Details for: CAPN15

Gene ID: 6650

Symbol: CAPN15

Ensembl ID: ENSG00000103326

Description: calpain 15

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 87.0486
    Cell Significance Index: -13.5400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 54.8408
    Cell Significance Index: -13.9100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 33.4763
    Cell Significance Index: -13.6000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 30.1962
    Cell Significance Index: -15.5300
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 23.4269
    Cell Significance Index: -15.7200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 14.3808
    Cell Significance Index: -13.7300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 11.6955
    Cell Significance Index: -14.4200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 5.7860
    Cell Significance Index: -15.5000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.6948
    Cell Significance Index: -14.5800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 3.1256
    Cell Significance Index: -9.6000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 2.6775
    Cell Significance Index: -5.8600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.9062
    Cell Significance Index: 54.9200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.8444
    Cell Significance Index: 299.9700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.8001
    Cell Significance Index: 178.0700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.2655
    Cell Significance Index: 147.4900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.1987
    Cell Significance Index: 25.9700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.1470
    Cell Significance Index: 124.7600
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.1054
    Cell Significance Index: 9.4000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.0401
    Cell Significance Index: 47.1500
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.9517
    Cell Significance Index: 14.2600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.8362
    Cell Significance Index: 165.9500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.6699
    Cell Significance Index: 9.1400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.6239
    Cell Significance Index: 43.1500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.4550
    Cell Significance Index: 12.7200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.4147
    Cell Significance Index: 83.1800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3966
    Cell Significance Index: 20.6000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3218
    Cell Significance Index: 222.5700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.3154
    Cell Significance Index: 9.0400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.2884
    Cell Significance Index: 7.2100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.2849
    Cell Significance Index: 10.0100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2550
    Cell Significance Index: 45.9600
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.2473
    Cell Significance Index: 3.6500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2284
    Cell Significance Index: 14.7400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.1962
    Cell Significance Index: 5.3400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1873
    Cell Significance Index: 3.9900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1859
    Cell Significance Index: 66.6800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1857
    Cell Significance Index: 167.6600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.1571
    Cell Significance Index: 7.9400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1519
    Cell Significance Index: 11.6600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1411
    Cell Significance Index: 24.1000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1325
    Cell Significance Index: 72.3400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1193
    Cell Significance Index: 5.6100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.1179
    Cell Significance Index: 6.1400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.1097
    Cell Significance Index: 2.9400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0949
    Cell Significance Index: 4.4300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0899
    Cell Significance Index: 11.0500
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.0882
    Cell Significance Index: 0.5800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0844
    Cell Significance Index: 16.0700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0776
    Cell Significance Index: 10.6600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0560
    Cell Significance Index: 24.7800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0203
    Cell Significance Index: 2.3900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0081
    Cell Significance Index: 15.1600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0025
    Cell Significance Index: 4.6700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0004
    Cell Significance Index: 0.5500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0009
    Cell Significance Index: -0.1200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0047
    Cell Significance Index: -2.9800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0057
    Cell Significance Index: -7.8000
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0093
    Cell Significance Index: -0.1500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0110
    Cell Significance Index: -8.3300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0122
    Cell Significance Index: -8.9400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0126
    Cell Significance Index: -5.7000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0144
    Cell Significance Index: -10.6400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0153
    Cell Significance Index: -1.0800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0173
    Cell Significance Index: -1.0900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0224
    Cell Significance Index: -12.6200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0229
    Cell Significance Index: -2.9300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0280
    Cell Significance Index: -17.5100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0366
    Cell Significance Index: -3.7400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0371
    Cell Significance Index: -0.9900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0383
    Cell Significance Index: -5.5700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0388
    Cell Significance Index: -4.4500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0420
    Cell Significance Index: -12.0900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0452
    Cell Significance Index: -3.3700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0516
    Cell Significance Index: -1.1300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0516
    Cell Significance Index: -0.8900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0520
    Cell Significance Index: -2.9200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0682
    Cell Significance Index: -1.2600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0755
    Cell Significance Index: -15.9100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0821
    Cell Significance Index: -3.6300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1151
    Cell Significance Index: -4.3600
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1159
    Cell Significance Index: -1.2000
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.1202
    Cell Significance Index: -1.8300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1252
    Cell Significance Index: -4.0100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1284
    Cell Significance Index: -13.3700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1342
    Cell Significance Index: -8.2300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1508
    Cell Significance Index: -2.1600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1789
    Cell Significance Index: -14.1700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1867
    Cell Significance Index: -9.8000
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.1986
    Cell Significance Index: -3.3500
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.2252
    Cell Significance Index: -3.3300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2354
    Cell Significance Index: -3.9400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2356
    Cell Significance Index: -5.0000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2474
    Cell Significance Index: -6.3600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.2572
    Cell Significance Index: -5.0200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2586
    Cell Significance Index: -9.0600
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.2634
    Cell Significance Index: -3.7500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2656
    Cell Significance Index: -8.4600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2865
    Cell Significance Index: -9.3800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.2883
    Cell Significance Index: -2.6600
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.2905
    Cell Significance Index: -4.0300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** CAPN15 exhibits several key characteristics that distinguish it from other calpain family members: 1. **Calcium-dependent activity**: CAPN15 is activated by calcium ions, which is essential for its proteolytic activity. 2. **Specific substrate recognition**: CAPN15 exhibits specificity for certain substrates, including the extracellular matrix proteins, which suggests its role in regulating tissue architecture and remodeling. 3. **Cell type-specific expression**: CAPN15 is expressed in various cell types, suggesting its involvement in different cellular processes and functions. **Pathways and Functions** CAPN15 is involved in several cellular pathways, including: 1. **Proteolysis**: CAPN15 regulates the degradation of extracellular matrix proteins, which is essential for tissue remodeling and maintenance. 2. **Cytoskeletal dynamics**: CAPN15 modulates the activity of cytoskeletal proteins, such as actin and tubulin, which is crucial for maintaining cell shape and function. 3. **Cell signaling**: CAPN15 regulates the activity of signaling molecules, including GABA, which is involved in neuronal development and function. 4. **Metal ion binding**: CAPN15 binds to metal ions, such as calcium and magnesium, which is necessary for its enzymatic activity. **Clinical Significance** Dysregulation of CAPN15 has been implicated in various diseases, including: 1. **Neurodegenerative disorders**: Mutations in CAPN15 have been associated with neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. 2. **Cancer**: CAPN15 has been implicated in cancer progression, including the degradation of extracellular matrix proteins and the modulation of cell signaling pathways. 3. **Kidney disease**: CAPN15 has been shown to play a role in kidney disease, including the regulation of extracellular matrix proteins and the modulation of cell signaling pathways. In conclusion, Calpain-15 is a calcium-dependent cysteine-type endopeptidase enzyme that plays a critical role in maintaining cellular homeostasis across various tissues. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the mechanisms of CAPN15 and its potential therapeutic applications.

