Details for: JUN
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 1064.9636
Cell Significance Index: -165.6500 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 588.4049
Cell Significance Index: -149.2500 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 367.6799
Cell Significance Index: -173.5900 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 347.4050
Cell Significance Index: -178.7000 - Cell Name: ileal goblet cell (CL1000326)
Fold Change: 258.9482
Cell Significance Index: -173.7600 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 134.6601
Cell Significance Index: -166.0300 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 43.6406
Cell Significance Index: -134.0400 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 43.4650
Cell Significance Index: -171.5200 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 42.5610
Cell Significance Index: -114.0200 - Cell Name: theca cell (CL0000503)
Fold Change: 26.1667
Cell Significance Index: 153.7300 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 21.1689
Cell Significance Index: -46.3300 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 12.0956
Cell Significance Index: 346.7300 - Cell Name: odontoblast (CL0000060)
Fold Change: 11.3025
Cell Significance Index: 1448.9100 - Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 11.1653
Cell Significance Index: 197.3100 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 7.8873
Cell Significance Index: 274.0800 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 7.3745
Cell Significance Index: 1012.7200 - Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 6.8816
Cell Significance Index: 88.1300 - Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
Fold Change: 6.8815
Cell Significance Index: 42.3500 - Cell Name: peg cell (CL4033014)
Fold Change: 6.3012
Cell Significance Index: 145.5800 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 6.0742
Cell Significance Index: 285.4800 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: 5.7403
Cell Significance Index: 405.9800 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 5.6061
Cell Significance Index: 2478.6000 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 5.4022
Cell Significance Index: 251.8800 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 5.0725
Cell Significance Index: 106.1800 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 5.0400
Cell Significance Index: 375.6300 - Cell Name: granulosa cell (CL0000501)
Fold Change: 4.4502
Cell Significance Index: 117.0200 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 4.2083
Cell Significance Index: 271.5000 - Cell Name: lactocyte (CL0002325)
Fold Change: 4.0211
Cell Significance Index: 519.5000 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 3.9891
Cell Significance Index: 108.5800 - Cell Name: cell in vitro (CL0001034)
Fold Change: 3.8283
Cell Significance Index: 2090.7500 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 3.3750
Cell Significance Index: 414.9900 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 3.1457
Cell Significance Index: 58.1400 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 2.8384
Cell Significance Index: 511.6800 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: 2.5855
Cell Significance Index: 295.1300 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 2.5415
Cell Significance Index: 73.2300 - Cell Name: kidney cell (CL1000497)
Fold Change: 2.0246
Cell Significance Index: 16.1700 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 1.9608
Cell Significance Index: 334.8100 - Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 1.5150
Cell Significance Index: 16.4700 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.8233
Cell Significance Index: 37.3200 - Cell Name: seromucus secreting cell (CL0000159)
Fold Change: 0.6392
Cell Significance Index: 13.3300 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.5938
Cell Significance Index: 70.0300 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.3765
Cell Significance Index: 13.2300 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.3341
Cell Significance Index: 66.3100 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.2651
Cell Significance Index: 13.7700 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.2236
Cell Significance Index: 11.7400 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 0.2112
Cell Significance Index: 154.8200 - Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 0.1972
Cell Significance Index: 2.2400 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.1802
Cell Significance Index: 3.0200 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.1429
Cell Significance Index: 23.2400 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.1385
Cell Significance Index: 104.8200 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.0971
Cell Significance Index: 9.6100 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.0847
Cell Significance Index: 16.1300 - Cell Name: abnormal cell (CL0001061)
Fold Change: 0.0780
Cell Significance Index: 7.9700 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0496
Cell Significance Index: 67.5100 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0094
Cell Significance Index: -17.7700 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0634
Cell Significance Index: -12.7100 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0696
Cell Significance Index: -24.9600 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0912
Cell Significance Index: -140.4000 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0917
Cell Significance Index: -67.9600 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0931
Cell Significance Index: -171.7700 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.1047
Cell Significance Index: -65.3700 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.1064
Cell Significance Index: -2.8400 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.1493
Cell Significance Index: -2.0400 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.2255
