Gene JUN - ENSG00000177606 | NCBI Gene ID: 3725

Details for: JUN

Gene ID: 3725

Symbol: JUN

Ensembl ID: ENSG00000177606

Description: Jun proto-oncogene, AP-1 transcription factor subunit

Associated with

Activation of anterior hox genes in hindbrain development during early embryogenesis
(R-HSA-5617472)
Activation of hox genes during differentiation
(R-HSA-5619507)
Activation of the ap-1 family of transcription factors
(R-HSA-450341)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular senescence
(R-HSA-2559583)
Cytokine signaling in immune system
(R-HSA-1280215)
Defective intrinsic pathway for apoptosis
(R-HSA-9734009)
Deregulated cdk5 triggers multiple neurodegenerative pathways in alzheimer's disease models
(R-HSA-8862803)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of programmed cell death
(R-HSA-9645723)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Esr-mediated signaling
(R-HSA-8939211)
Estrogen-dependent gene expression
(R-HSA-9018519)
Fc epsilon receptor (fceri) signaling
(R-HSA-2454202)
Fceri mediated mapk activation
(R-HSA-2871796)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Innate immune system
(R-HSA-168249)
Interleukin-17 signaling
(R-HSA-448424)
Intracellular signaling by second messengers
(R-HSA-9006925)
Killing mechanisms
(R-HSA-9664420)
Leishmania infection
(R-HSA-9658195)
Mapk6/mapk4 signaling
(R-HSA-5687128)
Mapk family signaling cascades
(R-HSA-5683057)
Map kinase activation
(R-HSA-450294)
Mapk targets/ nuclear events mediated by map kinases
(R-HSA-450282)
Myd88 cascade initiated on plasma membrane
(R-HSA-975871)
Myd88 dependent cascade initiated on endosome
(R-HSA-975155)
Myd88-independent tlr4 cascade
(R-HSA-166166)
Myd88:mal(tirap) cascade initiated on plasma membrane
(R-HSA-166058)
Neurodegenerative diseases
(R-HSA-8863678)
Oxidative stress induced senescence
(R-HSA-2559580)
Parasitic infection pathways
(R-HSA-9824443)
Pip3 activates akt signaling
(R-HSA-1257604)
Pre-notch expression and processing
(R-HSA-1912422)
Pre-notch transcription and translation
(R-HSA-1912408)
Pten regulation
(R-HSA-6807070)
Regulation of pten gene transcription
(R-HSA-8943724)
Rna polymerase ii transcription
(R-HSA-73857)
Senescence-associated secretory phenotype (sasp)
(R-HSA-2559582)
Signaling by alk fusions and activated point mutants
(R-HSA-9725370)
Signaling by alk in cancer
(R-HSA-9700206)
Signaling by interleukins
(R-HSA-449147)
Signaling by notch
(R-HSA-157118)
Signaling by nuclear receptors
(R-HSA-9006931)
Signal transduction
(R-HSA-162582)
Toll-like receptor cascades
(R-HSA-168898)
Toll like receptor 2 (tlr2) cascade
(R-HSA-181438)
Toll like receptor 3 (tlr3) cascade
(R-HSA-168164)
Toll like receptor 4 (tlr4) cascade
(R-HSA-166016)
Toll like receptor 5 (tlr5) cascade
(R-HSA-168176)
Toll like receptor 7/8 (tlr7/8) cascade
(R-HSA-168181)
Toll like receptor 9 (tlr9) cascade
(R-HSA-168138)
Toll like receptor 10 (tlr10) cascade
(R-HSA-168142)
Toll like receptor tlr1:tlr2 cascade
(R-HSA-168179)
Toll like receptor tlr6:tlr2 cascade
(R-HSA-168188)
Tp53 regulates transcription of dna repair genes
(R-HSA-6796648)
Traf6 mediated induction of nfkb and map kinases upon tlr7/8 or 9 activation
(R-HSA-975138)
Transcriptional regulation by tp53
(R-HSA-3700989)
Trif(ticam1)-mediated tlr4 signaling
(R-HSA-937061)
Wnt5:fzd7-mediated leishmania damping
(R-HSA-9673324)
Camp response element binding
(GO:0035497)
Cellular response to reactive oxygen species
(GO:0034614)
Dna-binding transcription activator activity, rna polymerase ii-specific
(GO:0001228)
Dna-binding transcription factor activity
(GO:0003700)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Dna-binding transcription repressor activity, rna polymerase ii-specific
(GO:0001227)
Dna binding
(GO:0003677)
Enzyme binding
(GO:0019899)
General transcription initiation factor binding
(GO:0140296)
Gtpase activator activity
(GO:0005096)
Identical protein binding
(GO:0042802)
Negative regulation by host of viral transcription
(GO:0043922)
Negative regulation of dna binding
(GO:0043392)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Positive regulation of apoptotic process
(GO:0043065)
Protein binding
(GO:0005515)
R-smad binding
(GO:0070412)
Regulation of cell population proliferation
(GO:0042127)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Release from viral latency
(GO:0019046)
