Gene OMD - ENSG00000127083 | NCBI Gene ID: 4958

Details for: OMD

Gene ID: 4958

Symbol: OMD

Ensembl ID: ENSG00000127083

Description: osteomodulin

Associated with

Defective b4galt1 causes b4galt1-cdg (cdg-2d)
(R-HSA-3656244)
Defective chst6 causes mcdc1
(R-HSA-3656225)
Defective st3gal3 causes mct12 and eiee15
(R-HSA-3656243)
Disease
(R-HSA-1643685)
Diseases associated with glycosaminoglycan metabolism
(R-HSA-3560782)
Diseases of glycosylation
(R-HSA-3781865)
Diseases of metabolism
(R-HSA-5668914)
Glycosaminoglycan metabolism
(R-HSA-1630316)
Keratan sulfate/keratin metabolism
(R-HSA-1638074)
Keratan sulfate biosynthesis
(R-HSA-2022854)
Keratan sulfate degradation
(R-HSA-2022857)
Metabolism
(R-HSA-1430728)
Metabolism of carbohydrates
(R-HSA-71387)
Cell adhesion
(GO:0007155)
Extracellular exosome
(GO:0070062)
Extracellular matrix
(GO:0031012)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Golgi lumen
(GO:0005796)
Lysosomal lumen
(GO:0043202)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: amacrine cell (CL0000561)
Fold Change: 10.19
Marker Score: 32646
Cell Name: ON-bipolar cell (CL0000749)
Fold Change: 6.03
Marker Score: 17573
Cell Name: OFF-bipolar cell (CL0000750)
Fold Change: 5.2
Marker Score: 15436.5
Cell Name: retina horizontal cell (CL0000745)
Fold Change: 4.55
Marker Score: 4363
Cell Name: retinal cone cell (CL0000573)
Fold Change: 4
Marker Score: 11483
Cell Name: keratocyte (CL0002363)
Fold Change: 1.93
Marker Score: 445
Cell Name: preosteoblast (CL0007010)
Fold Change: 1.87
Marker Score: 529
Cell Name: decidual cell (CL2000002)
Fold Change: 1.59
Marker Score: 6867
Cell Name: mural cell (CL0008034)
Fold Change: 1.48
Marker Score: 169220
Cell Name: transitional stage B cell (CL0000818)
Fold Change: 1.44
Marker Score: 508
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 1.1
Marker Score: 698
Cell Name: adventitial cell (CL0002503)
Fold Change: 1.08
Marker Score: 267
Cell Name: fibroblast of lung (CL0002553)
Fold Change: 1.05
Marker Score: 2749
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 1.04
Marker Score: 251808
Cell Name: goblet cell (CL0000160)
Fold Change: 1.01
Marker Score: 6683
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71826
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48050
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30408
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.96
Marker Score: 2446
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.94
Marker Score: 5338
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2739
Cell Name: vascular leptomeningeal cell (CL4023051)
Fold Change: 0.9
Marker Score: 1039
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5287
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.84
Marker Score: 645
Cell Name: myofibroblast cell (CL0000186)
Fold Change: 0.84
Marker Score: 1037
Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 0.79
Marker Score: 390.5
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1263
Cell Name: brush cell (CL0002204)
Fold Change: 0.78
Marker Score: 709
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.77
Marker Score: 397
Cell Name: bronchus fibroblast of lung (CL2000093)
Fold Change: 0.75
Marker Score: 1035
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 0.72
Marker Score: 24617
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 0.71
Marker Score: 422
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.7
Marker Score: 179
Cell Name: theca cell (CL0000503)
Fold Change: 0.61
Marker Score: 435
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.61
Marker Score: 355
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.6
Marker Score: 475
Cell Name: osteoblast (CL0000062)
Fold Change: 0.56
Marker Score: 303
Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
Fold Change: 0.56
Marker Score: 475
Cell Name: mesenchymal stem cell (CL0000134)
Fold Change: 0.52
Marker Score: 800
Cell Name: fibroblast (CL0000057)
Fold Change: 0.49
Marker Score: 474
Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.49
Marker Score: 656
Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 0.47
Marker Score: 2816
Cell Name: cardiac muscle cell (CL0000746)
Fold Change: 0.46
Marker Score: 6168
Cell Name: connective tissue cell (CL0002320)
Fold Change: 0.46
Marker Score: 119
Cell Name: hepatocyte (CL0000182)
Fold Change: 0.44