Cell Significance Index: -143.2200 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.2308
Cell Significance Index: -130.1600 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: -0.2397
Cell Significance Index: -165.7600 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.2463
Cell Significance Index: -111.7900 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.4150
Cell Significance Index: -87.4000 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.5379
Cell Significance Index: -154.7700 - Cell Name: supporting cell (CL0000630)
Fold Change: -0.5553
Cell Significance Index: -2.5700 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.5884
Cell Significance Index: -15.7400 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.5961
Cell Significance Index: -68.2900 - Cell Name: paneth cell of colon (CL0009009)
Fold Change: -0.7007
Cell Significance Index: -10.5000 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.8800
Cell Significance Index: -49.3800 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.9883
Cell Significance Index: -143.6700 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.9931
Cell Significance Index: -50.1900 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -1.0631
Cell Significance Index: -29.7100 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -1.0662
Cell Significance Index: -124.2500 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: -1.1222
Cell Significance Index: -67.3700 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -1.1485
Cell Significance Index: -88.1400 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -1.4263
Cell Significance Index: -87.6700 - Cell Name: neuron associated cell (CL0000095)
Fold Change: -1.4458
Cell Significance Index: -59.2400 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -1.6039
Cell Significance Index: -167.0000 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: -1.6365
Cell Significance Index: -15.0700 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -1.6691
Cell Significance Index: -112.2300 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -1.7690
Cell Significance Index: -56.6600 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -1.7766
Cell Significance Index: -44.4100 - Cell Name: preadipocyte (CL0002334)
Fold Change: -1.8112
Cell Significance Index: -35.3500 - Cell Name: pro-T cell (CL0000827)
Fold Change: -1.8190
Cell Significance Index: -46.4700 - Cell Name: cone retinal bipolar cell (CL0000752)
Fold Change: -1.9162
Cell Significance Index: -14.7700 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -1.9538
Cell Significance Index: -154.7400 - Cell Name: perivascular cell (CL4033054)
Fold Change: -2.1506
Cell Significance Index: -9.9300 - Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -2.2046
Cell Significance Index: -13.3200 - Cell Name: pulmonary interstitial fibroblast (CL0002241)
Fold Change: -2.5765
Cell Significance Index: -15.9400 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -2.7190
Cell Significance Index: -171.3700 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -2.8335
Cell Significance Index: -173.7200 - Cell Name: type I muscle cell (CL0002211)
Fold Change: -3.3366
Cell Significance Index: -81.4100 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -3.3505
Cell Significance Index: -98.4000 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -3.7435
Cell Significance Index: -137.4200 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -3.7740
Cell Significance Index: -97.0100
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 1547800440
Symbol: JUN_HUMAN
Name: Activator protein 1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 3194415
Title: Structure and chromosomal localization of the functional intronless human JUN protooncogene.
PubMed ID: 3194415
PubMed ID: 2825349
Title: Human proto-oncogene c-jun encodes a DNA binding protein with structural and functional properties of transcription factor AP-1.
PubMed ID: 2825349
PubMed ID: 16710414
Title: The DNA sequence and biological annotation of human chromosome 1.
PubMed ID: 16710414
DOI: 10.1038/nature04727
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 1846781
Title: Activation of protein kinase C decreases phosphorylation of c-Jun at sites that negatively regulate its DNA-binding activity.
PubMed ID: 1846781
PubMed ID: 8464713
Title: c-Jun is phosphorylated by the DNA-dependent protein kinase in vitro; definition of the minimal kinase recognition motif.
PubMed ID: 8464713
PubMed ID: 8855261
Title: Regulation of mitogen-activated protein kinases by a calcium/calmodulin-dependent protein kinase cascade.
PubMed ID: 8855261
PubMed ID: 8663478
Title: Cross-talk between different enhancer elements during mitogenic induction of the human stromelysin-1 gene.
PubMed ID: 8663478
PubMed ID: 8837781
Title: A new group of conserved coactivators that increase the specificity of AP-1 transcription factors.
PubMed ID: 8837781
DOI: 10.1038/383453a0
PubMed ID: 9732876
Title: Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-beta-induced transcription.
PubMed ID: 9732876
DOI: 10.1038/29814
PubMed ID: 10196196
Title: SPI-B activates transcription via a unique proline, serine, and threonine domain and exhibits DNA binding affinity differences from PU.1.
PubMed ID: 10196196
PubMed ID: 10376527
Title: Role of the ATFa/JNK2 complex in Jun activation.
PubMed ID: 10376527
PubMed ID: 10995748
Title: Structural and functional characterization of the transforming growth factor-beta -induced Smad3/c-Jun transcriptional cooperativity.
PubMed ID: 10995748
PubMed ID: 11689449
Title: A specific lysine in c-Jun is required for transcriptional repression by E1A and is acetylated by p300.
PubMed ID: 11689449
PubMed ID: 12087103
Title: Correlation of transcriptional repression by p21(SNFT) with changes in DNA.NF-AT complex interactions.
PubMed ID: 12087103
PubMed ID: 12618758
Title: An unexpected role for FosB in activation-induced cell death of T cells.
PubMed ID: 12618758
PubMed ID: 15467742
Title: Transcriptional repression of MMP-1 by p21SNFT and reduced in vitro invasiveness of hepatocarcinoma cells.
