GPC3 | ENSG00000147257 | NCBI 2719

Details for: GPC3

Gene ID: 2719

Symbol: GPC3

Ensembl ID: ENSG00000147257

Description: glypican 3

Associated with

A tetrasaccharide linker sequence is required for gag synthesis
(R-HSA-1971475)
Attachment and entry
(R-HSA-9694614)
Chondroitin sulfate/dermatan sulfate metabolism
(R-HSA-1793185)
Defective b3galt6 causes edsp2 and semdjl1
(R-HSA-4420332)
Defective b3gat3 causes jdssdhd
(R-HSA-3560801)
Defective b4galt7 causes eds, progeroid type
(R-HSA-3560783)
Defective ext1 causes exostoses 1, trps2 and chds
(R-HSA-3656253)
Defective ext2 causes exostoses 2
(R-HSA-3656237)
Disease
(R-HSA-1643685)
Diseases associated with glycosaminoglycan metabolism
(R-HSA-3560782)
Diseases of glycosylation
(R-HSA-3781865)
Diseases of metabolism
(R-HSA-5668914)
Early sars-cov-2 infection events
(R-HSA-9772572)
Glycosaminoglycan metabolism
(R-HSA-1630316)
Heparan sulfate/heparin (hs-gag) metabolism
(R-HSA-1638091)
Hs-gag biosynthesis
(R-HSA-2022928)
Hs-gag degradation
(R-HSA-2024096)
Infectious disease
(R-HSA-5663205)
Metabolism
(R-HSA-1430728)
Metabolism of carbohydrates
(R-HSA-71387)
Metabolism of fat-soluble vitamins
(R-HSA-6806667)
Metabolism of proteins
(R-HSA-392499)
Metabolism of vitamins and cofactors
(R-HSA-196854)
Post-translational protein modification
(R-HSA-597592)
Post-translational protein phosphorylation
(R-HSA-8957275)
Regulation of insulin-like growth factor (igf) transport and uptake by insulin-like growth factor binding proteins (igfbps)
(R-HSA-381426)
Respiratory syncytial virus (rsv) attachment and entry
(R-HSA-9820960)
Respiratory syncytial virus infection pathway
(R-HSA-9820952)
Retinoid metabolism and transport
(R-HSA-975634)
Rsv-host interactions
(R-HSA-9833110)
Sars-cov-2 infection
(R-HSA-9694516)
Sars-cov infections
(R-HSA-9679506)
Sensory perception
(R-HSA-9709957)
Viral infection pathways
(R-HSA-9824446)
Visual phototransduction
(R-HSA-2187338)
Anatomical structure morphogenesis
(GO:0009653)
Anterior/posterior axis specification
(GO:0009948)
Body morphogenesis
(GO:0010171)
Bone mineralization
(GO:0030282)
Branching involved in ureteric bud morphogenesis
(GO:0001658)
Canonical wnt signaling pathway
(GO:0060070)
Cell migration
(GO:0016477)
Cell migration involved in gastrulation
(GO:0042074)
Cell proliferation involved in kidney development
(GO:0072111)
Cell proliferation involved in metanephros development
(GO:0072203)
Cell surface
(GO:0009986)
Collagen-containing extracellular matrix
(GO:0062023)
Coronary vasculature development
(GO:0060976)
Embryonic hindlimb morphogenesis
(GO:0035116)
Endoplasmic reticulum lumen
(GO:0005788)
Epithelial cell proliferation
(GO:0050673)
Golgi lumen
(GO:0005796)
Lung development
(GO:0030324)
Lysosomal lumen
(GO:0043202)
Mesenchymal cell proliferation involved in ureteric bud development
(GO:0072138)
Mesonephric duct morphogenesis
(GO:0072180)
Negative regulation of canonical wnt signaling pathway
(GO:0090090)
Negative regulation of epithelial cell proliferation
(GO:0050680)
Negative regulation of growth
(GO:0045926)
Negative regulation of peptidase activity
(GO:0010466)
Negative regulation of smoothened signaling pathway
(GO:0045879)
Osteoclast differentiation
(GO:0030316)
Peptidyl-dipeptidase inhibitor activity
(GO:0060422)
Plasma membrane
(GO:0005886)
Positive regulation of bmp signaling pathway
(GO:0030513)
Positive regulation of canonical wnt signaling pathway
(GO:0090263)
Positive regulation of d-glucose import
(GO:0046326)
Positive regulation of endocytosis
(GO:0045807)
Positive regulation of protein catabolic process
(GO:0045732)
Positive regulation of smoothened signaling pathway
(GO:0045880)
Positive regulation of wnt signaling pathway, planar cell polarity pathway
(GO:2000096)
Protein binding
(GO:0005515)
Regulation of canonical wnt signaling pathway
(GO:0060828)
Regulation of non-canonical wnt signaling pathway
(GO:2000050)
Regulation of protein localization to membrane
(GO:1905475)
Response to bacterium
(GO:0009617)
Side of membrane
(GO:0098552)
Smoothened signaling pathway
(GO:0007224)
Wnt signaling pathway, planar cell polarity pathway
(GO:0060071)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 64.2635
Cell Significance Index: -16.3000
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 40.6039
Cell Significance Index: -19.1700
Cell Name: pulmonary interstitial fibroblast (CL0002241)
Fold Change: 20.2207
Cell Significance Index: 125.1000
Cell Name: kidney cell (CL1000497)
Fold Change: 17.6200
Cell Significance Index: 140.6800
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 12.7953
Cell Significance Index: 163.8700
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 9.9591
Cell Significance Index: 346.0800
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 9.9316
Cell Significance Index: 107.9700
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 9.8612
Cell Significance Index: 206.4100
Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 6.9075
Cell Significance Index: 147.6500
Cell Name: neoplastic cell (CL0001063)
Fold Change: 6.8443
Cell Significance Index: 1358.2800
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 4.1206
Cell Significance Index: -16.2600
Cell Name: theca cell (CL0000503)
Fold Change: 3.9183
Cell Significance Index: 23.0200
Cell Name: chondroblast (CL0000058)
Fold Change: 3.1925
