Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 802.1461
Cell Significance Index: -124.7700 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 487.5743
Cell Significance Index: -123.6700 - Cell Name: embryonic stem cell (CL0002322)
Fold Change: 297.7684
Cell Significance Index: -122.6700 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 256.9989
Cell Significance Index: -121.3400 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 254.3709
Cell Significance Index: -103.3400 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 225.8424
Cell Significance Index: -116.1700 - Cell Name: ileal goblet cell (CL1000326)
Fold Change: 182.1475
Cell Significance Index: -122.2300 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 109.0241
Cell Significance Index: -104.0900 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 101.0174
Cell Significance Index: -124.5500 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 34.6253
Cell Significance Index: -106.3500 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 31.7153
Cell Significance Index: -125.1500 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 30.1770
Cell Significance Index: -80.8400 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 28.0363
Cell Significance Index: -61.3600 - Cell Name: oral mucosa squamous cell (CL1001576)
Fold Change: 14.3280
Cell Significance Index: 123.1200 - Cell Name: thyroid follicular cell (CL0002258)
Fold Change: 13.5371
Cell Significance Index: 143.8300 - Cell Name: stem cell of epidermis (CL1000428)
Fold Change: 12.5218
Cell Significance Index: 37.2400 - Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
Fold Change: 10.9332
Cell Significance Index: 67.2900 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 8.2260
Cell Significance Index: 613.0800 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 7.1054
Cell Significance Index: 203.6800 - Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 6.6410
Cell Significance Index: 117.3600 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 6.4272
Cell Significance Index: 302.0700 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 6.3152
Cell Significance Index: 58.1600 - Cell Name: odontoblast (CL0000060)
Fold Change: 5.5154
Cell Significance Index: 707.0400 - Cell Name: lactocyte (CL0002325)
Fold Change: 5.4531
Cell Significance Index: 704.5000 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 5.3541
Cell Significance Index: 112.0700 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 5.2294
Cell Significance Index: 142.3400 - Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 5.1882
Cell Significance Index: 58.9400 - Cell Name: prostate gland microvascular endothelial cell (CL2000059)
Fold Change: 5.0725
Cell Significance Index: 36.4300 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 5.0558
Cell Significance Index: 93.4500 - Cell Name: cell in vitro (CL0001034)
Fold Change: 5.0070
Cell Significance Index: 2734.4300 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 4.4983
Cell Significance Index: 132.1100 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 4.3395
Cell Significance Index: 1918.5900 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 4.2586
Cell Significance Index: 113.7100 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 4.2563
Cell Significance Index: 523.3500 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: 4.0545
Cell Significance Index: 286.7500 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 3.8450
Cell Significance Index: 3471.7400 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: 3.3852
Cell Significance Index: 176.3300 - Cell Name: extravillous trophoblast (CL0008036)
Fold Change: 3.1287
Cell Significance Index: 19.4400 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 3.0866
Cell Significance Index: 556.4100 - Cell Name: peg cell (CL4033014)
Fold Change: 2.6823
Cell Significance Index: 61.9700 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 2.4215
Cell Significance Index: 112.9000 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 2.3660
Cell Significance Index: 152.6400 - Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: 2.2920
Cell Significance Index: 14.1900 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 2.1205
Cell Significance Index: 291.2000 - Cell Name: preadipocyte (CL0002334)
Fold Change: 2.1105
Cell Significance Index: 41.1900 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 1.8703
Cell Significance Index: 40.5200 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.6498
Cell Significance Index: 85.7000 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 1.5317
Cell Significance Index: 42.8100 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 1.0618
Cell Significance Index: 1634.5500 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.8529
Cell Significance Index: 1572.9200 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: 0.5563
Cell Significance Index: 28.1200 - Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: 0.4684
Cell Significance Index: 2.8300 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.4186
Cell Significance Index: 316.8600 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.3762
Cell Significance Index: 74.6500 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.3047
Cell Significance Index: 57.9800 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0455
Cell Significance Index: 61.8300 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.0298
Cell Significance Index: 5.0900 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 0.0257
Cell Significance Index: 0.6600 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.0235
Cell Significance Index: 1.0700 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0080