Response to endoplasmic reticulum stress
(GO:0034976)
Rna binding
(GO:0003723)
Rna polymerase ii-specific dna-binding transcription factor binding
(GO:0061629)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Sequence-specific double-stranded dna binding
(GO:1990837)
Transcription cis-regulatory region binding
(GO:0000976)
Transcription factor binding
(GO:0008134)
Transforming growth factor beta receptor signaling pathway
(GO:0007179)
Ubiquitin-like protein ligase binding
(GO:0044389)
Ubiquitin protein ligase binding
(GO:0031625)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: uterine smooth muscle cell (CL0002601)
Fold Change: 5.28
Marker Score: 6883
Cell Name: acinar cell (CL0000622)
Fold Change: 4.71
Marker Score: 3321
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 4.63
Marker Score: 157673
Cell Name: theca cell (CL0000503)
Fold Change: 4.52
Marker Score: 3241
Cell Name: taste receptor cell (CL0000209)
Fold Change: 4.28
Marker Score: 3697
Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
Fold Change: 4.24
Marker Score: 10773
Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
Fold Change: 4.15
Marker Score: 6012
Cell Name: IgA plasma cell (CL0000987)
Fold Change: 4.14
Marker Score: 3522
Cell Name: alpha-beta T cell (CL0000789)
Fold Change: 4.06
Marker Score: 3078
Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
Fold Change: 3.97
Marker Score: 11130
Cell Name: T-helper 22 cell (CL0001042)
Fold Change: 3.96
Marker Score: 16991
Cell Name: supporting cell (CL0000630)
Fold Change: 3.76
Marker Score: 7056
Cell Name: epithelial cell of lower respiratory tract (CL0002632)
Fold Change: 3.73
Marker Score: 15559.5
Cell Name: CD38-negative naive B cell (CL0002102)
Fold Change: 3.66
Marker Score: 7670
Cell Name: mature T cell (CL0002419)
Fold Change: 3.64
Marker Score: 36086
Cell Name: thyroid follicular cell (CL0002258)
Fold Change: 3.63
Marker Score: 2842
Cell Name: endocrine cell (CL0000163)
Fold Change: 3.55
Marker Score: 1837
Cell Name: pulmonary artery endothelial cell (CL1001568)
Fold Change: 3.52
Marker Score: 3027
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 3.5
Marker Score: 7964
Cell Name: pancreatic A cell (CL0000171)
Fold Change: 3.49
Marker Score: 3420
Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: 3.49
Marker Score: 22263
Cell Name: mature gamma-delta T cell (CL0000800)
Fold Change: 3.48
Marker Score: 10985.5
Cell Name: IgG-negative class switched memory B cell (CL0002117)
Fold Change: 3.41
Marker Score: 3360
Cell Name: epithelial cell of lung (CL0000082)
Fold Change: 3.41
Marker Score: 17927
Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
Fold Change: 3.41
Marker Score: 2471
Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
Fold Change: 3.35
Marker Score: 4927
Cell Name: mesodermal cell (CL0000222)
Fold Change: 3.32
Marker Score: 43841
Cell Name: intestine goblet cell (CL0019031)
Fold Change: 3.31
Marker Score: 3175
Cell Name: type I NK T cell (CL0000921)
Fold Change: 3.29
Marker Score: 2580
Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
Fold Change: 3.27
Marker Score: 2011
Cell Name: endothelial cell of uterus (CL0009095)
Fold Change: 3.25
Marker Score: 6484
Cell Name: double negative thymocyte (CL0002489)
Fold Change: 3.24
Marker Score: 4476
Cell Name: natural T-regulatory cell (CL0000903)
Fold Change: 3.24
Marker Score: 1665
Cell Name: memory T cell (CL0000813)
Fold Change: 3.2
Marker Score: 1375
Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
Fold Change: 3.16
Marker Score: 2590
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 3.14
Marker Score: 20429
Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: 3.14
Marker Score: 165863
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 3.13
Marker Score: 3247
Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: 3.12
Marker Score: 5108.5
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 3.11
Marker Score: 5263
Cell Name: fibroblast of lung (CL0002553)
Fold Change: 3.1
Marker Score: 8116
Cell Name: myoepithelial cell of mammary gland (CL0002324)
Fold Change: 3.08
Marker Score: 15146
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 3.08
Marker Score: 11857
Cell Name: fibroblast (CL0000057)
Fold Change: 3.07
Marker Score: 2962
Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
Fold Change: 3.05
Marker Score: 2236
Cell Name: type II pneumocyte (CL0002063)
