JUN | ENSG00000177606 | NCBI 3725

Details for: JUN

Gene ID: 3725

Symbol: JUN

Ensembl ID: ENSG00000177606

Description: Jun proto-oncogene, AP-1 transcription factor subunit

Associated with

Activation of anterior hox genes in hindbrain development during early embryogenesis
(R-HSA-5617472)
Activation of hox genes during differentiation
(R-HSA-5619507)
Activation of the ap-1 family of transcription factors
(R-HSA-450341)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular senescence
(R-HSA-2559583)
Cytokine signaling in immune system
(R-HSA-1280215)
Defective intrinsic pathway for apoptosis
(R-HSA-9734009)
Deregulated cdk5 triggers multiple neurodegenerative pathways in alzheimer's disease models
(R-HSA-8862803)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of programmed cell death
(R-HSA-9645723)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Esr-mediated signaling
(R-HSA-8939211)
Estrogen-dependent gene expression
(R-HSA-9018519)
Fc epsilon receptor (fceri) signaling
(R-HSA-2454202)
Fceri mediated mapk activation
(R-HSA-2871796)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Innate immune system
(R-HSA-168249)
Interleukin-17 signaling
(R-HSA-448424)
Intracellular signaling by second messengers
(R-HSA-9006925)
Killing mechanisms
(R-HSA-9664420)
Leishmania infection
(R-HSA-9658195)
Mapk6/mapk4 signaling
(R-HSA-5687128)
Mapk family signaling cascades
(R-HSA-5683057)
Map kinase activation
(R-HSA-450294)
Mapk targets/ nuclear events mediated by map kinases
(R-HSA-450282)
Myd88 cascade initiated on plasma membrane
(R-HSA-975871)
Myd88 dependent cascade initiated on endosome
(R-HSA-975155)
Myd88-independent tlr4 cascade
(R-HSA-166166)
Myd88:mal(tirap) cascade initiated on plasma membrane
(R-HSA-166058)
Neurodegenerative diseases
(R-HSA-8863678)
Oxidative stress induced senescence
(R-HSA-2559580)
Parasitic infection pathways
(R-HSA-9824443)
Pip3 activates akt signaling
(R-HSA-1257604)
Pre-notch expression and processing
(R-HSA-1912422)
Pre-notch transcription and translation
(R-HSA-1912408)
Pten regulation
(R-HSA-6807070)
Regulation of pten gene transcription
(R-HSA-8943724)
Rna polymerase ii transcription
(R-HSA-73857)
Senescence-associated secretory phenotype (sasp)
(R-HSA-2559582)
Signaling by alk fusions and activated point mutants
(R-HSA-9725370)
Signaling by alk in cancer
(R-HSA-9700206)
Signaling by interleukins
(R-HSA-449147)
Signaling by notch
(R-HSA-157118)
Signaling by nuclear receptors
(R-HSA-9006931)
Signal transduction
(R-HSA-162582)
Toll-like receptor cascades
(R-HSA-168898)
Toll like receptor 2 (tlr2) cascade
(R-HSA-181438)
Toll like receptor 3 (tlr3) cascade
(R-HSA-168164)
Toll like receptor 4 (tlr4) cascade
(R-HSA-166016)
Toll like receptor 5 (tlr5) cascade
(R-HSA-168176)
Toll like receptor 7/8 (tlr7/8) cascade
(R-HSA-168181)
Toll like receptor 9 (tlr9) cascade
(R-HSA-168138)
Toll like receptor 10 (tlr10) cascade
(R-HSA-168142)
Toll like receptor tlr1:tlr2 cascade
(R-HSA-168179)
Toll like receptor tlr6:tlr2 cascade
(R-HSA-168188)
Tp53 regulates transcription of dna repair genes
(R-HSA-6796648)
Traf6 mediated induction of nfkb and map kinases upon tlr7/8 or 9 activation
(R-HSA-975138)
Transcriptional regulation by tp53
(R-HSA-3700989)
Trif (ticam1)-mediated tlr4 signaling
(R-HSA-937061)
Wnt5:fzd7-mediated leishmania damping
(R-HSA-9673324)
Camp response element binding
(GO:0035497)
Dna-binding transcription activator activity, rna polymerase ii-specific
(GO:0001228)
Dna-binding transcription factor activity
(GO:0003700)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Dna-binding transcription repressor activity, rna polymerase ii-specific
(GO:0001227)
Dna binding
(GO:0003677)
Enzyme binding
(GO:0019899)
General transcription initiation factor binding
(GO:0140296)
Gtpase activator activity
(GO:0005096)
Identical protein binding
(GO:0042802)
Negative regulation by host of viral transcription
(GO:0043922)
Negative regulation of dna-templated transcription
(GO:0045892)
Negative regulation of dna binding
(GO:0043392)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Positive regulation by host of viral transcription
(GO:0043923)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of dna-templated transcription
(GO:0045893)
Protein binding
(GO:0005515)
R-smad binding
