Details for: CL0002548

Cell ID: CL0002548

Cell Name: fibroblast of cardiac tissue

Marker Score Threshold: 6009
(Derived using integrated single-cell and genomic data)

Description: A fibroblast that is part of the heart.

Synonyms: cardiac fibroblast

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: CACNA1C (ENSG00000151067)
    Fold Change: 9.7
    Ensembl ID: ENSG00000151067
  • Gene Symbol: ACTC1 (ENSG00000159251)
    Fold Change: 5.86
    Ensembl ID: ENSG00000159251
  • Gene Symbol: SLC26A3 (ENSG00000091138)
    Fold Change: 5.5
    Ensembl ID: ENSG00000091138
  • Gene Symbol: ACTA1 (ENSG00000143632)
    Fold Change: 4.74
    Ensembl ID: ENSG00000143632
  • Gene Symbol: CACNB2 (ENSG00000165995)
    Fold Change: 3.6
    Ensembl ID: ENSG00000165995
  • Gene Symbol: COL19A1 (ENSG00000082293)
    Fold Change: 2.99
    Ensembl ID: ENSG00000082293
  • Gene Symbol: DAB1 (ENSG00000173406)
    Fold Change: 2.9
    Ensembl ID: ENSG00000173406
  • Gene Symbol: CRYAB (ENSG00000109846)
    Fold Change: 2.67
    Ensembl ID: ENSG00000109846
  • Gene Symbol: CDH12 (ENSG00000154162)
    Fold Change: 2.62
    Ensembl ID: ENSG00000154162
  • Gene Symbol: BMP5 (ENSG00000112175)
    Fold Change: 2.46
    Ensembl ID: ENSG00000112175
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 2.18
    Ensembl ID: ENSG00000166710
  • Gene Symbol: DDX5 (ENSG00000108654)
    Fold Change: 2.02
    Ensembl ID: ENSG00000108654
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 1.97
    Ensembl ID: ENSG00000075624
  • Gene Symbol: CKM (ENSG00000104879)
    Fold Change: 1.96
    Ensembl ID: ENSG00000104879
  • Gene Symbol: DPP6 (ENSG00000130226)
    Fold Change: 1.74
    Ensembl ID: ENSG00000130226
  • Gene Symbol: ACTN2 (ENSG00000077522)
    Fold Change: 1.72
    Ensembl ID: ENSG00000077522
  • Gene Symbol: CIRBP (ENSG00000099622)
    Fold Change: 1.69
    Ensembl ID: ENSG00000099622
  • Gene Symbol: CDH2 (ENSG00000170558)
    Fold Change: 1.57
    Ensembl ID: ENSG00000170558
  • Gene Symbol: SEPTIN7 (ENSG00000122545)
    Fold Change: 1.57
    Ensembl ID: ENSG00000122545
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 1.48
    Ensembl ID: ENSG00000184009
  • Gene Symbol: DGKB (ENSG00000136267)
    Fold Change: 1.47
    Ensembl ID: ENSG00000136267
  • Gene Symbol: CST3 (ENSG00000101439)
    Fold Change: 1.41
    Ensembl ID: ENSG00000101439
  • Gene Symbol: CD63 (ENSG00000135404)
    Fold Change: 1.39
    Ensembl ID: ENSG00000135404
  • Gene Symbol: DMPK (ENSG00000104936)
    Fold Change: 1.38
    Ensembl ID: ENSG00000104936
  • Gene Symbol: CSNK1A1 (ENSG00000113712)
    Fold Change: 1.36
    Ensembl ID: ENSG00000113712
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 1.35
    Ensembl ID: ENSG00000198668
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 1.34
    Ensembl ID: ENSG00000067560
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 1.33
    Ensembl ID: ENSG00000152518
  • Gene Symbol: CHRM5 (ENSG00000184984)
    Fold Change: 1.32
    Ensembl ID: ENSG00000184984
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 1.32
    Ensembl ID: ENSG00000077549
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.27
    Ensembl ID: ENSG00000153113
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 1.26
    Ensembl ID: ENSG00000185650
  • Gene Symbol: CDC42 (ENSG00000070831)
    Fold Change: 1.23
    Ensembl ID: ENSG00000070831
  • Gene Symbol: KLF6 (ENSG00000067082)
    Fold Change: 1.22
    Ensembl ID: ENSG00000067082
  • Gene Symbol: GRK3 (ENSG00000100077)
    Fold Change: 1.2
    Ensembl ID: ENSG00000100077
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.2
    Ensembl ID: ENSG00000182718
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 1.18
    Ensembl ID: ENSG00000133639
  • Gene Symbol: CRYAA (ENSG00000160202)
    Fold Change: 1.15
    Ensembl ID: ENSG00000160202
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.15
    Ensembl ID: ENSG00000085224
  • Gene Symbol: FOXN3 (ENSG00000053254)
    Fold Change: 1.13
    Ensembl ID: ENSG00000053254
  • Gene Symbol: DLG2 (ENSG00000150672)
    Fold Change: 1.13
    Ensembl ID: ENSG00000150672
  • Gene Symbol: CLK1 (ENSG00000013441)
    Fold Change: 1.13
    Ensembl ID: ENSG00000013441
  • Gene Symbol: COX4I1 (ENSG00000131143)
    Fold Change: 1.13
    Ensembl ID: ENSG00000131143
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.11
    Ensembl ID: ENSG00000116489
  • Gene Symbol: ZFHX3 (ENSG00000140836)
    Fold Change: 1.11
    Ensembl ID: ENSG00000140836
  • Gene Symbol: COL5A1 (ENSG00000130635)
    Fold Change: 1.1
    Ensembl ID: ENSG00000130635
  • Gene Symbol: COL6A3 (ENSG00000163359)
    Fold Change: 1.1
    Ensembl ID: ENSG00000163359
  • Gene Symbol: COL6A1 (ENSG00000142156)
    Fold Change: 1.1
    Ensembl ID: ENSG00000142156
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 1.1
