Details for: CL1000296

Cell ID: CL1000296

Cell Name: epithelial cell of urethra

Marker Score Threshold: 788
(Derived using integrated single-cell and genomic data)

Description: An epithelial cell that is part of the urethra.

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: SFN (ENSG00000175793)
    Fold Change: 3.51
    Ensembl ID: ENSG00000175793
  • Gene Symbol: KRT17 (ENSG00000128422)
    Fold Change: 3.48
    Ensembl ID: ENSG00000128422
  • Gene Symbol: CLDN4 (ENSG00000189143)
    Fold Change: 3.46
    Ensembl ID: ENSG00000189143
  • Gene Symbol: KLF5 (ENSG00000102554)
    Fold Change: 3.45
    Ensembl ID: ENSG00000102554
  • Gene Symbol: KRT19 (ENSG00000171345)
    Fold Change: 3.42
    Ensembl ID: ENSG00000171345
  • Gene Symbol: AQP3 (ENSG00000165272)
    Fold Change: 3.42
    Ensembl ID: ENSG00000165272
  • Gene Symbol: CD9 (ENSG00000010278)
    Fold Change: 3.42
    Ensembl ID: ENSG00000010278
  • Gene Symbol: CLDN7 (ENSG00000181885)
    Fold Change: 3.37
    Ensembl ID: ENSG00000181885
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 3.35
    Ensembl ID: ENSG00000182718
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 3.34
    Ensembl ID: ENSG00000135046
  • Gene Symbol: H3 3A (ENSG00000163041)
    Fold Change: 3.32
    Ensembl ID: ENSG00000163041
  • Gene Symbol: KRT18 (ENSG00000111057)
    Fold Change: 3.32
    Ensembl ID: ENSG00000111057
  • Gene Symbol: KRT8 (ENSG00000170421)
    Fold Change: 3.31
    Ensembl ID: ENSG00000170421
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 3.29
    Ensembl ID: ENSG00000145741
  • Gene Symbol: FAU (ENSG00000149806)
    Fold Change: 3.28
    Ensembl ID: ENSG00000149806
  • Gene Symbol: KRT7 (ENSG00000135480)
    Fold Change: 3.28
    Ensembl ID: ENSG00000135480
  • Gene Symbol: EEF1A1 (ENSG00000156508)
    Fold Change: 3.28
    Ensembl ID: ENSG00000156508
  • Gene Symbol: RPSA (ENSG00000168028)
    Fold Change: 3.28
    Ensembl ID: ENSG00000168028
  • Gene Symbol: HINT1 (ENSG00000169567)
    Fold Change: 3.28
    Ensembl ID: ENSG00000169567
  • Gene Symbol: FTH1 (ENSG00000167996)
    Fold Change: 3.28
    Ensembl ID: ENSG00000167996
  • Gene Symbol: FTL (ENSG00000087086)
    Fold Change: 3.28
    Ensembl ID: ENSG00000087086
  • Gene Symbol: COX7C (ENSG00000127184)
    Fold Change: 3.27
    Ensembl ID: ENSG00000127184
  • Gene Symbol: GSTP1 (ENSG00000084207)
    Fold Change: 3.27
    Ensembl ID: ENSG00000084207
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 3.27
    Ensembl ID: ENSG00000075624
  • Gene Symbol: COX4I1 (ENSG00000131143)
    Fold Change: 3.27
    Ensembl ID: ENSG00000131143
  • Gene Symbol: GAPDH (ENSG00000111640)
    Fold Change: 3.27
    Ensembl ID: ENSG00000111640
  • Gene Symbol: CD59 (ENSG00000085063)
    Fold Change: 3.27
    Ensembl ID: ENSG00000085063
  • Gene Symbol: HMGA1 (ENSG00000137309)
    Fold Change: 3.27
    Ensembl ID: ENSG00000137309
  • Gene Symbol: CLIC1 (ENSG00000213719)
    Fold Change: 3.26
    Ensembl ID: ENSG00000213719
  • Gene Symbol: ELF3 (ENSG00000163435)
    Fold Change: 3.26
    Ensembl ID: ENSG00000163435
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 3.25
    Ensembl ID: ENSG00000166710
  • Gene Symbol: CFL1 (ENSG00000172757)
