Details for: CL1000449

Cell ID: CL1000449

Cell Name: epithelial cell of nephron

Marker Score Threshold: 2088
(Derived using integrated single-cell and genomic data)

Description: An epithelial cell that is part of the nephron.

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 2.87
    Ensembl ID: ENSG00000075624
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.82
    Ensembl ID: ENSG00000184009
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 2.8
    Ensembl ID: ENSG00000135390
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 2.75
    Ensembl ID: ENSG00000169100
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 2.74
    Ensembl ID: ENSG00000124172
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 2.73
    Ensembl ID: ENSG00000110955
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 2.71
    Ensembl ID: ENSG00000154518
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 2.7
    Ensembl ID: ENSG00000152234
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 2.65
    Ensembl ID: ENSG00000169020
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 2.64
    Ensembl ID: ENSG00000154723
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 2.62
    Ensembl ID: ENSG00000241837
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 2.59
    Ensembl ID: ENSG00000100823
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.51
    Ensembl ID: ENSG00000067560
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 2.46
    Ensembl ID: ENSG00000142192
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 2.43
    Ensembl ID: ENSG00000165629
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 2.41
    Ensembl ID: ENSG00000116459
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 2.4
    Ensembl ID: ENSG00000166710
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 2.36
    Ensembl ID: ENSG00000005022
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 2.36
    Ensembl ID: ENSG00000143761
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 2.28
    Ensembl ID: ENSG00000143727
  • Gene Symbol: ADH5 (ENSG00000197894)
    Fold Change: 2.26
    Ensembl ID: ENSG00000197894
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 2.26
    Ensembl ID: ENSG00000168374
  • Gene Symbol: ARL3 (ENSG00000138175)
    Fold Change: 2.18
    Ensembl ID: ENSG00000138175
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 2.15
    Ensembl ID: ENSG00000177556
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 2.14
    Ensembl ID: ENSG00000198931
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 2.14
    Ensembl ID: ENSG00000104765
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 2.09
    Ensembl ID: ENSG00000117410
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 2.06
    Ensembl ID: ENSG00000084234
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 2.06
    Ensembl ID: ENSG00000128272
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 2.01
    Ensembl ID: ENSG00000004059
  • Gene Symbol: PARP1 (ENSG00000143799)
    Fold Change: 1.96
    Ensembl ID: ENSG00000143799
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.96
    Ensembl ID: ENSG00000159199
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.95
    Ensembl ID: ENSG00000085224
  • Gene Symbol: BNIP3 (ENSG00000176171)
    Fold Change: 1.94
    Ensembl ID: ENSG00000176171
  • Gene Symbol: AK2 (ENSG00000004455)
    Fold Change: 1.88
    Ensembl ID: ENSG00000004455
  • Gene Symbol: AHCY (ENSG00000101444)
    Fold Change: 1.85
    Ensembl ID: ENSG00000101444
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.84
    Ensembl ID: ENSG00000164111
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.77
    Ensembl ID: ENSG00000163399
  • Gene Symbol: ARL2 (ENSG00000213465)
    Fold Change: 1.77
    Ensembl ID: ENSG00000213465
  • Gene Symbol: AKR1B1 (ENSG00000085662)
    Fold Change: 1.72
    Ensembl ID: ENSG00000085662
  • Gene Symbol: ACTL6A (ENSG00000136518)
    Fold Change: 1.72
    Ensembl ID: ENSG00000136518
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.68
    Ensembl ID: ENSG00000070961
  • Gene Symbol: ALDH7A1 (ENSG00000164904)
    Fold Change: 1.67
    Ensembl ID: ENSG00000164904
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.66
    Ensembl ID: ENSG00000123505
  • Gene Symbol: AAMP (ENSG00000127837)
    Fold Change: 1.66
    Ensembl ID: ENSG00000127837
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.64
    Ensembl ID: ENSG00000141522
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: 1.61
    Ensembl ID: ENSG00000087088
  • Gene Symbol: GET3 (ENSG00000198356)
    Fold Change: 1.59
    Ensembl ID: ENSG00000198356
  • Gene Symbol: BAD (ENSG00000002330)
    Fold Change: 1.59
    Ensembl ID: ENSG00000002330
  • Gene Symbol: RHOC (ENSG00000155366)
