Details for: CL1000343

Cell ID: CL1000343

Cell Name: paneth cell of epithelium of small intestine

Contexts:

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(Cell Significance Index is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers.)

Description: A paneth cell that is part of the epithelium of small intestine.

Image representation

Depiction of paneth cell of epithelium of small intestine
Courtesy of SwissBioPics

Genes (max top 200)

(CSI Score: Combines effect size and statistical significance for paneth cell of epithelium of small intestine. A higher CSI Score generally indicates a more significant expression difference.)

  • 1. Gene Symbol: DEFA6 (ENSG00000164822)
    CSI Score: 5.68
    Ensembl ID: ENSG00000164822
  • 2. Gene Symbol: PRSS2 (ENSG00000275896)
    CSI Score: 5.29
    Ensembl ID: ENSG00000275896
  • 3. Gene Symbol: DEFA5 (ENSG00000164816)
    CSI Score: 5.29
    Ensembl ID: ENSG00000164816
  • 4. Gene Symbol: GUCA2A (ENSG00000197273)
    CSI Score: 5.19
    Ensembl ID: ENSG00000197273
  • 5. Gene Symbol: LYZ (ENSG00000090382)
    CSI Score: 5.04
    Ensembl ID: ENSG00000090382
  • 6. Gene Symbol: REG1A (ENSG00000115386)
    CSI Score: 4.77
    Ensembl ID: ENSG00000115386
  • 7. Gene Symbol: REG3A (ENSG00000172016)
    CSI Score: 4.56
    Ensembl ID: ENSG00000172016
  • 8. Gene Symbol: TFF3 (ENSG00000160180)
    CSI Score: 4.53
    Ensembl ID: ENSG00000160180
  • 9. Gene Symbol: CLCA1 (ENSG00000016490)
    CSI Score: 3.85
    Ensembl ID: ENSG00000016490
  • 10. Gene Symbol: PDIA2 (ENSG00000185615)
    CSI Score: 3.53
    Ensembl ID: ENSG00000185615
  • 11. Gene Symbol: ANO7 (ENSG00000146205)
    CSI Score: 3.42
    Ensembl ID: ENSG00000146205
  • 12. Gene Symbol: NOXO1 (ENSG00000196408)
    CSI Score: 3.15
    Ensembl ID: ENSG00000196408
  • 13. Gene Symbol: REP15 (ENSG00000174236)
    CSI Score: 3.04
    Ensembl ID: ENSG00000174236
  • 14. Gene Symbol: ENTPD8 (ENSG00000188833)
    CSI Score: 3.03
    Ensembl ID: ENSG00000188833
  • 15. Gene Symbol: TENT5C (ENSG00000183508)
    CSI Score: 2.79
    Ensembl ID: ENSG00000183508
  • 16. Gene Symbol: PLA2G2A (ENSG00000188257)
    CSI Score: 2.57
    Ensembl ID: ENSG00000188257
  • 17. Gene Symbol: PROM1 (ENSG00000007062)
    CSI Score: 2.53
    Ensembl ID: ENSG00000007062
  • 18. Gene Symbol: IGFBP2 (ENSG00000115457)
    CSI Score: 2.52
    Ensembl ID: ENSG00000115457
  • 19. Gene Symbol: HES6 (ENSG00000144485)
    CSI Score: 2.41
    Ensembl ID: ENSG00000144485
  • 20. Gene Symbol: TBC1D8B (ENSG00000133138)
    CSI Score: 2.37
    Ensembl ID: ENSG00000133138
  • 21. Gene Symbol: SERPINA1 (ENSG00000197249)
    CSI Score: 2.23
    Ensembl ID: ENSG00000197249
  • 22. Gene Symbol: PYCR1 (ENSG00000183010)
    CSI Score: 2.09
    Ensembl ID: ENSG00000183010
  • 23. Gene Symbol: RNASE1 (ENSG00000129538)
    CSI Score: 1.96
    Ensembl ID: ENSG00000129538
  • 24. Gene Symbol: HPCAL1 (ENSG00000115756)
    CSI Score: 1.94
    Ensembl ID: ENSG00000115756
  • 25. Gene Symbol: FBXL4 (ENSG00000112234)
    CSI Score: 1.83
    Ensembl ID: ENSG00000112234
  • 26. Gene Symbol: PLPP5 (ENSG00000147535)
    CSI Score: 1.73
    Ensembl ID: ENSG00000147535
  • 27. Gene Symbol: PROX1 (ENSG00000117707)
    CSI Score: 1.63