(GO:0070412)
Regulation of cell population proliferation
(GO:0042127)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Release from viral latency
(GO:0019046)
Response to endoplasmic reticulum stress
(GO:0034976)
Rna binding
(GO:0003723)
Rna polymerase ii-specific dna-binding transcription factor binding
(GO:0061629)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Sequence-specific double-stranded dna binding
(GO:1990837)
Transcription cis-regulatory region binding
(GO:0000976)
Transforming growth factor beta receptor signaling pathway
(GO:0007179)
Ubiquitin-like protein ligase binding
(GO:0044389)
Ubiquitin protein ligase binding
(GO:0031625)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 1064.9636
Cell Significance Index: -165.6500
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 588.4049
Cell Significance Index: -149.2500
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 367.6799
Cell Significance Index: -173.5900
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 347.4050
Cell Significance Index: -178.7000
Cell Name: ileal goblet cell (CL1000326)
Fold Change: 258.9482
Cell Significance Index: -173.7600
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 134.6601
Cell Significance Index: -166.0300
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 43.6406
Cell Significance Index: -134.0400
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 43.4650
Cell Significance Index: -171.5200
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 42.5610
Cell Significance Index: -114.0200
Cell Name: theca cell (CL0000503)
Fold Change: 26.1667
Cell Significance Index: 153.7300
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 21.1689
Cell Significance Index: -46.3300
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 12.0956
Cell Significance Index: 346.7300
Cell Name: odontoblast (CL0000060)
Fold Change: 11.3025
Cell Significance Index: 1448.9100
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 11.1653
Cell Significance Index: 197.3100
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 7.8873
Cell Significance Index: 274.0800
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 7.3745
Cell Significance Index: 1012.7200
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 6.8816
Cell Significance Index: 88.1300
Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
Fold Change: 6.8815
Cell Significance Index: 42.3500
Cell Name: peg cell (CL4033014)
Fold Change: 6.3012
Cell Significance Index: 145.5800
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 6.0742
Cell Significance Index: 285.4800
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 5.7403
Cell Significance Index: 405.9800
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 5.6061
Cell Significance Index: 2478.6000
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 5.4022
Cell Significance Index: 251.8800
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 5.0725
Cell Significance Index: 106.1800
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 5.0400
Cell Significance Index: 375.6300
Cell Name: granulosa cell (CL0000501)
Fold Change: 4.4502
Cell Significance Index: 117.0200
Cell Name: early pro-B cell (CL0002046)
Fold Change: 4.2083
Cell Significance Index: 271.5000
Cell Name: lactocyte (CL0002325)
Fold Change: 4.0211
Cell Significance Index: 519.5000
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 3.9891
Cell Significance Index: 108.5800
Cell Name: cell in vitro (CL0001034)
Fold Change: 3.8283
Cell Significance Index: 2090.7500
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 3.3750
Cell Significance Index: 414.9900
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 3.1457
Cell Significance Index: 58.1400
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 2.8384
Cell Significance Index: 511.6800
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: 2.5855
Cell Significance Index: 295.1300
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 2.5415
Cell Significance Index: 73.2300
Cell Name: kidney cell (CL1000497)
Fold Change: 2.0246
Cell Significance Index: 16.1700
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 1.9608
Cell Significance Index: 334.8100
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 1.5150
Cell Significance Index: 16.4700