Fold Change: 3.04
Marker Score: 19822
Cell Name: capillary endothelial cell (CL0002144)
Fold Change: 3
Marker Score: 3227
Cell Name: epithelial cell of exocrine pancreas (CL1001433)
Fold Change: 2.98
Marker Score: 1677
Cell Name: colon epithelial cell (CL0011108)
Fold Change: 2.96
Marker Score: 9302
Cell Name: type I pneumocyte (CL0002062)
Fold Change: 2.95
Marker Score: 3553
Cell Name: peritubular capillary endothelial cell (CL1001033)
Fold Change: 2.94
Marker Score: 684
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 2.92
Marker Score: 32897
Cell Name: myofibroblast cell (CL0000186)
Fold Change: 2.89
Marker Score: 3573
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 2.89
Marker Score: 691
Cell Name: class switched memory B cell (CL0000972)
Fold Change: 2.89
Marker Score: 2716.5
Cell Name: mucous neck cell (CL0000651)
Fold Change: 2.88
Marker Score: 6528
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 2.87
Marker Score: 7018
Cell Name: decidual cell (CL2000002)
Fold Change: 2.87
Marker Score: 12362
Cell Name: early promyelocyte (CL0002154)
Fold Change: 2.86
Marker Score: 2289
Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
Fold Change: 2.85
Marker Score: 2431
Cell Name: mesenchymal stem cell (CL0000134)
Fold Change: 2.85
Marker Score: 4385.5
Cell Name: epithelial cell (CL0000066)
Fold Change: 2.85
Marker Score: 4527
Cell Name: stem cell of epidermis (CL1000428)
Fold Change: 2.83
Marker Score: 957.5
Cell Name: enterocyte (CL0000584)
Fold Change: 2.82
Marker Score: 13551
Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
Fold Change: 2.81
Marker Score: 2369
Cell Name: immature B cell (CL0000816)
Fold Change: 2.8
Marker Score: 1856
Cell Name: smooth muscle cell of large intestine (CL1000279)
Fold Change: 2.8
Marker Score: 1059
Cell Name: type G enteroendocrine cell (CL0000508)
Fold Change: 2.8
Marker Score: 964
Cell Name: Sertoli cell (CL0000216)
Fold Change: 2.78
Marker Score: 16514
Cell Name: blood cell (CL0000081)
Fold Change: 2.78
Marker Score: 32357
Cell Name: basal cell (CL0000646)
Fold Change: 2.78
Marker Score: 3585
Cell Name: Mueller cell (CL0000636)
Fold Change: 2.78
Marker Score: 3850
Cell Name: cell in vitro (CL0001034)
Fold Change: 2.77
Marker Score: 96039
Cell Name: paneth cell (CL0000510)
Fold Change: 2.76
Marker Score: 1921
Cell Name: endothelial cell of vascular tree (CL0002139)
Fold Change: 2.75
Marker Score: 3996
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 2.75
Marker Score: 153730
Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
Fold Change: 2.75
Marker Score: 1249
Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 2.75
Marker Score: 2933
Cell Name: enteroendocrine cell (CL0000164)
Fold Change: 2.75
Marker Score: 1422
Cell Name: CD4-positive helper T cell (CL0000492)
Fold Change: 2.74
Marker Score: 2976
Cell Name: club cell (CL0000158)
Fold Change: 2.73
Marker Score: 3182
Cell Name: smooth muscle cell (CL0000192)
Fold Change: 2.7
Marker Score: 1775
Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
Fold Change: 2.69
Marker Score: 1162
Cell Name: bronchial goblet cell (CL1000312)
Fold Change: 2.67
Marker Score: 1317
Cell Name: endothelial cell (CL0000115)
Fold Change: 2.66
Marker Score: 2387
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: 2.66
Marker Score: 20779
Cell Name: pericyte (CL0000669)
Fold Change: 2.66
Marker Score: 1552
Cell Name: granulosa cell (CL0000501)
Fold Change: 2.65
Marker Score: 26696
Cell Name: stromal cell (CL0000499)
Fold Change: 2.64
Marker Score: 3098.5
Cell Name: peptic cell (CL0000155)
Fold Change: 2.64
Marker Score: 1106
Cell Name: mucosal invariant T cell (CL0000940)
Fold Change: 2.64
Marker Score: 2348
Cell Name: early pro-B cell (CL0002046)
Fold Change: 2.63
Marker Score: 26657
Cell Name: myelocyte (CL0002193)
Fold Change: 2.62
Marker Score: 1134
Cell Name: DN3 thymocyte (CL0000807)
Fold Change: 2.62
Marker Score: 1309
Cell Name: duct epithelial cell (CL0000068)
Fold Change: 2.61
Marker Score: 1220.5
Cell Name: Unknown (CL0000548)
Fold Change: 2.6
Marker Score: 1898
Cell Name: adventitial cell (CL0002503)
Fold Change: 2.6
Marker Score: 643
Cell Name: DN1 thymic pro-T cell (CL0000894)
Fold Change: 2.6
Marker Score: 806
Cell Name: basophil (CL0000767)
Fold Change: 2.6
Marker Score: 1234
Cell Name: ependymal cell (CL0000065)
Fold Change: 2.59
Marker Score: 905

