Details for: CERCAM

Gene ID: 51148

Symbol: CERCAM

Ensembl ID: ENSG00000167123

Description: cerebral endothelial cell adhesion molecule

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 141.9523
    Cell Significance Index: -22.0800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 83.2271
    Cell Significance Index: -21.1100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 46.7251
    Cell Significance Index: -22.0600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 43.0762
    Cell Significance Index: -17.5000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 18.3400
    Cell Significance Index: -17.5100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 17.9244
    Cell Significance Index: -22.1000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 8.1994
    Cell Significance Index: -21.9700
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 6.5494
    Cell Significance Index: 105.0800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.5891
    Cell Significance Index: -22.0600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.2219
    Cell Significance Index: -9.2400
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.6631
    Cell Significance Index: 34.1100
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.7653
    Cell Significance Index: 4.7400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.6064
    Cell Significance Index: 83.2800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.5971
    Cell Significance Index: 171.8000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.5442
    Cell Significance Index: 11.3900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.4746
    Cell Significance Index: 22.1300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.3212
    Cell Significance Index: 41.1700
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.2452
    Cell Significance Index: 3.8900
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.1785
    Cell Significance Index: 1.6200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.1722
    Cell Significance Index: 3.3600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1559
    Cell Significance Index: 31.2800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1511
    Cell Significance Index: 82.5200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1124
    Cell Significance Index: 19.1900
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.0798
    Cell Significance Index: 0.6700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0557
    Cell Significance Index: 19.9800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0499
    Cell Significance Index: 91.9800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0385
    Cell Significance Index: 59.2700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0349
    Cell Significance Index: 4.0700
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.0270
    Cell Significance Index: 0.2900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0260
    Cell Significance Index: 4.6800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0230
    Cell Significance Index: 10.1900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0188
    Cell Significance Index: 0.3200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.0084
    Cell Significance Index: 0.2400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0067
    Cell Significance Index: 12.6900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0067
    Cell Significance Index: 9.0700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0013
    Cell Significance Index: -0.2500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: -0.0049
    Cell Significance Index: -4.4200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0072
    Cell Significance Index: -5.3200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0097
    Cell Significance Index: -6.0500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: -0.0128
    Cell Significance Index: -2.4300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0171
    Cell Significance Index: -9.6600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0205
    Cell Significance Index: -14.1600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0240
    Cell Significance Index: -15.2300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0247
    Cell Significance Index: -18.1000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0276
    Cell Significance Index: -20.8800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0346
    Cell Significance Index: -15.6900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0428
    Cell Significance Index: -3.1900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0478
    Cell Significance Index: -10.0600
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0627
    Cell Significance Index: -0.9700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0633
    Cell Significance Index: -7.2500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0686
    Cell Significance Index: -8.4400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0892
    Cell Significance Index: -9.1100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0952
    Cell Significance Index: -13.8400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0960
    Cell Significance Index: -10.9600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.1058
    Cell Significance Index: -17.2200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1067
    Cell Significance Index: -13.7900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1165
    Cell Significance Index: -7.5200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1632
    Cell Significance Index: -4.5600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1672
    Cell Significance Index: -7.8600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.1754
    Cell Significance Index: -19.0800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1806
    Cell Significance Index: -21.3000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1811
    Cell Significance Index: -9.4100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.1885
    Cell Significance Index: -18.6500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1892
    Cell Significance Index: -13.3800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1909
    Cell Significance Index: -9.6500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2038
    Cell Significance Index: -21.2200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2042
    Cell Significance Index: -12.5500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2151
    Cell Significance Index: -13.1900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2348
    Cell Significance Index: -15.7900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2385
    Cell Significance Index: -18.3100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2425
    Cell Significance Index: -6.6000
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: -0.2464
    Cell Significance Index: -1.8900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2493
    Cell Significance Index: -19.7500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.2599
    Cell Significance Index: -17.9700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2809
    Cell Significance Index: -14.6300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2850
    Cell Significance Index: -7.6100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2932
    Cell Significance Index: -7.7100
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.3063
    Cell Significance Index: -4.2500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.3068
    Cell Significance Index: -18.4200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.3332
    Cell Significance Index: -5.7100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3422
    Cell Significance Index: -21.5700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.3637
    Cell Significance Index: -12.7800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.3670
    Cell Significance Index: -16.6400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3728
    Cell Significance Index: -20.9200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3850
    Cell Significance Index: -13.3800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4224
    Cell Significance Index: -22.1800
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.4289
    Cell Significance Index: -2.6700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.4389
    Cell Significance Index: -9.6100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.4653
    Cell Significance Index: -11.6300
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.4737
    Cell Significance Index: -5.1500
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.4840
    Cell Significance Index: -6.9500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.4873
    Cell Significance Index: -12.5300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.4887
    Cell Significance Index: -14.0800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.5097
    Cell Significance Index: -22.5500
  • Cell Name: embryonic fibroblast (CL2000042)
    Fold Change: -0.5101
    Cell Significance Index: -2.4400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.5223
    Cell Significance Index: -13.9700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.5232
    Cell Significance Index: -18.3300
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: -0.5486
    Cell Significance Index: -3.4500
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.5719
    Cell Significance Index: -3.5800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.5867
    Cell Significance Index: -19.2100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Cell Type-Specific Expression**: CERCAM is predominantly expressed in cells of hematopoietic origin, such as polychromatophilic erythroblasts and hematopoietic oligopotent progenitor cells. Its expression is also observed in smooth muscle fibers, ciliated cells, and epithelial cells, including Langerhans cells and decidual cells. 2. **Transmembrane Glycoprotein**: The CERCAM protein is a transmembrane glycoprotein, consisting of a single transmembrane domain, a cytoplasmic tail, and a cell surface domain. This structure enables it to interact with other cell surface molecules and regulate cell adhesion. 3. **Adhesion Function**: CERCAM mediates cell-cell adhesion by interacting with other adhesion molecules, such as integrins and selectins. This interaction is crucial for maintaining the integrity of endothelial barriers and regulating the trafficking of immune cells. **Pathways and Functions** 1. **Endothelial Barrier Function**: CERCAM plays a critical role in maintaining the integrity of endothelial barriers, which regulate the exchange of molecules and cells between the bloodstream and tissues. 2. **Immune Cell Trafficking**: CERCAM influences the trafficking of immune cells, such as T cells and dendritic cells, by modulating their adhesion to endothelial cells. 3. **Cell Signaling**: CERCAM interacts with other signaling molecules, such as integrins and growth factor receptors, to regulate cell proliferation, migration, and survival. **Clinical Significance** 1. **Inflammatory Disorders**: Abnormal expression of CERCAM has been linked to various inflammatory disorders, including atherosclerosis, arthritis, and autoimmune diseases. 2. **Cancer Metastasis**: CERCAM has been implicated in the metastasis of cancer cells, as it facilitates the adhesion of cancer cells to endothelial cells and promotes their migration to distant organs. 3. **Neurological Disorders**: CERCAM has been shown to play a role in neurological disorders, such as multiple sclerosis and Alzheimer's disease, where endothelial barrier dysfunction contributes to disease pathogenesis. In conclusion, the cerebral endothelial cell adhesion molecule, CERCAM, plays a critical role in maintaining the integrity of endothelial barriers and regulating immune cell trafficking. Its dysregulation has been implicated in various inflammatory and cancerous disorders, highlighting the importance of further research on this gene and its potential therapeutic applications.