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.8233
Cell Significance Index: 37.3200
Cell Name: seromucus secreting cell (CL0000159)
Fold Change: 0.6392
Cell Significance Index: 13.3300
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.5938
Cell Significance Index: 70.0300
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.3765
Cell Significance Index: 13.2300
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.3341
Cell Significance Index: 66.3100
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.2651
Cell Significance Index: 13.7700
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.2236
Cell Significance Index: 11.7400
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 0.2112
Cell Significance Index: 154.8200
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 0.1972
Cell Significance Index: 2.2400
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.1802
Cell Significance Index: 3.0200
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.1429
Cell Significance Index: 23.2400
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.1385
Cell Significance Index: 104.8200
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.0971
Cell Significance Index: 9.6100
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.0847
Cell Significance Index: 16.1300
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.0780
Cell Significance Index: 7.9700
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0496
Cell Significance Index: 67.5100
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0094
Cell Significance Index: -17.7700
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0634
Cell Significance Index: -12.7100
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0696
Cell Significance Index: -24.9600
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0912
Cell Significance Index: -140.4000
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0917
Cell Significance Index: -67.9600
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0931
Cell Significance Index: -171.7700
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.1047
Cell Significance Index: -65.3700
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.1064
Cell Significance Index: -2.8400
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.1493
Cell Significance Index: -2.0400
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.2255
Cell Significance Index: -143.2200
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.2308
Cell Significance Index: -130.1600
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: -0.2397
Cell Significance Index: -165.7600
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.2463
Cell Significance Index: -111.7900
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.4150
Cell Significance Index: -87.4000
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.5379
Cell Significance Index: -154.7700
Cell Name: supporting cell (CL0000630)
Fold Change: -0.5553
Cell Significance Index: -2.5700
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.5884
Cell Significance Index: -15.7400
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.5961
Cell Significance Index: -68.2900
Cell Name: paneth cell of colon (CL0009009)
Fold Change: -0.7007
Cell Significance Index: -10.5000
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.8800
Cell Significance Index: -49.3800
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.9883
Cell Significance Index: -143.6700
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.9931
Cell Significance Index: -50.1900
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -1.0631
Cell Significance Index: -29.7100
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -1.0662
Cell Significance Index: -124.2500
Cell Name: gut absorptive cell (CL0000677)
Fold Change: -1.1222
Cell Significance Index: -67.3700
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -1.1485
Cell Significance Index: -88.1400
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -1.4263
Cell Significance Index: -87.6700
Cell Name: neuron associated cell (CL0000095)
Fold Change: -1.4458
Cell Significance Index: -59.2400
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -1.6039
Cell Significance Index: -167.0000
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: -1.6365
Cell Significance Index: -15.0700