    Fold Change: 1.56
    Ensembl ID: ENSG00000155366
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.55
    Ensembl ID: ENSG00000130402
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 1.54
    Ensembl ID: ENSG00000143878
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 1.54
    Ensembl ID: ENSG00000099624
  • Gene Symbol: ATIC (ENSG00000138363)
    Fold Change: 1.52
    Ensembl ID: ENSG00000138363
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.51
    Ensembl ID: ENSG00000115307
  • Gene Symbol: ACADM (ENSG00000117054)
    Fold Change: 1.48
    Ensembl ID: ENSG00000117054
  • Gene Symbol: ATP6AP1 (ENSG00000071553)
    Fold Change: 1.47
    Ensembl ID: ENSG00000071553
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.47
    Ensembl ID: ENSG00000148700
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.46
    Ensembl ID: ENSG00000072778
  • Gene Symbol: PLIN2 (ENSG00000147872)
    Fold Change: 1.46
    Ensembl ID: ENSG00000147872
  • Gene Symbol: ARL1 (ENSG00000120805)
    Fold Change: 1.45
    Ensembl ID: ENSG00000120805
  • Gene Symbol: BCL7A (ENSG00000110987)
    Fold Change: 1.43
    Ensembl ID: ENSG00000110987
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.43
    Ensembl ID: ENSG00000104763
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.42
    Ensembl ID: ENSG00000069849
  • Gene Symbol: SLC25A4 (ENSG00000151729)
    Fold Change: 1.37
    Ensembl ID: ENSG00000151729
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.36
    Ensembl ID: ENSG00000149925
  • Gene Symbol: BIN1 (ENSG00000136717)
    Fold Change: 1.31
    Ensembl ID: ENSG00000136717
  • Gene Symbol: ALDH9A1 (ENSG00000143149)
    Fold Change: 1.31
    Ensembl ID: ENSG00000143149
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 1.3
    Ensembl ID: ENSG00000142599
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.3
    Ensembl ID: ENSG00000182718
  • Gene Symbol: ANXA6 (ENSG00000197043)
    Fold Change: 1.3
    Ensembl ID: ENSG00000197043
  • Gene Symbol: ALDH2 (ENSG00000111275)
    Fold Change: 1.3
    Ensembl ID: ENSG00000111275
  • Gene Symbol: ARL4D (ENSG00000175906)
    Fold Change: 1.29
    Ensembl ID: ENSG00000175906
  • Gene Symbol: ARF3 (ENSG00000134287)
    Fold Change: 1.28
    Ensembl ID: ENSG00000134287
  • Gene Symbol: ATP6V1E1 (ENSG00000131100)
    Fold Change: 1.27
    Ensembl ID: ENSG00000131100
  • Gene Symbol: ALDH3A2 (ENSG00000072210)
    Fold Change: 1.26
    Ensembl ID: ENSG00000072210
  • Gene Symbol: ACO2 (ENSG00000100412)
    Fold Change: 1.26
    Ensembl ID: ENSG00000100412
  • Gene Symbol: BLMH (ENSG00000108578)
    Fold Change: 1.23
    Ensembl ID: ENSG00000108578
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.22
    Ensembl ID: ENSG00000087274
  • Gene Symbol: ABCF1 (ENSG00000204574)
    Fold Change: 1.22
    Ensembl ID: ENSG00000204574
  • Gene Symbol: BAG1 (ENSG00000107262)
    Fold Change: 1.2
    Ensembl ID: ENSG00000107262
  • Gene Symbol: ADSL (ENSG00000239900)
    Fold Change: 1.2
    Ensembl ID: ENSG00000239900
  • Gene Symbol: ACAT2 (ENSG00000120437)
    Fold Change: 1.2
    Ensembl ID: ENSG00000120437
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.18
    Ensembl ID: ENSG00000138279
  • Gene Symbol: AP2B1 (ENSG00000006125)
    Fold Change: 1.17
    Ensembl ID: ENSG00000006125
  • Gene Symbol: ADSS2 (ENSG00000035687)
    Fold Change: 1.16
    Ensembl ID: ENSG00000035687
  • Gene Symbol: ANXA4 (ENSG00000196975)
    Fold Change: 1.14
    Ensembl ID: ENSG00000196975
  • Gene Symbol: ATP1B1 (ENSG00000143153)
    Fold Change: 1.14
    Ensembl ID: ENSG00000143153
  • Gene Symbol: BMP4 (ENSG00000125378)
    Fold Change: 1.12
    Ensembl ID: ENSG00000125378
  • Gene Symbol: ARHGAP5 (ENSG00000100852)
    Fold Change: 1.12
    Ensembl ID: ENSG00000100852
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.1
    Ensembl ID: ENSG00000165527
  • Gene Symbol: APEH (ENSG00000164062)
    Fold Change: 1.09
    Ensembl ID: ENSG00000164062
  • Gene Symbol: BPHL (ENSG00000137274)
    Fold Change: 1.08
    Ensembl ID: ENSG00000137274
  • Gene Symbol: ACYP1 (ENSG00000119640)
    Fold Change: 1.07
    Ensembl ID: ENSG00000119640
  • Gene Symbol: BLVRA (ENSG00000106605)
    Fold Change: 1.07
    Ensembl ID: ENSG00000106605
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.06
    Ensembl ID: ENSG00000160710
  • Gene Symbol: BCAT2 (ENSG00000105552)
    Fold Change: 1.06
    Ensembl ID: ENSG00000105552
  • Gene Symbol: ADAM10 (ENSG00000137845)
    Fold Change: 1.05
    Ensembl ID: ENSG00000137845
  • Gene Symbol: ANK3 (ENSG00000151150)
    Fold Change: 1.04
    Ensembl ID: ENSG00000151150
  • Gene Symbol: BIRC2 (ENSG00000110330)
    Fold Change: 1
    Ensembl ID: ENSG00000110330
Hovered Details