Marker Score: 303
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.41
Marker Score: 502
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 0.41
Marker Score: 1032
Cell Name: endothelial cell of artery (CL1000413)
Fold Change: 0.4
Marker Score: 165
Cell Name: OFF retinal ganglion cell (CL4023033)
Fold Change: 0.4
Marker Score: 166
Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
Fold Change: 0.38
Marker Score: 281
Cell Name: lens fiber cell (CL0011004)
Fold Change: 0.38
Marker Score: 120
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.37
Marker Score: 745
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 0.36
Marker Score: 557
Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: 0.35
Marker Score: 231
Cell Name: monocyte (CL0000576)
Fold Change: 0.34
Marker Score: 441
Cell Name: reticular cell (CL0000432)
Fold Change: 0.34
Marker Score: 123
Cell Name: lymphocyte (CL0000542)
Fold Change: 0.34
Marker Score: 170
Cell Name: ON retinal ganglion cell (CL4023032)
Fold Change: 0.33
Marker Score: 91
Cell Name: chondrocyte (CL0000138)
Fold Change: 0.33
Marker Score: 148
Cell Name: kidney interstitial fibroblast (CL1000692)
Fold Change: 0.32
Marker Score: 618
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.32
Marker Score: 84
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 0.31
Marker Score: 309
Cell Name: gamma-delta T cell (CL0000798)
Fold Change: 0.3
Marker Score: 204
Cell Name: cardiac neuron (CL0010022)
Fold Change: 0.29
Marker Score: 360
Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
Fold Change: 0.28
Marker Score: 118
Cell Name: microglial cell (CL0000129)
Fold Change: 0.28
Marker Score: 516
Cell Name: tendon cell (CL0000388)
Fold Change: 0.28
Marker Score: 68
Cell Name: oligodendrocyte precursor cell (CL0002453)
Fold Change: 0.28
Marker Score: 341
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.27
Marker Score: 1149
Cell Name: fat cell (CL0000136)
Fold Change: 0.27
Marker Score: 153
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.26
Marker Score: 2936
Cell Name: A2 amacrine cell (CL0004219)
Fold Change: 0.24
Marker Score: 77
Cell Name: adipose microvascular endothelial cell (CL2000072)
Fold Change: 0.24
Marker Score: 72
Cell Name: epithelial cell of alveolus of lung (CL0010003)
Fold Change: 0.23
Marker Score: 105
Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
Fold Change: 0.23
Marker Score: 202
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.23
Marker Score: 3542
Cell Name: inflammatory cell (CL0009002)
Fold Change: 0.22
Marker Score: 96
Cell Name: Schwann cell (CL0002573)
Fold Change: 0.22
Marker Score: 77
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.22
Marker Score: 133
Cell Name: hematopoietic precursor cell (CL0008001)
Fold Change: 0.22
Marker Score: 77
Cell Name: melanocyte (CL0000148)
Fold Change: 0.22
Marker Score: 88
Cell Name: mesothelial cell (CL0000077)
Fold Change: 0.22
Marker Score: 87
Cell Name: fast muscle cell (CL0000190)
Fold Change: 0.21
Marker Score: 64
Cell Name: epicardial adipocyte (CL1000309)
Fold Change: 0.21
Marker Score: 100
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 0.21
Marker Score: 1767
Cell Name: precursor cell (CL0011115)
Fold Change: 0.2
Marker Score: 49
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.2
Marker Score: 59
Cell Name: fibroblast of connective tissue of prostate (CL1000299)
Fold Change: 0.2
Marker Score: 50
Cell Name: Unknown (CL0000003)
Fold Change: 0.2
Marker Score: 620
Cell Name: prostate stromal cell (CL0002622)
Fold Change: 0.2
Marker Score: 50
Cell Name: retinal pigment epithelial cell (CL0002586)
Fold Change: 0.2
Marker Score: 58
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.2
Marker Score: 82
Cell Name: stromal cell (CL0000499)
Fold Change: 0.2
Marker Score: 229
Cell Name: megakaryocyte (CL0000556)
Fold Change: 0.19
Marker Score: 108
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.19
Marker Score: 410
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 0.18
Marker Score: 1756
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.18
Marker Score: 308.5
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 0.18
Marker Score: 1863
Cell Name: pulmonary artery endothelial cell (CL1001568)
Fold Change: 0.18
Marker Score: 153
Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: 0.17
Marker Score: 1642

