Details for: NTM

Gene ID: 50863

Symbol: NTM

Ensembl ID: ENSG00000182667

Description: neurotrimin

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 109.5373
    Cell Significance Index: -104.5800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 11.4069
    Cell Significance Index: -24.9700
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: 11.2333
    Cell Significance Index: 157.0800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 9.2294
    Cell Significance Index: 581.7000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 5.6054
    Cell Significance Index: 2010.5700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 5.0794
    Cell Significance Index: 111.2200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 4.6461
    Cell Significance Index: 285.5700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 4.6455
    Cell Significance Index: 79.6100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 4.4455
    Cell Significance Index: 168.3400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 4.3461
    Cell Significance Index: 192.2400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 4.2842
    Cell Significance Index: 288.0700
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: 3.3638
    Cell Significance Index: 35.0400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 3.0429
    Cell Significance Index: 610.4100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 2.7941
    Cell Significance Index: 1932.4700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 2.6361
    Cell Significance Index: 63.2200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.9708
    Cell Significance Index: 110.5900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 1.0719
    Cell Significance Index: 30.5900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.8973
    Cell Significance Index: 1689.4300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4465
    Cell Significance Index: 403.1700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4068
    Cell Significance Index: 77.4200
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: 0.1059
    Cell Significance Index: 1.3200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0461
    Cell Significance Index: 0.5500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0609
    Cell Significance Index: -82.7800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0612
    Cell Significance Index: -112.8600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0657
    Cell Significance Index: -41.7400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0677
    Cell Significance Index: -104.1500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0726
    Cell Significance Index: -14.4000
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0795
    Cell Significance Index: -1.2300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1011
    Cell Significance Index: -14.7000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1042
    Cell Significance Index: -3.6600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.1649
    Cell Significance Index: -120.9000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.1655
    Cell Significance Index: -122.5700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.1837
    Cell Significance Index: -139.0100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.2229
    Cell Significance Index: -139.1900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.2345
    Cell Significance Index: -128.0900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.2528
    Cell Significance Index: -111.7500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.2530
    Cell Significance Index: -142.6700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.2586
    Cell Significance Index: -117.3800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.2599
    Cell Significance Index: -42.2800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.2666
    Cell Significance Index: -26.3700
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -0.3006
    Cell Significance Index: -3.7900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.3798
    Cell Significance Index: -109.2800
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.4910
    Cell Significance Index: -21.3500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.5370
    Cell Significance Index: -96.8100
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.5380
    Cell Significance Index: -6.7900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.6799
    Cell Significance Index: -143.2100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.6852
    Cell Significance Index: -71.3500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.7148
    Cell Significance Index: -77.7500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.7702
    Cell Significance Index: -34.9100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.8262
    Cell Significance Index: -101.5900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.8389
    Cell Significance Index: -24.1700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.8644
    Cell Significance Index: -110.8100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.8733
    Cell Significance Index: -149.1200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.8932
    Cell Significance Index: -122.6600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.9401
    Cell Significance Index: -121.4600
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.9965
    Cell Significance Index: -17.2300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -1.0499
    Cell Significance Index: -29.3400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -1.0747
    Cell Significance Index: -126.7400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -1.1489
    Cell Significance Index: -133.8900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -1.1828
    Cell Significance Index: -120.8200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.2178
    Cell Significance Index: -74.6600
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -1.2502
    Cell Significance Index: -24.7200
  • Cell Name: neural cell (CL0002319)
    Fold Change: -1.2618
    Cell Significance Index: -14.7200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -1.2821
    Cell Significance Index: -88.6700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -1.2824
    Cell Significance Index: -67.3300
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -1.2835
    Cell Significance Index: -14.6900
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: -1.3715
    Cell Significance Index: -15.2400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -1.3796
    Cell Significance Index: -158.0600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -1.3815
    Cell Significance Index: -29.3200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -1.4919
    Cell Significance Index: -21.3700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -1.5309
    Cell Significance Index: -121.2500
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -1.5907
    Cell Significance Index: -13.1300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -1.5944
    Cell Significance Index: -39.8600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -1.5985
    Cell Significance Index: -122.6700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -1.6155
    Cell Significance Index: -120.4000
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -1.6318
    Cell Significance Index: -20.2400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -1.6629
    Cell Significance Index: -99.8300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.6888
    Cell Significance Index: -55.2900
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -1.7072
    Cell Significance Index: -18.6000
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -1.9661
    Cell Significance Index: -21.0800
  • Cell Name: neuron (CL0000540)
    Fold Change: -1.9970
    Cell Significance Index: -18.9300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -1.9993
    Cell Significance Index: -104.1400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -2.2816
    Cell Significance Index: -79.9300
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -2.3276
    Cell Significance Index: -46.7300
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -2.3422
    Cell Significance Index: -30.3800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -2.3607
    Cell Significance Index: -122.6300
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -2.3858
    Cell Significance Index: -51.5500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -2.4648
    Cell Significance Index: -115.8500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -2.6764
    Cell Significance Index: -85.2400
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -2.7564
    Cell Significance Index: -36.7700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -2.7840
    Cell Significance Index: -54.3400
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -2.8257
    Cell Significance Index: -70.4900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -2.9274
    Cell Significance Index: -93.7600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -3.1062
    Cell Significance Index: -67.3000
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -3.1110
    Cell Significance Index: -29.6000
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -3.2091
    Cell Significance Index: -38.9000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -3.2693
    Cell Significance Index: -152.4300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -3.4177
    Cell Significance Index: -87.8500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -3.4303
    Cell Significance Index: -119.2000
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -3.5351
    Cell Significance Index: -73.7800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Cell Type-Specific Expression:** NTM is expressed in a wide range of cell types, including ciliated cells of the bronchus, Langerhans cells of the epidermis, hippocampal astrocytes, photoreceptor cells of the eye, and neurons in the brain. 2. **Post-Translational Modification:** NTM is involved in the synthesis of GPI-anchored proteins, a type of protein modification that plays a crucial role in cell-cell interactions and signaling pathways. 3. **Protein Binding:** NTM interacts with various proteins, including those involved in cell adhesion, signaling, and protein modification. **Pathways and Functions:** 1. **Cell Adhesion:** NTM is involved in the regulation of cell adhesion, a critical process for maintaining tissue structure and function. 2. **Neuron Recognition:** NTM plays a role in neuron recognition, a process essential for neural development and function. 3. **Protein Modification:** NTM is involved in the synthesis of GPI-anchored proteins, which are modified post-translationally to facilitate cell-cell interactions and signaling. 4. **Metabolism of Proteins:** NTM may be involved in the regulation of protein metabolism, including protein degradation and synthesis. **Clinical Significance:** 1. **Disease Diagnosis:** NTM's expression profile may be used as a biomarker for diagnosing various diseases, including respiratory and neurological disorders. 2. **Cancer Research:** NTM's role in cell adhesion and protein modification may be exploited to understand cancer progression and develop targeted therapies. 3. **Neurological Disorders:** NTM's involvement in neuron recognition and protein modification may be linked to the pathogenesis of neurological disorders, such as Alzheimer's disease and Parkinson's disease. 4. **Immunological Disorders:** NTM's expression profile may be used to understand immunological disorders, such as autoimmune diseases and allergies. In conclusion, NTM is a novel gene that plays a crucial role in various cellular processes, including cell adhesion, protein modification, and neuron recognition. Its expression profile highlights its potential as a biomarker for differentiating various cell types and understanding disease mechanisms. Further research is necessary to fully elucidate the functions and clinical significance of NTM.

