Details for: ZFP36

Gene ID: 7538

Symbol: ZFP36

Ensembl ID: ENSG00000128016

Description: ZFP36 ring finger protein

Associated with

  • Metabolism of rna
    (R-HSA-8953854)
  • Regulation of mrna stability by proteins that bind au-rich elements
    (R-HSA-450531)
  • Tristetraprolin (ttp, zfp36) binds and destabilizes mrna
    (R-HSA-450513)
  • 3'-utr-mediated mrna destabilization
    (GO:0061158)
  • 3'-utr-mediated mrna stabilization
    (GO:0070935)
  • 14-3-3 protein binding
    (GO:0071889)
  • C-c chemokine binding
    (GO:0019957)
  • Ccr4-not complex
    (GO:0030014)
  • Cellular response to epidermal growth factor stimulus
    (GO:0071364)
  • Cellular response to fibroblast growth factor stimulus
    (GO:0044344)
  • Cellular response to glucocorticoid stimulus
    (GO:0071385)
  • Cellular response to granulocyte macrophage colony-stimulating factor stimulus
    (GO:0097011)
  • Cellular response to lipopolysaccharide
    (GO:0071222)
  • Cellular response to tumor necrosis factor
    (GO:0071356)
  • Cytoplasm
    (GO:0005737)
  • Cytoplasmic stress granule
    (GO:0010494)
  • Cytosol
    (GO:0005829)
  • Dna binding
    (GO:0003677)
  • Enzyme binding
    (GO:0019899)
  • Exosome (rnase complex)
    (GO:0000178)
  • Heat shock protein binding
    (GO:0031072)
  • Hematopoietic stem cell differentiation
    (GO:0060218)
  • Mapk cascade
    (GO:0000165)
  • Metal ion binding
    (GO:0046872)
  • Mirna-mediated gene silencing by inhibition of translation
    (GO:0035278)
  • Mrna 3'-utr au-rich region binding
    (GO:0035925)
  • Mrna binding
    (GO:0003729)
  • Mrna catabolic process
    (GO:0006402)
  • Mrna transport
    (GO:0051028)
  • Myeloid cell differentiation
    (GO:0030099)
  • Negative regulation of erythrocyte differentiation
    (GO:0045647)
  • Negative regulation of hematopoietic stem cell differentiation
    (GO:1902037)
  • Negative regulation of inflammatory response
    (GO:0050728)
  • Negative regulation of interleukin-2 production
    (GO:0032703)
  • Negative regulation of polynucleotide adenylyltransferase activity
    (GO:1904246)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Negative regulation of viral transcription
    (GO:0032897)
  • Nuclear-transcribed mrna catabolic process, deadenylation-dependent decay
    (GO:0000288)
  • Nuclear-transcribed mrna catabolic process, deadenylation-independent decay
    (GO:0031086)
  • Nuclear-transcribed mrna poly(a) tail shortening
    (GO:0000289)
  • Nucleus
    (GO:0005634)
  • P-body
    (GO:0000932)
  • P38mapk cascade
    (GO:0038066)
  • Positive regulation of deadenylation-independent decapping of nuclear-transcribed mrna
    (GO:1901835)
  • Positive regulation of fat cell differentiation
    (GO:0045600)
  • Positive regulation of intracellular mrna localization
    (GO:1904582)
  • Positive regulation of mirna-mediated gene silencing
    (GO:2000637)
  • Positive regulation of nuclear-transcribed mrna catabolic process, deadenylation-dependent decay
    (GO:1900153)
  • Positive regulation of nuclear-transcribed mrna poly(a) tail shortening
    (GO:0060213)
  • Protein-containing complex binding
    (GO:0044877)
  • Protein binding
    (GO:0005515)
  • Protein kinase binding
    (GO:0019901)
  • Regulation of keratinocyte apoptotic process
    (GO:1902172)
  • Regulation of keratinocyte differentiation
    (GO:0045616)
  • Regulation of keratinocyte proliferation
    (GO:0010837)
  • Regulation of mrna stability
    (GO:0043488)
  • Regulation of tumor necrosis factor production
    (GO:0032680)
  • Response to starvation
    (GO:0042594)
  • Response to wounding
    (GO:0009611)
  • Ribonucleoprotein complex
    (GO:1990904)
  • Rna binding
    (GO:0003723)
  • Rna polymerase binding
    (GO:0070063)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 690.2173
    Cell Significance Index: -107.3600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 356.9973
    Cell Significance Index: -90.5500
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 279.5016
    Cell Significance Index: -115.1400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 263.3677
    Cell Significance Index: -107.0000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 239.4611
    Cell Significance Index: -113.0600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 232.5494
    Cell Significance Index: -119.6200
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 169.0853
    Cell Significance Index: -113.4600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 116.6073
    Cell Significance Index: -111.3300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 87.0753
    Cell Significance Index: -107.3600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 33.8374
    Cell Significance Index: -103.9300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 27.4832
    Cell Significance Index: -108.4500
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 21.9065
    Cell Significance Index: 58.6900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 20.0403
    Cell Significance Index: -43.8600
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 13.2217
    Cell Significance Index: 233.6500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 11.8298
    Cell Significance Index: 339.1100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 10.9039
    Cell Significance Index: -29.2100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 10.5212