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**Key characteristics:** * JUN proto-oncogene is a member of the JUN family of transcription factors. * It is a key regulator of cell differentiation and proliferation. * It is involved in various cellular responses to stimuli, including growth factor signaling, stress, and inflammation. * It is also involved in the regulation of tissue development and disease. **Pathways and functions:** * JUN binds to DNA sequences known as DNA-binding motifs (DBMs) in the promoters of target genes. * It is a key activator of the hox gene cluster, which is responsible for the specification of regional identities in the body. * It is also involved in the regulation of cell proliferation, survival, and differentiation. * JUN signaling can be activated by various growth factor receptors, including EGF and BMPs. * It can also be activated by stress factors and inflammatory cytokines. * JUN signaling can lead to the activation of various downstream targets, including the MAPK signaling pathway, the PI3K/AKT pathway, and the transcription factor NF-κB. **Clinical significance:** * Mutations in JUN genes have been linked to a number of human cancers, including lung cancer, breast cancer, and colon cancer. * Inhibition of JUN signaling has been shown to inhibit cancer growth and metastasis. * Therefore, JUN is a promising target for cancer therapy. **Additional notes:** * JUN is a highly conserved gene, with a similar gene found in many other species. * It is a heterodimeric protein, consisting of two subunits, JUN-N and JUN-C. * JUN-N is the dominant subunit, and JUN-C is the recessive subunit.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Activator protein 1