Cell Significance Index: 18.7400
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 2.9334
Cell Significance Index: -6.4200
Cell Name: enteric smooth muscle cell (CL0002504)
Fold Change: 2.7983
Cell Significance Index: 14.7300
Cell Name: preadipocyte (CL0002334)
Fold Change: 2.7412
Cell Significance Index: 53.5000
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 2.6704
Cell Significance Index: 76.5500
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 2.0059
Cell Significance Index: 53.5600
Cell Name: embryonic fibroblast (CL2000042)
Fold Change: 1.5992
Cell Significance Index: 7.6500
Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: 1.3077
Cell Significance Index: 31.6800
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 1.1907
Cell Significance Index: 226.6100
Cell Name: Purkinje cell (CL0000121)
Fold Change: 0.9134
Cell Significance Index: 20.0000
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.8037
Cell Significance Index: 79.5000
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 0.7866
Cell Significance Index: 20.2200
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.7726
Cell Significance Index: 16.4600
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: 0.7109
Cell Significance Index: 35.9300
Cell Name: muscle fibroblast (CL1001609)
Fold Change: 0.6612
Cell Significance Index: 4.0500
Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: 0.6494
Cell Significance Index: 4.4000
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.5690
Cell Significance Index: 513.7400
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.4438
Cell Significance Index: 72.1800
Cell Name: odontoblast (CL0000060)
Fold Change: 0.4417
Cell Significance Index: 56.6200
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.3984
Cell Significance Index: 142.8900
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 0.3403
Cell Significance Index: 39.6600
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.3299
Cell Significance Index: 19.8100
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.1830
Cell Significance Index: 12.6600
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 0.1468
Cell Significance Index: 2.5200
Cell Name: hepatoblast (CL0005026)
Fold Change: 0.1118
Cell Significance Index: 1.8800
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 0.0858
Cell Significance Index: 62.9300
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.0657
Cell Significance Index: 13.1900
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.0533
Cell Significance Index: 36.8600
Cell Name: mesodermal cell (CL0000222)
Fold Change: 0.0511
Cell Significance Index: 0.3200
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.0147
Cell Significance Index: 6.4900
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0082
Cell Significance Index: 15.5300
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.0077
Cell Significance Index: 0.0800
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.0014
Cell Significance Index: 0.0400
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0001
Cell Significance Index: -0.2700
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0007
Cell Significance Index: -1.1300
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.0014
Cell Significance Index: -0.0500
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0033
Cell Significance Index: -4.5200
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.0092
Cell Significance Index: -0.2000
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: -0.0097
Cell Significance Index: -0.1500
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0098
Cell Significance Index: -1.7700
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0109
Cell Significance Index: -8.2600
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.0112
Cell Significance Index: -0.2800
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.0149
Cell Significance Index: -0.2500
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0206
Cell Significance Index: -15.2500
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0226
Cell Significance Index: -14.3800
Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0258
Cell Significance Index: -14.0900
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.0318
Cell Significance Index: -1.4400
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0321
Cell Significance Index: -20.0200
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0329
Cell Significance Index: -18.5800
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0382
Cell Significance Index: -5.5600
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0387
Cell Significance Index: -17.5600
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0387
Cell Significance Index: -11.1300
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0477
Cell Significance Index: -5.8600
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0547
Cell Significance Index: -9.3500
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0628
Cell Significance Index: -8.6200
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.0741
Cell Significance Index: -2.0700
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0991
Cell Significance Index: -20.8700
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.1077
Cell Significance Index: -6.6000
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.1140