    Cell Significance Index: 194.4600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 7.8880
    Cell Significance Index: 214.7100
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 6.1558
    Cell Significance Index: 65.4100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 5.4106
    Cell Significance Index: 281.8300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 5.2004
    Cell Significance Index: 666.6600
  • Cell Name: theca cell (CL0000503)
    Fold Change: 5.1183
    Cell Significance Index: 30.0700
  • Cell Name: peg cell (CL4033014)
    Fold Change: 4.2342
    Cell Significance Index: 97.8300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 3.6921
    Cell Significance Index: 275.1700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 3.4160
    Cell Significance Index: 160.5500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 3.1912
    Cell Significance Index: 1410.9000
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 3.1239
    Cell Significance Index: 19.2300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 3.0739
    Cell Significance Index: 143.3200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 2.8539
    Cell Significance Index: 368.7000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 2.4312
    Cell Significance Index: 438.2700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 2.3318
    Cell Significance Index: 286.7200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 2.2698
    Cell Significance Index: 160.5300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.2650
    Cell Significance Index: 311.0500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.8392
    Cell Significance Index: 118.6600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.5456
    Cell Significance Index: 152.8900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.2420
    Cell Significance Index: 678.2900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.0050
    Cell Significance Index: 191.2600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.8185
    Cell Significance Index: 96.5300
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.7974
    Cell Significance Index: 5.2900
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.6387
    Cell Significance Index: 8.1800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.4158
    Cell Significance Index: 47.4700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.3305
    Cell Significance Index: 8.8400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3182
    Cell Significance Index: 16.5300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2696
    Cell Significance Index: 43.8400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.2498
    Cell Significance Index: 189.0800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.2482
    Cell Significance Index: 2.8200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.1085
    Cell Significance Index: 11.0800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0279
    Cell Significance Index: 0.9800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0244
    Cell Significance Index: 22.0600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0018
    Cell Significance Index: 3.4100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0164
    Cell Significance Index: -0.8300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0165
    Cell Significance Index: -0.7500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0279
    Cell Significance Index: -17.4400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0403
    Cell Significance Index: -1.0600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0511
    Cell Significance Index: -78.7200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0609
    Cell Significance Index: -112.3200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0692
    Cell Significance Index: -51.2500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0694
    Cell Significance Index: -94.4100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.1159
    Cell Significance Index: -84.9500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.1337
    Cell Significance Index: -84.8900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1643
    Cell Significance Index: -92.6400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1913
    Cell Significance Index: -7.8400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.2050
    Cell Significance Index: -93.0400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.2594
    Cell Significance Index: -44.2900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.2813
    Cell Significance Index: -2.5900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.3116
    Cell Significance Index: -111.7600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.3361
    Cell Significance Index: -70.8000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.3528
    Cell Significance Index: -70.0100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.3883
    Cell Significance Index: -111.7200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3902
    Cell Significance Index: -6.5300
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.4262
    Cell Significance Index: -10.4000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.4691
    Cell Significance Index: -9.8200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.5409
