Details for: OMD

Gene ID: 4958

Symbol: OMD

Ensembl ID: ENSG00000127083

Description: osteomodulin

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 28.1104
    Cell Significance Index: -11.5800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 4.3755
    Cell Significance Index: 560.9100
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 3.7504
    Cell Significance Index: 59.5000
  • Cell Name: theca cell (CL0000503)
    Fold Change: 2.1991
    Cell Significance Index: 12.9200
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.9150
    Cell Significance Index: 17.3800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.9658
    Cell Significance Index: 18.8500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.9314
    Cell Significance Index: 19.3200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.7849
    Cell Significance Index: 22.5000
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.6664
    Cell Significance Index: 9.5700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.5013
    Cell Significance Index: 25.3300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3353
    Cell Significance Index: 66.5500
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.2332
    Cell Significance Index: 1.5800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1881
    Cell Significance Index: 5.4200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1879
    Cell Significance Index: 25.8100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0908
    Cell Significance Index: 18.2100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0614
    Cell Significance Index: 11.0700
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.0519
    Cell Significance Index: 1.6400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0501
    Cell Significance Index: 2.8100
  • Cell Name: chondroblast (CL0000058)
    Fold Change: 0.0409
    Cell Significance Index: 0.2400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0279
    Cell Significance Index: 51.4800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0264
    Cell Significance Index: 3.2400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0234
    Cell Significance Index: 35.9500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0214
    Cell Significance Index: 29.0400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0163
    Cell Significance Index: 11.2900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0113
    Cell Significance Index: 21.2200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0085
    Cell Significance Index: 2.4500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0062
    Cell Significance Index: 2.2200
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.0013
    Cell Significance Index: 0.0200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0011
    Cell Significance Index: 0.7100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0101
    Cell Significance Index: -4.4700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0110
    Cell Significance Index: -1.6000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0148
    Cell Significance Index: -10.8800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0150
    Cell Significance Index: -0.6700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0168
    Cell Significance Index: -7.6300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0175
    Cell Significance Index: -13.2400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0180
    Cell Significance Index: -13.3100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0194
    Cell Significance Index: -1.4900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0217
    Cell Significance Index: -11.8300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0231
    Cell Significance Index: -13.0500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0237
    Cell Significance Index: -14.8000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0304
    Cell Significance Index: -1.1500
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.0332
    Cell Significance Index: -0.3200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0675
    Cell Significance Index: -14.2300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0868
    Cell Significance Index: -11.2200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0869
    Cell Significance Index: -14.8400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0974
    Cell Significance Index: -1.6700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0999
    Cell Significance Index: -10.4000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1001
    Cell Significance Index: -11.8100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1040
    Cell Significance Index: -12.1200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1054
    Cell Significance Index: -10.7700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1118
    Cell Significance Index: -12.8100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1288
    Cell Significance Index: -3.6000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1360
    Cell Significance Index: -3.5000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1468
    Cell Significance Index: -6.9000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1496
    Cell Significance Index: -11.1500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1791
    Cell Significance Index: -8.3500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1861
    Cell Significance Index: -12.0100
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1882
    Cell Significance Index: -8.1800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2021
    Cell Significance Index: -7.0800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.2032
    Cell Significance Index: -7.1400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2188
    Cell Significance Index: -4.5800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2380
    Cell Significance Index: -7.5800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2404
    Cell Significance Index: -7.8700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2454
    Cell Significance Index: -12.7500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3089
    Cell Significance Index: -11.3400
  • Cell Name: stromal cell of endometrium (CL0002255)
    Fold Change: -0.3125
    Cell Significance Index: -4.4500
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.3152
    Cell Significance Index: -7.6900
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.3190
    Cell Significance Index: -6.4900
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.3190
    Cell Significance Index: -3.8800
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.3235
    Cell Significance Index: -8.0700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3237
    Cell Significance Index: -11.2500
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.3248
    Cell Significance Index: -4.0500
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.3277
    Cell Significance Index: -5.2700
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.3344
    Cell Significance Index: -13.7000
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.3347
    Cell Significance Index: -4.9400
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.3471
    Cell Significance Index: -7.5000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.3513
    Cell Significance Index: -9.3800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3520
    Cell Significance Index: -7.4700
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.3660
    Cell Significance Index: -4.6200
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.3696
    Cell Significance Index: -7.9000
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.3746
    Cell Significance Index: -6.3100
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: -0.3838
    Cell Significance Index: -2.7900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3867
    Cell Significance Index: -11.3900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3937
    Cell Significance Index: -10.5300
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.4064
    Cell Significance Index: -6.0800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.4064
    Cell Significance Index: -10.8900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.4096
    Cell Significance Index: -12.0300
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.4128
    Cell Significance Index: -8.6200
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.4180
    Cell Significance Index: -10.4400
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: -0.4181
    Cell Significance Index: -3.8800
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.4193
    Cell Significance Index: -10.4600
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.4198
    Cell Significance Index: -6.2800
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.4246
    Cell Significance Index: -8.5300
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.4287
    Cell Significance Index: -4.6600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.4453
    Cell Significance Index: -12.1200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.4537
    Cell Significance Index: -11.9300
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: -0.4563
    Cell Significance Index: -7.8400
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.4569
    Cell Significance Index: -11.6400
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.4574
    Cell Significance Index: -5.3900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.4580
    Cell Significance Index: -11.7000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Glycosaminoglycan Binding**: OMD binds to keratan sulfate (KS), a type of GAG, and regulates its metabolism and degradation. 2. **Cell Adhesion**: OMD interacts with cell surface receptors, such as CD44 and L-selectin, to facilitate cell adhesion and migration. 3. **Extracellular Matrix Function**: OMD is involved in the formation and maintenance of the ECM, which provides structural support and regulates cellular behavior. 4. **Regulation of Glycosylation**: OMD modulates glycosylation processes, including the synthesis and degradation of GAGs, to maintain proper cellular function. 5. **Disease Association**: Defects in OMD have been linked to various diseases, including those associated with glycosylation and metabolism disorders. **Pathways and Functions:** 1. **Glycosaminoglycan Metabolism**: OMD regulates the synthesis and degradation of KS, a key GAG involved in ECM function and cellular behavior. 2. **Extracellular Matrix Function**: OMD interacts with ECM proteins to maintain tissue structure and regulate cellular behavior. 3. **Cell Adhesion and Migration**: OMD facilitates cell adhesion and migration through interactions with cell surface receptors. 4. **Regulation of Glycosylation**: OMD modulates glycosylation processes, including the synthesis and degradation of GAGs, to maintain proper cellular function. 5. **Disease Pathogenesis**: Defects in OMD have been linked to various diseases, including those associated with glycosylation and metabolism disorders. **Clinical Significance:** Dysregulation of OMD has been implicated in various diseases, including: 1. **Glycosylation Disorders**: Defects in OMD have been linked to diseases associated with glycosylation, such as mucopolysaccharidosis and glycosaminoglycan storage diseases. 2. **Metabolic Disorders**: OMD dysregulation has also been implicated in metabolic disorders, including diabetes and obesity. 3. **Cancer**: Aberrant expression of OMD has been observed in various cancers, including breast and ovarian cancer. 4. **Neurological Disorders**: OMD dysregulation has been linked to neurological disorders, including Alzheimer's disease and Parkinson's disease. In conclusion, osteomodulin is a critical regulator of glycosaminoglycan metabolism and extracellular matrix function. Dysregulation of OMD has been implicated in various diseases, highlighting the importance of this protein in maintaining tissue homeostasis and preventing disease. Further research is needed to fully understand the mechanisms by which OMD regulates cellular behavior and to develop therapeutic strategies to target OMD dysregulation in disease.