Cell Significance Index: -11.6500
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.1258
Cell Significance Index: -4.0300
Cell Name: lactocyte (CL0002325)
Fold Change: -0.1445
Cell Significance Index: -18.6700
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.1496
Cell Significance Index: -7.0300
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.1516
Cell Significance Index: -15.7900
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.1657
Cell Significance Index: -12.3500
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.1703
Cell Significance Index: -11.4500
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1720
Cell Significance Index: -19.7000
Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.1725
Cell Significance Index: -2.4700
Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.1876
Cell Significance Index: -13.2700
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.1892
Cell Significance Index: -22.3100
Cell Name: Hofbauer cell (CL3000001)
Fold Change: -0.2085
Cell Significance Index: -1.7000
Cell Name: extravillous trophoblast (CL0008036)
Fold Change: -0.2124
Cell Significance Index: -1.3200
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.2169
Cell Significance Index: -13.3300
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.2226
Cell Significance Index: -17.0800
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.2256
Cell Significance Index: -17.8700
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.2313
Cell Significance Index: -12.9800
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.2353
Cell Significance Index: -6.9300
Cell Name: colon endothelial cell (CL1001572)
Fold Change: -0.2358
Cell Significance Index: -0.1800
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.2415
Cell Significance Index: -10.6800
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.2876
Cell Significance Index: -10.8900
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.3038
Cell Significance Index: -19.1500
Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.3158
Cell Significance Index: -16.4500
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.3194
Cell Significance Index: -16.5900
Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: -0.3285
Cell Significance Index: -4.9500
Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.3298
Cell Significance Index: -21.2800
Cell Name: keratocyte (CL0002363)
Fold Change: -0.3719
Cell Significance Index: -5.9000
Cell Name: syncytiotrophoblast cell (CL0000525)
Fold Change: -0.3774
Cell Significance Index: -3.5900
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.3790
Cell Significance Index: -19.9000
Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.3912
Cell Significance Index: -17.0100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** GPC3 is a transmembrane glycoprotein composed of a core protein with six N-linked glycosylation sites and a heparan sulfate (HS) chain. The HS chain is essential for the recognition and binding of GPC3 to growth factors, receptors, and other proteins, which modulates its functions. GPC3 is characterized by its ability to interact with various signaling molecules, including Wnt proteins, BMPs, and insulin-like growth factors (IGFs), and regulate their activities. It is also involved in the regulation of cell migration, proliferation, and differentiation, particularly during embryonic development and tissue homeostasis. **Pathways and Functions** GPC3 is involved in various signaling pathways, including: 1. **Wnt signaling pathway**: GPC3 is a positive regulator of the canonical Wnt pathway, which is essential for embryonic development, tissue homeostasis, and cancer. 2. **BMP signaling pathway**: GPC3 is a positive regulator of the BMP pathway, which is involved in embryonic development, cell differentiation, and cancer. 3. **IGF signaling pathway**: GPC3 is a positive regulator of the IGF pathway, which is involved in cell growth, differentiation, and apoptosis. 4. **Cell migration**: GPC3 is involved in the regulation of cell migration, particularly during embryonic development and tissue homeostasis. 5. **Cell proliferation**: GPC3 is involved in the regulation of cell proliferation, particularly during embryonic development and tissue homeostasis. **Clinical Significance** GPC3 is involved in various diseases, including: 1. **Hepatocellular carcinoma**: GPC3 is overexpressed in hepatocellular carcinoma (HCC) and is used as a biomarker for diagnosis and prognosis. 2. **Kidney disease**: GPC3 is involved in kidney development and homeostasis, and its dysregulation is associated with kidney disease. 3. **Cancer**: GPC3 is involved in cancer development and progression, particularly in HCC and other solid tumors. 4. **Neurological disorders**: GPC3 is involved in neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, GPC3 is a multifunctional protein that plays a crucial role in various cellular processes, including cell signaling, migration, proliferation, and differentiation. Its dysregulation is associated with various diseases, including cancer, kidney disease, and neurological disorders. Further studies are needed to fully understand the mechanisms of GPC3 and its clinical significance.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Genular Protein ID: 2380943112

