Details for: CL0000128

Cell ID: CL0000128

Cell Name: oligodendrocyte

Marker Score Threshold: 2,394
(Derived using integrated single-cell and genomic data)

Description: A class of large neuroglial (macroglial) cells in the central nervous system. Form the insulating myelin sheath of axons in the central nervous system.

Synonyms: OLs, oligodendroglia

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: DLG2 (ENSG00000150672)
    Fold Change: 4.84
    Ensembl ID: ENSG00000150672
  • Gene Symbol: ANK3 (ENSG00000151150)
    Fold Change: 4.79
    Ensembl ID: ENSG00000151150
  • Gene Symbol: NCAM2 (ENSG00000154654)
    Fold Change: 4.77
    Ensembl ID: ENSG00000154654
  • Gene Symbol: GPM6B (ENSG00000046653)
    Fold Change: 4.75
    Ensembl ID: ENSG00000046653
  • Gene Symbol: DST (ENSG00000151914)
    Fold Change: 4.74
    Ensembl ID: ENSG00000151914
  • Gene Symbol: MBP (ENSG00000197971)
    Fold Change: 4.61
    Ensembl ID: ENSG00000197971
  • Gene Symbol: SEPTIN7 (ENSG00000122545)
    Fold Change: 4.59
    Ensembl ID: ENSG00000122545
  • Gene Symbol: LSAMP (ENSG00000185565)
    Fold Change: 4.43
    Ensembl ID: ENSG00000185565
  • Gene Symbol: APBB2 (ENSG00000163697)
    Fold Change: 4.4
    Ensembl ID: ENSG00000163697
  • Gene Symbol: ALCAM (ENSG00000170017)
    Fold Change: 4.36
    Ensembl ID: ENSG00000170017
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 4.25
    Ensembl ID: ENSG00000142599
  • Gene Symbol: FTH1 (ENSG00000167996)
    Fold Change: 4.08
    Ensembl ID: ENSG00000167996
  • Gene Symbol: ERBB4 (ENSG00000178568)
    Fold Change: 3.94
    Ensembl ID: ENSG00000178568
  • Gene Symbol: GRID1 (ENSG00000182771)
    Fold Change: 3.93
    Ensembl ID: ENSG00000182771
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 3.9
    Ensembl ID: ENSG00000142192
  • Gene Symbol: ADGRB3 (ENSG00000135298)
    Fold Change: 3.88
    Ensembl ID: ENSG00000135298
  • Gene Symbol: APLP1 (ENSG00000105290)
    Fold Change: 3.79
    Ensembl ID: ENSG00000105290
  • Gene Symbol: DLG1 (ENSG00000075711)
    Fold Change: 3.78
    Ensembl ID: ENSG00000075711
  • Gene Symbol: ABCA2 (ENSG00000107331)
    Fold Change: 3.76
    Ensembl ID: ENSG00000107331
  • Gene Symbol: ANK2 (ENSG00000145362)
    Fold Change: 3.7
    Ensembl ID: ENSG00000145362
  • Gene Symbol: MAN2A1 (ENSG00000112893)
    Fold Change: 3.64
    Ensembl ID: ENSG00000112893
  • Gene Symbol: GNAQ (ENSG00000156052)
    Fold Change: 3.64
    Ensembl ID: ENSG00000156052
  • Gene Symbol: COX2 (ENSG00000198712)
    Fold Change: 3.63
    Ensembl ID: ENSG00000198712
  • Gene Symbol: NCAM1 (ENSG00000149294)
    Fold Change: 3.62
    Ensembl ID: ENSG00000149294
  • Gene Symbol: DPYD (ENSG00000188641)
    Fold Change: 3.61
    Ensembl ID: ENSG00000188641
  • Gene Symbol: MOBP (ENSG00000168314)
    Fold Change: 3.58
    Ensembl ID: ENSG00000168314
  • Gene Symbol: CTNND2 (ENSG00000169862)
    Fold Change: 3.54
    Ensembl ID: ENSG00000169862
  • Gene Symbol: CNP (ENSG00000173786)
    Fold Change: 3.52
    Ensembl ID: ENSG00000173786
  • Gene Symbol: HSP90AA1 (ENSG00000080824)
    Fold Change: 3.51
    Ensembl ID: ENSG00000080824
  • Gene Symbol: DMD (ENSG00000198947)
    Fold Change: 3.46
    Ensembl ID: ENSG00000198947
  • Gene Symbol: GAB1 (ENSG00000109458)
    Fold Change: 3.46
