Details for: ND3

Gene ID: 4537

Symbol: ND3

Ensembl ID: ENSG00000198840

Description: NADH dehydrogenase subunit 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 830.1868
    Cell Significance Index: -391.9500
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 801.8893
    Cell Significance Index: -412.4800
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 586.1207
    Cell Significance Index: -393.3000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 140.3694
    Cell Significance Index: -376.0300
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 64.6554
    Cell Significance Index: 514.4300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: 49.7970
    Cell Significance Index: 3943.9300
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 49.1642
    Cell Significance Index: 689.6000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 43.1936
    Cell Significance Index: 31669.4300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 39.6922
    Cell Significance Index: 1457.0700
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 32.9210
    Cell Significance Index: 485.9100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 31.5823
    Cell Significance Index: 9087.1700
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: 19.1267
    Cell Significance Index: 398.9000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 12.2921
    Cell Significance Index: 1255.6400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 11.0103
    Cell Significance Index: 101.3900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 10.8196
    Cell Significance Index: 5908.8300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 9.7625
    Cell Significance Index: 442.5000
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 9.4734
    Cell Significance Index: 142.7600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 9.3181
    Cell Significance Index: 253.6300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 9.2393
    Cell Significance Index: 1268.8100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 8.6203
    Cell Significance Index: 1105.0700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 8.4838
    Cell Significance Index: 445.4300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 7.8626
    Cell Significance Index: 210.3200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 7.6340
    Cell Significance Index: 938.6800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 7.3559
    Cell Significance Index: 800.1000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 7.3341
    Cell Significance Index: 211.3100
  • Cell Name: peg cell (CL4033014)
    Fold Change: 7.0565
    Cell Significance Index: 163.0300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 6.4920
    Cell Significance Index: 119.9900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 5.8840
    Cell Significance Index: 168.6700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 5.7471
    Cell Significance Index: 1036.0200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 5.5164
    Cell Significance Index: 712.6800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 5.2307
    Cell Significance Index: 389.8400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 4.9941
    Cell Significance Index: 494.0300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 4.8058
    Cell Significance Index: 225.8700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 4.7904
    Cell Significance Index: 4325.4100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 4.7216
    Cell Significance Index: 220.1500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 4.6819
    Cell Significance Index: 302.0500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 4.3995
    Cell Significance Index: 115.6900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 3.9125
    Cell Significance Index: 76.3600
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 3.4393
    Cell Significance Index: 57.9400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 3.2993
    Cell Significance Index: 198.0700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 2.8778
    Cell Significance Index: 2178.2800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 2.6937
    Cell Significance Index: 68.8200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 2.4771
    Cell Significance Index: 402.8700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 2.4154
    Cell Significance Index: 27.4400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.1726
    Cell Significance Index: 779.2900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.0385
    Cell Significance Index: 208.3200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.0328
    Cell Significance Index: 196.5500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.9620
    Cell Significance Index: 33.8100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.8208
    Cell Significance Index: 162.9000
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.5036
    Cell Significance Index: 6.4500
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.4917
    Cell Significance Index: 3.7900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.2730
    Cell Significance Index: 7.2900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.1778
    Cell Significance Index: -334.8600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.2774
    Cell Significance Index: -511.5400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.2970
    Cell Significance Index: -50.7100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.3331
    Cell Significance Index: -512.7600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.3789
    Cell Significance Index: -515.2000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.4104
    Cell Significance Index: -21.3200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.4832
    Cell Significance Index: -357.9600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.5053
    Cell Significance Index: -34.9500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.5684
    Cell Significance Index: -360.9800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.6573