Symbol: GPC3_HUMAN

Name: Glypican-3

UniProtKB Accession Codes:

P51654 C9JLE3 G3V1R0 Q2L880 Q2L882

Database IDs:

Citations:

PubMed ID: 9021160

Title: Mapping of the Simpson-Golabi-Behmel overgrowth syndrome gene (GPC3) to chromosome X in human and rat by fluorescence in situ hybridization.

PubMed ID: 9021160

DOI: 10.1007/s003359900357

PubMed ID: 8589713

Title: Mutations in GPC3, a glypican gene, cause the Simpson-Golabi-Behmel overgrowth syndrome.

PubMed ID: 8589713

DOI: 10.1038/ng0396-241

PubMed ID: 9133586

Title: Cloning and characterization of human cDNAs encoding a protein with high homology to rat intestinal development protein OCI-5.

PubMed ID: 9133586

DOI: 10.1016/s0378-1119(96)00689-0

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 9339360

Title: Analysis of exon/intron structure and 400 kb of genomic sequence surrounding the 5'-promoter and 3'-terminal ends of the human glypican 3 (GPC3) gene.

PubMed ID: 9339360

DOI: 10.1006/geno.1997.4916

PubMed ID: 12851874

Title: Glypican-3: a novel serum and histochemical marker for hepatocellular carcinoma.

PubMed ID: 12851874

DOI: 10.1016/s0016-5085(03)00689-9

PubMed ID: 14610063

Title: Processing by proprotein convertases is required for glypican-3 modulation of cell survival, Wnt signaling, and gastrulation movements.

PubMed ID: 14610063

DOI: 10.1083/jcb.200302152

PubMed ID: 15059894

Title: Identification of soluble NH2-terminal fragment of glypican-3 as a serological marker for early-stage hepatocellular carcinoma.

PubMed ID: 15059894

DOI: 10.1158/0008-5472.can-03-2191

PubMed ID: 16024626

Title: Glypican-3 promotes the growth of hepatocellular carcinoma by stimulating canonical Wnt signaling.

PubMed ID: 16024626

DOI: 10.1158/0008-5472.can-04-4244

PubMed ID: 16227623

Title: Processing by convertases is not required for glypican-3-induced stimulation of hepatocellular carcinoma growth.

PubMed ID: 16227623

DOI: 10.1074/jbc.m507004200

PubMed ID: 17549790

Title: The Simpson-Golabi-Behmel syndrome causative glypican-3, binds to and inhibits the dipeptidyl peptidase activity of CD26.

PubMed ID: 17549790

DOI: 10.1002/pmic.200600654

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24496449

Title: Glypican-3 binds to Frizzled and plays a direct role in the stimulation of canonical Wnt signaling.

PubMed ID: 24496449

DOI: 10.1242/jcs.140871

PubMed ID: 26091039

Title: A single kinase generates the majority of the secreted phosphoproteome.

PubMed ID: 26091039

DOI: 10.1016/j.cell.2015.05.028

PubMed ID: 25653284

Title: Processing by convertases is required for glypican-3-induced inhibition of Hedgehog signaling.

PubMed ID: 25653284

DOI: 10.1074/jbc.m114.612705

PubMed ID: 29345911

Title: Role of glycanation and convertase maturation of soluble glypican-3 in inhibiting proliferation of hepatocellular carcinoma cells.

PubMed ID: 29345911

DOI: 10.1021/acs.biochem.7b01208

PubMed ID: 32337544

Title: An affinity chromatography and glycoproteomics workflow to profile the chondroitin sulfate proteoglycans that interact with malarial VAR2CSA in the placenta and in cancer.

PubMed ID: 32337544

DOI: 10.1093/glycob/cwaa039

PubMed ID: 10814714

Title: Mutational analysis of the GPC3/GPC4 glypican gene cluster on Xq26 in patients with Simpson-Golabi-Behmel syndrome: identification of loss-of-function mutations in the GPC3 gene.