    Ensembl ID: ENSG00000117707
  • 28. Gene Symbol: GOLGA5 (ENSG00000066455)
    CSI Score: 1.62
    Ensembl ID: ENSG00000066455
  • 29. Gene Symbol: CDKN1C (ENSG00000129757)
    CSI Score: 1.51
    Ensembl ID: ENSG00000129757
  • 30. Gene Symbol: DYRK4 (ENSG00000010219)
    CSI Score: 1.22
    Ensembl ID: ENSG00000010219
  • 31. Gene Symbol: SGTA (ENSG00000104969)
    CSI Score: 1.19
    Ensembl ID: ENSG00000104969
  • 32. Gene Symbol: FAM107B (ENSG00000065809)
    CSI Score: 1.13
    Ensembl ID: ENSG00000065809
  • 33. Gene Symbol: GFUS (ENSG00000104522)
    CSI Score: 1.08
    Ensembl ID: ENSG00000104522
  • 34. Gene Symbol: SEC11C (ENSG00000166562)
    CSI Score: 1.05
    Ensembl ID: ENSG00000166562
  • 35. Gene Symbol: MFSD3 (ENSG00000167700)
    CSI Score: 0.96
    Ensembl ID: ENSG00000167700
  • 36. Gene Symbol: PRUNE2 (ENSG00000106772)
    CSI Score: 0.93
    Ensembl ID: ENSG00000106772
  • 37. Gene Symbol: ME3 (ENSG00000151376)
    CSI Score: 0.92
    Ensembl ID: ENSG00000151376
  • 38. Gene Symbol: CRELD2 (ENSG00000184164)
    CSI Score: 0.9
    Ensembl ID: ENSG00000184164
  • 39. Gene Symbol: PELI1 (ENSG00000197329)
    CSI Score: 0.78
    Ensembl ID: ENSG00000197329
  • 40. Gene Symbol: DEF8 (ENSG00000140995)
    CSI Score: 0.75
    Ensembl ID: ENSG00000140995
  • 41. Gene Symbol: DEPP1 (ENSG00000165507)
    CSI Score: 0.71
    Ensembl ID: ENSG00000165507
  • 42. Gene Symbol: SETBP1 (ENSG00000152217)
    CSI Score: 0.58
    Ensembl ID: ENSG00000152217
  • 43. Gene Symbol: PRDX4 (ENSG00000123131)
    CSI Score: 0.56
    Ensembl ID: ENSG00000123131
  • 44. Gene Symbol: TMX4 (ENSG00000125827)
    CSI Score: 0.41
    Ensembl ID: ENSG00000125827
  • 45. Gene Symbol: BACE1 (ENSG00000186318)
    CSI Score: 0.38
    Ensembl ID: ENSG00000186318
  • 46. Gene Symbol: SSR4 (ENSG00000180879)
    CSI Score: 0.36
    Ensembl ID: ENSG00000180879
  • 47. Gene Symbol: CTNNB1 (ENSG00000168036)
    CSI Score: 0.33
    Ensembl ID: ENSG00000168036
  • 48. Gene Symbol: DUSP10 (ENSG00000143507)
    CSI Score: 0.24
    Ensembl ID: ENSG00000143507
  • 49. Gene Symbol: HSPB1 (ENSG00000106211)
    CSI Score: 0.24
    Ensembl ID: ENSG00000106211
  • 50. Gene Symbol: SELENOM (ENSG00000198832)
    CSI Score: 0.23
    Ensembl ID: ENSG00000198832
  • 51. Gene Symbol: HERPUD1 (ENSG00000051108)
    CSI Score: 0.22
    Ensembl ID: ENSG00000051108
  • 52. Gene Symbol: SRM (ENSG00000116649)
    CSI Score: 0.2
    Ensembl ID: ENSG00000116649
  • 53. Gene Symbol: FKBP11 (ENSG00000134285)
    CSI Score: 0.15
    Ensembl ID: ENSG00000134285
  • 54. Gene Symbol: SRSF6 (ENSG00000124193)
    CSI Score: 0.14
    Ensembl ID: ENSG00000124193
  • 55. Gene Symbol: NUCB2 (ENSG00000070081)
    CSI Score: 0.13
    Ensembl ID: ENSG00000070081
  • 56. Gene Symbol: IFI6 (ENSG00000126709)
    CSI Score: 0.11
    Ensembl ID: ENSG00000126709
  • 57. Gene Symbol: SYNC (ENSG00000162520)
    CSI Score: 0.07
    Ensembl ID: ENSG00000162520
  • 58. Gene Symbol: PRKAR1A (ENSG00000108946)
    CSI Score: 0.04
    Ensembl ID: ENSG00000108946
  • 59. Gene Symbol: SMOC2 (ENSG00000112562)
    CSI Score: 0.01
    Ensembl ID: ENSG00000112562
  • 60. Gene Symbol: SELENOK (ENSG00000113811)
    CSI Score: -0.05
    Ensembl ID: ENSG00000113811

