Gene GPC3 - ENSG00000147257 | NCBI Gene ID: 2719

Details for: GPC3

Gene ID: 2719

Symbol: GPC3

Ensembl ID: ENSG00000147257

Description: glypican 3

Associated with

A tetrasaccharide linker sequence is required for gag synthesis
(R-HSA-1971475)
Attachment and entry
(R-HSA-9694614)
Chondroitin sulfate/dermatan sulfate metabolism
(R-HSA-1793185)
Defective b3galt6 causes edsp2 and semdjl1
(R-HSA-4420332)
Defective b3gat3 causes jdssdhd
(R-HSA-3560801)
Defective b4galt7 causes eds, progeroid type
(R-HSA-3560783)
Defective ext1 causes exostoses 1, trps2 and chds
(R-HSA-3656253)
Defective ext2 causes exostoses 2
(R-HSA-3656237)
Disease
(R-HSA-1643685)
Diseases associated with glycosaminoglycan metabolism
(R-HSA-3560782)
Diseases of glycosylation
(R-HSA-3781865)
Diseases of metabolism
(R-HSA-5668914)
Early sars-cov-2 infection events
(R-HSA-9772572)
Glycosaminoglycan metabolism
(R-HSA-1630316)
Heparan sulfate/heparin (hs-gag) metabolism
(R-HSA-1638091)
Hs-gag biosynthesis
(R-HSA-2022928)
Hs-gag degradation
(R-HSA-2024096)
Infectious disease
(R-HSA-5663205)
Metabolism
(R-HSA-1430728)
Metabolism of carbohydrates
(R-HSA-71387)
Metabolism of fat-soluble vitamins
(R-HSA-6806667)
Metabolism of proteins
(R-HSA-392499)
Metabolism of vitamins and cofactors
(R-HSA-196854)
Post-translational protein modification
(R-HSA-597592)
Post-translational protein phosphorylation
(R-HSA-8957275)
Regulation of insulin-like growth factor (igf) transport and uptake by insulin-like growth factor binding proteins (igfbps)
(R-HSA-381426)
Respiratory syncytial virus (rsv) attachment and entry
(R-HSA-9820960)
Respiratory syncytial virus infection pathway
(R-HSA-9820952)
Retinoid metabolism and transport
(R-HSA-975634)
Rsv-host interactions
(R-HSA-9833110)
Sars-cov-2 infection
(R-HSA-9694516)
Sars-cov infections
(R-HSA-9679506)
Sensory perception
(R-HSA-9709957)
Viral infection pathways
(R-HSA-9824446)
Visual phototransduction
(R-HSA-2187338)
Anatomical structure morphogenesis
(GO:0009653)
Anterior/posterior axis specification
(GO:0009948)
Body morphogenesis
(GO:0010171)
Bone mineralization
(GO:0030282)
Branching involved in ureteric bud morphogenesis
(GO:0001658)
Canonical wnt signaling pathway
(GO:0060070)
Cell migration
(GO:0016477)
Cell migration involved in gastrulation
(GO:0042074)
Cell proliferation involved in kidney development
(GO:0072111)
Cell proliferation involved in metanephros development
(GO:0072203)
Cell surface
(GO:0009986)
Collagen-containing extracellular matrix
(GO:0062023)
Coronary vasculature development
(GO:0060976)
Embryonic hindlimb morphogenesis
(GO:0035116)
Endoplasmic reticulum lumen
(GO:0005788)
Epithelial cell proliferation
(GO:0050673)
Golgi lumen
(GO:0005796)
Lung development
(GO:0030324)
Lysosomal lumen
(GO:0043202)
Mesenchymal cell proliferation involved in ureteric bud development
(GO:0072138)
Mesonephric duct morphogenesis
(GO:0072180)
Negative regulation of canonical wnt signaling pathway
(GO:0090090)
Negative regulation of epithelial cell proliferation
(GO:0050680)
Negative regulation of growth
(GO:0045926)
Negative regulation of smoothened signaling pathway
(GO:0045879)
Osteoclast differentiation
(GO:0030316)
Peptidyl-dipeptidase inhibitor activity
(GO:0060422)
Plasma membrane
(GO:0005886)
Positive regulation of bmp signaling pathway
(GO:0030513)
Positive regulation of canonical wnt signaling pathway
(GO:0090263)
Positive regulation of endocytosis
(GO:0045807)
Positive regulation of glucose import
(GO:0046326)
Positive regulation of protein catabolic process
(GO:0045732)
Positive regulation of smoothened signaling pathway
(GO:0045880)
Positive regulation of wnt signaling pathway, planar cell polarity pathway
(GO:2000096)
Protein binding
(GO:0005515)
Regulation of canonical wnt signaling pathway
(GO:0060828)
Regulation of non-canonical wnt signaling pathway
(GO:2000050)
Regulation of protein localization to membrane
(GO:1905475)
Response to bacterium
(GO:0009617)
Side of membrane
(GO:0098552)
Smoothened signaling pathway
