Details for: CL0002504

Cell ID: CL0002504

Cell Name: enteric smooth muscle cell

Marker Score Threshold: 2354
(Derived using integrated single-cell and genomic data)

Description: A smooth muscle cell of the intestine.

Synonyms: intestinal smooth muscle cell

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ACTG2 (ENSG00000163017)
    Fold Change: 2.92
    Ensembl ID: ENSG00000163017
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 2.79
    Ensembl ID: ENSG00000241837
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 2.77
    Ensembl ID: ENSG00000075624
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 2.75
    Ensembl ID: ENSG00000169100
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 2.74
    Ensembl ID: ENSG00000145741
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 2.73
    Ensembl ID: ENSG00000135390
  • Gene Symbol: ACTA2 (ENSG00000107796)
    Fold Change: 2.72
    Ensembl ID: ENSG00000107796
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 2.7
    Ensembl ID: ENSG00000166710
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 2.66
    Ensembl ID: ENSG00000124172
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.66
    Ensembl ID: ENSG00000184009
  • Gene Symbol: ACTN1 (ENSG00000072110)
    Fold Change: 2.62
    Ensembl ID: ENSG00000072110
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 2.54
    Ensembl ID: ENSG00000185650
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 2.54
    Ensembl ID: ENSG00000154518
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 2.51
    Ensembl ID: ENSG00000152234
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 2.49
    Ensembl ID: ENSG00000133639
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 2.48
    Ensembl ID: ENSG00000154723
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.47
    Ensembl ID: ENSG00000067560
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 2.44
    Ensembl ID: ENSG00000110955
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 2.43
    Ensembl ID: ENSG00000005022
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 2.43
    Ensembl ID: ENSG00000169020
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 2.37
    Ensembl ID: ENSG00000099624
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 2.36
    Ensembl ID: ENSG00000172270
  • Gene Symbol: ALDH1A1 (ENSG00000165092)
    Fold Change: 2.36
    Ensembl ID: ENSG00000165092
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 2.33
    Ensembl ID: ENSG00000143761
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 2.28
    Ensembl ID: ENSG00000165629
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 2.24
    Ensembl ID: ENSG00000116459
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 2.23
    Ensembl ID: ENSG00000142192
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 2.19
    Ensembl ID: ENSG00000128272
  • Gene Symbol: ANXA6 (ENSG00000197043)
    Fold Change: 2.18
    Ensembl ID: ENSG00000197043
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 2.09
    Ensembl ID: ENSG00000100823
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 2.05
    Ensembl ID: ENSG00000130402
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 2.05
    Ensembl ID: ENSG00000149925
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 2.05
    Ensembl ID: ENSG00000085224
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.99
    Ensembl ID: ENSG00000177556
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.97
    Ensembl ID: ENSG00000159199
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.97
    Ensembl ID: ENSG00000104964
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.95
    Ensembl ID: ENSG00000143727
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.94
    Ensembl ID: ENSG00000084234
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.85
    Ensembl ID: ENSG00000168374
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.83
    Ensembl ID: ENSG00000108561
  • Gene Symbol: ARL2 (ENSG00000213465)
    Fold Change: 1.82
    Ensembl ID: ENSG00000213465
  • Gene Symbol: RHOC (ENSG00000155366)
    Fold Change: 1.81
    Ensembl ID: ENSG00000155366
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.76
    Ensembl ID: ENSG00000004059
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.74
    Ensembl ID: ENSG00000198931
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 1.71
    Ensembl ID: ENSG00000152518
  • Gene Symbol: ADH5 (ENSG00000197894)
    Fold Change: 1.69
    Ensembl ID: ENSG00000197894
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 1.62
    Ensembl ID: ENSG00000142599
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.6
    Ensembl ID: ENSG00000141522
  • Gene Symbol: SLC25A4 (ENSG00000151729)
    Fold Change: 1.6
    Ensembl ID: ENSG00000151729