Cell Significance Index: 14.9800 - Cell Name: abnormal cell (CL0001061)
Fold Change: 0.0077
Cell Significance Index: 0.7900 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0176
Cell Significance Index: -13.0600 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.0507
Cell Significance Index: -5.7900 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.0532
Cell Significance Index: -0.8900 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0560
Cell Significance Index: -35.5900 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0564
Cell Significance Index: -35.2000 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.1048
Cell Significance Index: -76.8200 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.1258
Cell Significance Index: -57.1100 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.1339
Cell Significance Index: -75.5000 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: -0.1572
Cell Significance Index: -108.7300 - Cell Name: colon goblet cell (CL0009039)
Fold Change: -0.1638
Cell Significance Index: -16.2000 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.3129
Cell Significance Index: -112.2300 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.3406
Cell Significance Index: -97.9900 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.3408
Cell Significance Index: -4.6500 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.3806
Cell Significance Index: -80.1700 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.5137
Cell Significance Index: -12.8400 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.5451
Cell Significance Index: -64.2800 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.5780
Cell Significance Index: -66.2200 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.6041
Cell Significance Index: -87.8200 - Cell Name: paneth cell of colon (CL0009009)
Fold Change: -0.6160
Cell Significance Index: -9.2300 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.6325
Cell Significance Index: -126.8700 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.7189
Cell Significance Index: -23.0300 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.7337
Cell Significance Index: -85.5000 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.9739
Cell Significance Index: -74.7400 - Cell Name: corneal epithelial cell (CL0000575)
Fold Change: -1.1338
Cell Significance Index: -16.1400 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -1.1466
Cell Significance Index: -119.3900 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -1.3347
Cell Significance Index: -105.7100 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -1.3877
Cell Significance Index: -29.5600 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -1.5058
Cell Significance Index: -92.3200 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: -1.5084
Cell Significance Index: -15.6200 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -1.6500
Cell Significance Index: -86.6300 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -1.7120
Cell Significance Index: -45.8000 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -1.9227
Cell Significance Index: -129.2800 - Cell Name: neuron associated cell (CL0000095)
Fold Change: -1.9492
Cell Significance Index: -79.8700 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -2.0264
Cell Significance Index: -127.7200 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -2.0643
Cell Significance Index: -115.8400 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -2.1157
Cell Significance Index: -130.0400 - Cell Name: basal epithelial cell of prostatic duct (CL0002236)
Fold Change: -2.2170
Cell Significance Index: -19.6800 - Cell Name: type I muscle cell (CL0002211)
Fold Change: -2.2287
Cell Significance Index: -54.3800 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -2.2319
Cell Significance Index: -65.7400
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 1081526677
Symbol: ANXA2_HUMAN
Name: Annexin A2
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 3013422
Title: Two human 35 kd inhibitors of phospholipase A2 are related to substrates of pp60v-src and of the epidermal growth factor receptor/kinase.
PubMed ID: 3013422
PubMed ID: 2174397
Title: Characterization of the human lipocortin-2-encoding multigene family: its structure suggests the existence of a short amino acid unit undergoing duplication.
PubMed ID: 2174397
PubMed ID: 17974005
Title: The full-ORF clone resource of the German cDNA consortium.
PubMed ID: 17974005
PubMed ID: 16572171
Title: Analysis of the DNA sequence and duplication history of human chromosome 15.
PubMed ID: 16572171
DOI: 10.1038/nature04601
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 1825830
Title: The protein-tyrosine kinase substrate, calpactin I heavy chain (p36), is part of the primer recognition protein complex that interacts with DNA polymerase alpha.
PubMed ID: 1825830
PubMed ID: 8110754
Title: Identification and characterization of alpha-protein kinase C binding proteins in normal and transformed REF52 cells.
PubMed ID: 8110754
DOI: 10.1021/bi00171a023
PubMed ID: 8117306
Title: An endothelial cell-surface form of annexin II binds human cytomegalovirus.
PubMed ID: 8117306
PubMed ID: 8449982
Title: Annexin II is a major component of fusogenic endosomal vesicles.
PubMed ID: 8449982
PubMed ID: 2946940
Title: The protein-tyrosine kinase substrate p36 is also a substrate for protein kinase C in vitro and in vivo.
PubMed ID: 2946940
PubMed ID: 14522961
Title: CEACAM1, a cell-cell adhesion molecule, directly associates with annexin II in a three-dimensional model of mammary morphogenesis.
PubMed ID: 14522961
PubMed ID: 14654843
Title: Proteomic characterization of the human centrosome by protein correlation profiling.