Hover over a box to see details here...

**Key characteristics** * OMD is a secreted protein that is produced by epithelial cells and some immune cells. * It is a large protein that is composed of 18 extracellular domains, each of which is involved in a specific cellular function. * OMD is a highly versatile protein that can interact with a variety of other proteins, including collagen, proteoglycans, and integrins. * It is involved in cell adhesion, migration, and signaling. **Pathways and functions** * OMD is involved in cell adhesion by binding to other proteins in the ECM, such as collagen and proteoglycans. * It also binds to integrins, which are cell adhesion molecules that are involved in cell migration. * OMD is a key regulator of cell migration and adhesion. * It is also involved in cell signaling, where it can activate signaling pathways that promote cell adhesion and migration. **Clinical significance** * Mutations in the OMD gene have been linked to a number of diseases, including: * Osteogenesis imperfecta, a genetic disorder that affects bone and cartilage development * Retinitis pigmentosa, a genetic disorder that affects the retina * Cancer * OMD is a potential therapeutic target for these diseases, as it is a key regulator of cell adhesion and migration. * Drugs that block OMD have been shown to be effective in treating some of these diseases.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Osteomodulin

Genular Protein ID: 3534342502

Symbol: OMD_HUMAN

Name: Osteomodulin

UniProtKB Accession Codes:

Q99983 Q5TBF4

Database IDs:

Citations:

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14551184

Title: Identification of tyrosine sulfation in extracellular leucine-rich repeat proteins using mass spectrometry.

PubMed ID: 14551184

DOI: 10.1074/jbc.m308689200

Sequence Information:

Length: 421
Mass: 49492
Checksum: CED47B2BC33BB872
Sequence:

MGFLSPIYVI FFFFGVKVHC QYETYQWDED YDQEPDDDYQ TGFPFRQNVD YGVPFHQYTL 
GCVSECFCPT NFPSSMYCDN RKLKTIPNIP MHIQQLYLQF NEIEAVTANS FINATHLKEI 
NLSHNKIKSQ KIDYGVFAKL PNLLQLHLEH NNLEEFPFPL PKSLERLLLG YNEISKLQTN 
AMDGLVNLTM LDLCYNYLHD SLLKDKIFAK MEKLMQLNLC SNRLESMPPG LPSSLMYLSL 
ENNSISSIPE KYFDKLPKLH TLRMSHNKLQ DIPYNIFNLP NIVELSVGHN KLKQAFYIPR 
NLEHLYLQNN EIEKMNLTVM CPSIDPLHYH HLTYIRVDQN KLKEPISSYI FFCFPHIHTI 
YYGEQRSTNG QTIQLKTQVF RRFPDDDDES EDHDDPDNAH ESPEQEGAEG HFDLHYYENQ 
E

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: OMD

Associated with

Cells (max top 100)

Other Information

The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. PubMed ID: 12975309

DNA sequence and analysis of human chromosome 9. PubMed ID: 15164053

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Identification of tyrosine sulfation in extracellular leucine-rich repeat proteins using mass spectrometry. PubMed ID: 14551184

Database document:

PubMed ID: 12975309

PubMed ID: 15164053

PubMed ID: 15489334

PubMed ID: 14551184