PubMed ID: 10814714

DOI: 10.1093/hmg/9.9.1321

Sequence Information:

Length: 580
Mass: 65563
Checksum: 19485B76D3CE15FC
Sequence:

MAGTVRTACL VVAMLLSLDF PGQAQPPPPP PDATCHQVRS FFQRLQPGLK WVPETPVPGS 
DLQVCLPKGP TCCSRKMEEK YQLTARLNME QLLQSASMEL KFLIIQNAAV FQEAFEIVVR 
HAKNYTNAMF KNNYPSLTPQ AFEFVGEFFT DVSLYILGSD INVDDMVNEL FDSLFPVIYT 
QLMNPGLPDS ALDINECLRG ARRDLKVFGN FPKLIMTQVS KSLQVTRIFL QALNLGIEVI 
NTTDHLKFSK DCGRMLTRMW YCSYCQGLMM VKPCGGYCNV VMQGCMAGVV EIDKYWREYI 
LSLEELVNGM YRIYDMENVL LGLFSTIHDS IQYVQKNAGK LTTTIGKLCA HSQQRQYRSA 
YYPEDLFIDK KVLKVAHVEH EETLSSRRRE LIQKLKSFIS FYSALPGYIC SHSPVAENDT 
LCWNGQELVE RYSQKAARNG MKNQFNLHEL KMKGPEPVVS QIIDKLKHIN QLLRTMSMPK 
GRVLDKNLDE EGFESGDCGD DEDECIGGSG DGMIKVKNQL RFLAELAYDL DVDDAPGNSQ 
QATPKDNEIS TFHNLGNVHS PLKLLTSMAI SVVCFFFLVH

Genular Protein ID: 147062696

Symbol: Q53H15_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q53H15

Database IDs:

Citations:

PubMed ID: 8125298

Title: Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.

PubMed ID: 8125298

DOI: 10.1016/0378-1119(94)90802-8

PubMed ID: 9373149

Title: Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.

PubMed ID: 9373149

DOI: 10.1016/S0378-1119(97)00411-3

Sequence Information:

Length: 580
Mass: 65595
Checksum: ECA8BADDD3D4A45C
Sequence:

MAGTVRTACL VVAMLLSLDF PGQAQPPPPP PDATCHQVRS FFQRLQPGLK WVPETPVPGS 
DLQVCLPKGP TCCSRKMEEK YQLTARLNME QLLQSASMEL KFLIIQNAAV FQEAFEIVVR 
HAKNYTNAMF KNNYPSLTPQ AFEFVGEFFT DVSLYILGSD INVDDMVNEL FDSLFPVIYT 
QLMNPGLPDS ALDINECLRG ARRDLKVFGN FPKLIMTQVS KSLQVTRIFL QALNLGIEVI 
NTTDHLKFSK DCGRMLTRMW YCSYCQGLMM VKPCGGYCNV VMQGCMAGVV EIDKYWREYI 
LSLEELVNGM YRIYDMENVL LGLFSTIHDS IQYVQKNAGK LTTTIGKLCA HSQQRQYRSA 
YYPEDLFIDK KVLKVAHVEH EETLSSRRRE LIQKLKSFIS FYSALPGYIC SHSPVAENDT 
LCWNGQELME RYSQKAARNG MKNQFNLHEL KMKGPEPVVS QIIDKLKHIN QLLRTMSMPK 
GRVLDKNLDE EGFESGDCGD DEDECIGGSG DGMIKVKNQL RFLAELAYDL DVDDAPGNSQ 
QATPKDNEIS TFHNLGNVHS PLKLLTSMAI SVVCFFFLVH

Genular Protein ID: 1812149662

Symbol: B4DTD8_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DTD8

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

Sequence Information:

Length: 564
Mass: 63728
Checksum: FC5B36FD989E8414
Sequence:

