Details for: ND3
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 830.1868
Cell Significance Index: -391.9500 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 801.8893
Cell Significance Index: -412.4800 - Cell Name: ileal goblet cell (CL1000326)
Fold Change: 586.1207
Cell Significance Index: -393.3000 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 140.3694
Cell Significance Index: -376.0300 - Cell Name: glandular epithelial cell (CL0000150)
Fold Change: 64.6554
Cell Significance Index: 514.4300 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: 49.7970
Cell Significance Index: 3943.9300 - Cell Name: Sertoli cell (CL0000216)
Fold Change: 49.1642
Cell Significance Index: 689.6000 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 43.1936
Cell Significance Index: 31669.4300 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: 39.6922
Cell Significance Index: 1457.0700 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: 32.9210
Cell Significance Index: 485.9100 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 31.5823
Cell Significance Index: 9087.1700 - Cell Name: seromucus secreting cell (CL0000159)
Fold Change: 19.1267
Cell Significance Index: 398.9000 - Cell Name: abnormal cell (CL0001061)
Fold Change: 12.2921
Cell Significance Index: 1255.6400 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 11.0103
Cell Significance Index: 101.3900 - Cell Name: cell in vitro (CL0001034)
Fold Change: 10.8196
Cell Significance Index: 5908.8300 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 9.7625
Cell Significance Index: 442.5000 - Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: 9.4734
Cell Significance Index: 142.7600 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 9.3181
Cell Significance Index: 253.6300 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 9.2393
Cell Significance Index: 1268.8100 - Cell Name: odontoblast (CL0000060)
Fold Change: 8.6203
Cell Significance Index: 1105.0700 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: 8.4838
Cell Significance Index: 445.4300 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 7.8626
Cell Significance Index: 210.3200 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 7.6340
Cell Significance Index: 938.6800 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 7.3559
Cell Significance Index: 800.1000 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 7.3341
Cell Significance Index: 211.3100 - Cell Name: peg cell (CL4033014)
Fold Change: 7.0565
Cell Significance Index: 163.0300 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 6.4920
Cell Significance Index: 119.9900 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 5.8840
Cell Significance Index: 168.6700 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 5.7471
Cell Significance Index: 1036.0200 - Cell Name: lactocyte (CL0002325)
Fold Change: 5.5164
Cell Significance Index: 712.6800 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 5.2307
Cell Significance Index: 389.8400 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 4.9941
Cell Significance Index: 494.0300 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 4.8058
Cell Significance Index: 225.8700 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 4.7904
Cell Significance Index: 4325.4100 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 4.7216
Cell Significance Index: 220.1500 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 4.6819
Cell Significance Index: 302.0500 - Cell Name: granulosa cell (CL0000501)
Fold Change: 4.3995
Cell Significance Index: 115.6900 - Cell Name: preadipocyte (CL0002334)
Fold Change: 3.9125
Cell Significance Index: 76.3600 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 3.4393
Cell Significance Index: 57.9400 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 3.2993
Cell Significance Index: 198.0700 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 2.8778
Cell Significance Index: 2178.2800 - Cell Name: pro-T cell (CL0000827)
Fold Change: 2.6937
Cell Significance Index: 68.8200 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 2.4771
Cell Significance Index: 402.8700 - Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 2.4154
Cell Significance Index: 27.4400 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 2.1726
Cell Significance Index: 779.2900 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.0385
Cell Significance Index: 208.3200 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 1.0328
Cell Significance Index: 196.5500 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.9620
Cell Significance Index: 33.8100 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.8208
Cell Significance Index: 162.9000 - Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 0.5036
Cell Significance Index: 6.4500 - Cell Name: cone retinal bipolar cell (CL0000752)
Fold Change: 0.4917
Cell Significance Index: 3.7900 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.2730
Cell Significance Index: 7.2900 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.1778
Cell Significance Index: -334.8600 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.2774
Cell Significance Index: -511.5400 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.2970
Cell Significance Index: -50.7100 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.3331
Cell Significance Index: -512.7600 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.3789
Cell Significance Index: -515.2000 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.4104
Cell Significance Index: -21.3200 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.4832
Cell Significance Index: -357.9600 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: -0.5053
Cell Significance Index: -34.9500 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.5684
Cell Significance Index: -360.9800 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.6573
Cell Significance Index: -370.6900 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.6579
Cell Significance Index: -44.2400 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.7532
Cell Significance Index: -470.3600 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.8000
Cell Significance Index: -363.1000 - Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: -1.0330
Cell Significance Index: -18.2600 - Cell Name: kidney cortex collecting duct epithelial cell (CL1000549)