Genular Protein ID: 1547800440

Symbol: JUN_HUMAN

Name: Activator protein 1

UniProtKB Accession Codes:

P05412 Q6FHM7 Q96G93

Database IDs:

Citations:

PubMed ID: 3194415

Title: Structure and chromosomal localization of the functional intronless human JUN protooncogene.

PubMed ID: 3194415

DOI: 10.1073/pnas.85.23.9148

PubMed ID: 2825349

Title: Human proto-oncogene c-jun encodes a DNA binding protein with structural and functional properties of transcription factor AP-1.

PubMed ID: 2825349

DOI: 10.1126/science.2825349

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1846781

Title: Activation of protein kinase C decreases phosphorylation of c-Jun at sites that negatively regulate its DNA-binding activity.

PubMed ID: 1846781

DOI: 10.1016/0092-8674(91)90241-p

PubMed ID: 8464713

Title: c-Jun is phosphorylated by the DNA-dependent protein kinase in vitro; definition of the minimal kinase recognition motif.

PubMed ID: 8464713

DOI: 10.1093/nar/21.5.1289

PubMed ID: 8855261

Title: Regulation of mitogen-activated protein kinases by a calcium/calmodulin-dependent protein kinase cascade.

PubMed ID: 8855261

DOI: 10.1073/pnas.93.20.10803

PubMed ID: 8663478

Title: Cross-talk between different enhancer elements during mitogenic induction of the human stromelysin-1 gene.

PubMed ID: 8663478

DOI: 10.1074/jbc.271.30.18231

PubMed ID: 8837781

Title: A new group of conserved coactivators that increase the specificity of AP-1 transcription factors.

PubMed ID: 8837781

DOI: 10.1038/383453a0

PubMed ID: 9732876

Title: Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-beta-induced transcription.

PubMed ID: 9732876

DOI: 10.1038/29814

PubMed ID: 10196196

Title: SPI-B activates transcription via a unique proline, serine, and threonine domain and exhibits DNA binding affinity differences from PU.1.

PubMed ID: 10196196

DOI: 10.1074/jbc.274.16.11115

PubMed ID: 10376527

Title: Role of the ATFa/JNK2 complex in Jun activation.

PubMed ID: 10376527

DOI: 10.1038/sj.onc.1202723

PubMed ID: 10995748

Title: Structural and functional characterization of the transforming growth factor-beta -induced Smad3/c-Jun transcriptional cooperativity.

PubMed ID: 10995748

DOI: 10.1074/jbc.m004731200

PubMed ID: 11689449

Title: A specific lysine in c-Jun is required for transcriptional repression by E1A and is acetylated by p300.

PubMed ID: 11689449

DOI: 10.1093/emboj/20.21.6095

PubMed ID: 12087103

Title: Correlation of transcriptional repression by p21(SNFT) with changes in DNA.NF-AT complex interactions.

PubMed ID: 12087103

DOI: 10.1074/jbc.m205048200

PubMed ID: 12618758

Title: An unexpected role for FosB in activation-induced cell death of T cells.

PubMed ID: 12618758

DOI: 10.1038/sj.onc.1206126

PubMed ID: 15467742

Title: Transcriptional repression of MMP-1 by p21SNFT and reduced in vitro invasiveness of hepatocarcinoma cells.

PubMed ID: 15467742

DOI: 10.1038/sj.onc.1208109

PubMed ID: 14739463

Title: The ubiquitin ligase SCFFbw7 antagonizes apoptotic JNK signaling.

PubMed ID: 14739463

DOI: 10.1126/science.1092880

PubMed ID: 17210646

Title: Cyclic AMP stimulates SF-1-dependent CYP11A1 expression through homeodomain-interacting protein kinase 3-mediated Jun N-terminal kinase and c-Jun phosphorylation.

PubMed ID: 17210646

DOI: 10.1128/mcb.02253-06

PubMed ID: 16478997

Title: Sp1 deacetylation induced by phorbol ester recruits p300 to activate 12(S)-lipoxygenase gene transcription.

PubMed ID: 16478997

DOI: 10.1128/mcb.26.5.1770-1785.2006

PubMed ID: 17804415

Title: Stress-induced c-Jun activation mediated by Polo-like kinase 3 in corneal epithelial cells.

PubMed ID: 17804415

DOI: 10.1074/jbc.m702791200

PubMed ID: 18650425

Title: Activation of Polo-like kinase 3 by hypoxic stresses.