(GO:0007224)
Wnt signaling pathway, planar cell polarity pathway
(GO:0060071)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: hepatoblast (CL0005026)
Fold Change: 13.74
Marker Score: 45022
Cell Name: mesodermal cell (CL0000222)
Fold Change: 3.21
Marker Score: 42294
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 2.98
Marker Score: 19408
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 2.95
Marker Score: 6170.5
Cell Name: skeletal muscle satellite cell (CL0000594)
Fold Change: 2.9
Marker Score: 1942
Cell Name: mesenchymal stem cell (CL0000134)
Fold Change: 2.76
Marker Score: 4247
Cell Name: alveolar type 2 fibroblast cell (CL4028006)
Fold Change: 2.72
Marker Score: 1515
Cell Name: erythroblast (CL0000765)
Fold Change: 2.48
Marker Score: 1547
Cell Name: kidney cell (CL1000497)
Fold Change: 2.41
Marker Score: 1609
Cell Name: syncytiotrophoblast cell (CL0000525)
Fold Change: 1.9
Marker Score: 1561
Cell Name: fibroblast of lung (CL0002553)
Fold Change: 1.89
Marker Score: 4939
Cell Name: Kupffer cell (CL0000091)
Fold Change: 1.86
Marker Score: 1865
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 1.86
Marker Score: 63301
Cell Name: nephron tubule epithelial cell (CL1000494)
Fold Change: 1.85
Marker Score: 434
Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: 1.79
Marker Score: 4805
Cell Name: Unknown (CL0002371)
Fold Change: 1.75
Marker Score: 1864
Cell Name: double negative thymocyte (CL0002489)
Fold Change: 1.71
Marker Score: 2354
Cell Name: enteric smooth muscle cell (CL0002504)
Fold Change: 1.7
Marker Score: 4005
Cell Name: Purkinje cell (CL0000121)
Fold Change: 1.7
Marker Score: 57258
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 1.66
Marker Score: 3145
Cell Name: kidney interstitial fibroblast (CL1000692)
Fold Change: 1.57
Marker Score: 3026.5
Cell Name: fibroblast of breast (CL4006000)
Fold Change: 1.54
Marker Score: 877
Cell Name: trophoblast giant cell (CL0002488)
Fold Change: 1.54
Marker Score: 497
Cell Name: mural cell (CL0008034)
Fold Change: 1.47
Marker Score: 168321
Cell Name: multi-ciliated epithelial cell (CL0005012)
Fold Change: 1.44
Marker Score: 2730
Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 1.44
Marker Score: 709
Cell Name: epithelial cell of glomerular capsule (CL1000450)
Fold Change: 1.42
Marker Score: 361
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 1.32
Marker Score: 2685
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 1.32
Marker Score: 3108
Cell Name: Mueller cell (CL0000636)
Fold Change: 1.17
Marker Score: 1626.5
Cell Name: adventitial cell (CL0002503)
Fold Change: 1.13
Marker Score: 278
Cell Name: theca cell (CL0000503)
Fold Change: 1.11
Marker Score: 797
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 1.07
Marker Score: 678.5
Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.02
Marker Score: 6208
Cell Name: interstitial cell of Cajal (CL0002088)
Fold Change: 1.02
Marker Score: 353
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71787
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48012
Cell Name: cardiac mesenchymal cell (CL0000569)
Fold Change: 0.98
Marker Score: 242
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30405
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.97
Marker Score: 502
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.97
Marker Score: 15220
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.97
Marker Score: 457
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2411
Cell Name: vascular leptomeningeal cell (CL4023051)
Fold Change: 0.95
Marker Score: 1088
Cell Name: respiratory epithelial cell (CL0002368)
Fold Change: 0.94
Marker Score: 515
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.93
Marker Score: 561
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.93
Marker Score: 1509
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.92
Marker Score: 369
Cell Name: myofibroblast cell (CL0000186)
Fold Change: 0.91
Marker Score: 1127
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2732
Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 0.9
Marker Score: 5433
Cell Name: mesangial cell (CL0000650)
Fold Change: 0.9
Marker Score: 1089
Cell Name: cell of skeletal muscle (CL0000188)
Fold Change: 0.9
Marker Score: 684
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.9
Marker Score: 322
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.89
Marker Score: 369
Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: 0.89
Marker Score: 900
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.88
Marker Score: 5024
Cell Name: mesothelial cell of epicardium (CL0011019)
Fold Change: 0.85
Marker Score: 272
Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.82
Marker Score: 265
Cell Name: kidney collecting duct cell (CL1001225)
Fold Change: 0.82
Marker Score: 161
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.81
Marker Score: 620
Cell Name: Leydig cell (CL0000178)
Fold Change: 0.8
Marker Score: 866
Cell Name: malignant cell (CL0001064)
Fold Change: 0.8
Marker Score: 10764
Cell Name: muscle precursor cell (CL0000680)
Fold Change: 0.79
Marker Score: 204
Cell Name: taste receptor cell (CL0000209)
Fold Change: 0.77
Marker Score: 666
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.76
Marker Score: 3187
Cell Name: brush cell (CL0002204)
Fold Change: 0.76
Marker Score: 692
Cell Name: stromal cell (CL0000499)
Fold Change: 0.76
Marker Score: 887.5
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.76
Marker Score: 392
Cell Name: kidney collecting duct intercalated cell (CL1001432)
Fold Change: 0.74
Marker Score: 1227
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.74
Marker Score: 471
Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
Fold Change: 0.73
Marker Score: 305
Cell Name: pancreatic stellate cell (CL0002410)
Fold Change: 0.71
Marker Score: 451
Cell Name: fibroblast (CL0000057)
Fold Change: 0.71
Marker Score: 687
Cell Name: acinar cell (CL0000622)
Fold Change: 0.71
Marker Score: 498
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.7
Marker Score: 2769
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.69
Marker Score: 178
Cell Name: mesothelial cell (CL0000077)
Fold Change: 0.66
Marker Score: 266
Cell Name: neural cell (CL0002319)
Fold Change: 0.66
Marker Score: 318
Cell Name: enterocyte of colon (CL1000347)
Fold Change: 0.65
Marker Score: 994
Cell Name: inflammatory cell (CL0009002)
Fold Change: 0.63
Marker Score: 270
Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 0.63
Marker Score: 196
Cell Name: mature NK T cell (CL0000814)
Fold Change: 0.62
Marker Score: 287
Cell Name: subcutaneous fat cell (CL0002521)
Fold Change: 0.62
Marker Score: 226
Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
Fold Change: 0.61
Marker Score: 662
Cell Name: lactocyte (CL0002325)
Fold Change: 0.59
Marker Score: 9546
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: 0.59
Marker Score: 626
Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.59
Marker Score: 281
Cell Name: connective tissue cell (CL0002320)
Fold Change: 0.56
Marker Score: 146
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.56
Marker Score: 444
Cell Name: mesenchymal lymphangioblast (CL0005021)
Fold Change: 0.56
Marker Score: 124
Cell Name: epithelial cell of lower respiratory tract (CL0002632)
Fold Change: 0.55
Marker Score: 2309
Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: 0.55
Marker Score: 363
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.55
Marker Score: 173
Cell Name: colon epithelial cell (CL0011108)
Fold Change: 0.53
Marker Score: 1676
Cell Name: progenitor cell of endocrine pancreas (CL0002351)
Fold Change: 0.52
Marker Score: 112
Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.51
Marker Score: 1985
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.51
Marker Score: 236
Cell Name: ventricular cardiac muscle cell (CL2000046)
Fold Change: 0.5
Marker Score: 208
Cell Name: smooth muscle cell of large intestine (CL1000279)
Fold Change: 0.49
Marker Score: 187