    Cell Significance Index: -61.9700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.5473
    Cell Significance Index: -109.7900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.5865
    Cell Significance Index: -85.2500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.6717
    Cell Significance Index: -46.4500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.7020
    Cell Significance Index: -81.8100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.7448
    Cell Significance Index: -11.1600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.7572
    Cell Significance Index: -82.3600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.7696
    Cell Significance Index: -10.5000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.7961
    Cell Significance Index: -19.9000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.9258
    Cell Significance Index: -27.1900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.9484
    Cell Significance Index: -18.5100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.9784
    Cell Significance Index: -101.8700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -1.0663
    Cell Significance Index: -29.8000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -1.1356
    Cell Significance Index: -87.1500
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -1.2713
    Cell Significance Index: -9.1300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -1.3520
    Cell Significance Index: -36.1000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -1.4542
    Cell Significance Index: -115.1700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.6015
    Cell Significance Index: -98.1900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -1.7324
    Cell Significance Index: -116.4900
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -1.7917
    Cell Significance Index: -12.1400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -1.8283
    Cell Significance Index: -115.2400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -1.8579
    Cell Significance Index: -114.2000
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -1.9808
    Cell Significance Index: -31.9600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -1.9843
    Cell Significance Index: -42.9900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -2.0460
    Cell Significance Index: -58.9500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -2.0580
    Cell Significance Index: -65.9200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -2.1610
    Cell Significance Index: -113.4600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -2.1620
    Cell Significance Index: -121.3200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ZFP36 is a member of the RING finger protein family, characterized by its ability to bind and stabilize specific mRNAs through its 3'-UTR binding domain. The gene is specifically expressed in various cell types, including immune cells, epithelial cells, and endothelial cells. ZFP36's expression is tightly regulated by various cellular signals, including growth factors, cytokines, and stress stimuli. The protein's expression is also influenced by post-translational modifications, such as phosphorylation and ubiquitination. **Pathways and Functions:** ZFP36's involvement in mRNA stability regulation is mediated through its interaction with the CCR4-NOT complex, a key component of the 3'-UTR mediated mRNA destabilization process. This process involves the recognition and binding of specific mRNAs by ZFP36, followed by the recruitment of the CCR4-NOT complex, which leads to the degradation of the mRNA. ZFP36's role in mRNA stability regulation is further underscored by its involvement in various cellular responses, including: * Inflammation: ZFP36's ability to regulate mRNA stability of pro-inflammatory mRNAs, such as those involved in the production of cytokines and chemokines. * Apoptosis: ZFP36's role in regulating mRNA stability of pro-apoptotic mRNAs, such as those involved in the production of Bcl-2 family proteins. * Differentiation: ZFP36's involvement in regulating mRNA stability of mRNAs involved in cell differentiation, such as those involved in the production of keratinocyte-specific proteins. **Clinical Significance:** ZFP36's role in regulating mRNA stability has significant implications for the development of various diseases, including: * Cancer: ZFP36's ability to regulate mRNA stability of tumor suppressor genes, such as p53, may contribute to cancer development and progression. * Autoimmune diseases: ZFP36's involvement in regulating mRNA stability of pro-inflammatory mRNAs may contribute to the development of autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. * Neurological disorders: ZFP36's role in regulating mRNA stability of mRNAs involved in neuronal function and survival may contribute to the development of neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, ZFP36 is a complex gene that plays a crucial role in regulating mRNA stability, particularly in the context of immune responses. Its involvement in various cellular processes, including inflammation, apoptosis, and differentiation, has significant implications for the development of various diseases. Further research is needed to fully elucidate the mechanisms underlying ZFP36's role in mRNA stability regulation and its clinical significance.