MAGTVRTACL VVAMLLSLDF PGQAQPPPPP PDATCHQVRS FFQRLQPGLK WVPETPVPGS 
DLQVCLPKGP TCCSRKMEEK YQLTARLNME QLLQSAKAFE IVVRHAKNYT NAMFKNNYPS 
LTPQAFEFVG EFFTDVSLYI LGSDINVDDM VNELFDSLFP VIYTQLMNPG LPDSALDINE 
CLRGARRDLK VFGNFPKLIM TQVSKSLQVT RIFLQALNLG IEVINTTDHL KFSKDCGRML 
TRMWYCSYCQ GLMMVKPCGG YCNVVMQGCM AGVVEIDKYW REYILSLEEL VNGMYRIYDM 
ENVLLGLFST IHDSIQYVQK NAGKLTTTIG KLCAHSQQRQ YRSAYYPEDL FIDKKVLKVA 
HVEHEETLSS RRRELIQKLK SFISFYSALP GYICSHSPVA ENDTLCWNGQ ELVERYSQKA 
ARNGMKNQFN LHELKMKGPE PVVSQIIDKL KHINQLLRTM SMPKGRVLDK NLDEEGFESG 
DCGDDEDECI GGSGDGMIKV KNQLRFLAEL AYDLDVDDAP GNSQQATPKD NEISTFHNLG 
NVHSPLKLLT SMAISVVCFF FLVH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: GPC3

Associated with

Cells (max top 100)

Other Information

Mapping of the Simpson-Golabi-Behmel overgrowth syndrome gene (GPC3) to chromosome X in human and rat by fluorescence in situ hybridization. PubMed ID: 9021160

Mutations in GPC3, a glypican gene, cause the Simpson-Golabi-Behmel overgrowth syndrome. PubMed ID: 8589713

Cloning and characterization of human cDNAs encoding a protein with high homology to rat intestinal development protein OCI-5. PubMed ID: 9133586

The DNA sequence of the human X chromosome. PubMed ID: 15772651

Analysis of exon/intron structure and 400 kb of genomic sequence surrounding the 5'-promoter and 3'-terminal ends of the human glypican 3 (GPC3) gene. PubMed ID: 9339360

Glypican-3: a novel serum and histochemical marker for hepatocellular carcinoma. PubMed ID: 12851874

Processing by proprotein convertases is required for glypican-3 modulation of cell survival, Wnt signaling, and gastrulation movements. PubMed ID: 14610063

Identification of soluble NH2-terminal fragment of glypican-3 as a serological marker for early-stage hepatocellular carcinoma. PubMed ID: 15059894

Glypican-3 promotes the growth of hepatocellular carcinoma by stimulating canonical Wnt signaling. PubMed ID: 16024626

Processing by convertases is not required for glypican-3-induced stimulation of hepatocellular carcinoma growth. PubMed ID: 16227623

The Simpson-Golabi-Behmel syndrome causative glypican-3, binds to and inhibits the dipeptidyl peptidase activity of CD26. PubMed ID: 17549790

Initial characterization of the human central proteome. PubMed ID: 21269460

Glypican-3 binds to Frizzled and plays a direct role in the stimulation of canonical Wnt signaling. PubMed ID: 24496449

A single kinase generates the majority of the secreted phosphoproteome. PubMed ID: 26091039

Processing by convertases is required for glypican-3-induced inhibition of Hedgehog signaling. PubMed ID: 25653284

Role of glycanation and convertase maturation of soluble glypican-3 in inhibiting proliferation of hepatocellular carcinoma cells. PubMed ID: 29345911

An affinity chromatography and glycoproteomics workflow to profile the chondroitin sulfate proteoglycans that interact with malarial VAR2CSA in the placenta and in cancer. PubMed ID: 32337544

Mutational analysis of the GPC3/GPC4 glypican gene cluster on Xq26 in patients with Simpson-Golabi-Behmel syndrome: identification of loss-of-function mutations in the GPC3 gene. PubMed ID: 10814714

Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. PubMed ID: 8125298

Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. PubMed ID: 9373149

Initial sequencing and analysis of the human genome. PubMed ID: 11237011

Finishing the euchromatic sequence of the human genome. PubMed ID: 15496913

The DNA sequence of the human X chromosome. PubMed ID: 15772651

Database document:

PubMed ID: 9021160

PubMed ID: 8589713

PubMed ID: 9133586

PubMed ID: 15772651

PubMed ID: 9339360

PubMed ID: 12851874

PubMed ID: 14610063

PubMed ID: 15059894

PubMed ID: 16024626

PubMed ID: 16227623

PubMed ID: 17549790

PubMed ID: 21269460

PubMed ID: 24496449

PubMed ID: 26091039

PubMed ID: 25653284

PubMed ID: 29345911

PubMed ID: 32337544

PubMed ID: 10814714

PubMed ID: 8125298

PubMed ID: 9373149

PubMed ID: 11237011

PubMed ID: 15496913

PubMed ID: 15772651