    Ensembl ID: ENSG00000109458
  • Gene Symbol: FTL (ENSG00000087086)
    Fold Change: 3.44
    Ensembl ID: ENSG00000087086
  • Gene Symbol: DOCK3 (ENSG00000088538)
    Fold Change: 3.43
    Ensembl ID: ENSG00000088538
  • Gene Symbol: GRIA4 (ENSG00000152578)
    Fold Change: 3.43
    Ensembl ID: ENSG00000152578
  • Gene Symbol: APOD (ENSG00000189058)
    Fold Change: 3.36
    Ensembl ID: ENSG00000189058
  • Gene Symbol: COX3 (ENSG00000198938)
    Fold Change: 3.36
    Ensembl ID: ENSG00000198938
  • Gene Symbol: GRM3 (ENSG00000198822)
    Fold Change: 3.35
    Ensembl ID: ENSG00000198822
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 3.35
    Ensembl ID: ENSG00000075624
  • Gene Symbol: FUT8 (ENSG00000033170)
    Fold Change: 3.34
    Ensembl ID: ENSG00000033170
  • Gene Symbol: EPB41L2 (ENSG00000079819)
    Fold Change: 3.31
    Ensembl ID: ENSG00000079819
  • Gene Symbol: ATP1B1 (ENSG00000143153)
    Fold Change: 3.27
    Ensembl ID: ENSG00000143153
  • Gene Symbol: MYO5A (ENSG00000197535)
    Fold Change: 3.26
    Ensembl ID: ENSG00000197535
  • Gene Symbol: LPP (ENSG00000145012)
    Fold Change: 3.19
    Ensembl ID: ENSG00000145012
  • Gene Symbol: ND3 (ENSG00000198840)
    Fold Change: 3.19
    Ensembl ID: ENSG00000198840
  • Gene Symbol: MAP1B (ENSG00000131711)
    Fold Change: 3.16
    Ensembl ID: ENSG00000131711
  • Gene Symbol: MKLN1 (ENSG00000128585)
    Fold Change: 3.16
    Ensembl ID: ENSG00000128585
  • Gene Symbol: FHIT (ENSG00000189283)
    Fold Change: 3.16
    Ensembl ID: ENSG00000189283
  • Gene Symbol: COX1 (ENSG00000198804)
    Fold Change: 3.14
    Ensembl ID: ENSG00000198804
  • Gene Symbol: DPYSL2 (ENSG00000092964)
    Fold Change: 3.14
    Ensembl ID: ENSG00000092964
  • Gene Symbol: HNRNPA2B1 (ENSG00000122566)
    Fold Change: 3.13
    Ensembl ID: ENSG00000122566
  • Gene Symbol: RBPJ (ENSG00000168214)
    Fold Change: 3.09
    Ensembl ID: ENSG00000168214
  • Gene Symbol: CIRBP (ENSG00000099622)
    Fold Change: 3.06
    Ensembl ID: ENSG00000099622
  • Gene Symbol: GSN (ENSG00000148180)
    Fold Change: 3.03
    Ensembl ID: ENSG00000148180
  • Gene Symbol: SCARB2 (ENSG00000138760)
    Fold Change: 3.02
    Ensembl ID: ENSG00000138760
  • Gene Symbol: LAMP2 (ENSG00000005893)
    Fold Change: 3.01
    Ensembl ID: ENSG00000005893
  • Gene Symbol: GNAS (ENSG00000087460)
    Fold Change: 2.97
    Ensembl ID: ENSG00000087460
  • Gene Symbol: MYO1D (ENSG00000176658)
    Fold Change: 2.97
    Ensembl ID: ENSG00000176658
  • Gene Symbol: CRYAB (ENSG00000109846)
    Fold Change: 2.97
    Ensembl ID: ENSG00000109846
  • Gene Symbol: GAPDH (ENSG00000111640)
    Fold Change: 2.96
    Ensembl ID: ENSG00000111640
  • Gene Symbol: GRID2 (ENSG00000152208)
    Fold Change: 2.94
    Ensembl ID: ENSG00000152208
  • Gene Symbol: MAG (ENSG00000105695)
    Fold Change: 2.9
    Ensembl ID: ENSG00000105695
  • Gene Symbol: DOCK1 (ENSG00000150760)
    Fold Change: 2.88
    Ensembl ID: ENSG00000150760
  • Gene Symbol: MOG (ENSG00000204655)
    Fold Change: 2.88
    Ensembl ID: ENSG00000204655
  • Gene Symbol: ND4 (ENSG00000198886)
    Fold Change: 2.86
    Ensembl ID: ENSG00000198886
  • Gene Symbol: CACNA2D1 (ENSG00000153956)
    Fold Change: 2.86
    Ensembl ID: ENSG00000153956
  • Gene Symbol: CYTB (ENSG00000198727)
