Details for: CL1000343

Cell ID: CL1000343

Cell Name: paneth cell of epithelium of small intestine

Marker Score Threshold: 248
(Derived using integrated single-cell and genomic data)

Description: A paneth cell that is part of the epithelium of small intestine.

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 3.77
    Ensembl ID: ENSG00000169100
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 3.44
    Ensembl ID: ENSG00000075624
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 3.22
    Ensembl ID: ENSG00000166710
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 2.87
    Ensembl ID: ENSG00000145741
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.73
    Ensembl ID: ENSG00000184009
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 2.69
    Ensembl ID: ENSG00000135390
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 2.61
    Ensembl ID: ENSG00000133639
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.55
    Ensembl ID: ENSG00000067560
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 2.52
    Ensembl ID: ENSG00000198668
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 2.42
    Ensembl ID: ENSG00000124172
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 2.24
    Ensembl ID: ENSG00000099624
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 2.23
    Ensembl ID: ENSG00000182718
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 2.17
    Ensembl ID: ENSG00000130402
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 2.14
    Ensembl ID: ENSG00000143933
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 2.13
    Ensembl ID: ENSG00000169020
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 2.12
    Ensembl ID: ENSG00000122359
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 2.04
    Ensembl ID: ENSG00000179218
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 2.03
    Ensembl ID: ENSG00000163399
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 2.02
    Ensembl ID: ENSG00000185650
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 2.01
    Ensembl ID: ENSG00000143761
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 2
    Ensembl ID: ENSG00000072778
  • Gene Symbol: ATF3 (ENSG00000162772)
    Fold Change: 2
    Ensembl ID: ENSG00000162772
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 1.97
    Ensembl ID: ENSG00000134825
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 1.95
    Ensembl ID: ENSG00000143878
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 1.93
    Ensembl ID: ENSG00000005022
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 1.91
    Ensembl ID: ENSG00000152518
  • Gene Symbol: BLVRB (ENSG00000090013)
    Fold Change: 1.89
    Ensembl ID: ENSG00000090013
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.85
    Ensembl ID: ENSG00000110955
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.82
    Ensembl ID: ENSG00000084234
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 1.82
    Ensembl ID: ENSG00000154723
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 1.8
    Ensembl ID: ENSG00000154518
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.79
    Ensembl ID: ENSG00000172270
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.77
    Ensembl ID: ENSG00000152234
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.75
    Ensembl ID: ENSG00000128272
  • Gene Symbol: ALDOB (ENSG00000136872)
    Fold Change: 1.73
    Ensembl ID: ENSG00000136872
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.7
    Ensembl ID: ENSG00000198931
  • Gene Symbol: ALDH1A1 (ENSG00000165092)
    Fold Change: 1.68
    Ensembl ID: ENSG00000165092
  • Gene Symbol: ARHGAP5 (ENSG00000100852)
    Fold Change: 1.68
    Ensembl ID: ENSG00000100852
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.67
    Ensembl ID: ENSG00000117410
  • Gene Symbol: DST (ENSG00000151914)
    Fold Change: 1.65
    Ensembl ID: ENSG00000151914
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.64
    Ensembl ID: ENSG00000164111
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.64
    Ensembl ID: ENSG00000168374
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.62
    Ensembl ID: ENSG00000165629
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.62
    Ensembl ID: ENSG00000085224
  • Gene Symbol: ATP1B1 (ENSG00000143153)
    Fold Change: 1.6
    Ensembl ID: ENSG00000143153
  • Gene Symbol: BAG1 (ENSG00000107262)
    Fold Change: 1.6
    Ensembl ID: ENSG00000107262
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.58
    Ensembl ID: ENSG00000148700
  • Gene Symbol: ANPEP (ENSG00000166825)
    Fold Change: 1.58
    Ensembl ID: ENSG00000166825
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.57
    Ensembl ID: ENSG00000104964
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 1.57
    Ensembl ID: ENSG00000111348
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.52
    Ensembl ID: ENSG00000104765
  • Gene Symbol: KLF5 (ENSG00000102554)
    Fold Change: 1.49
    Ensembl ID: ENSG00000102554
  • Gene Symbol: RHOC (ENSG00000155366)
    Fold Change: 1.49
    Ensembl ID: ENSG00000155366
  • Gene Symbol: RND3 (ENSG00000115963)
    Fold Change: 1.49
    Ensembl ID: ENSG00000115963
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.48
    Ensembl ID: ENSG00000241837
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 1.48
    Ensembl ID: ENSG00000135046
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.48
    Ensembl ID: ENSG00000141522
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.43
    Ensembl ID: ENSG00000149925
  • Gene Symbol: PTTG1IP (ENSG00000183255)
    Fold Change: 1.41
    Ensembl ID: ENSG00000183255
  • Gene Symbol: CA2 (ENSG00000104267)
    Fold Change: 1.39
    Ensembl ID: ENSG00000104267
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 1.37
    Ensembl ID: ENSG00000142192
  • Gene Symbol: AREG (ENSG00000109321)
    Fold Change: 1.37
    Ensembl ID: ENSG00000109321
  • Gene Symbol: ASL (ENSG00000126522)
    Fold Change: 1.35
    Ensembl ID: ENSG00000126522
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.33
    Ensembl ID: ENSG00000116459
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.32
    Ensembl ID: ENSG00000104763
  • Gene Symbol: ALDH2 (ENSG00000111275)
    Fold Change: 1.32
    Ensembl ID: ENSG00000111275
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.32
    Ensembl ID: ENSG00000069849
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.32
    Ensembl ID: ENSG00000160014
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.31
    Ensembl ID: ENSG00000123505
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 1.31
    Ensembl ID: ENSG00000100300
  • Gene Symbol: AOC1 (ENSG00000002726)
    Fold Change: 1.28
    Ensembl ID: ENSG00000002726
  • Gene Symbol: ACOX1 (ENSG00000161533)
    Fold Change: 1.28
    Ensembl ID: ENSG00000161533
  • Gene Symbol: KLF9 (ENSG00000119138)
    Fold Change: 1.28
    Ensembl ID: ENSG00000119138
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.27
    Ensembl ID: ENSG00000159199
  • Gene Symbol: ACO2 (ENSG00000100412)
    Fold Change: 1.25
    Ensembl ID: ENSG00000100412
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.24
    Ensembl ID: ENSG00000138279
  • Gene Symbol: ATP2A2 (ENSG00000174437)
    Fold Change: 1.24
    Ensembl ID: ENSG00000174437
  • Gene Symbol: BST2 (ENSG00000130303)
    Fold Change: 1.21
    Ensembl ID: ENSG00000130303
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.21
    Ensembl ID: ENSG00000165527
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.2
    Ensembl ID: ENSG00000115307
  • Gene Symbol: ANXA4 (ENSG00000196975)
    Fold Change: 1.2
    Ensembl ID: ENSG00000196975
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.19
    Ensembl ID: ENSG00000177556
  • Gene Symbol: ACAA1 (ENSG00000060971)
    Fold Change: 1.18
    Ensembl ID: ENSG00000060971
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.14
    Ensembl ID: ENSG00000108561
  • Gene Symbol: ATM (ENSG00000149311)
    Fold Change: 1.14
    Ensembl ID: ENSG00000149311
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.13
    Ensembl ID: ENSG00000160710
  • Gene Symbol: ANXA6 (ENSG00000197043)
    Fold Change: 1.13
    Ensembl ID: ENSG00000197043
  • Gene Symbol: PARP1 (ENSG00000143799)
    Fold Change: 1.1
    Ensembl ID: ENSG00000143799
  • Gene Symbol: ADAM10 (ENSG00000137845)
    Fold Change: 1.09
    Ensembl ID: ENSG00000137845
  • Gene Symbol: CRYBG1 (ENSG00000112297)
    Fold Change: 1.08
    Ensembl ID: ENSG00000112297
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.07
    Ensembl ID: ENSG00000143727
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 1.07
    Ensembl ID: ENSG00000142599
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.06
    Ensembl ID: ENSG00000087274
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.05
    Ensembl ID: ENSG00000100823
  • Gene Symbol: ALDH3A2 (ENSG00000072210)
    Fold Change: 1.04
    Ensembl ID: ENSG00000072210
  • Gene Symbol: PLIN2 (ENSG00000147872)
    Fold Change: 1.02
    Ensembl ID: ENSG00000147872
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.02
    Ensembl ID: ENSG00000070961
  • Gene Symbol: PARP4 (ENSG00000102699)
    Fold Change: 1.01
    Ensembl ID: ENSG00000102699
  • Gene Symbol: RHOG (ENSG00000177105)
    Fold Change: 1
    Ensembl ID: ENSG00000177105
  • Gene Symbol: ASPH (ENSG00000198363)
    Fold Change: N/A
    Ensembl ID: ENSG00000198363
Hovered Details