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -1.6691
Cell Significance Index: -112.2300
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -1.7690
Cell Significance Index: -56.6600
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -1.7766
Cell Significance Index: -44.4100
Cell Name: preadipocyte (CL0002334)
Fold Change: -1.8112
Cell Significance Index: -35.3500
Cell Name: pro-T cell (CL0000827)
Fold Change: -1.8190
Cell Significance Index: -46.4700
Cell Name: cone retinal bipolar cell (CL0000752)
Fold Change: -1.9162
Cell Significance Index: -14.7700
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -1.9538
Cell Significance Index: -154.7400
Cell Name: perivascular cell (CL4033054)
Fold Change: -2.1506
Cell Significance Index: -9.9300
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -2.2046
Cell Significance Index: -13.3200
Cell Name: pulmonary interstitial fibroblast (CL0002241)
Fold Change: -2.5765
Cell Significance Index: -15.9400
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -2.7190
Cell Significance Index: -171.3700
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -2.8335
Cell Significance Index: -173.7200
Cell Name: type I muscle cell (CL0002211)
Fold Change: -3.3366
Cell Significance Index: -81.4100
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -3.3505
Cell Significance Index: -98.4000
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -3.7435
Cell Significance Index: -137.4200
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -3.7740
Cell Significance Index: -97.0100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics:** 1. **Transcriptional regulation:** Jun is a transcriptional activator that regulates the expression of target genes by binding to specific DNA sequences. 2. **AP-1 complex formation:** Jun interacts with other transcription factors, such as c-Fos, c-Jun, and ATF, to form the AP-1 complex. 3. **Cellular stress response:** Jun regulates the expression of genes involved in stress response, including heat shock proteins and antioxidant enzymes. 4. **Immune response:** Jun is involved in regulating the expression of genes involved in immune responses, including cytokines and chemokines. 5. **Cancer progression:** Jun has been implicated in cancer progression, including tumor growth, metastasis, and resistance to therapy. **Pathways and Functions:** 1. **Cellular stress response:** Jun regulates the expression of heat shock proteins, antioxidant enzymes, and other genes involved in stress response. 2. **Immune response:** Jun regulates the expression of cytokines, chemokines, and other genes involved in immune responses. 3. **Apoptosis:** Jun regulates the expression of genes involved in apoptosis, including pro-apoptotic and anti-apoptotic proteins. 4. **Cell proliferation:** Jun regulates the expression of genes involved in cell proliferation, including cyclin-dependent kinases and cell cycle regulators. 5. **Neurodegenerative diseases:** Jun has been implicated in neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. **Clinical Significance:** 1. **Cancer:** Jun is overexpressed in various types of cancer, including breast, lung, and colon cancer. 2. **Autoimmune disorders:** Jun has been implicated in autoimmune disorders, including rheumatoid arthritis and lupus. 3. **Neurodegenerative diseases:** Jun has been implicated in neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. 4. **Infectious diseases:** Jun regulates the expression of genes involved in immune responses, making it a potential target for therapeutic interventions in infectious diseases. 5. **Regulation of cell population proliferation:** Jun regulates the expression of genes involved in cell proliferation, making it a potential target for therapeutic interventions in diseases characterized by uncontrolled cell growth. In conclusion, the Jun proto-oncogene is a key regulator of cellular responses to stimuli and stress, and its dysregulation has been implicated in various diseases, including cancer, autoimmune disorders, and neurodegenerative diseases. Further research is needed to fully understand the role of Jun in these diseases and to identify potential therapeutic targets.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Activator protein 1