Genular Protein ID: 1840491214

Symbol: NTRI_HUMAN

Name: Neurotrimin

UniProtKB Accession Codes:

Q9P121 A0MTT2 Q6UXJ3 Q86VJ9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 4 ExpressionAtlas 1 GO 5 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 RNAct 1 Reactome 1 RefSeq 4 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

Sequence Information:

  • Length: 344
  • Mass: 37971
  • Checksum: DA4D12C295ABBE3A
  • Sequence:
    • MGVCGYLFLP WKCLVVVSLR LLFLVPTGVP VRSGDATFPK AMDNVTVRQG ESATLRCTID 
NRVTRVAWLN RSTILYAGND KWCLDPRVVL LSNTQTQYSI EIQNVDVYDE GPYTCSVQTD 
NHPKTSRVHL IVQVSPKIVE ISSDISINEG NNISLTCIAT GRPEPTVTWR HISPKAVGFV 
SEDEYLEIQG ITREQSGDYE CSASNDVAAP VVRRVKVTVN YPPYISEAKG TGVPVGQKGT 
LQCEASAVPS AEFQWYKDDK RLIEGKKGVK VENRPFLSKL IFFNVSEHDY GNYTCVASNK 
LGHTNASIML FGPGAVSEVS NGTSRRAGCV WLLPLLVLHL LLKF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.