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Hovered Details

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**Key Characteristics** 1. **Epithelial Cell of Nephron**: The cell is a type of epithelial cell located in the nephron, which is a critical component of the kidney's filtration system. 2. **Actin Filaments**: The cell contains actin filaments, which are essential for maintaining cell shape, movement, and intracellular signaling. 3. **Adherens Junctions**: The cell exhibits adherens junctions, which are critical for maintaining cell-cell adhesion and polarity. 4. **Apical Junction Complexes**: The cell contains apical junction complexes, which are involved in the regulation of ion and water transport. 5. **Signaling Pathways**: The cell is involved in various signaling pathways, including those involved in cell migration, differentiation, and survival. 6. **Cytoplasmic Cytoskeleton**: The cell has a well-organized cytoplasmic cytoskeleton, which is essential for maintaining cell shape and intracellular signaling. **Clinical Significance** 1. **Kidney Function**: The epithelial cell of the nephron plays a critical role in maintaining kidney function, including the regulation of ion and water transport. 2. **Blood-Brain Barrier**: The cell is involved in maintaining the blood-brain barrier, which is essential for preventing the entry of toxins and pathogens into the brain. 3. **Disease Association**: Dysregulation of the cell's signaling pathways and cytoskeleton organization has been implicated in various diseases, including kidney disease, cancer, and neurological disorders. 4. **Therapeutic Targets**: The cell's genes, particularly ACTB and ACTG1, have been identified as potential therapeutic targets for the treatment of various diseases. 5. **Cell-Based Therapies**: The cell's ability to respond to environmental changes and signaling pathways makes it an attractive candidate for cell-based therapies, including gene therapy and regenerative medicine. In conclusion, the epithelial cell of the nephron is a complex cell type that plays a critical role in maintaining kidney function and overall health. Its unique characteristics, including the presence of actin filaments, adherens junctions, and apical junction complexes, make it an essential component of the kidney's filtration system. The cell's involvement in various signaling pathways and its potential as a therapeutic target make it an attractive candidate for further research and development of novel therapeutic strategies.