PubMed ID: 15467742
PubMed ID: 14739463
Title: The ubiquitin ligase SCFFbw7 antagonizes apoptotic JNK signaling.
PubMed ID: 14739463
PubMed ID: 17210646
Title: Cyclic AMP stimulates SF-1-dependent CYP11A1 expression through homeodomain-interacting protein kinase 3-mediated Jun N-terminal kinase and c-Jun phosphorylation.
PubMed ID: 17210646
DOI: 10.1128/mcb.02253-06
PubMed ID: 16478997
Title: Sp1 deacetylation induced by phorbol ester recruits p300 to activate 12(S)-lipoxygenase gene transcription.
PubMed ID: 16478997
PubMed ID: 17804415
Title: Stress-induced c-Jun activation mediated by Polo-like kinase 3 in corneal epithelial cells.
PubMed ID: 17804415
PubMed ID: 18650425
Title: Activation of Polo-like kinase 3 by hypoxic stresses.
PubMed ID: 18650425
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 22083952
Title: The forkhead transcription factor FOXK2 promotes AP-1-mediated transcriptional regulation.
PubMed ID: 22083952
DOI: 10.1128/mcb.05504-11
PubMed ID: 20852630
Title: Identification of a co-activator that links growth factor signalling to c-Jun/AP-1 activation.
PubMed ID: 20852630
DOI: 10.1038/ncb2098
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21177766
Title: P21-activated protein kinase (PAK2)-mediated c-Jun phosphorylation at 5 threonine sites promotes cell transformation.
PubMed ID: 21177766
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 22307329
Title: DYRK2 priming phosphorylation of c-Jun and c-Myc modulates cell cycle progression in human cancer cells.
PubMed ID: 22307329
DOI: 10.1172/jci60818
PubMed ID: 23624934
Title: Arginine methylation of the c-Jun coactivator RACO-1 is required for c-Jun/AP-1 activation.
PubMed ID: 23624934
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24559171
Title: Cancer/testis antigen PAGE4, a regulator of c-Jun transactivation, is phosphorylated by homeodomain-interacting protein kinase 1, a component of the stress-response pathway.
PubMed ID: 24559171
DOI: 10.1021/bi500013w
PubMed ID: 24263171
Title: The Stress-response protein prostate-associated gene 4, interacts with c-Jun and potentiates its transactivation.
PubMed ID: 24263171
PubMed ID: 24623306
Title: A KRAS-directed transcriptional silencing pathway that mediates the CpG island methylator phenotype.
PubMed ID: 24623306
DOI: 10.7554/elife.02313
PubMed ID: 26242913
Title: Phosphorylation-induced conformational ensemble switching in an intrinsically disordered cancer/testis antigen.
PubMed ID: 26242913
PubMed ID: 27458189
Title: Synaptonuclear messenger PRR7 inhibits c-Jun ubiquitination and regulates NMDA-mediated excitotoxicity.
PubMed ID: 27458189
PubMed ID: 28112733
Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.
PubMed ID: 28112733
DOI: 10.1038/nsmb.3366
PubMed ID: 31341047
Title: Identification of ARKL1 as a Negative Regulator of Epstein-Barr Virus Reactivation.
PubMed ID: 31341047
DOI: 10.1128/jvi.00989-19
PubMed ID: 31527692
Title: VRK1 functional insufficiency due to alterations in protein stability or kinase activity of human VRK1 pathogenic variants implicated in neuromotor syndromes.
PubMed ID: 31527692
PubMed ID: 7816143
Title: Crystal structure of the heterodimeric bZIP transcription factor c-Fos-c-Jun bound to DNA.
PubMed ID: 7816143
DOI: 10.1038/373257a0
PubMed ID: 8662824
Title: High resolution NMR solution structure of the leucine zipper domain of the c-Jun homodimer.
PubMed ID: 8662824
Sequence Information:
- Length: 331
- Mass: 35676
- Checksum: 0695E23AC4D33561
- Sequence:
MTAKMETTFY DDALNASFLP SESGPYGYSN PKILKQSMTL NLADPVGSLK PHLRAKNSDL LTSPDVGLLK LASPELERLI IQSSNGHITT TPTPTQFLCP KNVTDEQEGF AEGFVRALAE LHSQNTLPSV TSAAQPVNGA GMVAPAVASV AGGSGSGGFS ASLHSEPPVY ANLSNFNPGA LSSGGGAPSY GAAGLAFPAQ PQQQQQPPHH LPQQMPVQHP RLQALKEEPQ TVPEMPGETP PLSPIDMESQ ERIKAERKRM RNRIAASKCR KRKLERIARL EEKVKTLKAQ NSELASTANM LREQVAQLKQ KVMNHVNSGC QLMLTQQLQT F
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.