    Fold Change: 3.25
    Ensembl ID: ENSG00000172757
  • Gene Symbol: LGALS3 (ENSG00000131981)
    Fold Change: 3.25
    Ensembl ID: ENSG00000131981
  • Gene Symbol: CD63 (ENSG00000135404)
    Fold Change: 3.25
    Ensembl ID: ENSG00000135404
  • Gene Symbol: EEF1D (ENSG00000104529)
    Fold Change: 3.24
    Ensembl ID: ENSG00000104529
  • Gene Symbol: COX7A2 (ENSG00000112695)
    Fold Change: 3.24
    Ensembl ID: ENSG00000112695
  • Gene Symbol: CSTB (ENSG00000160213)
    Fold Change: 3.24
    Ensembl ID: ENSG00000160213
  • Gene Symbol: EEF1B2 (ENSG00000114942)
    Fold Change: 3.24
    Ensembl ID: ENSG00000114942
  • Gene Symbol: H3 3B (ENSG00000132475)
    Fold Change: 3.23
    Ensembl ID: ENSG00000132475
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 3.23
    Ensembl ID: ENSG00000184009
  • Gene Symbol: HSPB1 (ENSG00000106211)
    Fold Change: 3.22
    Ensembl ID: ENSG00000106211
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 3.22
    Ensembl ID: ENSG00000169100
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 3.22
    Ensembl ID: ENSG00000124172
  • Gene Symbol: COX6A1 (ENSG00000111775)
    Fold Change: 3.19
    Ensembl ID: ENSG00000111775
  • Gene Symbol: CXCL8 (ENSG00000169429)
    Fold Change: 3.19
    Ensembl ID: ENSG00000169429
  • Gene Symbol: HSP90AA1 (ENSG00000080824)
    Fold Change: 3.18
    Ensembl ID: ENSG00000080824
  • Gene Symbol: COX6C (ENSG00000164919)
    Fold Change: 3.17
    Ensembl ID: ENSG00000164919
  • Gene Symbol: COX5B (ENSG00000135940)
    Fold Change: 3.16
    Ensembl ID: ENSG00000135940
  • Gene Symbol: HSP90AB1 (ENSG00000096384)
    Fold Change: 3.16
    Ensembl ID: ENSG00000096384
  • Gene Symbol: COX6B1 (ENSG00000126267)
    Fold Change: 3.14
    Ensembl ID: ENSG00000126267
  • Gene Symbol: EIF3E (ENSG00000104408)
    Fold Change: 3.14
    Ensembl ID: ENSG00000104408
  • Gene Symbol: HMGB1 (ENSG00000189403)
    Fold Change: 3.14
    Ensembl ID: ENSG00000189403
  • Gene Symbol: HNRNPA1 (ENSG00000135486)
    Fold Change: 3.14
    Ensembl ID: ENSG00000135486
  • Gene Symbol: EEF2 (ENSG00000167658)
    Fold Change: 3.13
    Ensembl ID: ENSG00000167658
  • Gene Symbol: EMP1 (ENSG00000134531)
    Fold Change: 3.12
    Ensembl ID: ENSG00000134531
  • Gene Symbol: GLUL (ENSG00000135821)
    Fold Change: 3.09
    Ensembl ID: ENSG00000135821
  • Gene Symbol: GADD45A (ENSG00000116717)
    Fold Change: 3.09
    Ensembl ID: ENSG00000116717
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 3.09
    Ensembl ID: ENSG00000135390
  • Gene Symbol: CST3 (ENSG00000101439)
    Fold Change: 3.09
    Ensembl ID: ENSG00000101439
  • Gene Symbol: KRT13 (ENSG00000171401)
    Fold Change: 3.09
    Ensembl ID: ENSG00000171401
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 3.09
    Ensembl ID: ENSG00000143933
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 3.09
    Ensembl ID: ENSG00000100300
  • Gene Symbol: HLA A (ENSG00000206503)
    Fold Change: 3.08
    Ensembl ID: ENSG00000206503
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 3.05
    Ensembl ID: ENSG00000165527
  • Gene Symbol: HLA C (ENSG00000204525)
    Fold Change: 3.05
    Ensembl ID: ENSG00000204525
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 3.04