Fold Change: -1.0686
Cell Significance Index: -1.1300 - Cell Name: enterocyte (CL0000584)
Fold Change: -1.1428
Cell Significance Index: -7.0900 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -1.5378
Cell Significance Index: -176.1800 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -2.0134
Cell Significance Index: -50.3300 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -2.0607
Cell Significance Index: -434.0400 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -2.3426
Cell Significance Index: -131.4600 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -2.7491
Cell Significance Index: -399.6100 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -3.4628
Cell Significance Index: -75.0200 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -3.4877
Cell Significance Index: -58.3700 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -3.5277
Cell Significance Index: -103.6100 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -3.5875
Cell Significance Index: -373.5400 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -3.7061
Cell Significance Index: -128.7900 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -4.4538
Cell Significance Index: -280.7100 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -4.5993
Cell Significance Index: -147.3100 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -4.6582
Cell Significance Index: -357.4700 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -4.7531
Cell Significance Index: -135.6400 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -4.8501
Cell Significance Index: -101.5200 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -5.2558
Cell Significance Index: -322.2300 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -5.3019
Cell Significance Index: -325.8800 - Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: -6.1199
Cell Significance Index: -105.5000 - Cell Name: neuron associated cell (CL0000095)
Fold Change: -6.1335
Cell Significance Index: -251.3200 - Cell Name: paneth cell of colon (CL0009009)
Fold Change: -6.3427
Cell Significance Index: -95.0400 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: -7.3609
Cell Significance Index: -76.2000 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -7.6747
Cell Significance Index: -163.4500 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -8.0687
Cell Significance Index: -356.9000 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -8.8636
Cell Significance Index: -447.9400 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -9.2024
Cell Significance Index: -271.0500 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -9.6212
Cell Significance Index: -247.3100 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -9.8039
Cell Significance Index: -371.2500 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -10.2217
Cell Significance Index: -212.0400 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -10.3200
Cell Significance Index: -361.5300 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -10.9474
Cell Significance Index: -358.4200 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -11.1147
Cell Significance Index: -353.9900 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -11.5037
Cell Significance Index: -248.5400
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 4018764030
Symbol: NU3M_HUMAN
Name: NADH dehydrogenase subunit 3
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 7219534
Title: Sequence and organization of the human mitochondrial genome.
PubMed ID: 7219534
DOI: 10.1038/290457a0
PubMed ID: 12949126
Title: Lineage-specific selection in human mtDNA: lack of polymorphisms in a segment of MTND5 gene in haplogroup J.
PubMed ID: 12949126
PubMed ID: 11130070
Title: Mitochondrial genome variation and the origin of modern humans.
PubMed ID: 11130070
DOI: 10.1038/35047064
PubMed ID: 12840039
Title: Mitochondrial genome variation and evolutionary history of Australian and New Guinean aborigines.
PubMed ID: 12840039
DOI: 10.1101/gr.686603
PubMed ID: 14760490
Title: Single nucleotide polymorphisms over the entire mtDNA genome that increase the power of forensic testing in Caucasians.
PubMed ID: 14760490
PubMed ID: 3921850
Title: Six unidentified reading frames of human mitochondrial DNA encode components of the respiratory-chain NADH dehydrogenase.
PubMed ID: 3921850
DOI: 10.1038/314592a0
PubMed ID: 12611891
Title: The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification.
PubMed ID: 12611891
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 32320651
Title: Dissecting the Roles of Mitochondrial Complex I Intermediate Assembly Complex Factors in the Biogenesis of Complex I.
PubMed ID: 32320651
PubMed ID: 33753518
Title: TMEM70 and TMEM242 help to assemble the rotor ring of human ATP synthase and interact with assembly factors for complex I.
PubMed ID: 33753518
PubMed ID: 6343397
Title: Assignment of a polymorphic polypeptide to the human mitochondrial DNA unidentified reading frame 3 gene by a new peptide mapping strategy.
PubMed ID: 6343397
PubMed ID: 1757091
Title: Normal variants of human mitochondrial DNA and translation products: the building of a reference data base.
PubMed ID: 1757091
DOI: 10.1007/bf00206061
PubMed ID: 11456298
Title: Progressive mitochondrial disease resulting from a novel missense mutation in the mitochondrial DNA ND3 gene.
PubMed ID: 11456298
DOI: 10.1002/ana.1084
PubMed ID: 14705112
Title: De novo mutations in the mitochondrial ND3 gene as a cause of infantile mitochondrial encephalopathy and complex I deficiency.
PubMed ID: 14705112
DOI: 10.1002/ana.10787
PubMed ID: 17152068
Title: A novel recurrent mitochondrial DNA mutation in ND3 gene is associated with isolated complex I deficiency causing Leigh syndrome and dystonia.
PubMed ID: 17152068
DOI: 10.1002/ajmg.a.31565
PubMed ID: 20818383
Title: High-throughput, pooled sequencing identifies mutations in NUBPL and FOXRED1 in human complex I deficiency.
PubMed ID: 20818383
DOI: 10.1038/ng.659
PubMed ID: 25118196
Title: Rapid identification of a novel complex I MT-ND3 m.10134C>A mutation in a Leigh syndrome patient.
PubMed ID: 25118196
Sequence Information:
- Length: 115
- Mass: 13186
- Checksum: FA9E0C13B5108EE6
- Sequence:
MNFALILMIN TLLALLLMII TFWLPQLNGY MEKSTPYECG FDPMSPARVP FSMKFFLVAI TFLLFDLEIA LLLPLPWALQ TTNLPLMVMS SLLLIIILAL SLAYEWLQKG LDWTE
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.