  • Gene Symbol: ATP2B4 (ENSG00000058668)
    Fold Change: 1.57
    Ensembl ID: ENSG00000058668
  • Gene Symbol: AHCY (ENSG00000101444)
    Fold Change: 1.56
    Ensembl ID: ENSG00000101444
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.55
    Ensembl ID: ENSG00000164111
  • Gene Symbol: ACTC1 (ENSG00000159251)
    Fold Change: 1.55
    Ensembl ID: ENSG00000159251
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.54
    Ensembl ID: ENSG00000182718
  • Gene Symbol: DST (ENSG00000151914)
    Fold Change: 1.53
    Ensembl ID: ENSG00000151914
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.51
    Ensembl ID: ENSG00000104765
  • Gene Symbol: ARL3 (ENSG00000138175)
    Fold Change: 1.49
    Ensembl ID: ENSG00000138175
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.46
    Ensembl ID: ENSG00000087274
  • Gene Symbol: PARP1 (ENSG00000143799)
    Fold Change: 1.45
    Ensembl ID: ENSG00000143799
  • Gene Symbol: BAD (ENSG00000002330)
    Fold Change: 1.43
    Ensembl ID: ENSG00000002330
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.43
    Ensembl ID: ENSG00000070961
  • Gene Symbol: BST2 (ENSG00000130303)
    Fold Change: 1.42
    Ensembl ID: ENSG00000130303
  • Gene Symbol: CCND1 (ENSG00000110092)
    Fold Change: 1.42
    Ensembl ID: ENSG00000110092
  • Gene Symbol: BNIP3 (ENSG00000176171)
    Fold Change: 1.38
    Ensembl ID: ENSG00000176171
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 1.38
    Ensembl ID: ENSG00000143878
  • Gene Symbol: AAMP (ENSG00000127837)
    Fold Change: 1.37
    Ensembl ID: ENSG00000127837
  • Gene Symbol: ALDH1B1 (ENSG00000137124)
    Fold Change: 1.37
    Ensembl ID: ENSG00000137124
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.34
    Ensembl ID: ENSG00000117410
  • Gene Symbol: BMPR2 (ENSG00000204217)
    Fold Change: 1.33
    Ensembl ID: ENSG00000204217
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.29
    Ensembl ID: ENSG00000122359
  • Gene Symbol: BMPR1A (ENSG00000107779)
    Fold Change: 1.29
    Ensembl ID: ENSG00000107779
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.28
    Ensembl ID: ENSG00000123505
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: 1.27
    Ensembl ID: ENSG00000087088
  • Gene Symbol: VPS51 (ENSG00000149823)
    Fold Change: 1.25
    Ensembl ID: ENSG00000149823
  • Gene Symbol: PLIN2 (ENSG00000147872)
    Fold Change: 1.24
    Ensembl ID: ENSG00000147872
  • Gene Symbol: AK2 (ENSG00000004455)
    Fold Change: 1.23
    Ensembl ID: ENSG00000004455
  • Gene Symbol: ALDH2 (ENSG00000111275)
    Fold Change: 1.22
    Ensembl ID: ENSG00000111275
  • Gene Symbol: ATP6V1E1 (ENSG00000131100)
    Fold Change: 1.21
    Ensembl ID: ENSG00000131100
  • Gene Symbol: ATP1B1 (ENSG00000143153)
    Fold Change: 1.19
    Ensembl ID: ENSG00000143153
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.17
    Ensembl ID: ENSG00000072778
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.16
    Ensembl ID: ENSG00000104763
  • Gene Symbol: ACTL6A (ENSG00000136518)
    Fold Change: 1.14
    Ensembl ID: ENSG00000136518
  • Gene Symbol: ABCF1 (ENSG00000204574)
    Fold Change: 1.13
    Ensembl ID: ENSG00000204574
  • Gene Symbol: MPPED2 (ENSG00000066382)
    Fold Change: 1.12
    Ensembl ID: ENSG00000066382
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.11
    Ensembl ID: ENSG00000115307
  • Gene Symbol: ARHGAP5 (ENSG00000100852)
    Fold Change: 1.1
    Ensembl ID: ENSG00000100852
  • Gene Symbol: RND3 (ENSG00000115963)
    Fold Change: 1.09
    Ensembl ID: ENSG00000115963
  • Gene Symbol: ADSL (ENSG00000239900)
    Fold Change: 1.09
    Ensembl ID: ENSG00000239900
  • Gene Symbol: AP2B1 (ENSG00000006125)
    Fold Change: 1.09
    Ensembl ID: ENSG00000006125
  • Gene Symbol: ARL1 (ENSG00000120805)
    Fold Change: 1.08
    Ensembl ID: ENSG00000120805
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.08
    Ensembl ID: ENSG00000165527
  • Gene Symbol: APOC1 (ENSG00000130208)
    Fold Change: 1.07
    Ensembl ID: ENSG00000130208
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.06
    Ensembl ID: ENSG00000148700
  • Gene Symbol: ATP6V0C (ENSG00000185883)
    Fold Change: 1.05
    Ensembl ID: ENSG00000185883
  • Gene Symbol: GET3 (ENSG00000198356)
    Fold Change: 1.05
    Ensembl ID: ENSG00000198356
  • Gene Symbol: BAG1 (ENSG00000107262)
    Fold Change: 1.04
    Ensembl ID: ENSG00000107262
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.04
    Ensembl ID: ENSG00000069849
  • Gene Symbol: ACO2 (ENSG00000100412)
    Fold Change: 1.03
    Ensembl ID: ENSG00000100412
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.03
    Ensembl ID: ENSG00000160710
  • Gene Symbol: C1S (ENSG00000182326)
    Fold Change: 1.02
    Ensembl ID: ENSG00000182326
Hovered Details