Gene ID: A unique numerical identifier for this specific gene.
Symbol: Shortened abbreviation or name that represents this gene.
Ensembl Gene ID: A unique identifier assigned by Ensembl for genomic data mapping.
CSI Score: A combined effect size and statistical significance measure for paneth cell of epithelium of small intestine. Higher scores indicate a stronger, more significant difference in expression.
(Previously described as "Fold Change", but now represents Cliff's Delta × –log10(p).)

Gene ID: A unique numerical identifier for this specific gene.
Symbol: Shortened abbreviation or name that represents this gene.
Ensembl Gene ID: A unique identifier assigned by Ensembl for genomic data mapping.
CSI Score: A combined effect size and statistical significance measure for paneth cell of epithelium of small intestine. Higher scores indicate a stronger, more significant difference in expression.
Average CSI: csi sum / gene count
**Key Characteristics** Paneth cells are characterized by the following key features: 1. **Location**: Paneth cells are found in the crypts of Lieberkühn in the small intestine, specifically in the duodenum and jejunum. 2. **Gene Expression**: Paneth cells express a unique set of genes, including those involved in antimicrobial peptide production (e.g., defensins), immune response (e.g., cytokines), and metabolic regulation (e.g., ATP:ADP antiporter). 3. **Antimicrobial Peptide Production**: Paneth cells produce antimicrobial peptides, such as defensins, which help to maintain a healthy gut microbiome. 4. **Immune Response**: Paneth cells are involved in the regulation of the immune response, including the production of cytokines and the activation of immune cells. 5. **Metabolic Regulation**: Paneth cells are involved in the regulation of metabolic processes, including the production of ATP and the transport of small molecules across the plasma membrane. **Clinical Significance** Paneth cells play a crucial role in maintaining intestinal homeostasis and immune function, and dysregulation of paneth cell function has been implicated in various diseases, including: 1. **Inflammatory Bowel Disease (IBD)**: Paneth cell dysfunction has been implicated in the pathogenesis of IBD, including Crohn's disease and ulcerative colitis. 2. **Cancer**: Paneth cell dysfunction has been linked to an increased risk of colorectal cancer. 3. **Gastrointestinal Disorders**: Paneth cell dysfunction has been implicated in various gastrointestinal disorders, including irritable bowel syndrome (IBS) and gastroesophageal reflux disease (GERD). **Pathways** Paneth cells are involved in various signaling pathways, including: 1. **Apoptotic Process**: Paneth cells are involved in the regulation of the apoptotic process, which helps to maintain tissue homeostasis. 2. **ATP:ADP Antiporter Activity**: Paneth cells express ATP:ADP antiporter, which helps to regulate metabolic processes. 3. **Disease**: Paneth cell dysfunction has been implicated in various diseases, including IBD, cancer, and gastrointestinal disorders. 4. **Host Interactions of HIV Factors**: Paneth cells are involved in the regulation of host interactions with HIV factors. 5. **Infectious Disease**: Paneth cells are involved in the regulation of infectious disease, including the production of antimicrobial peptides and the activation of immune cells. In conclusion, paneth cells are specialized epithelial cells that play a crucial role in maintaining intestinal homeostasis and immune function. Their unique gene expression profile and involvement in various signaling pathways make them an important target for the study of various diseases.