Details for: FKBP7

Gene ID: 51661

Symbol: FKBP7

Ensembl ID: ENSG00000079150

Description: FKBP prolyl isomerase 7

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 86.6950
    Cell Significance Index: -13.4900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 46.9951
    Cell Significance Index: -11.9200
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 29.8582
    Cell Significance Index: -12.3000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 28.0859
    Cell Significance Index: -13.2600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 27.9749
    Cell Significance Index: -11.3700
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 19.9397
    Cell Significance Index: -13.3800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 11.9404
    Cell Significance Index: -11.4000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 11.0507
    Cell Significance Index: -13.6300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.9872
    Cell Significance Index: -13.3600
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 4.4024
    Cell Significance Index: 56.3800
  • Cell Name: theca cell (CL0000503)
    Fold Change: 4.0366
    Cell Significance Index: 23.7200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.4516
    Cell Significance Index: -13.6200
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 2.5231
    Cell Significance Index: 15.6100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 2.2841
    Cell Significance Index: 47.8100
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 1.9114
    Cell Significance Index: 20.7800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.5529
    Cell Significance Index: 213.2500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.1246
    Cell Significance Index: 39.0800
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.9421
    Cell Significance Index: 8.5500
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.9012
    Cell Significance Index: 7.5700
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.8875
    Cell Significance Index: 14.0800
  • Cell Name: chondroblast (CL0000058)
    Fold Change: 0.8433
    Cell Significance Index: 4.9500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7144
    Cell Significance Index: 70.6700
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.5999
    Cell Significance Index: 4.7900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.5976
    Cell Significance Index: 76.6100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5811
    Cell Significance Index: 34.8900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5651
    Cell Significance Index: 510.2000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.5431
    Cell Significance Index: 14.2800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5171
    Cell Significance Index: 56.2500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4172
    Cell Significance Index: 67.8500
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.3212
    Cell Significance Index: 1.6900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.2446
    Cell Significance Index: 28.5100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2437
    Cell Significance Index: 16.8600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.2421
    Cell Significance Index: 2.7500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2188
    Cell Significance Index: 43.4300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.1954
    Cell Significance Index: 5.6000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1939
    Cell Significance Index: 10.8800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1806
    Cell Significance Index: 8.4200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1499
    Cell Significance Index: 66.2900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.1212
    Cell Significance Index: 3.1000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0789
    Cell Significance Index: 1.3200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0772
    Cell Significance Index: 42.1700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0689
    Cell Significance Index: 1.1800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0522
    Cell Significance Index: 1.4200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.0451
    Cell Significance Index: 0.8800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0449
    Cell Significance Index: 8.5500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0293
    Cell Significance Index: 0.6400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0244
    Cell Significance Index: 4.4000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0177
    Cell Significance Index: 33.2800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0175
    Cell Significance Index: 3.5200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0161
    Cell Significance Index: 0.9900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0143
    Cell Significance Index: 0.6500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0077
    Cell Significance Index: 0.2700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0076
    Cell Significance Index: 0.2200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0020
    Cell Significance Index: 1.3600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0001
    Cell Significance Index: -0.0700
  • Cell Name: supporting cell (CL0000630)
    Fold Change: -0.0022
    Cell Significance Index: -0.0100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0068
    Cell Significance Index: -12.5500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0069
    Cell Significance Index: -10.6000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0078
    Cell Significance Index: -2.8100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0094
    Cell Significance Index: -0.5900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0112
    Cell Significance Index: -8.4900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0123
    Cell Significance Index: -16.7200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0140
    Cell Significance Index: -10.2400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0152
    Cell Significance Index: -11.2900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0157
    Cell Significance Index: -7.1400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0179
    Cell Significance Index: -2.2000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0183
    Cell Significance Index: -2.3700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0198
    Cell Significance Index: -11.1800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0201