Genular Protein ID: 2593039445

Symbol: TTP_HUMAN

Name: G0/G1 switch regulatory protein 24

UniProtKB Accession Codes:

P26651 B2RA54

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 57 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2062660

Title: The human TTP protein: sequence, alignment with related proteins, and chromosomal localization of the mouse and human genes.

PubMed ID: 2062660

DOI: 10.1093/nar/19.12.3454

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9703499

Title: Feedback inhibition of macrophage tumor necrosis factor-alpha production by tristetraprolin.

PubMed ID: 9703499

DOI: 10.1126/science.281.5379.1001

PubMed ID: 10330172

Title: Evidence that tristetraprolin binds to AU-rich elements and promotes the deadenylation and destabilization of tumor necrosis factor alpha mRNA.

PubMed ID: 10330172

DOI: 10.1128/mcb.19.6.4311

PubMed ID: 10751406

Title: Interactions of CCCH zinc finger proteins with mRNA. Binding of tristetraprolin-related zinc finger proteins to Au-rich elements and destabilization of mRNA.

PubMed ID: 10751406

DOI: 10.1074/jbc.m001696200

PubMed ID: 11719186

Title: AU binding proteins recruit the exosome to degrade ARE-containing mRNAs.

PubMed ID: 11719186

DOI: 10.1016/s0092-8674(01)00578-5

PubMed ID: 11279239

Title: Interactions of CCCH zinc finger proteins with mRNA: tristetraprolin-mediated AU-rich element-dependent mRNA degradation can occur in the absence of a poly(A) tail.

PubMed ID: 11279239

DOI: 10.1074/jbc.m100680200

PubMed ID: 12115244

Title: Analysis of the function, expression, and subcellular distribution of human tristetraprolin.

PubMed ID: 12115244

DOI: 10.1002/art.10235

PubMed ID: 14679154

Title: Interaction of retroviral Tax oncoproteins with tristetraprolin and regulation of tumor necrosis factor-alpha expression.

PubMed ID: 14679154

DOI: 10.1093/jnci/djg118

PubMed ID: 12748283

Title: Tristetraprolin and its family members can promote the cell-free deadenylation of AU-rich element-containing mRNAs by poly(A) ribonuclease.

PubMed ID: 12748283

DOI: 10.1128/mcb.23.11.3798-3812.2003

PubMed ID: 14766228

Title: Direct association of tristetraprolin with the nucleoporin CAN/Nup214.

PubMed ID: 14766228

DOI: 10.1016/j.bbrc.2004.01.080

PubMed ID: 15014438

Title: MK2-induced tristetraprolin:14-3-3 complexes prevent stress granule association and ARE-mRNA decay.

PubMed ID: 15014438

DOI: 10.1038/sj.emboj.7600163

PubMed ID: 15187101

Title: The role of mRNA turnover in the regulation of tristetraprolin expression: evidence for an extracellular signal-regulated kinase-specific, AU-rich element-dependent, autoregulatory pathway.

PubMed ID: 15187101

DOI: 10.4049/jimmunol.172.12.7263

PubMed ID: 15766526

Title: Involvement of microRNA in AU-rich element-mediated mRNA instability.

PubMed ID: 15766526

DOI: 10.1016/j.cell.2004.12.038

PubMed ID: 15687258

Title: Recruitment and activation of mRNA decay enzymes by two ARE-mediated decay activation domains in the proteins TTP and BRF-1.

PubMed ID: 15687258

DOI: 10.1101/gad.1282305

PubMed ID: 15634918

Title: Tristetraprolin down-regulates IL-2 gene expression through AU-rich element-mediated mRNA decay.

PubMed ID: 15634918

DOI: 10.4049/jimmunol.174.2.953

PubMed ID: 16364915

Title: Multiple processing body factors and the ARE binding protein TTP activate mRNA decapping.

PubMed ID: 16364915

DOI: 10.1016/j.molcel.2005.10.031

PubMed ID: 16126846

Title: Involvement of KSRP in the post-transcriptional regulation of human iNOS expression-complex interplay of KSRP with TTP and HuR.

PubMed ID: 16126846

DOI: 10.1093/nar/gki797

PubMed ID: 16262601

Title: Identification of the anti-inflammatory protein tristetraprolin as a hyperphosphorylated protein by mass spectrometry and site-directed mutagenesis.

PubMed ID: 16262601

DOI: 10.1042/bj20051316

PubMed ID: 16508015

Title: Posttranslational regulation of tristetraprolin subcellular localization and protein stability by p38 mitogen-activated protein kinase and extracellular signal-regulated kinase pathways.

PubMed ID: 16508015

DOI: 10.1128/mcb.26.6.2408-2418.2006

PubMed ID: 17030620

Title: Novel mRNA targets for tristetraprolin (TTP) identified by global analysis of stabilized transcripts in TTP-deficient fibroblasts.

PubMed ID: 17030620

DOI: 10.1128/mcb.00945-06

PubMed ID: 16702957

Title: Tristetraprolin regulates Cyclin D1 and c-Myc mRNA stability in response to rapamycin in an Akt-dependent manner via p38 MAPK signaling.

PubMed ID: 16702957

DOI: 10.1038/sj.onc.1209645

PubMed ID: 17369404

Title: TTP and BRF proteins nucleate processing body formation to silence mRNAs with AU-rich elements.