Genular Protein ID: 1038885613

Symbol: GT253_HUMAN

Name: Inactive glycosyltransferase 25 family member 3

UniProtKB Accession Codes:

Q5T4B2 A7MD00 C4AMA2 Q0VDF3 Q2VPJ4 Q4KMP2 Q5T4B1 Q8N107 Q96EZ5 Q9P226 Q9UMW5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CAZy 1 CCDS 2 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 12 Ensembl 2 ExpressionAtlas 1 GO 5 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 6 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10608765

Title: Cerebral cell adhesion molecule: a novel leukocyte adhesion determinant on blood-brain barrier capillary endothelium.

PubMed ID: 10608765

DOI: 10.1086/315163

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10819331

Title: Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10819331

DOI: 10.1093/dnares/7.2.143

PubMed ID: 19075007

Title: Core glycosylation of collagen is initiated by two beta(1-O)galactosyltransferases.

PubMed ID: 19075007

DOI: 10.1128/mcb.02085-07

PubMed ID: 22216269

Title: Identification of domains and amino acids essential to the collagen galactosyltransferase activity of GLT25D1.

PubMed ID: 22216269

DOI: 10.1371/journal.pone.0029390

Sequence Information:

  • Length: 595
  • Mass: 67592
  • Checksum: FC2157AD8C7AC558
  • Sequence:
    • MRAARAAPLL QLLLLLGPWL EAAGVAESPL PAVVLAILAR NAEHSLPHYL GALERLDYPR 
ARMALWCATD HNVDNTTEML QEWLAAVGDD YAAVVWRPEG EPRFYPDEEG PKHWTKERHQ 
FLMELKQEAL TFARNWGADY ILFADTDNIL TNNQTLRLLM GQGLPVVAPM LDSQTYYSNF 
WCGITPQGYY RRTAEYFPTK NRQRRGCFRV PMVHSTFLAS LRAEGADQLA FYPPHPNYTW 
PFDDIIVFAY ACQAAGVSVH VCNEHRYGYM NVPVKSHQGL EDERVNFIHL ILEALVDGPR 
MQASAHVTRP SKRPSKIGFD EVFVISLARR PDRRERMLAS LWEMEISGRV VDAVDGWMLN 
SSAIRNLGVD LLPGYQDPYS GRTLTKGEVG CFLSHYSIWE EVVARGLARV LVFEDDVRFE 
SNFRGRLERL MEDVEAEKLS WDLIYLGRKQ VNPEKETAVE GLPGLVVAGY SYWTLAYALR 
LAGARKLLAS QPLRRMLPVD EFLPIMFDQH PNEQYKAHFW PRDLVAFSAQ PLLAAPTHYA 
GDAEWLSDTE TSSPWDDDSG RLISWSGSQK TLRSPRLDLT GSSGHSLQPQ PRDEL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.