Details for: TMA7

Gene ID: 51372

Symbol: TMA7

Ensembl ID: ENSG00000232112

Description: translation machinery associated 7 homolog

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 818.2186
    Cell Significance Index: -127.2700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 532.4405
    Cell Significance Index: -135.0500
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 425.8551
    Cell Significance Index: -175.4300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 356.2634
    Cell Significance Index: -168.2000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 335.0213
    Cell Significance Index: -172.3300
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 251.1542
    Cell Significance Index: -168.5300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 127.2065
    Cell Significance Index: -156.8400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 43.4029
    Cell Significance Index: -171.2700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 34.4690
    Cell Significance Index: -105.8700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 27.5901
    Cell Significance Index: -73.9100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 23.3575
    Cell Significance Index: -51.1200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 6.2699
    Cell Significance Index: 131.2400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 5.5984
    Cell Significance Index: 147.2100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 5.4703
    Cell Significance Index: 257.1000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 5.1893
    Cell Significance Index: 638.0700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 4.9814
    Cell Significance Index: 897.9900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 4.9555
    Cell Significance Index: 584.4100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 4.8399
    Cell Significance Index: 664.6600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 4.5196
    Cell Significance Index: 123.0200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 4.3201
    Cell Significance Index: 115.5600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 4.1774
    Cell Significance Index: 77.2100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 4.0324
    Cell Significance Index: 45.8100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 4.0249
    Cell Significance Index: 2198.0900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 3.9821
    Cell Significance Index: 36.6700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 3.9229
    Cell Significance Index: 277.4500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 3.9115
    Cell Significance Index: 291.5200
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 3.8933
    Cell Significance Index: 23.9600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 3.7385
    Cell Significance Index: 1652.9000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 3.6717
    Cell Significance Index: 171.1900
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 3.2995
    Cell Significance Index: 35.8700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 3.1649
    Cell Significance Index: 92.9500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 3.1265
    Cell Significance Index: 400.8100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 2.8587
    Cell Significance Index: 369.3300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 2.7708
    Cell Significance Index: 145.4800
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 2.7003
    Cell Significance Index: 21.5600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.5868
    Cell Significance Index: 166.8900
  • Cell Name: peg cell (CL4033014)
    Fold Change: 2.5602
    Cell Significance Index: 59.1500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 2.2319
    Cell Significance Index: 220.7900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.9926
    Cell Significance Index: 57.4100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.9413
    Cell Significance Index: 55.6500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.6852
    Cell Significance Index: 58.5600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.2703
    Cell Significance Index: 65.9900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.0448
    Cell Significance Index: 178.4100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.8722
    Cell Significance Index: 54.9700
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.8545
    Cell Significance Index: 15.1000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.8292
    Cell Significance Index: 627.6600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.7684
    Cell Significance Index: 146.2300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.6233
    Cell Significance Index: 125.0400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.5326
    Cell Significance Index: 14.2200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3658
    Cell Significance Index: 16.5800
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.3061
    Cell Significance Index: 3.9200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.2959
    Cell Significance Index: 216.9600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1979
    Cell Significance Index: 39.2800
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.1686
    Cell Significance Index: 2.5600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1615
    Cell Significance Index: 57.9500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.1449
    Cell Significance Index: 2.4300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0496
    Cell Significance Index: -93.4800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0513
    Cell Significance Index: -38.0300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0829
    Cell Significance Index: -51.7500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0980
    Cell Significance Index: -10.0200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.1019
    Cell Significance Index: -187.8400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.1219
    Cell Significance Index: -187.7000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.1485
    Cell Significance Index: -201.8700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.2037
    Cell Significance Index: -129.3700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.2048
    Cell Significance Index: -115.5000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.2202
    Cell Significance Index: -35.8100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.2395
    Cell Significance Index: -165.6800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2979
    Cell Significance Index: -62.7500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.3176
    Cell Significance Index: -144.1600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.4304
    Cell Significance Index: -49.3100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.4391
    Cell Significance Index: -126.3400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.6065
    Cell Significance Index: -16.9500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.8100