PubMed ID: 17369404

DOI: 10.1101/gad.1494707

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 18367721

Title: Identification of TTP mRNA targets in human dendritic cells reveals TTP as a critical regulator of dendritic cell maturation.

PubMed ID: 18367721

DOI: 10.1261/rna.748408

PubMed ID: 19188452

Title: Stimulation of polo-like kinase 3 mRNA decay by tristetraprolin.

PubMed ID: 19188452

DOI: 10.1128/mcb.00982-08

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 20166898

Title: ZFP36L1 is regulated by growth factors and cytokines in keratinocytes and influences their VEGF production.

PubMed ID: 20166898

DOI: 10.3109/08977190903578660

PubMed ID: 20702587

Title: ZFP36L1 negatively regulates erythroid differentiation of CD34+ hematopoietic stem cells by interfering with the Stat5b pathway.

PubMed ID: 20702587

DOI: 10.1091/mbc.e10-01-0040

PubMed ID: 20221403

Title: Phosphorylation of human tristetraprolin in response to its interaction with the Cbl interacting protein CIN85.

PubMed ID: 20221403

DOI: 10.1371/journal.pone.0009588

PubMed ID: 21775632

Title: Hypoxia-inducible factor-1alpha mRNA: a new target for destabilization by tristetraprolin in endothelial cells.

PubMed ID: 21775632

DOI: 10.1091/mbc.e10-07-0617

PubMed ID: 21078877

Title: Phosphorylation of tristetraprolin by MK2 impairs AU-rich element mRNA decay by preventing deadenylase recruitment.

PubMed ID: 21078877

DOI: 10.1128/mcb.00717-10

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 21964062

Title: Protor-2 interacts with tristetraprolin to regulate mRNA stability during stress.

PubMed ID: 21964062

DOI: 10.1016/j.cellsig.2011.09.015

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25106868

Title: ZFP36L1 and ZFP36L2 control LDLR mRNA stability via the ERK-RSK pathway.

PubMed ID: 25106868

DOI: 10.1093/nar/gku652

PubMed ID: 25815583

Title: Post-transcriptional regulation of satellite cell quiescence by TTP-mediated mRNA decay.

PubMed ID: 25815583

DOI: 10.7554/elife.03390

PubMed ID: 27193233

Title: Destabilization of the ornithine decarboxylase mRNA transcript by the RNA-binding protein tristetraprolin.

PubMed ID: 27193233

DOI: 10.1007/s00726-016-2261-9

PubMed ID: 27182009

Title: Functional analysis of ZFP36 proteins in keratinocytes.

PubMed ID: 27182009

DOI: 10.1016/j.ejcb.2016.04.007

PubMed ID: 26926077

Title: Interaction with pyruvate kinase M2 destabilizes tristetraprolin by proteasome degradation and regulates cell proliferation in breast cancer.

PubMed ID: 26926077

DOI: 10.1038/srep22449

PubMed ID: 31439631

Title: Molecular basis for GIGYF-Me31B complex assembly in 4EHP-mediated translational repression.

PubMed ID: 31439631

DOI: 10.1101/gad.329219.119

PubMed ID: 23644599

Title: Structural basis for the recruitment of the human CCR4-NOT deadenylase complex by tristetraprolin.

PubMed ID: 23644599

DOI: 10.1038/nsmb.2572

Sequence Information:

  • Length: 326
  • Mass: 34003
  • Checksum: DDD9AD950AF7AF98
  • Sequence:
    • MDLTAIYESL LSLSPDVPVP SDHGGTESSP GWGSSGPWSL SPSDSSPSGV TSRLPGRSTS 
LVEGRSCGWV PPPPGFAPLA PRLGPELSPS PTSPTATSTT PSRYKTELCR TFSESGRCRY 
GAKCQFAHGL GELRQANRHP KYKTELCHKF YLQGRCPYGS RCHFIHNPSE DLAAPGHPPV 
LRQSISFSGL PSGRRTSPPP PGLAGPSLSS SSFSPSSSPP PPGDLPLSPS AFSAAPGTPL 
ARRDPTPVCC PSCRRATPIS VWGPLGGLVR TPSVQSLGSD PDEYASSGSS LGGSDSPVFE 
AGVFAPPQPV AAPRRLPIFN RISVSE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.