Details for: IL11RA

Gene ID: 3590

Symbol: IL11RA

Ensembl ID: ENSG00000137070

Description: interleukin 11 receptor subunit alpha

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 82.5483
    Cell Significance Index: -12.8400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 49.0847
    Cell Significance Index: -12.4500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 25.9678
    Cell Significance Index: -12.2600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 25.4765
    Cell Significance Index: -10.3500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 11.1444
    Cell Significance Index: -10.6400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 10.4302
    Cell Significance Index: -12.8600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 4.6638
    Cell Significance Index: 97.6200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.5504
    Cell Significance Index: -12.1900
  • Cell Name: chondroblast (CL0000058)
    Fold Change: 3.6985
    Cell Significance Index: 21.7100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.2602
    Cell Significance Index: -12.8700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 2.7004
    Cell Significance Index: -5.9100
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.8346
    Cell Significance Index: 23.5000
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 1.4950
    Cell Significance Index: 20.9700
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.4107
    Cell Significance Index: 22.3800
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.1364
    Cell Significance Index: 5.9800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.9792
    Cell Significance Index: 96.8700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.9025
    Cell Significance Index: 115.6900
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.8860
    Cell Significance Index: 14.6000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8336
    Cell Significance Index: 752.6800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.7572
    Cell Significance Index: 20.2900
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.7330
    Cell Significance Index: 4.5400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.5850
    Cell Significance Index: 6.3600
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.5697
    Cell Significance Index: 9.1400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.5294
    Cell Significance Index: 13.9200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4907
    Cell Significance Index: 79.8100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4568
    Cell Significance Index: 49.6900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4151
    Cell Significance Index: 11.9600
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.3757
    Cell Significance Index: 3.2500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3726
    Cell Significance Index: 164.7500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.3138
    Cell Significance Index: 8.7700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3118
    Cell Significance Index: 18.7200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3115
    Cell Significance Index: 61.8100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.2759
    Cell Significance Index: 14.3700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.2717
    Cell Significance Index: 78.1700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2645
    Cell Significance Index: 11.9900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2559
    Cell Significance Index: 17.7000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2189
    Cell Significance Index: 41.6500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2188
    Cell Significance Index: 4.7400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2089
    Cell Significance Index: 41.9000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1931
    Cell Significance Index: 69.2700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1812
    Cell Significance Index: 24.8900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.1768
    Cell Significance Index: 3.4500
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 0.1660
    Cell Significance Index: 0.9800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1145
    Cell Significance Index: 8.7900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0888
    Cell Significance Index: 4.6600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0714
    Cell Significance Index: 3.1600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0691
    Cell Significance Index: 2.6200
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.0677
    Cell Significance Index: 1.0200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0665
    Cell Significance Index: 2.3400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0460
    Cell Significance Index: 1.6000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0435
    Cell Significance Index: 2.0300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0400
    Cell Significance Index: 1.0000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0390
    Cell Significance Index: 2.7600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0343
    Cell Significance Index: 4.4300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0293
    Cell Significance Index: 5.2800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0227
    Cell Significance Index: 0.3800
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.0220
    Cell Significance Index: 0.2300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0206
    Cell Significance Index: 0.5600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0134
    Cell Significance Index: 7.3000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0125
    Cell Significance Index: 0.1700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0113
    Cell Significance Index: 21.2300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0083
    Cell Significance Index: 12.8100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0043
    Cell Significance Index: 7.8600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0005
    Cell Significance Index: -0.3300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0039
    Cell Significance Index: -0.5700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0053
    Cell Significance Index: -7.1900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0099
    Cell Significance Index: -7.2900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0106
    Cell Significance Index: -7.9900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0115
    Cell Significance Index: -5.2400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0158
    Cell Significance Index: -11.6800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0163
    Cell Significance Index: -2.0100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0212
    Cell Significance Index: -13.2600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0215
    Cell Significance Index: -12.1100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0264
    Cell Significance Index: -0.3900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0420
    Cell Significance Index: -2.6500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0446
    Cell Significance Index: -0.9500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0455
    Cell Significance Index: -5.3000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0455
    Cell Significance Index: -7.7700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0520
    Cell Significance Index: -5.3100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0573
    Cell Significance Index: -2.9000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0587
    Cell Significance Index: -6.7300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0628
    Cell Significance Index: -13.2300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0726
    Cell Significance Index: -3.4100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0753
    Cell Significance Index: -4.8600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0764
    Cell Significance Index: -2.1900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0817
    Cell Significance Index: -5.0200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0880
    Cell Significance Index: -10.3800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0918
    Cell Significance Index: -6.1700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0933
    Cell Significance Index: -6.9600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1135
    Cell Significance Index: -11.8200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1157
    Cell Significance Index: -3.0900
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.1182
    Cell Significance Index: -0.7400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1207
    Cell Significance Index: -6.2700
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.1265
    Cell Significance Index: -1.0100
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.1391
    Cell Significance Index: -1.7300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1393
    Cell Significance Index: -4.4600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1434
    Cell Significance Index: -11.3600
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.1480
    Cell Significance Index: -2.4900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1592
    Cell Significance Index: -4.6900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1793
    Cell Significance Index: -10.0600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** IL11RA is a transmembrane receptor protein that belongs to the cytokine receptor superfamily. It is expressed on various cell types, including Sertoli cells, granulosa cells, mesodermal cells, and mesenchymal stem cells. The protein is composed of two subunits, alpha and beta, which are connected by a disulfide bond. The alpha subunit is responsible for binding IL-11, while the beta subunit is involved in signal transduction. IL11RA is highly expressed in tissues involved in immune response, development, and tissue repair. **Pathways and Functions:** IL11RA is involved in several signaling pathways, including the IL-6-type cytokine receptor ligand interactions, interleukin-11 binding, and interleukin-11 receptor activity. The IL-11/IL11RA signaling pathway plays a crucial role in regulating immune responses, including the activation of immune cells, such as T cells and macrophages. IL-11 also promotes the proliferation of mesenchymal stem cells, which are essential for tissue repair and development. Additionally, IL11RA is involved in the regulation of cell population proliferation and the positive regulation of cell growth. **Clinical Significance:** IL11RA has been implicated in various diseases, including autoimmune disorders, such as rheumatoid arthritis and multiple sclerosis. The abnormal expression of IL11RA has been linked to the development of these diseases. Moreover, IL11RA has been shown to play a role in the regulation of inflammation and tissue repair. Its dysregulation has been associated with fibrosis, a condition characterized by excessive scarring of tissues. Furthermore, IL11RA has been investigated as a potential target for the treatment of various diseases, including cancer and cardiovascular diseases. In conclusion, IL11RA is a critical component of the IL-11 signaling pathway, playing a significant role in immune regulation, development, and tissue repair. Its dysregulation has been implicated in various diseases, making it a promising target for therapeutic interventions. Further research is needed to fully understand the complex functions of IL11RA and its role in human disease. **References:** * [Insert relevant references here] Note: As an expert immunologist, I would like to emphasize the importance of further research on IL11RA and its role in human disease. The current understanding of IL11RA is based on its expression and function in various cell types and tissues. However, more studies are needed to elucidate the specific mechanisms by which IL11RA regulates immune responses and tissue repair.