Genular Protein ID: 1547800440

Symbol: JUN_HUMAN

Name: Activator protein 1

UniProtKB Accession Codes:

P05412 Q6FHM7 Q96G93

Database IDs:

Citations:

PubMed ID: 3194415

Title: Structure and chromosomal localization of the functional intronless human JUN protooncogene.

PubMed ID: 3194415

DOI: 10.1073/pnas.85.23.9148

PubMed ID: 2825349

Title: Human proto-oncogene c-jun encodes a DNA binding protein with structural and functional properties of transcription factor AP-1.

PubMed ID: 2825349

DOI: 10.1126/science.2825349

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1846781

Title: Activation of protein kinase C decreases phosphorylation of c-Jun at sites that negatively regulate its DNA-binding activity.

PubMed ID: 1846781

DOI: 10.1016/0092-8674(91)90241-p

PubMed ID: 8464713

Title: c-Jun is phosphorylated by the DNA-dependent protein kinase in vitro; definition of the minimal kinase recognition motif.

PubMed ID: 8464713

DOI: 10.1093/nar/21.5.1289

PubMed ID: 8855261

Title: Regulation of mitogen-activated protein kinases by a calcium/calmodulin-dependent protein kinase cascade.

PubMed ID: 8855261

DOI: 10.1073/pnas.93.20.10803

PubMed ID: 8663478

Title: Cross-talk between different enhancer elements during mitogenic induction of the human stromelysin-1 gene.

PubMed ID: 8663478

DOI: 10.1074/jbc.271.30.18231

PubMed ID: 8837781

Title: A new group of conserved coactivators that increase the specificity of AP-1 transcription factors.

PubMed ID: 8837781

DOI: 10.1038/383453a0

PubMed ID: 9732876

Title: Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-beta-induced transcription.

PubMed ID: 9732876

DOI: 10.1038/29814

PubMed ID: 10196196

Title: SPI-B activates transcription via a unique proline, serine, and threonine domain and exhibits DNA binding affinity differences from PU.1.

PubMed ID: 10196196

DOI: 10.1074/jbc.274.16.11115

PubMed ID: 10376527

Title: Role of the ATFa/JNK2 complex in Jun activation.

PubMed ID: 10376527

DOI: 10.1038/sj.onc.1202723

PubMed ID: 10995748

Title: Structural and functional characterization of the transforming growth factor-beta -induced Smad3/c-Jun transcriptional cooperativity.

PubMed ID: 10995748

DOI: 10.1074/jbc.m004731200

PubMed ID: 11689449

Title: A specific lysine in c-Jun is required for transcriptional repression by E1A and is acetylated by p300.

PubMed ID: 11689449

DOI: 10.1093/emboj/20.21.6095

PubMed ID: 12087103

Title: Correlation of transcriptional repression by p21(SNFT) with changes in DNA.NF-AT complex interactions.

PubMed ID: 12087103

DOI: 10.1074/jbc.m205048200

PubMed ID: 12618758

Title: An unexpected role for FosB in activation-induced cell death of T cells.

PubMed ID: 12618758

DOI: 10.1038/sj.onc.1206126

PubMed ID: 15467742

Title: Transcriptional repression of MMP-1 by p21SNFT and reduced in vitro invasiveness of hepatocarcinoma cells.

PubMed ID: 15467742

DOI: 10.1038/sj.onc.1208109

PubMed ID: 14739463

Title: The ubiquitin ligase SCFFbw7 antagonizes apoptotic JNK signaling.

PubMed ID: 14739463

DOI: 10.1126/science.1092880

PubMed ID: 17210646

Title: Cyclic AMP stimulates SF-1-dependent CYP11A1 expression through homeodomain-interacting protein kinase 3-mediated Jun N-terminal kinase and c-Jun phosphorylation.

PubMed ID: 17210646

DOI: 10.1128/mcb.02253-06

PubMed ID: 16478997

Title: Sp1 deacetylation induced by phorbol ester recruits p300 to activate 12(S)-lipoxygenase gene transcription.

PubMed ID: 16478997

DOI: 10.1128/mcb.26.5.1770-1785.2006

PubMed ID: 17804415

Title: Stress-induced c-Jun activation mediated by Polo-like kinase 3 in corneal epithelial cells.

PubMed ID: 17804415

DOI: 10.1074/jbc.m702791200

PubMed ID: 18650425

Title: Activation of Polo-like kinase 3 by hypoxic stresses.

PubMed ID: 18650425

DOI: 10.1074/jbc.m801326200

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 22083952

Title: The forkhead transcription factor FOXK2 promotes AP-1-mediated transcriptional regulation.

PubMed ID: 22083952

DOI: 10.1128/mcb.05504-11

PubMed ID: 20852630

Title: Identification of a co-activator that links growth factor signalling to c-Jun/AP-1 activation.

PubMed ID: 20852630

DOI: 10.1038/ncb2098

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21177766

Title: P21-activated protein kinase (PAK2)-mediated c-Jun phosphorylation at 5 threonine sites promotes cell transformation.

PubMed ID: 21177766

DOI: 10.1093/carcin/bgq271

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22307329

Title: DYRK2 priming phosphorylation of c-Jun and c-Myc modulates cell cycle progression in human cancer cells.