PubMed ID: 18650425

DOI: 10.1074/jbc.m801326200

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 22083952

Title: The forkhead transcription factor FOXK2 promotes AP-1-mediated transcriptional regulation.

PubMed ID: 22083952

DOI: 10.1128/mcb.05504-11

PubMed ID: 20852630

Title: Identification of a co-activator that links growth factor signalling to c-Jun/AP-1 activation.

PubMed ID: 20852630

DOI: 10.1038/ncb2098

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21177766

Title: P21-activated protein kinase (PAK2)-mediated c-Jun phosphorylation at 5 threonine sites promotes cell transformation.

PubMed ID: 21177766

DOI: 10.1093/carcin/bgq271

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22307329

Title: DYRK2 priming phosphorylation of c-Jun and c-Myc modulates cell cycle progression in human cancer cells.

PubMed ID: 22307329

DOI: 10.1172/jci60818

PubMed ID: 23624934

Title: Arginine methylation of the c-Jun coactivator RACO-1 is required for c-Jun/AP-1 activation.

PubMed ID: 23624934

DOI: 10.1038/emboj.2013.98

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24559171

Title: Cancer/testis antigen PAGE4, a regulator of c-Jun transactivation, is phosphorylated by homeodomain-interacting protein kinase 1, a component of the stress-response pathway.

PubMed ID: 24559171

DOI: 10.1021/bi500013w

PubMed ID: 24263171

Title: The Stress-response protein prostate-associated gene 4, interacts with c-Jun and potentiates its transactivation.

PubMed ID: 24263171

DOI: 10.1016/j.bbadis.2013.11.014

PubMed ID: 24623306

Title: A KRAS-directed transcriptional silencing pathway that mediates the CpG island methylator phenotype.

PubMed ID: 24623306

DOI: 10.7554/elife.02313

PubMed ID: 26242913

Title: Phosphorylation-induced conformational ensemble switching in an intrinsically disordered cancer/testis antigen.

PubMed ID: 26242913

DOI: 10.1074/jbc.m115.658583

PubMed ID: 27458189

Title: Synaptonuclear messenger PRR7 inhibits c-Jun ubiquitination and regulates NMDA-mediated excitotoxicity.

PubMed ID: 27458189

DOI: 10.15252/embj.201593070

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 31341047

Title: Identification of ARKL1 as a Negative Regulator of Epstein-Barr Virus Reactivation.

PubMed ID: 31341047

DOI: 10.1128/jvi.00989-19

PubMed ID: 7816143

Title: Crystal structure of the heterodimeric bZIP transcription factor c-Fos-c-Jun bound to DNA.

PubMed ID: 7816143

DOI: 10.1038/373257a0

PubMed ID: 8662824

Title: High resolution NMR solution structure of the leucine zipper domain of the c-Jun homodimer.

PubMed ID: 8662824

DOI: 10.1074/jbc.271.23.13663

Sequence Information:

Length: 331
Mass: 35676
Checksum: 0695E23AC4D33561
Sequence:

MTAKMETTFY DDALNASFLP SESGPYGYSN PKILKQSMTL NLADPVGSLK PHLRAKNSDL 
LTSPDVGLLK LASPELERLI IQSSNGHITT TPTPTQFLCP KNVTDEQEGF AEGFVRALAE 
LHSQNTLPSV TSAAQPVNGA GMVAPAVASV AGGSGSGGFS ASLHSEPPVY ANLSNFNPGA 
LSSGGGAPSY GAAGLAFPAQ PQQQQQPPHH LPQQMPVQHP RLQALKEEPQ TVPEMPGETP 
PLSPIDMESQ ERIKAERKRM RNRIAASKCR KRKLERIARL EEKVKTLKAQ NSELASTANM 
LREQVAQLKQ KVMNHVNSGC QLMLTQQLQT F

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: JUN

Associated with

Cells (max top 100)

Other Information

Structure and chromosomal localization of the functional intronless human JUN protooncogene. PubMed ID: 3194415

Human proto-oncogene c-jun encodes a DNA binding protein with structural and functional properties of transcription factor AP-1. PubMed ID: 2825349

The DNA sequence and biological annotation of human chromosome 1. PubMed ID: 16710414