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Hovered Details

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**Key Characteristics** Paneth cells are characterized by their: 1. **Location**: Paneth cells are found in the crypts of Lieberkühn, the epithelial lining of the small intestine. 2. **Morphology**: Paneth cells are large, polyhedral cells with a distinctive granular appearance. 3. **Expression of genes**: Paneth cells express specific genes, including SLC25A6, which is involved in mitochondrial ATP/ADP antiporter activity. 4. **Apoptotic process**: Paneth cells undergo programmed cell death (apoptosis) in response to various stimuli, including inflammation and infection. **Clinical Significance** Paneth cells play a crucial role in maintaining intestinal homeostasis and immune function. Dysregulation of Paneth cell function has been implicated in various diseases, including: 1. **Inflammatory bowel disease (IBD)**: Paneth cell dysfunction has been linked to the pathogenesis of IBD, including Crohn's disease and ulcerative colitis. 2. **Cancer**: Paneth cells have been implicated in the development of intestinal cancer, including colorectal cancer. 3. **Immune system disorders**: Paneth cells play a critical role in the development and function of the immune system, and dysregulation of Paneth cell function has been implicated in various immune system disorders. **Molecular Mechanisms** Paneth cells are involved in various cellular processes, including: 1. **Apoptosis**: Paneth cells undergo programmed cell death (apoptosis) in response to various stimuli, including inflammation and infection. 2. **Protein metabolism**: Paneth cells are involved in the metabolism of proteins, including the degradation and recycling of proteins. 3. **Immune responses**: Paneth cells play a critical role in the development and function of the immune system, and are involved in the presentation of antigens to T-cells. **Gene Symbol and Ensembl ID** The gene symbol for Paneth cell is SLC25A6, and the Ensembl ID is ENSG00000169100.