Genular Protein ID: 2081955019

Symbol: CAN15_HUMAN

Name: Calpain-15

UniProtKB Accession Codes:

O75808 B1B1M4 Q2KHS2 Q8WTY9 Q9BUW0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EC 1 EMBL 7 Ensembl 1 ExpressionAtlas 1 GO 4 Gene3D 3 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MEROPS 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9722942

Title: SOLH, a human homologue of the Drosophila melanogaster small optic lobes gene is a member of the calpain and zinc-finger gene families and maps to human chromosome 16p13.3 near CATM (cataract with microphthalmia).

PubMed ID: 9722942

DOI: 10.1006/geno.1998.5395

PubMed ID: 11157797

Title: Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16.

PubMed ID: 11157797

DOI: 10.1093/hmg/10.4.339

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 32885237

Title: Biallelic variants in the small optic lobe calpain CAPN15 are associated with congenital eye anomalies, deafness and other neurodevelopmental deficits.

PubMed ID: 32885237

DOI: 10.1093/hmg/ddaa198

Sequence Information:

  • Length: 1086
  • Mass: 117314
  • Checksum: 9809A5CF9134A12C
  • Sequence:
    • MATVGEWSCV RCTFLNPAGQ RQCSICEAPR HKPDLNHILR LSVEEQKWPC ARCTFRNFLG 
KEACEVCGFT PEPAPGAAFL PVLNGVLPKP PAILGEPKGS CQEEAGPVRT AGLVATEPAR 
GQCEDKDEEE KEEQEEEEGA AEPRGGWACP RCTLHNTPVA SSCSVCGGPR RLSLPRIPPE 
ALVVPEVVAP AGFHVVPAAP PPGLPGEGAE ANPPATSQGP AAEPEPPRVP PFSPFSSTLQ 
NNPVPRSRRE VPPQLQPPVP EAAQPSPSAG CRGAPQGSGW AGASRLAELL SGKRLSVLEE 
EATEGGTSRV EAGSSTSGSD IIDLAGDTVR YTPASPSSPD FTTWSCAKCT LRNPTVAPRC 
SACGCSKLHG FQEHGEPPTH CPDCGADKPS PCGRSCGRVS SAQKAARVLP ERPGQWACPA 
CTLLNALRAK HCAACHTPQL LVAQRRGAAP LRRRESMHVE QRRQTDEGEA KALWENIVAF 
CRENNVSFVD DSFPPGPESV GFPAGDSVQQ RVRQWLRPQE INCSVFRDHR ATWSVFHTLR 
PSDILQGLLG NCWFLSALAV LAERPDLVER VMVTRSLCAE GAYQVRLCKD GTWTTVLVDD 
MLPCDEAGCL LFSQAQRKQL WVALIEKALA KLHGSYFALQ AGRAIEGLAT LTGAPCESLA 
LQLSSTNPRE EPVDTDLIWA KMLSSKEAGF LMGASCGGGN MKVDDSAYES LGLRPRHAYS 
ILDVRDVQGT RLLRLRNPWG RFSWNGSWSD EWPHWPGHLR GELMPHGSSE GVFWMEYGDF 
VRYFDSVDIC KVHSDWQEAR VQGCFPSSAS APVGVTALTV LERASLEFAL FQEGSRRSDA 
VDSHLLDLCI LVFRATFGSG GHLSLGRLLA HSKRAVKKFV SCDVMLEPGE YAVVCCAFNH 
WGPPLPGTPA PQASSPSAGV PRASPEPPGH VLAVYSSRLV MVEPVEAQPT TLADAIILLT 
ESRGERHEGR EGMTCYYLTH GWAGLIVVVE NRHPKAYLHV QCDCTDSFNV VSTRGSLRTQ 
DSVPPLHRQV LVILSQLEGN AGFSITHRLA HRKAAQAFLS DWTASKGTHS PPLTPEVAGL 
HGPRPL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.