1, a cell-cell adhesion molecule, directly associates with annexin II in a three-dimensional model of mammary morphogenesis.

PubMed ID: 14522961

DOI: 10.1074/jbc.m309115200

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 15302870

Title: An annexin 2 phosphorylation switch mediates p11-dependent translocation of annexin 2 to the cell surface.

PubMed ID: 15302870

DOI: 10.1074/jbc.m408078200

PubMed ID: 16139798

Title: Proteomic identification of proteins conjugated to ISG15 in mouse and human cells.

PubMed ID: 16139798

DOI: 10.1016/j.bbrc.2005.08.132

PubMed ID: 17081065

Title: Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes.

PubMed ID: 17081065

DOI: 10.1021/pr060363j

PubMed ID: 18799458

Title: Annexin A2 is a C-terminal PCSK9-binding protein that regulates endogenous low density lipoprotein receptor levels.

PubMed ID: 18799458

DOI: 10.1074/jbc.m805971200

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21886777

Title: Cochlin induced TREK-1 co-expression and annexin A2 secretion: role in trabecular meshwork cell elongation and motility.

PubMed ID: 21886777

DOI: 10.1371/journal.pone.0023070

PubMed ID: 22848640

Title: Annexin A2 is a natural extrahepatic inhibitor of the PCSK9-induced LDL receptor degradation.

PubMed ID: 22848640

DOI: 10.1371/journal.pone.0041865

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24808179

Title: Annexin A2 reduces PCSK9 protein levels via a translational mechanism and interacts with the M1 and M2 domains of PCSK9.

PubMed ID: 24808179

DOI: 10.1074/jbc.m113.541094

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25114211

Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.

PubMed ID: 25114211

DOI: 10.1073/pnas.1413825111

PubMed ID: 25139904

Title: Annexin A2 mediates Mycoplasma pneumoniae community-acquired respiratory distress syndrome toxin binding to eukaryotic cells.

PubMed ID: 25139904

DOI: 10.1128/mbio.01497-14

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27121050

Title: UBAP2 negatively regulates the invasion of hepatocellular carcinoma cell by ubiquitinating and degradating Annexin A2.

PubMed ID: 27121050

DOI: 10.18632/oncotarget.8783

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 8636985

Title: The crystal structure and ion channel activity of human annexin II, a peripheral membrane protein.

PubMed ID: 8636985

DOI: 10.1006/jmbi.1996.0205

PubMed ID: 28669632

Title: Regulation of the Equilibrium between Closed and Open Conformations of Annexin A2 by N-Terminal Phosphorylation and S100A4-Binding.

PubMed ID: 28669632

DOI: 10.1016/j.str.2017.06.001

Sequence Information:

  • Length: 339
  • Mass: 38604
  • Checksum: 5126E1337A0CBEA1
  • Sequence:
    • MSTVHEILCK LSLEGDHSTP PSAYGSVKAY TNFDAERDAL NIETAIKTKG VDEVTIVNIL 
TNRSNAQRQD IAFAYQRRTK KELASALKSA LSGHLETVIL GLLKTPAQYD ASELKASMKG 
LGTDEDSLIE IICSRTNQEL QEINRVYKEM YKTDLEKDII SDTSGDFRKL MVALAKGRRA 
EDGSVIDYEL IDQDARDLYD AGVKRKGTDV PKWISIMTER SVPHLQKVFD RYKSYSPYDM 
LESIRKEVKG DLENAFLNLV QCIQNKPLYF ADRLYDSMKG KGTRDKVLIR IMVSRSEVDM 
LKIRSEFKRK YGKSLYYYIQ QDTKGDYQKA LLYLCGGDD

Genular Protein ID: 2176305815

Symbol: H0YL33_HUMAN

Name: N/A

UniProtKB Accession Codes:

H0YL33 H0YN52

Database IDs:

ARBA 11 Antibodypedia 1 Bgee 1 CTD 1 ChiTaRS 1 EMBL 1 EPD 1 Ensembl 3 GO 7 Gene3D 1 GeneTree 1 HGNC 1 HOGENOM 2 InterPro 5 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 PANTHER 2 PRINTS 2 PROSITE 2 Pfam 1 Proteomes 2 ProteomicsDB 2 RefSeq 3 RuleBase 1 SMART 1 SUPFAM 1 UCSC 2 VEuPathDB 1

Citations:

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

Sequence Information:

  • Length: 222
  • Mass: 25872
  • Checksum: 64C9A4B3B5B24CBE
  • Sequence:
    • MKGLGTDEDS LIEIICSRTN QELQEINRVY KEMYKTDLEK DIISDTSGDF RKLMVALAKG 
RRAEDGSVID YELIDQDARD LYDAGVKRKG TDVPKWISIM TERSVPHLQK VFDRYKSYSP 
YDMLESIRKE VKGDLENAFL NLVQCIQNKP LYFADRLYDS MKGKGTRDKV LIRIMVSRSE 
VDMLKIRSEF KRKYGKSLYY YIQQDTKGDY QKALLYLCGG DD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.