    Ensembl ID: ENSG00000133639
  • Gene Symbol: DDX5 (ENSG00000108654)
    Fold Change: 3.04
    Ensembl ID: ENSG00000108654
  • Gene Symbol: CEACAM1 (ENSG00000079385)
    Fold Change: 3.03
    Ensembl ID: ENSG00000079385
  • Gene Symbol: HMGN1 (ENSG00000205581)
    Fold Change: 3.03
    Ensembl ID: ENSG00000205581
  • Gene Symbol: EIF4A2 (ENSG00000156976)
    Fold Change: 3.03
    Ensembl ID: ENSG00000156976
  • Gene Symbol: GPX2 (ENSG00000176153)
    Fold Change: 3.02
    Ensembl ID: ENSG00000176153
  • Gene Symbol: COX8A (ENSG00000176340)
    Fold Change: 3.02
    Ensembl ID: ENSG00000176340
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 3.02
    Ensembl ID: ENSG00000005022
  • Gene Symbol: HNRNPC (ENSG00000092199)
    Fold Change: 3
    Ensembl ID: ENSG00000092199
  • Gene Symbol: HSPE1 (ENSG00000115541)
    Fold Change: 2.99
    Ensembl ID: ENSG00000115541
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 2.97
    Ensembl ID: ENSG00000122359
  • Gene Symbol: HLA B (ENSG00000234745)
    Fold Change: 2.97
    Ensembl ID: ENSG00000234745
  • Gene Symbol: GNG5 (ENSG00000174021)
    Fold Change: 2.96
    Ensembl ID: ENSG00000174021
  • Gene Symbol: DUSP5 (ENSG00000138166)
    Fold Change: 2.94
    Ensembl ID: ENSG00000138166
  • Gene Symbol: LMNA (ENSG00000160789)
    Fold Change: 2.94
    Ensembl ID: ENSG00000160789
  • Gene Symbol: COX7B (ENSG00000131174)
    Fold Change: 2.93
    Ensembl ID: ENSG00000131174
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 2.93
    Ensembl ID: ENSG00000153113
  • Gene Symbol: HNRNPA2B1 (ENSG00000122566)
    Fold Change: 2.92
    Ensembl ID: ENSG00000122566
  • Gene Symbol: EIF6 (ENSG00000242372)
    Fold Change: 2.91
    Ensembl ID: ENSG00000242372
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 2.91
    Ensembl ID: ENSG00000154518
  • Gene Symbol: EIF4A1 (ENSG00000161960)
    Fold Change: 2.9
    Ensembl ID: ENSG00000161960
  • Gene Symbol: GPX4 (ENSG00000167468)
    Fold Change: 2.89
    Ensembl ID: ENSG00000167468
  • Gene Symbol: CEBPD (ENSG00000221869)
    Fold Change: 2.88
    Ensembl ID: ENSG00000221869
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 2.86
    Ensembl ID: ENSG00000099624
  • Gene Symbol: GUK1 (ENSG00000143774)
    Fold Change: 2.86
    Ensembl ID: ENSG00000143774
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 2.86
    Ensembl ID: ENSG00000168374
  • Gene Symbol: EIF4G2 (ENSG00000110321)
    Fold Change: 2.85
    Ensembl ID: ENSG00000110321
  • Gene Symbol: CSNK1A1 (ENSG00000113712)
    Fold Change: 2.84
    Ensembl ID: ENSG00000113712
  • Gene Symbol: KRT10 (ENSG00000186395)
    Fold Change: 2.84
    Ensembl ID: ENSG00000186395
  • Gene Symbol: IFNGR2 (ENSG00000159128)
    Fold Change: 2.84
    Ensembl ID: ENSG00000159128
  • Gene Symbol: HNRNPK (ENSG00000165119)
    Fold Change: 2.83
    Ensembl ID: ENSG00000165119
  • Gene Symbol: H2AZ1 (ENSG00000164032)
    Fold Change: 2.81
    Ensembl ID: ENSG00000164032
  • Gene Symbol: CD55 (ENSG00000196352)
    Fold Change: 2.8
    Ensembl ID: ENSG00000196352
  • Gene Symbol: HLA E (ENSG00000204592)
    Fold Change: 2.79
    Ensembl ID: ENSG00000204592
  • Gene Symbol: CDC42 (ENSG00000070831)
    Fold Change: 2.78
    Ensembl ID: ENSG00000070831