    Cell Significance Index: -1.4200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0205
    Cell Significance Index: -5.8900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0241
    Cell Significance Index: -15.0800
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.0259
    Cell Significance Index: -0.2700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0263
    Cell Significance Index: -3.8200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0345
    Cell Significance Index: -3.5300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0352
    Cell Significance Index: -0.7500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0395
    Cell Significance Index: -0.8200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0409
    Cell Significance Index: -2.6400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0501
    Cell Significance Index: -8.5600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0563
    Cell Significance Index: -4.1900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0592
    Cell Significance Index: -3.1100
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.0676
    Cell Significance Index: -0.4400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0715
    Cell Significance Index: -15.0600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0732
    Cell Significance Index: -8.6400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0746
    Cell Significance Index: -2.0000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0968
    Cell Significance Index: -4.5500
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.0990
    Cell Significance Index: -1.7500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1043
    Cell Significance Index: -11.9500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1048
    Cell Significance Index: -2.9300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1124
    Cell Significance Index: -11.7100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1146
    Cell Significance Index: -3.0700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1150
    Cell Significance Index: -2.8800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1212
    Cell Significance Index: -7.4300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1222
    Cell Significance Index: -9.3800
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.1238
    Cell Significance Index: -1.8800
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.1294
    Cell Significance Index: -1.8600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1361
    Cell Significance Index: -7.0900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1539
    Cell Significance Index: -12.1900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1542
    Cell Significance Index: -8.0100
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.1846
    Cell Significance Index: -1.7800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1907
    Cell Significance Index: -12.8200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** FKBP7 exhibits several key characteristics that distinguish it from other genes. These include: * **Calcium ion binding**: FKBP7 has the ability to bind calcium ions, which is essential for various cellular processes, including muscle contraction and nerve transmission. * **Endoplasmic reticulum function**: FKBP7 is involved in the function of the endoplasmic reticulum, a organelle responsible for protein synthesis and folding. * **Protein-prolyl cis-trans isomerase activity**: FKBP7 possesses peptidyl-prolyl cis-trans isomerase activity, which is essential for the proper folding of proteins. * **FK506 binding**: FKBP7 is known to bind FK506, a potent immunosuppressive agent that inhibits calcineurin, a key regulator of the immune response. **Pathways and Functions** FKBP7 is involved in several cellular pathways, including: * **Calcium signaling**: FKBP7 plays a crucial role in calcium signaling, which is essential for various cellular processes, including muscle contraction and nerve transmission. * **Endoplasmic reticulum function**: FKBP7 is involved in the function of the endoplasmic reticulum, which is essential for protein synthesis and folding. * **Protein folding**: FKBP7 possesses peptidyl-prolyl cis-trans isomerase activity, which is essential for the proper folding of proteins. * **Immune regulation**: FKBP7 is involved in the regulation of the immune response, including the inhibition of calcineurin by FK506. **Clinical Significance** FKBP7 has several clinical implications, including: * **Immunosuppression**: FKBP7 is involved in the regulation of the immune response, and its dysregulation can lead to immunosuppression, which is a hallmark of various diseases, including cancer and autoimmune disorders. * **Cancer therapy**: FKBP7 is a target for cancer therapy, as its inhibition can lead to the inhibition of calcineurin, which is essential for cancer cell proliferation and survival. * **Neurological disorders**: FKBP7 is involved in the regulation of calcium signaling, which is essential for various neurological processes, including muscle contraction and nerve transmission. Dysregulation of FKBP7 has been implicated in various neurological disorders, including Parkinson's disease and Alzheimer's disease. In conclusion, FKBP7 is a fascinating gene that plays a crucial role in various cellular processes, including calcium ion binding, endoplasmic reticulum function, and protein-prolyl cis-trans isomerase activity. Its clinical significance is evident, as its dysregulation can lead to immunosuppression, cancer therapy, and neurological disorders. Further research is needed to fully understand the role of FKBP7 in human health and disease.

Genular Protein ID: 762215195

Symbol: FKBP7_HUMAN

Name: Peptidyl-prolyl cis-trans isomerase FKBP7

UniProtKB Accession Codes:

Q9Y680 Q4ZG70 Q6V3B2 Q86U65 Q96DA4 Q9Y6B0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChEBI 11 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 2 EMBL 8 Ensembl 4 ExpressionAtlas 1 GO 5 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 RefSeq 2 Rhea 3 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10931946

Title: Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning.

PubMed ID: 10931946

DOI: 10.1073/pnas.160270997

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 222
  • Mass: 25794
  • Checksum: 362957BAD3C5C2A6
  • Sequence:
    • MPKTMHFLFR FIVFFYLWGL FTAQRQKKEE STEEVKIEVL HRPENCSKTS KKGDLLNAHY 
DGYLAKDGSK FYCSRTQNEG HPKWFVLGVG QVIKGLDIAM TDMCPGEKRK VVIPPSFAYG 
KEGYAEGKIP PDATLIFEIE LYAVTKGPRS IETFKQIDMD NDRQLSKAEI NLYLQREFEK 
DEKPRDKSYQ DAVLEDIFKK NDHDGDGFIS PKEYNVYQHD EL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.