    Ensembl ID: ENSG00000142192
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 1.1
    Ensembl ID: ENSG00000142599
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.1
    Ensembl ID: ENSG00000127022
  • Gene Symbol: CUX1 (ENSG00000257923)
    Fold Change: 1.09
    Ensembl ID: ENSG00000257923
  • Gene Symbol: DOCK3 (ENSG00000088538)
    Fold Change: 1.09
    Ensembl ID: ENSG00000088538
  • Gene Symbol: COL15A1 (ENSG00000204291)
    Fold Change: 1.09
    Ensembl ID: ENSG00000204291
  • Gene Symbol: COL4A1 (ENSG00000187498)
    Fold Change: 1.09
    Ensembl ID: ENSG00000187498
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.09
    Ensembl ID: ENSG00000164111
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.09
    Ensembl ID: ENSG00000163399
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.08
    Ensembl ID: ENSG00000104964
  • Gene Symbol: DST (ENSG00000151914)
    Fold Change: 1.08
    Ensembl ID: ENSG00000151914
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.08
    Ensembl ID: ENSG00000130402
  • Gene Symbol: COL4A2 (ENSG00000134871)
    Fold Change: 1.08
    Ensembl ID: ENSG00000134871
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.08
    Ensembl ID: ENSG00000143761
  • Gene Symbol: CAMK2D (ENSG00000145349)
    Fold Change: 1.08
    Ensembl ID: ENSG00000145349
  • Gene Symbol: CD34 (ENSG00000174059)
    Fold Change: 1.07
    Ensembl ID: ENSG00000174059
  • Gene Symbol: LDLRAD4 (ENSG00000168675)
    Fold Change: 1.07
    Ensembl ID: ENSG00000168675
  • Gene Symbol: DDX3X (ENSG00000215301)
    Fold Change: 1.07
    Ensembl ID: ENSG00000215301
  • Gene Symbol: DMD (ENSG00000198947)
    Fold Change: 1.07
    Ensembl ID: ENSG00000198947
  • Gene Symbol: CLTA (ENSG00000122705)
    Fold Change: 1.06
    Ensembl ID: ENSG00000122705
  • Gene Symbol: CKMT2 (ENSG00000131730)
    Fold Change: 1.06
    Ensembl ID: ENSG00000131730
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 1.06
    Ensembl ID: ENSG00000169100
  • Gene Symbol: DPYSL2 (ENSG00000092964)
    Fold Change: 1.06
    Ensembl ID: ENSG00000092964
  • Gene Symbol: CDH13 (ENSG00000140945)
    Fold Change: 1.06
    Ensembl ID: ENSG00000140945
  • Gene Symbol: APBB2 (ENSG00000163697)
    Fold Change: 1.06
    Ensembl ID: ENSG00000163697
  • Gene Symbol: CALD1 (ENSG00000122786)
    Fold Change: 1.05
    Ensembl ID: ENSG00000122786
  • Gene Symbol: ARG2 (ENSG00000081181)
    Fold Change: 1.05
    Ensembl ID: ENSG00000081181
  • Gene Symbol: COL6A2 (ENSG00000142173)
    Fold Change: 1.05
    Ensembl ID: ENSG00000142173
  • Gene Symbol: CBLB (ENSG00000114423)
    Fold Change: 1.05
    Ensembl ID: ENSG00000114423
  • Gene Symbol: KLF9 (ENSG00000119138)
    Fold Change: 1.05
    Ensembl ID: ENSG00000119138
  • Gene Symbol: DPYD (ENSG00000188641)
    Fold Change: 1.04
    Ensembl ID: ENSG00000188641
  • Gene Symbol: DOCK1 (ENSG00000150760)
    Fold Change: 1.04
    Ensembl ID: ENSG00000150760
  • Gene Symbol: ANK2 (ENSG00000145362)
    Fold Change: 1.04
    Ensembl ID: ENSG00000145362
  • Gene Symbol: ADGRB3 (ENSG00000135298)
    Fold Change: 1.04
    Ensembl ID: ENSG00000135298
  • Gene Symbol: ABL1 (ENSG00000097007)
    Fold Change: 1.03
    Ensembl ID: ENSG00000097007
  • Gene Symbol: ANK3 (ENSG00000151150)
    Fold Change: 1.03
    Ensembl ID: ENSG00000151150
  • Gene Symbol: COL8A1 (ENSG00000144810)
    Fold Change: 1.03
    Ensembl ID: ENSG00000144810
  • Gene Symbol: CACNA2D1 (ENSG00000153956)
    Fold Change: 1.02
    Ensembl ID: ENSG00000153956
  • Gene Symbol: RUNX2 (ENSG00000124813)
    Fold Change: 1.02
    Ensembl ID: ENSG00000124813
  • Gene Symbol: ACTN1 (ENSG00000072110)
    Fold Change: 1.02
    Ensembl ID: ENSG00000072110
  • Gene Symbol: CTNNB1 (ENSG00000168036)
    Fold Change: 1.02
    Ensembl ID: ENSG00000168036
  • Gene Symbol: VCAN (ENSG00000038427)
    Fold Change: 1.01
    Ensembl ID: ENSG00000038427
  • Gene Symbol: CTBP2 (ENSG00000175029)
    Fold Change: 1.01
    Ensembl ID: ENSG00000175029
  • Gene Symbol: CTNNA1 (ENSG00000044115)
    Fold Change: 1.01
    Ensembl ID: ENSG00000044115
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 1.01
    Ensembl ID: ENSG00000143878
  • Gene Symbol: COL1A2 (ENSG00000164692)
    Fold Change: 1.01
    Ensembl ID: ENSG00000164692
  • Gene Symbol: CTNNA2 (ENSG00000066032)
    Fold Change: 1.01
    Ensembl ID: ENSG00000066032
  • Gene Symbol: COX5B (ENSG00000135940)
    Fold Change: 1.01
    Ensembl ID: ENSG00000135940
  • Gene Symbol: ABCA1 (ENSG00000165029)
    Fold Change: 1
    Ensembl ID: ENSG00000165029
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 1
    Ensembl ID: ENSG00000135390
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 1
    Ensembl ID: ENSG00000145741
  • Gene Symbol: LRBA (ENSG00000198589)
    Fold Change: 1
    Ensembl ID: ENSG00000198589
Hovered Details