PubMed ID: 22307329

DOI: 10.1172/jci60818

PubMed ID: 23624934

Title: Arginine methylation of the c-Jun coactivator RACO-1 is required for c-Jun/AP-1 activation.

PubMed ID: 23624934

DOI: 10.1038/emboj.2013.98

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24559171

Title: Cancer/testis antigen PAGE4, a regulator of c-Jun transactivation, is phosphorylated by homeodomain-interacting protein kinase 1, a component of the stress-response pathway.

PubMed ID: 24559171

DOI: 10.1021/bi500013w

PubMed ID: 24263171

Title: The Stress-response protein prostate-associated gene 4, interacts with c-Jun and potentiates its transactivation.

PubMed ID: 24263171

DOI: 10.1016/j.bbadis.2013.11.014

PubMed ID: 24623306

Title: A KRAS-directed transcriptional silencing pathway that mediates the CpG island methylator phenotype.

PubMed ID: 24623306

DOI: 10.7554/elife.02313

PubMed ID: 26242913

Title: Phosphorylation-induced conformational ensemble switching in an intrinsically disordered cancer/testis antigen.

PubMed ID: 26242913

DOI: 10.1074/jbc.m115.658583

PubMed ID: 27458189

Title: Synaptonuclear messenger PRR7 inhibits c-Jun ubiquitination and regulates NMDA-mediated excitotoxicity.

PubMed ID: 27458189

DOI: 10.15252/embj.201593070

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 31341047

Title: Identification of ARKL1 as a Negative Regulator of Epstein-Barr Virus Reactivation.

PubMed ID: 31341047

DOI: 10.1128/jvi.00989-19

PubMed ID: 31527692

Title: VRK1 functional insufficiency due to alterations in protein stability or kinase activity of human VRK1 pathogenic variants implicated in neuromotor syndromes.

PubMed ID: 31527692

DOI: 10.1038/s41598-019-49821-7

PubMed ID: 7816143

Title: Crystal structure of the heterodimeric bZIP transcription factor c-Fos-c-Jun bound to DNA.

PubMed ID: 7816143

DOI: 10.1038/373257a0

PubMed ID: 8662824

Title: High resolution NMR solution structure of the leucine zipper domain of the c-Jun homodimer.

PubMed ID: 8662824

DOI: 10.1074/jbc.271.23.13663

Sequence Information:

Length: 331
Mass: 35676
Checksum: 0695E23AC4D33561
Sequence:

MTAKMETTFY DDALNASFLP SESGPYGYSN PKILKQSMTL NLADPVGSLK PHLRAKNSDL 
LTSPDVGLLK LASPELERLI IQSSNGHITT TPTPTQFLCP KNVTDEQEGF AEGFVRALAE 
LHSQNTLPSV TSAAQPVNGA GMVAPAVASV AGGSGSGGFS ASLHSEPPVY ANLSNFNPGA 
LSSGGGAPSY GAAGLAFPAQ PQQQQQPPHH LPQQMPVQHP RLQALKEEPQ TVPEMPGETP 
PLSPIDMESQ ERIKAERKRM RNRIAASKCR KRKLERIARL EEKVKTLKAQ NSELASTANM 
LREQVAQLKQ KVMNHVNSGC QLMLTQQLQT F

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: JUN

Associated with

Cells (max top 100)

Other Information

Structure and chromosomal localization of the functional intronless human JUN protooncogene. PubMed ID: 3194415

Human proto-oncogene c-jun encodes a DNA binding protein with structural and functional properties of transcription factor AP-1. PubMed ID: 2825349

The DNA sequence and biological annotation of human chromosome 1. PubMed ID: 16710414

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Activation of protein kinase C decreases phosphorylation of c-Jun at sites that negatively regulate its DNA-binding activity. PubMed ID: 1846781

c-Jun is phosphorylated by the DNA-dependent protein kinase in vitro; definition of the minimal kinase recognition motif. PubMed ID: 8464713