    Cell Significance Index: -370.6900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.6579
    Cell Significance Index: -44.2400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.7532
    Cell Significance Index: -470.3600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.8000
    Cell Significance Index: -363.1000
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -1.0330
    Cell Significance Index: -18.2600
  • Cell Name: kidney cortex collecting duct epithelial cell (CL1000549)
    Fold Change: -1.0686
    Cell Significance Index: -1.1300
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -1.1428
    Cell Significance Index: -7.0900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -1.5378
    Cell Significance Index: -176.1800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -2.0134
    Cell Significance Index: -50.3300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -2.0607
    Cell Significance Index: -434.0400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -2.3426
    Cell Significance Index: -131.4600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -2.7491
    Cell Significance Index: -399.6100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -3.4628
    Cell Significance Index: -75.0200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -3.4877
    Cell Significance Index: -58.3700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -3.5277
    Cell Significance Index: -103.6100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -3.5875
    Cell Significance Index: -373.5400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -3.7061
    Cell Significance Index: -128.7900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -4.4538
    Cell Significance Index: -280.7100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -4.5993
    Cell Significance Index: -147.3100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -4.6582
    Cell Significance Index: -357.4700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -4.7531
    Cell Significance Index: -135.6400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -4.8501
    Cell Significance Index: -101.5200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -5.2558
    Cell Significance Index: -322.2300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -5.3019
    Cell Significance Index: -325.8800
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -6.1199
    Cell Significance Index: -105.5000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -6.1335
    Cell Significance Index: -251.3200
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -6.3427
    Cell Significance Index: -95.0400
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -7.3609
    Cell Significance Index: -76.2000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -7.6747
    Cell Significance Index: -163.4500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -8.0687
    Cell Significance Index: -356.9000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -8.8636
    Cell Significance Index: -447.9400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -9.2024
    Cell Significance Index: -271.0500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -9.6212
    Cell Significance Index: -247.3100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -9.8039
    Cell Significance Index: -371.2500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -10.2217
    Cell Significance Index: -212.0400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -10.3200
    Cell Significance Index: -361.5300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -10.9474
    Cell Significance Index: -358.4200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -11.1147
    Cell Significance Index: -353.9900
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -11.5037
    Cell Significance Index: -248.5400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ND3 is a transmembrane protein that belongs to the mitochondrial inner membrane. It is a component of the complex I of the respiratory electron transport chain, which is responsible for the transfer of electrons from NADH to ubiquinone. ND3 is highly conserved across species, suggesting its essential role in maintaining cellular homeostasis. The protein is expressed in various cell types, including skeletal muscle satellite cells, microglial cells, and pancreatic ductal cells. **Pathways and Functions:** ND3 is involved in several critical pathways, including: 1. **Aerobic Respiration:** ND3 plays a central role in the electron transport chain, facilitating the generation of ATP through chemiosmotic coupling. 2. **Mitochondrial Electron Transport:** ND3 is a key component of complex I, transferring electrons from NADH to ubiquinone. 3. **Proton Motive Force-Driven Mitochondrial ATP Synthesis:** ND3 contributes to the proton motive force, driving the synthesis of ATP through chemiosmotic coupling. 4. **Response to Oxidative Stress:** ND3 has been shown to be involved in the response to oxidative stress, with implications for cellular protection against reactive oxygen species. **Clinical Significance:** Dysregulation of ND3 has been implicated in various diseases, including: 1. **Mitochondrial Diseases:** Mutations in the ND3 gene have been associated with mitochondrial diseases, such as MELAS syndrome and Kearns-Sayre syndrome. 2. **Neurodegenerative Disorders:** ND3 has been linked to neurodegenerative disorders, including Alzheimer's disease and Parkinson's disease. 3. **Cancer:** Alterations in ND3 expression have been observed in various cancers, including breast and lung cancer. 4. **Cardiovascular Disease:** ND3 has been implicated in the development of cardiovascular disease, including hypertension and atherosclerosis. In conclusion, ND3 is a critical component of the mitochondrial respiratory chain complex I, playing a pivotal role in energy production and cellular homeostasis. Dysregulation of ND3 has been implicated in various diseases, highlighting the importance of this gene in maintaining cellular function and preventing disease. Further research is needed to fully elucidate the role of ND3 in human disease and to explore potential therapeutic strategies for the treatment of these disorders.

