Details for: IL11RA

Gene ID: 3590

Symbol: IL11RA

Ensembl ID: ENSG00000137070

Description: interleukin 11 receptor subunit alpha

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 1.61
    Marker Score: 9569.5
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.53
    Marker Score: 15372.5
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 1.45
    Marker Score: 19126
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 1.37
    Marker Score: 440
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 1.22
    Marker Score: 1877
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.21
    Marker Score: 1286.5
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.16
    Marker Score: 7563
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 1.1
    Marker Score: 474
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 1.05
    Marker Score: 397
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.05
    Marker Score: 16364
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.02
    Marker Score: 2398
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71792
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48016
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30405
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.97
    Marker Score: 224
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.95
    Marker Score: 491
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2409
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 0.95
    Marker Score: 328
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.94
    Marker Score: 445
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 0.94
    Marker Score: 210
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2727
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.89
    Marker Score: 5089
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5269
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 310
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.86
    Marker Score: 1071
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.83
    Marker Score: 1452
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.82
    Marker Score: 203
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.78
    Marker Score: 1470
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 0.77
    Marker Score: 667
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1257
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.75
    Marker Score: 704
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.74
    Marker Score: 6992
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.73
    Marker Score: 380
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.72
    Marker Score: 290.5
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.71
    Marker Score: 1923
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.71
    Marker Score: 539.5
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.7
    Marker Score: 1837
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.69
    Marker Score: 632
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.68
    Marker Score: 174
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.67
    Marker Score: 24774
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.66
    Marker Score: 170
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.65
    Marker Score: 2710
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 0.64
    Marker Score: 158
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.63
    Marker Score: 1480
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.61
    Marker Score: 940
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.6
    Marker Score: 647
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.56
    Marker Score: 235
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.55
    Marker Score: 3322
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 435
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.54
    Marker Score: 261
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.54
    Marker Score: 2219
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.53
    Marker Score: 563
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.52
    Marker Score: 1056
  • Cell Name: muscle precursor cell (CL0000680)
    Fold Change: 0.51
    Marker Score: 132
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.51
    Marker Score: 491
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.5
    Marker Score: 248
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.5
    Marker Score: 10623
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.5
    Marker Score: 1922
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.49
    Marker Score: 9824
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.49
    Marker Score: 141
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.49
    Marker Score: 2621
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.49
    Marker Score: 547
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.47
    Marker Score: 2040
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.47
    Marker Score: 3005
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 0.46
    Marker Score: 168
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.46
    Marker Score: 268
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.46
    Marker Score: 658
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.46
    Marker Score: 17373
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 0.46
    Marker Score: 430
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.46
    Marker Score: 304
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.46
    Marker Score: 562
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.45
    Marker Score: 941
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.44
    Marker Score: 1578
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.44
    Marker Score: 209
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.44
    Marker Score: 183
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.42
    Marker Score: 169
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.41
    Marker Score: 249
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.41
    Marker Score: 354
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.41
    Marker Score: 127
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.4
    Marker Score: 166
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.4
    Marker Score: 175
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.4
    Marker Score: 1116
  • Cell Name: ventricular cardiac muscle cell (CL2000046)
    Fold Change: 0.39
    Marker Score: 161
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.39
    Marker Score: 3680
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.38
    Marker Score: 259
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.38
    Marker Score: 103
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.38
    Marker Score: 639.5
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.37
    Marker Score: 98
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.37
    Marker Score: 243
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.37
    Marker Score: 127
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.36
    Marker Score: 3184
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.36
    Marker Score: 114
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.36
    Marker Score: 1399
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 0.36
    Marker Score: 160
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.35
    Marker Score: 379
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 0.35
    Marker Score: 300
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.35
    Marker Score: 239
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.35
    Marker Score: 1281
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 0.35
    Marker Score: 195
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.34
    Marker Score: 89