Regulation of mitogen-activated protein kinases by a calcium/calmodulin-dependent protein kinase cascade. PubMed ID: 8855261

Cross-talk between different enhancer elements during mitogenic induction of the human stromelysin-1 gene. PubMed ID: 8663478

A new group of conserved coactivators that increase the specificity of AP-1 transcription factors. PubMed ID: 8837781

Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-beta-induced transcription. PubMed ID: 9732876

SPI-B activates transcription via a unique proline, serine, and threonine domain and exhibits DNA binding affinity differences from PU.1. PubMed ID: 10196196

Role of the ATFa/JNK2 complex in Jun activation. PubMed ID: 10376527

Structural and functional characterization of the transforming growth factor-beta -induced Smad3/c-Jun transcriptional cooperativity. PubMed ID: 10995748

A specific lysine in c-Jun is required for transcriptional repression by E1A and is acetylated by p300. PubMed ID: 11689449

Correlation of transcriptional repression by p21(SNFT) with changes in DNA.NF-AT complex interactions. PubMed ID: 12087103

An unexpected role for FosB in activation-induced cell death of T cells. PubMed ID: 12618758

Transcriptional repression of MMP-1 by p21SNFT and reduced in vitro invasiveness of hepatocarcinoma cells. PubMed ID: 15467742

The ubiquitin ligase SCFFbw7 antagonizes apoptotic JNK signaling. PubMed ID: 14739463

Cyclic AMP stimulates SF-1-dependent CYP11A1 expression through homeodomain-interacting protein kinase 3-mediated Jun N-terminal kinase and c-Jun phosphorylation. PubMed ID: 17210646

Sp1 deacetylation induced by phorbol ester recruits p300 to activate 12(S)-lipoxygenase gene transcription. PubMed ID: 16478997

Stress-induced c-Jun activation mediated by Polo-like kinase 3 in corneal epithelial cells. PubMed ID: 17804415

Activation of Polo-like kinase 3 by hypoxic stresses. PubMed ID: 18650425

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

The forkhead transcription factor FOXK2 promotes AP-1-mediated transcriptional regulation. PubMed ID: 22083952

Identification of a co-activator that links growth factor signalling to c-Jun/AP-1 activation. PubMed ID: 20852630

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

P21-activated protein kinase (PAK2)-mediated c-Jun phosphorylation at 5 threonine sites promotes cell transformation. PubMed ID: 21177766

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

DYRK2 priming phosphorylation of c-Jun and c-Myc modulates cell cycle progression in human cancer cells. PubMed ID: 22307329

Arginine methylation of the c-Jun coactivator RACO-1 is required for c-Jun/AP-1 activation. PubMed ID: 23624934

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

Cancer/testis antigen PAGE4, a regulator of c-Jun transactivation, is phosphorylated by homeodomain-interacting protein kinase 1, a component of the stress-response pathway. PubMed ID: 24559171

The Stress-response protein prostate-associated gene 4, interacts with c-Jun and potentiates its transactivation. PubMed ID: 24263171

A KRAS-directed transcriptional silencing pathway that mediates the CpG island methylator phenotype. PubMed ID: 24623306

Phosphorylation-induced conformational ensemble switching in an intrinsically disordered cancer/testis antigen. PubMed ID: 26242913

Synaptonuclear messenger PRR7 inhibits c-Jun ubiquitination and regulates NMDA-mediated excitotoxicity. PubMed ID: 27458189

Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. PubMed ID: 28112733

Identification of ARKL1 as a Negative Regulator of Epstein-Barr Virus Reactivation. PubMed ID: 31341047

VRK1 functional insufficiency due to alterations in protein stability or kinase activity of human VRK1 pathogenic variants implicated in neuromotor syndromes. PubMed ID: 31527692

Crystal structure of the heterodimeric bZIP transcription factor c-Fos-c-Jun bound to DNA. PubMed ID: 7816143

High resolution NMR solution structure of the leucine zipper domain of the c-Jun homodimer. PubMed ID: 8662824