    Fold Change: 2.85
    Ensembl ID: ENSG00000198727
  • Gene Symbol: RNR2 (ENSG00000210082)
    Fold Change: 2.83
    Ensembl ID: ENSG00000210082
  • Gene Symbol: FGFR2 (ENSG00000066468)
    Fold Change: 2.8
    Ensembl ID: ENSG00000066468
  • Gene Symbol: ND2 (ENSG00000198763)
    Fold Change: 2.79
    Ensembl ID: ENSG00000198763
  • Gene Symbol: GNAI1 (ENSG00000127955)
    Fold Change: 2.78
    Ensembl ID: ENSG00000127955
  • Gene Symbol: GNAO1 (ENSG00000087258)
    Fold Change: 2.77
    Ensembl ID: ENSG00000087258
  • Gene Symbol: H3 3B (ENSG00000132475)
    Fold Change: 2.77
    Ensembl ID: ENSG00000132475
  • Gene Symbol: GLUL (ENSG00000135821)
    Fold Change: 2.73
    Ensembl ID: ENSG00000135821
  • Gene Symbol: MYO6 (ENSG00000196586)
    Fold Change: 2.7
    Ensembl ID: ENSG00000196586
  • Gene Symbol: BIN1 (ENSG00000136717)
    Fold Change: 2.67
    Ensembl ID: ENSG00000136717
  • Gene Symbol: HMGB1 (ENSG00000189403)
    Fold Change: 2.65
    Ensembl ID: ENSG00000189403
  • Gene Symbol: GPR37 (ENSG00000170775)
    Fold Change: 2.65
    Ensembl ID: ENSG00000170775
  • Gene Symbol: MYRF (ENSG00000124920)
    Fold Change: 2.62
    Ensembl ID: ENSG00000124920
  • Gene Symbol: GSK3B (ENSG00000082701)
    Fold Change: 2.59
    Ensembl ID: ENSG00000082701
  • Gene Symbol: DTNA (ENSG00000134769)
    Fold Change: 2.59
    Ensembl ID: ENSG00000134769
  • Gene Symbol: MBNL1 (ENSG00000152601)
    Fold Change: 2.58
    Ensembl ID: ENSG00000152601
  • Gene Symbol: FYN (ENSG00000010810)
    Fold Change: 2.57
    Ensembl ID: ENSG00000010810
  • Gene Symbol: ACYP2 (ENSG00000170634)
    Fold Change: 2.56
    Ensembl ID: ENSG00000170634
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 2.55
    Ensembl ID: ENSG00000198668
  • Gene Symbol: FOLH1 (ENSG00000086205)
    Fold Change: 2.54
    Ensembl ID: ENSG00000086205
  • Gene Symbol: CA2 (ENSG00000104267)
    Fold Change: 2.5
    Ensembl ID: ENSG00000104267
  • Gene Symbol: LIPA (ENSG00000107798)
    Fold Change: 2.5
    Ensembl ID: ENSG00000107798
  • Gene Symbol: ATP6 (ENSG00000198899)
    Fold Change: 2.48
    Ensembl ID: ENSG00000198899
  • Gene Symbol: MAPT (ENSG00000186868)
    Fold Change: 2.47
    Ensembl ID: ENSG00000186868
  • Gene Symbol: LDLRAD4 (ENSG00000168675)
    Fold Change: 2.46
    Ensembl ID: ENSG00000168675
  • Gene Symbol: GRIA2 (ENSG00000120251)
    Fold Change: 2.45
    Ensembl ID: ENSG00000120251
  • Gene Symbol: LPAR1 (ENSG00000198121)
    Fold Change: 2.44
    Ensembl ID: ENSG00000198121
  • Gene Symbol: KTN1 (ENSG00000126777)
    Fold Change: 2.44
    Ensembl ID: ENSG00000126777
  • Gene Symbol: AFF3 (ENSG00000144218)
    Fold Change: 2.44
    Ensembl ID: ENSG00000144218
  • Gene Symbol: BRAF (ENSG00000157764)
    Fold Change: 2.43
    Ensembl ID: ENSG00000157764
  • Gene Symbol: ND1 (ENSG00000198888)
    Fold Change: 2.43
    Ensembl ID: ENSG00000198888
  • Gene Symbol: PPP1R12B (ENSG00000077157)
    Fold Change: 2.43
    Ensembl ID: ENSG00000077157
  • Gene Symbol: DDX5 (ENSG00000108654)
    Fold Change: 2.43
    Ensembl ID: ENSG00000108654
  • Gene Symbol: IGF1R (ENSG00000140443)
    Fold Change: 2.42
    Ensembl ID: ENSG00000140443
  • Gene Symbol: GNB1 (ENSG00000078369)
    Fold Change: 2.42
    Ensembl ID: ENSG00000078369