    Cell Significance Index: -64.1500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.8275
    Cell Significance Index: -21.1400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.9094
    Cell Significance Index: -62.8900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.9615
    Cell Significance Index: -112.0500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.9824
    Cell Significance Index: -142.8100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -1.0131
    Cell Significance Index: -62.2700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.0686
    Cell Significance Index: -34.2300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -1.1319
    Cell Significance Index: -129.2000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -1.2760
    Cell Significance Index: -19.1200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -1.3510
    Cell Significance Index: -29.2700
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -1.3748
    Cell Significance Index: -23.7000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -1.6394
    Cell Significance Index: -170.7000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -1.7116
    Cell Significance Index: -23.3500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -2.0052
    Cell Significance Index: -134.8300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -2.0342
    Cell Significance Index: -156.1000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -2.1182
    Cell Significance Index: -25.2500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -2.2010
    Cell Significance Index: -123.5100
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -2.2741
    Cell Significance Index: -13.7400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -2.7487
    Cell Significance Index: -168.5200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -2.7583
    Cell Significance Index: -47.2700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -3.2094
    Cell Significance Index: -94.5300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -3.2282
    Cell Significance Index: -142.7900
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -3.5251
    Cell Significance Index: -49.4100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -3.7978
    Cell Significance Index: -97.6200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -3.8949
    Cell Significance Index: -147.4900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -4.1300
    Cell Significance Index: -151.6100
  • Cell Name: theca cell (CL0000503)
    Fold Change: -4.1770
    Cell Significance Index: -24.5400
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -4.2813
    Cell Significance Index: -23.3500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Cellular Expression:** TMA7 is expressed in polychromatophilic erythroblast, hematopoietic oligopotent progenitor cells, embryonic stem cells, smooth muscle fibers of the ileum, peripheral blood mononuclear cells, ileal goblet cells, orthochromatic erythroblasts, stromal cells of bone marrow, CD8-positive alpha-beta regulatory T cells, CD8-alpha-beta-positive alpha-beta intraepithelial T cells, and other cell types. 2. **Protein Structure:** TMA7 is a protein that belongs to the translation machinery-associated protein family, which is involved in the regulation of translation initiation and elongation. 3. **Function:** TMA7 has been implicated in the regulation of gene expression, cell proliferation, differentiation, and survival. It may play a role in the modulation of translation initiation and elongation, as well as in the regulation of protein synthesis. **Pathways and Functions:** 1. **Translation Regulation:** TMA7 is involved in the regulation of translation initiation and elongation, which are critical processes in protein synthesis. It may interact with other translation factors to modulate the translation of specific mRNAs. 2. **Cell Proliferation and Differentiation:** TMA7 has been implicated in the regulation of cell proliferation and differentiation, particularly in hematopoietic cells. It may play a role in the modulation of gene expression during cell development and differentiation. 3. **Apoptosis and Cell Survival:** TMA7 has been shown to regulate apoptosis and cell survival in various cell types. It may interact with other proteins to modulate the apoptotic pathway and promote cell survival. 4. **Immune Response:** TMA7 has been expressed in immune cells, including T cells and dendritic cells. It may play a role in the regulation of the immune response, particularly in the context of T cell activation and differentiation. **Clinical Significance:** 1. **Hematological Disorders:** TMA7 has been implicated in various hematological disorders, including leukemia and lymphoma. It may play a role in the regulation of cell proliferation and differentiation in these diseases. 2. **Immunological Disorders:** TMA7 has been expressed in immune cells, including T cells and dendritic cells. It may play a role in the regulation of the immune response in immunological disorders, such as autoimmune diseases and allergies. 3. **Cancer:** TMA7 has been shown to be overexpressed in certain types of cancer, including breast cancer and lung cancer. It may play a role in the regulation of cell proliferation and survival in these cancers. 4. **Regenerative Medicine:** TMA7 has been implicated in the regulation of cell proliferation and differentiation in embryonic stem cells. It may play a role in the development of regenerative therapies for various diseases, including cardiovascular disease and neurodegenerative disorders. In conclusion, TMA7 is a protein involved in the regulation of translation machinery and has been implicated in various cellular processes, including cell proliferation, differentiation, and survival. Its widespread expression across different tissues and cell types underscores its importance in maintaining cellular homeostasis. Further studies are needed to elucidate the mechanisms of TMA7 and its role in various diseases, including hematological, immunological, and cancer disorders.

Genular Protein ID: 3849309820

Symbol: TMA7_HUMAN

Name: Translation machinery-associated protein 7

UniProtKB Accession Codes:

Q9Y2S6 Q9P052

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 5 Ensembl 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 STRING 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11042152

Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.

PubMed ID: 11042152

DOI: 10.1101/gr.140200

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16096800

Title: Identification of differentially expressed genes HSPC016 in dermal papilla cells with aggregative behavior.

PubMed ID: 16096800

DOI: 10.1007/s00403-005-0583-7

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 28190768

Title: Serine ADP-ribosylation depends on HPF1.

PubMed ID: 28190768

DOI: 10.1016/j.molcel.2017.01.003

Sequence Information:

  • Length: 64
  • Mass: 7066
  • Checksum: E79BA054EC176B74
  • Sequence:
    • MSGREGGKKK PLKQPKKQAK EMDEEDKAFK QKQKEEQKKL EELKAKAAGK GPLATGGIKK 
SGKK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.