Genular Protein ID: 3607080383

Symbol: I11RA_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q14626 Q16542 Q5VZ80 Q7KYJ7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 DrugCentral 1 EMBL 9 EMDB 3 Ensembl 5 ExpressionAtlas 1 GO 12 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 5 PIR 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 1 SASBDB 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 7670098

Title: Molecular cloning of two isoforms of a receptor for the human hematopoietic cytokine interleukin-11.

PubMed ID: 7670098

PubMed ID: 8808281

Title: Molecular cloning and characterization of the human interleukin-11 receptor alpha-chain gene, IL11RA, located on chromosome 9p13.

PubMed ID: 8808281

DOI: 10.1006/geno.1996.0010

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11141475

Title: Increased expression of the interleukin-11 receptor and evidence of STAT3 activation in prostate carcinoma.

PubMed ID: 11141475

DOI: 10.1016/s0002-9440(10)63940-5

PubMed ID: 26876177

Title: Proteolytic Cleavage Governs Interleukin-11 Trans-signaling.

PubMed ID: 26876177

DOI: 10.1016/j.celrep.2016.01.053

PubMed ID: 30279168

Title: Soluble gp130 prevents interleukin-6 and interleukin-11 cluster signaling but not intracellular autocrine responses.

PubMed ID: 30279168

DOI: 10.1126/scisignal.aar7388

PubMed ID: 21741611

Title: Inactivation of IL11 signaling causes craniosynostosis, delayed tooth eruption, and supernumerary teeth.

PubMed ID: 21741611

DOI: 10.1016/j.ajhg.2011.05.024

Sequence Information:

  • Length: 422
  • Mass: 45222
  • Checksum: 1F8BC05C139FC326
  • Sequence:
    • MSSSCSGLSR VLVAVATALV SASSPCPQAW GPPGVQYGQP GRSVKLCCPG VTAGDPVSWF 
RDGEPKLLQG PDSGLGHELV LAQADSTDEG TYICQTLDGA LGGTVTLQLG YPPARPVVSC 
QAADYENFSC TWSPSQISGL PTRYLTSYRK KTVLGADSQR RSPSTGPWPC PQDPLGAARC 
VVHGAEFWSQ YRINVTEVNP LGASTRLLDV SLQSILRPDP PQGLRVESVP GYPRRLRASW 
TYPASWPCQP HFLLKFRLQY RPAQHPAWST VEPAGLEEVI TDAVAGLPHA VRVSARDFLD 
AGTWSTWSPE AWGTPSTGTI PKEIPAWGQL HTQPEVEPQV DSPAPPRPSL QPHPRLLDHR 
DSVEQVAVLA SLGILSFLGL VAGALALGLW LRLRRGGKDG SPKPGFLASV IPVDRRPGAP 
NL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.