Gene ID: A unique numerical identifier for this specific gene.
Symbol: Shortened abbreviation or name that represents this gene.
Ensembl Gene ID: A unique identifier assigned by Ensembl for genomic data mapping.
Fold Change: Indicates the ratio of the gene's expression level in oligodendrocyte cell compared to a baseline. A fold change greater than 1 suggests significant gene expression.

Gene ID: A unique numerical identifier for this specific gene.
Symbol: Shortened abbreviation or name that represents this gene.
Ensembl Gene ID: A unique identifier assigned by Ensembl for genomic data mapping.
Fold Change: Indicates the ratio of the gene's expression level in oligodendrocyte cell compared to a baseline. A fold change greater than 1 suggests significant gene expression.
**Key Characteristics** 1. **Myelination**: Oligodendrocytes produce myelin, a lipid-rich substance that surrounds axons and facilitates the transmission of electrical signals. 2. **Insulating properties**: Myelin acts as an insulator, reducing the resistance of axons to electrical signals and enabling rapid transmission. 3. **Cell-cell adhesion**: Oligodendrocytes express adhesion molecules, such as cadherins and N-cam, which facilitate cell-cell interactions and maintain the integrity of the CNS. 4. **Axon guidance**: Oligodendrocytes express guidance molecules, such as semaphorins and netrins, which regulate axon growth and targeting. 5. **Gene expression**: Oligodendrocytes express a range of genes involved in myelination, axon guidance, and cell-cell adhesion, including DLG2, ANK3, NCAM2, GPM6B, DST, MBP, SEPTIN7, and LSAMP. **Clinical Significance** 1. **Myelin disorders**: Dysfunction of oligodendrocytes has been implicated in various myelin disorders, including Multiple Sclerosis (MS), Leukodystrophies, and Progressive Multifocal Leukoencephalopathy (PML). 2. **Neurological disorders**: Oligodendrocyte dysfunction has been linked to various neurological disorders, including Alzheimer's disease, Parkinson's disease, and Amyotrophic Lateral Sclerosis (ALS). 3. **CNS development**: Oligodendrocytes play a crucial role in CNS development, and their dysfunction can lead to abnormalities in brain structure and function. 4. **Therapeutic targets**: Oligodendrocytes are potential therapeutic targets for the treatment of various neurological disorders, including MS, Leukodystrophies, and PML. In conclusion, oligodendrocytes are essential cells in the CNS that play a critical role in maintaining the integrity and function of the nervous system. Their dysfunction has been implicated in various neurological disorders, and understanding the molecular mechanisms underlying oligodendrocyte function is crucial for the development of novel therapeutic strategies.