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Hovered Details

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**Key Characteristics** 1. **Muscle Contraction**: ESMCs are capable of contracting and relaxing, which is essential for the movement of food through the digestive system. 2. **Intestinal Motility**: ESMCs play a crucial role in regulating intestinal motility, which is the movement of food through the digestive system. 3. **Blood Flow Regulation**: ESMCs also regulate blood flow to the intestinal tissue, which is essential for the delivery of oxygen and nutrients to the cells. 4. **Contractility**: ESMCs have a high contractility, which allows them to generate force and move food through the digestive system. 5. **Relaxation**: ESMCs also have the ability to relax, which is essential for the movement of food through the digestive system. **Clinical Significance** 1. **Gastrointestinal Motility Disorders**: ESMCs play a crucial role in regulating intestinal motility, and dysfunction of these cells can lead to gastrointestinal motility disorders such as constipation or diarrhea. 2. **Inflammatory Bowel Disease**: ESMCs have been implicated in the pathogenesis of inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis. 3. **Cancer**: Abnormalities in ESMCs have been associated with an increased risk of cancer, including colorectal cancer. 4. **Neurological Disorders**: ESMCs have been implicated in the pathogenesis of neurological disorders such as Parkinson's disease and multiple system atrophy. 5. **Pharmacological Targets**: ESMCs have been identified as potential targets for the treatment of various diseases, including gastrointestinal motility disorders and inflammatory bowel disease. **Genetic Makeup** The ESMC has a genetic makeup composed of the gene symbol ACTG2, which encodes a protein involved in muscle contraction. The ESMC also has several other genes that are involved in muscle contraction, including ATP5PO and ATP5MC2. **Pathways and Ontology** The ESMC is involved in various pathways and ontologies, including: 1. **Atp binding**: The ESMC has a high affinity for ATP, which is essential for muscle contraction. 2. **Blood microparticle**: The ESMC has been implicated in the formation of blood microparticles, which are small vesicles that can be released from the cell. 3. **Cell body**: The ESMC has a large cell body that contains the nucleus and other organelles. 4. **Cell periphery**: The ESMC has a distinct cell periphery that is involved in cell-cell interactions. 5. **Cytoskeleton**: The ESMC has a well-developed cytoskeleton that is essential for muscle contraction and relaxation. In conclusion, the Enteric Smooth Muscle Cell (ESMC) is a critical component of the gastrointestinal tract, and its dysfunction can lead to various diseases. The ESMC has a unique genetic makeup and is involved in various pathways and ontologies, including ATP binding, blood microparticles, cell body, cell periphery, and cytoskeleton. Understanding the biology of the ESMC is essential for the development of novel therapeutic strategies for gastrointestinal motility disorders and other diseases.