PubMed ID: 14654843
DOI: 10.1038/nature02166
PubMed ID: 15302870
Title: An annexin 2 phosphorylation switch mediates p11-dependent translocation of annexin 2 to the cell surface.
PubMed ID: 15302870
PubMed ID: 16139798
Title: Proteomic identification of proteins conjugated to ISG15 in mouse and human cells.
PubMed ID: 16139798
PubMed ID: 17081065
Title: Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes.
PubMed ID: 17081065
DOI: 10.1021/pr060363j
PubMed ID: 18799458
Title: Annexin A2 is a C-terminal PCSK9-binding protein that regulates endogenous low density lipoprotein receptor levels.
PubMed ID: 18799458
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21886777
Title: Cochlin induced TREK-1 co-expression and annexin A2 secretion: role in trabecular meshwork cell elongation and motility.
PubMed ID: 21886777
PubMed ID: 22848640
Title: Annexin A2 is a natural extrahepatic inhibitor of the PCSK9-induced LDL receptor degradation.
PubMed ID: 22848640
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24808179
Title: Annexin A2 reduces PCSK9 protein levels via a translational mechanism and interacts with the M1 and M2 domains of PCSK9.
PubMed ID: 24808179
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25114211
Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.
PubMed ID: 25114211
PubMed ID: 25139904
Title: Annexin A2 mediates Mycoplasma pneumoniae community-acquired respiratory distress syndrome toxin binding to eukaryotic cells.
PubMed ID: 25139904
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 27121050
Title: UBAP2 negatively regulates the invasion of hepatocellular carcinoma cell by ubiquitinating and degradating Annexin A2.
PubMed ID: 27121050
PubMed ID: 28112733
Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.
PubMed ID: 28112733
DOI: 10.1038/nsmb.3366
PubMed ID: 33310911
Title: PLEKHG4B enables actin cytoskeletal remodeling during epithelial cell-cell junction formation.
PubMed ID: 33310911
DOI: 10.1242/jcs.249078
PubMed ID: 8636985
Title: The crystal structure and ion channel activity of human annexin II, a peripheral membrane protein.
PubMed ID: 8636985
PubMed ID: 28669632
Title: Regulation of the Equilibrium between Closed and Open Conformations of Annexin A2 by N-Terminal Phosphorylation and S100A4-Binding.
PubMed ID: 28669632
Sequence Information:
- Length: 339
- Mass: 38604
- Checksum: 5126E1337A0CBEA1
- Sequence:
MSTVHEILCK LSLEGDHSTP PSAYGSVKAY TNFDAERDAL NIETAIKTKG VDEVTIVNIL TNRSNAQRQD IAFAYQRRTK KELASALKSA LSGHLETVIL GLLKTPAQYD ASELKASMKG LGTDEDSLIE IICSRTNQEL QEINRVYKEM YKTDLEKDII SDTSGDFRKL MVALAKGRRA EDGSVIDYEL IDQDARDLYD AGVKRKGTDV PKWISIMTER SVPHLQKVFD RYKSYSPYDM LESIRKEVKG DLENAFLNLV QCIQNKPLYF ADRLYDSMKG KGTRDKVLIR IMVSRSEVDM LKIRSEFKRK YGKSLYYYIQ QDTKGDYQKA LLYLCGGDD
Genular Protein ID: 2176305815
Symbol: H0YL33_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11237011
Title: Initial sequencing and analysis of the human genome.
PubMed ID: 11237011
DOI: 10.1038/35057062
PubMed ID: 15496913
Title: Finishing the euchromatic sequence of the human genome.
PubMed ID: 15496913
DOI: 10.1038/nature03001
PubMed ID: 16572171
Title: Analysis of the DNA sequence and duplication history of human chromosome 15.
PubMed ID: 16572171
DOI: 10.1038/nature04601
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
Sequence Information:
- Length: 222
- Mass: 25872
- Checksum: 64C9A4B3B5B24CBE
- Sequence:
MKGLGTDEDS LIEIICSRTN QELQEINRVY KEMYKTDLEK DIISDTSGDF RKLMVALAKG RRAEDGSVID YELIDQDARD LYDAGVKRKG TDVPKWISIM TERSVPHLQK VFDRYKSYSP YDMLESIRKE VKGDLENAFL NLVQCIQNKP LYFADRLYDS MKGKGTRDKV LIRIMVSRSE VDMLKIRSEF KRKYGKSLYY YIQQDTKGDY QKALLYLCGG DD
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.