Genular Protein ID: 3534342502

Symbol: OMD_HUMAN

Name: Osteomodulin

UniProtKB Accession Codes:

Q99983 Q5TBF4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 2 GO 7 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 5 RefSeq 1 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14551184

Title: Identification of tyrosine sulfation in extracellular leucine-rich repeat proteins using mass spectrometry.

PubMed ID: 14551184

DOI: 10.1074/jbc.m308689200

Sequence Information:

  • Length: 421
  • Mass: 49492
  • Checksum: CED47B2BC33BB872
  • Sequence:
    • MGFLSPIYVI FFFFGVKVHC QYETYQWDED YDQEPDDDYQ TGFPFRQNVD YGVPFHQYTL 
GCVSECFCPT NFPSSMYCDN RKLKTIPNIP MHIQQLYLQF NEIEAVTANS FINATHLKEI 
NLSHNKIKSQ KIDYGVFAKL PNLLQLHLEH NNLEEFPFPL PKSLERLLLG YNEISKLQTN 
AMDGLVNLTM LDLCYNYLHD SLLKDKIFAK MEKLMQLNLC SNRLESMPPG LPSSLMYLSL 
ENNSISSIPE KYFDKLPKLH TLRMSHNKLQ DIPYNIFNLP NIVELSVGHN KLKQAFYIPR 
NLEHLYLQNN EIEKMNLTVM CPSIDPLHYH HLTYIRVDQN KLKEPISSYI FFCFPHIHTI 
YYGEQRSTNG QTIQLKTQVF RRFPDDDDES EDHDDPDNAH ESPEQEGAEG HFDLHYYENQ 
E

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.