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Hovered Details

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**Key Characteristics** 1. **Cardiac Fibroblast**: This cell type is a type of fibroblast that is specifically found in cardiac tissue. 2. **Genetic Makeup**: The cell's genetic makeup is characterized by the presence of several genes, including CACNA1C, ACTC1, SLC26A3, ACTA1, and CACNB2. 3. **Calcium Ion Transport**: The cell is involved in calcium ion transport, which is essential for muscle contraction and signaling. 4. **Muscle Contraction**: The cell is involved in muscle contraction, which is essential for cardiac function. 5. **Cell Adhesion**: The cell is involved in cell adhesion, which is essential for maintaining tissue structure and function. 6. **Signaling**: The cell is involved in signaling, which is essential for transmitting and responding to signals. **Clinical Significance** 1. **Cardiac Function**: The cardiac fibroblast plays a crucial role in maintaining cardiac function, including contraction and relaxation. 2. **Cardiac Conduction**: The cell is involved in cardiac conduction, which is essential for maintaining a regular heartbeat. 3. **Muscle Diseases**: Mutations in the genes involved in cardiac fibroblast function can lead to muscle diseases, such as hypertrophic cardiomyopathy. 4. **Cardiac Fibrosis**: The cell's role in extracellular matrix organization and remodeling is essential for maintaining healthy cardiac tissue, and dysregulation of this process can lead to cardiac fibrosis. 5. **Regenerative Medicine**: Understanding the function and behavior of cardiac fibroblasts can inform the development of regenerative therapies for cardiac disease. **Pathways and Ontologies** 1. **Adrenaline/Noradrenaline Inhibition of Insulin Secretion**: The cell is involved in this pathway, which is essential for regulating glucose metabolism. 2. **Cardiac Conduction**: The cell is involved in this pathway, which is essential for maintaining a regular heartbeat. 3. **Muscle Contraction**: The cell is involved in this pathway, which is essential for cardiac function. 4. **Cell Adhesion**: The cell is involved in this pathway, which is essential for maintaining tissue structure and function. 5. **Signaling**: The cell is involved in this pathway, which is essential for transmitting and responding to signals. Overall, the cardiac fibroblast plays a crucial role in maintaining cardiac function, and dysregulation of its function can lead to various cardiac diseases. Understanding the cell's genetic makeup, signaling pathways, and clinical significance is essential for the development of novel therapeutic strategies for cardiac disease.