Hover over a box to see details here...

**Key characteristics:** - GPC3 is a type of glycan-associated protein (GAP). - It is a transmembrane protein that is expressed on the surface of cells. - It is a glycoprotein that is composed of a single polypeptide chain. - It is a key regulator of the metabolism of glycans. **Pathways and functions:** - GPC3 is involved in the regulation of the synthesis, degradation, and transport of glycans. - It is also involved in the regulation of the metabolism of other molecules that are attached to glycans, such as proteins and lipids. - It is involved in the regulation of cell migration and differentiation. - It is also involved in the regulation of inflammation. **Clinical significance:** - Mutations in GPC3 have been linked to several human diseases, including liver disease, cancer, and osteoporosis. - GPC3 is a potential target for the treatment of these diseases. **Additional notes:** - GPC3 is a relatively new protein, and there is still much that is unknown about its function. - It is a promising target for the development of new drugs for human diseases.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Genular Protein ID: 2380943112

Symbol: GPC3_HUMAN

Name: Glypican-3

UniProtKB Accession Codes:

P51654 C9JLE3 G3V1R0 Q2L880 Q2L882

Database IDs:

Citations:

PubMed ID: 9021160

Title: Mapping of the Simpson-Golabi-Behmel overgrowth syndrome gene (GPC3) to chromosome X in human and rat by fluorescence in situ hybridization.

PubMed ID: 9021160

DOI: 10.1007/s003359900357

PubMed ID: 8589713

Title: Mutations in GPC3, a glypican gene, cause the Simpson-Golabi-Behmel overgrowth syndrome.

PubMed ID: 8589713

DOI: 10.1038/ng0396-241

PubMed ID: 9133586

Title: Cloning and characterization of human cDNAs encoding a protein with high homology to rat intestinal development protein OCI-5.

PubMed ID: 9133586

DOI: 10.1016/s0378-1119(96)00689-0

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 9339360

Title: Analysis of exon/intron structure and 400 kb of genomic sequence surrounding the 5'-promoter and 3'-terminal ends of the human glypican 3 (GPC3) gene.

PubMed ID: 9339360

DOI: 10.1006/geno.1997.4916

PubMed ID: 12851874

Title: Glypican-3: a novel serum and histochemical marker for hepatocellular carcinoma.

PubMed ID: 12851874

DOI: 10.1016/s0016-5085(03)00689-9

PubMed ID: 14610063

Title: Processing by proprotein convertases is required for glypican-3 modulation of cell survival, Wnt signaling, and gastrulation movements.

PubMed ID: 14610063

DOI: 10.1083/jcb.200302152

PubMed ID: 15059894

Title: Identification of soluble NH2-terminal fragment of glypican-3 as a serological marker for early-stage hepatocellular carcinoma.

PubMed ID: 15059894

DOI: 10.1158/0008-5472.can-03-2191

PubMed ID: 16024626

Title: Glypican-3 promotes the growth of hepatocellular carcinoma by stimulating canonical Wnt signaling.

PubMed ID: 16024626

DOI: 10.1158/0008-5472.can-04-4244

PubMed ID: 16227623

Title: Processing by convertases is not required for glypican-3-induced stimulation of hepatocellular carcinoma growth.

PubMed ID: 16227623

DOI: 10.1074/jbc.m507004200

PubMed ID: 17549790

Title: The Simpson-Golabi-Behmel syndrome causative glypican-3, binds to and inhibits the dipeptidyl peptidase activity of CD26.

PubMed ID: 17549790

DOI: 10.1002/pmic.200600654

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24496449

Title: Glypican-3 binds to Frizzled and plays a direct role in the stimulation of canonical Wnt signaling.

PubMed ID: 24496449

DOI: 10.1242/jcs.140871

PubMed ID: 26091039

Title: A single kinase generates the majority of the secreted phosphoproteome.

PubMed ID: 26091039

DOI: 10.1016/j.cell.2015.05.028

PubMed ID: 25653284

Title: Processing by convertases is required for glypican-3-induced inhibition of Hedgehog signaling.

PubMed ID: 25653284

DOI: 10.1074/jbc.m114.612705

PubMed ID: 29345911

Title: Role of glycanation and convertase maturation of soluble glypican-3 in inhibiting proliferation of hepatocellular carcinoma cells.

PubMed ID: 29345911

DOI: 10.1021/acs.biochem.7b01208

PubMed ID: 32337544

Title: An affinity chromatography and glycoproteomics workflow to profile the chondroitin sulfate proteoglycans that interact with malarial VAR2CSA in the placenta and in cancer.

PubMed ID: 32337544

DOI: 10.1093/glycob/cwaa039

PubMed ID: 10814714

Title: Mutational analysis of the GPC3/GPC4 glypican gene cluster on Xq26 in patients with Simpson-Golabi-Behmel syndrome: identification of loss-of-function mutations in the GPC3 gene.