Gene ID: A unique numerical identifier for this specific gene.
Symbol: Shortened abbreviation or name that represents this gene.
Ensembl Gene ID: A unique identifier assigned by Ensembl for genomic data mapping.
Fold Change: Indicates the ratio of the gene's expression level in epithelial cell of urethra cell compared to a baseline. A fold change greater than 1 suggests significant gene expression.

Gene ID: A unique numerical identifier for this specific gene.
Symbol: Shortened abbreviation or name that represents this gene.
Ensembl Gene ID: A unique identifier assigned by Ensembl for genomic data mapping.
Fold Change: Indicates the ratio of the gene's expression level in epithelial cell of urethra cell compared to a baseline. A fold change greater than 1 suggests significant gene expression.
**Key Characteristics** * **Cell Type**: Epithelial cell of the urethra * **Gene Symbol**: SFN, KRT17, CLDN4, KLF5, KRT19, AQP3, CD9, CLDN7 * **Pathways/Ontologies**: Activation of Bcl-2 family proteins, apoptosis, cell cycle regulation, tight junction formation * **Cellular Processes**: Cell growth, differentiation, adhesion, migration, transport * **Structural Features**: Apical, basal, lateral plasma membranes; bicellular tight junctions; intermediate filaments (KRT17, KRT19); keratinization; cornified envelope **Clinical Significance** * **Urethral Epithelium**: The urethral epithelium plays a crucial role in maintaining the integrity of the urethra and preventing infections. * **Urinary Tract Infections**: Dysregulation of the urethral epithelium's tight junctions and barrier function can contribute to urinary tract infections. * **Cancer**: Abnormalities in the expression of genes involved in cell growth, differentiation, and adhesion can contribute to the development of cancer in the urethra. * **Regulatory Pathways**: The cell's involvement in regulatory pathways, such as apoptosis and cell cycle regulation, can impact its response to diseases and treatments. **Disease Associations** * **Urinary Tract Infections**: Dysregulation of the urethral epithelium's tight junctions and barrier function can contribute to urinary tract infections. * **Cancer**: Abnormalities in the expression of genes involved in cell growth, differentiation, and adhesion can contribute to the development of cancer in the urethra. * **Gastrointestinal Disorders**: Dysregulation of the urethral epithelium's tight junctions and barrier function can also contribute to gastrointestinal disorders, such as inflammatory bowel disease. **Research Implications** * **Understanding Urethral Epithelium**: Further research is needed to understand the complex interactions between the urethral epithelium and its surrounding tissues and to identify potential therapeutic targets for diseases affecting the urethra. * **Regulatory Pathways**: Investigation of the cell's involvement in regulatory pathways, such as apoptosis and cell cycle regulation, can provide insights into its response to diseases and treatments. * **Gene Expression Analysis**: Further analysis of gene expression in the urethral epithelium can identify potential biomarkers for disease and provide insights into the underlying mechanisms of disease.