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Activation of protein kinase C decreases phosphorylation of c-Jun at sites that negatively regulate its DNA-binding activity. PubMed ID: 1846781

c-Jun is phosphorylated by the DNA-dependent protein kinase in vitro; definition of the minimal kinase recognition motif. PubMed ID: 8464713

Regulation of mitogen-activated protein kinases by a calcium/calmodulin-dependent protein kinase cascade. PubMed ID: 8855261

Cross-talk between different enhancer elements during mitogenic induction of the human stromelysin-1 gene. PubMed ID: 8663478

A new group of conserved coactivators that increase the specificity of AP-1 transcription factors. PubMed ID: 8837781

Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-beta-induced transcription. PubMed ID: 9732876

SPI-B activates transcription via a unique proline, serine, and threonine domain and exhibits DNA binding affinity differences from PU.1. PubMed ID: 10196196

Role of the ATFa/JNK2 complex in Jun activation. PubMed ID: 10376527

Structural and functional characterization of the transforming growth factor-beta -induced Smad3/c-Jun transcriptional cooperativity. PubMed ID: 10995748

A specific lysine in c-Jun is required for transcriptional repression by E1A and is acetylated by p300. PubMed ID: 11689449

Correlation of transcriptional repression by p21(SNFT) with changes in DNA.NF-AT complex interactions. PubMed ID: 12087103

An unexpected role for FosB in activation-induced cell death of T cells. PubMed ID: 12618758

Transcriptional repression of MMP-1 by p21SNFT and reduced in vitro invasiveness of hepatocarcinoma cells. PubMed ID: 15467742

The ubiquitin ligase SCFFbw7 antagonizes apoptotic JNK signaling. PubMed ID: 14739463

Cyclic AMP stimulates SF-1-dependent CYP11A1 expression through homeodomain-interacting protein kinase 3-mediated Jun N-terminal kinase and c-Jun phosphorylation. PubMed ID: 17210646

Sp1 deacetylation induced by phorbol ester recruits p300 to activate 12(S)-lipoxygenase gene transcription. PubMed ID: 16478997

Stress-induced c-Jun activation mediated by Polo-like kinase 3 in corneal epithelial cells. PubMed ID: 17804415

Activation of Polo-like kinase 3 by hypoxic stresses. PubMed ID: 18650425

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

The forkhead transcription factor FOXK2 promotes AP-1-mediated transcriptional regulation. PubMed ID: 22083952

Identification of a co-activator that links growth factor signalling to c-Jun/AP-1 activation. PubMed ID: 20852630

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

P21-activated protein kinase (PAK2)-mediated c-Jun phosphorylation at 5 threonine sites promotes cell transformation. PubMed ID: 21177766

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

DYRK2 priming phosphorylation of c-Jun and c-Myc modulates cell cycle progression in human cancer cells. PubMed ID: 22307329

Arginine methylation of the c-Jun coactivator RACO-1 is required for c-Jun/AP-1 activation. PubMed ID: 23624934

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

Cancer/testis antigen PAGE4, a regulator of c-Jun transactivation, is phosphorylated by homeodomain-interacting protein kinase 1, a component of the stress-response pathway. PubMed ID: 24559171

The Stress-response protein prostate-associated gene 4, interacts with c-Jun and potentiates its transactivation. PubMed ID: 24263171

A KRAS-directed transcriptional silencing pathway that mediates the CpG island methylator phenotype. PubMed ID: 24623306

Phosphorylation-induced conformational ensemble switching in an intrinsically disordered cancer/testis antigen. PubMed ID: 26242913

Synaptonuclear messenger PRR7 inhibits c-Jun ubiquitination and regulates NMDA-mediated excitotoxicity. PubMed ID: 27458189

Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. PubMed ID: 28112733

Identification of ARKL1 as a Negative Regulator of Epstein-Barr Virus Reactivation. PubMed ID: 31341047

Crystal structure of the heterodimeric bZIP transcription factor c-Fos-c-Jun bound to DNA. PubMed ID: 7816143

High resolution NMR solution structure of the leucine zipper domain of the c-Jun homodimer. PubMed ID: 8662824