Genular Protein ID: 4018764030

Symbol: NU3M_HUMAN

Name: NADH dehydrogenase subunit 3

UniProtKB Accession Codes:

P03897

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CORUM 1 CTD 1 ChEBI 5 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 DrugCentral 1 EC 1 EMBL 100 Ensembl 1 ExpressionAtlas 1 GO 10 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MIM 5 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 3 PANTHER 2 PDB 2 PDBsum 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 Rhea 3 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7219534

Title: Sequence and organization of the human mitochondrial genome.

PubMed ID: 7219534

DOI: 10.1038/290457a0

PubMed ID: 12949126

Title: Lineage-specific selection in human mtDNA: lack of polymorphisms in a segment of MTND5 gene in haplogroup J.

PubMed ID: 12949126

DOI: 10.1093/molbev/msg230

PubMed ID: 11130070

Title: Mitochondrial genome variation and the origin of modern humans.

PubMed ID: 11130070

DOI: 10.1038/35047064

PubMed ID: 12840039

Title: Mitochondrial genome variation and evolutionary history of Australian and New Guinean aborigines.

PubMed ID: 12840039

DOI: 10.1101/gr.686603

PubMed ID: 14760490

Title: Single nucleotide polymorphisms over the entire mtDNA genome that increase the power of forensic testing in Caucasians.

PubMed ID: 14760490

DOI: 10.1007/s00414-004-0427-6

PubMed ID: 3921850

Title: Six unidentified reading frames of human mitochondrial DNA encode components of the respiratory-chain NADH dehydrogenase.

PubMed ID: 3921850

DOI: 10.1038/314592a0

PubMed ID: 12611891

Title: The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification.

PubMed ID: 12611891

DOI: 10.1074/jbc.c300064200

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 32320651

Title: Dissecting the Roles of Mitochondrial Complex I Intermediate Assembly Complex Factors in the Biogenesis of Complex I.

PubMed ID: 32320651

DOI: 10.1016/j.celrep.2020.107541

PubMed ID: 33753518

Title: TMEM70 and TMEM242 help to assemble the rotor ring of human ATP synthase and interact with assembly factors for complex I.

PubMed ID: 33753518

DOI: 10.1073/pnas.2100558118

PubMed ID: 6343397

Title: Assignment of a polymorphic polypeptide to the human mitochondrial DNA unidentified reading frame 3 gene by a new peptide mapping strategy.

PubMed ID: 6343397

DOI: 10.1016/s0021-9258(20)81969-3

PubMed ID: 1757091

Title: Normal variants of human mitochondrial DNA and translation products: the building of a reference data base.

PubMed ID: 1757091

DOI: 10.1007/bf00206061

PubMed ID: 11456298

Title: Progressive mitochondrial disease resulting from a novel missense mutation in the mitochondrial DNA ND3 gene.

PubMed ID: 11456298

DOI: 10.1002/ana.1084

PubMed ID: 14705112

Title: De novo mutations in the mitochondrial ND3 gene as a cause of infantile mitochondrial encephalopathy and complex I deficiency.

PubMed ID: 14705112

DOI: 10.1002/ana.10787

PubMed ID: 17152068

Title: A novel recurrent mitochondrial DNA mutation in ND3 gene is associated with isolated complex I deficiency causing Leigh syndrome and dystonia.

PubMed ID: 17152068

DOI: 10.1002/ajmg.a.31565

PubMed ID: 20818383

Title: High-throughput, pooled sequencing identifies mutations in NUBPL and FOXRED1 in human complex I deficiency.

PubMed ID: 20818383

DOI: 10.1038/ng.659

PubMed ID: 25118196

Title: Rapid identification of a novel complex I MT-ND3 m.10134C>A mutation in a Leigh syndrome patient.

PubMed ID: 25118196

DOI: 10.1371/journal.pone.0104879

Sequence Information:

  • Length: 115
  • Mass: 13186
  • Checksum: FA9E0C13B5108EE6
  • Sequence:
    • MNFALILMIN TLLALLLMII TFWLPQLNGY MEKSTPYECG FDPMSPARVP FSMKFFLVAI 
TFLLFDLEIA LLLPLPWALQ TTNLPLMVMS SLLLIIILAL SLAYEWLQKG LDWTE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.