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Other Information

**Key characteristics:** * The IL11RA gene is located on chromosome 17q21.1. * It is a single-exon gene with a size of approximately 2.5kb. * The protein encoded by IL11RA is a type I transmembrane receptor that is expressed in various cell types. * It is a key regulator of the immune response, and its expression is regulated by cytokines, growth factors, and other extracellular signals. **Pathways and functions:** * The IL11RA gene is a key component of the cytokine-mediated signaling pathway, which is involved in the regulation of immune responses. * It is also involved in developmental processes, cell migration, and tissue development. * In the immune system, IL11RA signaling is critical for the differentiation of naive CD4+ T cells into effector T cells, the activation of macrophages and dendritic cells, and the regulation of inflammation. * IL11RA signaling is also involved in the development and maintenance of the female reproductive tract. **Clinical significance:** * Mutations in the IL11RA gene have been linked to several human diseases, including endometriosis, polycystic ovary syndrome, and infertility. * In endometriosis, IL11RA signaling is dysregulated, leading to the formation of benign or malignant tumors in the female reproductive tract. * In polycystic ovary syndrome, mutations in IL11RA are associated with the development of ovarian cysts and tumors. **Conclusion:** The IL11RA gene plays a crucial role in regulating immune responses and developmental processes. Its expression and activity are highly regulated by cytokines and growth factors, and its dysfunction can lead to various diseases.

Genular Protein ID: 3607080383

Symbol: I11RA_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q14626 Q16542 Q5VZ80 Q7KYJ7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 DrugCentral 1 EMBL 9 Ensembl 5 ExpressionAtlas 1 GO 12 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PDB 2 PDBsum 1 PIR 1 PRO 1 PROSITE 3 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 1 SAM 1 SASBDB 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 7670098

Title: Molecular cloning of two isoforms of a receptor for the human hematopoietic cytokine interleukin-11.

PubMed ID: 7670098

PubMed ID: 8808281

Title: Molecular cloning and characterization of the human interleukin-11 receptor alpha-chain gene, IL11RA, located on chromosome 9p13.

PubMed ID: 8808281

DOI: 10.1006/geno.1996.0010

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11141475

Title: Increased expression of the interleukin-11 receptor and evidence of STAT3 activation in prostate carcinoma.

PubMed ID: 11141475

DOI: 10.1016/s0002-9440(10)63940-5

PubMed ID: 26876177

Title: Proteolytic Cleavage Governs Interleukin-11 Trans-signaling.

PubMed ID: 26876177

DOI: 10.1016/j.celrep.2016.01.053

PubMed ID: 30279168

Title: Soluble gp130 prevents interleukin-6 and interleukin-11 cluster signaling but not intracellular autocrine responses.

PubMed ID: 30279168

DOI: 10.1126/scisignal.aar7388

PubMed ID: 21741611

Title: Inactivation of IL11 signaling causes craniosynostosis, delayed tooth eruption, and supernumerary teeth.

PubMed ID: 21741611

DOI: 10.1016/j.ajhg.2011.05.024

Sequence Information:

  • Length: 422
  • Mass: 45222
  • Checksum: 1F8BC05C139FC326
  • Sequence:
    • MSSSCSGLSR VLVAVATALV SASSPCPQAW GPPGVQYGQP GRSVKLCCPG VTAGDPVSWF 
RDGEPKLLQG PDSGLGHELV LAQADSTDEG TYICQTLDGA LGGTVTLQLG YPPARPVVSC 
QAADYENFSC TWSPSQISGL PTRYLTSYRK KTVLGADSQR RSPSTGPWPC PQDPLGAARC 
VVHGAEFWSQ YRINVTEVNP LGASTRLLDV SLQSILRPDP PQGLRVESVP GYPRRLRASW 
TYPASWPCQP HFLLKFRLQY RPAQHPAWST VEPAGLEEVI TDAVAGLPHA VRVSARDFLD 
AGTWSTWSPE AWGTPSTGTI PKEIPAWGQL HTQPEVEPQV DSPAPPRPSL QPHPRLLDHR 
DSVEQVAVLA SLGILSFLGL VAGALALGLW LRLRRGGKDG SPKPGFLASV IPVDRRPGAP 
NL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.