PubMed ID: 10814714

DOI: 10.1093/hmg/9.9.1321

Sequence Information:

Length: 580
Mass: 65563
Checksum: 19485B76D3CE15FC
Sequence:

MAGTVRTACL VVAMLLSLDF PGQAQPPPPP PDATCHQVRS FFQRLQPGLK WVPETPVPGS 
DLQVCLPKGP TCCSRKMEEK YQLTARLNME QLLQSASMEL KFLIIQNAAV FQEAFEIVVR 
HAKNYTNAMF KNNYPSLTPQ AFEFVGEFFT DVSLYILGSD INVDDMVNEL FDSLFPVIYT 
QLMNPGLPDS ALDINECLRG ARRDLKVFGN FPKLIMTQVS KSLQVTRIFL QALNLGIEVI 
NTTDHLKFSK DCGRMLTRMW YCSYCQGLMM VKPCGGYCNV VMQGCMAGVV EIDKYWREYI 
LSLEELVNGM YRIYDMENVL LGLFSTIHDS IQYVQKNAGK LTTTIGKLCA HSQQRQYRSA 
YYPEDLFIDK KVLKVAHVEH EETLSSRRRE LIQKLKSFIS FYSALPGYIC SHSPVAENDT 
LCWNGQELVE RYSQKAARNG MKNQFNLHEL KMKGPEPVVS QIIDKLKHIN QLLRTMSMPK 
GRVLDKNLDE EGFESGDCGD DEDECIGGSG DGMIKVKNQL RFLAELAYDL DVDDAPGNSQ 
QATPKDNEIS TFHNLGNVHS PLKLLTSMAI SVVCFFFLVH

Genular Protein ID: 1812149662

Symbol: B4DTD8_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DTD8

Database IDs:

Citations:

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

Sequence Information:

Length: 564
Mass: 63728
Checksum: FC5B36FD989E8414
Sequence:

MAGTVRTACL VVAMLLSLDF PGQAQPPPPP PDATCHQVRS FFQRLQPGLK WVPETPVPGS 
DLQVCLPKGP TCCSRKMEEK YQLTARLNME QLLQSAKAFE IVVRHAKNYT NAMFKNNYPS 
LTPQAFEFVG EFFTDVSLYI LGSDINVDDM VNELFDSLFP VIYTQLMNPG LPDSALDINE 
CLRGARRDLK VFGNFPKLIM TQVSKSLQVT RIFLQALNLG IEVINTTDHL KFSKDCGRML 
TRMWYCSYCQ GLMMVKPCGG YCNVVMQGCM AGVVEIDKYW REYILSLEEL VNGMYRIYDM 
ENVLLGLFST IHDSIQYVQK NAGKLTTTIG KLCAHSQQRQ YRSAYYPEDL FIDKKVLKVA 
HVEHEETLSS RRRELIQKLK SFISFYSALP GYICSHSPVA ENDTLCWNGQ ELVERYSQKA 
ARNGMKNQFN LHELKMKGPE PVVSQIIDKL KHINQLLRTM SMPKGRVLDK NLDEEGFESG 
DCGDDEDECI GGSGDGMIKV KNQLRFLAEL AYDLDVDDAP GNSQQATPKD NEISTFHNLG 
NVHSPLKLLT SMAISVVCFF FLVH

Genular Protein ID: 147062696

Symbol: Q53H15_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q53H15

Database IDs:

Citations:

PubMed ID: 8125298

Title: Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.

PubMed ID: 8125298

DOI: 10.1016/0378-1119(94)90802-8

PubMed ID: 9373149

Title: Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.

PubMed ID: 9373149

DOI: 10.1016/S0378-1119(97)00411-3

Sequence Information:

Length: 580
Mass: 65595
Checksum: ECA8BADDD3D4A45C
Sequence:

MAGTVRTACL VVAMLLSLDF PGQAQPPPPP PDATCHQVRS FFQRLQPGLK WVPETPVPGS 
DLQVCLPKGP TCCSRKMEEK YQLTARLNME QLLQSASMEL KFLIIQNAAV FQEAFEIVVR 
HAKNYTNAMF KNNYPSLTPQ AFEFVGEFFT DVSLYILGSD INVDDMVNEL FDSLFPVIYT 
QLMNPGLPDS ALDINECLRG ARRDLKVFGN FPKLIMTQVS KSLQVTRIFL QALNLGIEVI 
NTTDHLKFSK DCGRMLTRMW YCSYCQGLMM VKPCGGYCNV VMQGCMAGVV EIDKYWREYI 
LSLEELVNGM YRIYDMENVL LGLFSTIHDS IQYVQKNAGK LTTTIGKLCA HSQQRQYRSA 
YYPEDLFIDK KVLKVAHVEH EETLSSRRRE LIQKLKSFIS FYSALPGYIC SHSPVAENDT 
LCWNGQELME RYSQKAARNG MKNQFNLHEL KMKGPEPVVS QIIDKLKHIN QLLRTMSMPK 
GRVLDKNLDE EGFESGDCGD DEDECIGGSG DGMIKVKNQL RFLAELAYDL DVDDAPGNSQ 
QATPKDNEIS TFHNLGNVHS PLKLLTSMAI SVVCFFFLVH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: GPC3

Associated with

Cells (max top 100)

Other Information

Mapping of the Simpson-Golabi-Behmel overgrowth syndrome gene (GPC3) to chromosome X in human and rat by fluorescence in situ hybridization. PubMed ID: 9021160

Mutations in GPC3, a glypican gene, cause the Simpson-Golabi-Behmel overgrowth syndrome. PubMed ID: 8589713

Cloning and characterization of human cDNAs encoding a protein with high homology to rat intestinal development protein OCI-5. PubMed ID: 9133586

The DNA sequence of the human X chromosome. PubMed ID: 15772651

Analysis of exon/intron structure and 400 kb of genomic sequence surrounding the 5'-promoter and 3'-terminal ends of the human glypican 3 (GPC3) gene. PubMed ID: 9339360

Glypican-3: a novel serum and histochemical marker for hepatocellular carcinoma. PubMed ID: 12851874

Processing by proprotein convertases is required for glypican-3 modulation of cell survival, Wnt signaling, and gastrulation movements. PubMed ID: 14610063

Identification of soluble NH2-terminal fragment of glypican-3 as a serological marker for early-stage hepatocellular carcinoma. PubMed ID: 15059894

Glypican-3 promotes the growth of hepatocellular carcinoma by stimulating canonical Wnt signaling. PubMed ID: 16024626

Processing by convertases is not required for glypican-3-induced stimulation of hepatocellular carcinoma growth. PubMed ID: 16227623

The Simpson-Golabi-Behmel syndrome causative glypican-3, binds to and inhibits the dipeptidyl peptidase activity of CD26. PubMed ID: 17549790

Initial characterization of the human central proteome. PubMed ID: 21269460

Glypican-3 binds to Frizzled and plays a direct role in the stimulation of canonical Wnt signaling. PubMed ID: 24496449

A single kinase generates the majority of the secreted phosphoproteome. PubMed ID: 26091039

Processing by convertases is required for glypican-3-induced inhibition of Hedgehog signaling. PubMed ID: 25653284

Role of glycanation and convertase maturation of soluble glypican-3 in inhibiting proliferation of hepatocellular carcinoma cells. PubMed ID: 29345911

An affinity chromatography and glycoproteomics workflow to profile the chondroitin sulfate proteoglycans that interact with malarial VAR2CSA in the placenta and in cancer. PubMed ID: 32337544

Mutational analysis of the GPC3/GPC4 glypican gene cluster on Xq26 in patients with Simpson-Golabi-Behmel syndrome: identification of loss-of-function mutations in the GPC3 gene. PubMed ID: 10814714

The DNA sequence of the human X chromosome. PubMed ID: 15772651

Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. PubMed ID: 8125298

Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. PubMed ID: 9373149

Database document:

PubMed ID: 9021160

PubMed ID: 8589713

PubMed ID: 9133586

PubMed ID: 15772651

PubMed ID: 9339360

PubMed ID: 12851874

PubMed ID: 14610063

PubMed ID: 15059894

PubMed ID: 16024626

PubMed ID: 16227623

PubMed ID: 17549790

PubMed ID: 21269460

PubMed ID: 24496449

PubMed ID: 26091039

PubMed ID: 25653284

PubMed ID: 29345911

PubMed ID: 32337544

PubMed ID: 10814714

PubMed ID: 15772651

PubMed ID: 8125298

PubMed ID: 9373149