Details for: CL1001602

Cell ID: CL1001602

Cell Name: cerebral cortex endothelial cell

Marker Score Threshold: 597
(Derived using integrated single-cell and genomic data)

Description: A distinct endothelial cell forming the walls of the capillaries within the cerebral cortex.

Synonyms: cerebral cortex endothelial cells, endothelial cells of cerebral cortex

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: BMPR2 (ENSG00000204217)
    Fold Change: 2.84
    Ensembl ID: ENSG00000204217
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 2.78
    Ensembl ID: ENSG00000142192
  • Gene Symbol: A2M (ENSG00000175899)
    Fold Change: 2.77
    Ensembl ID: ENSG00000175899
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 2.75
    Ensembl ID: ENSG00000166710
  • Gene Symbol: APBB2 (ENSG00000163697)
    Fold Change: 2.7
    Ensembl ID: ENSG00000163697
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 2.63
    Ensembl ID: ENSG00000142599
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 2.63
    Ensembl ID: ENSG00000172270
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 2.48
    Ensembl ID: ENSG00000087274
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 2.44
    Ensembl ID: ENSG00000075624
  • Gene Symbol: ADGRB3 (ENSG00000135298)
    Fold Change: 2.43
    Ensembl ID: ENSG00000135298
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 2.36
    Ensembl ID: ENSG00000198668
  • Gene Symbol: ANXA3 (ENSG00000138772)
    Fold Change: 2.34
    Ensembl ID: ENSG00000138772
  • Gene Symbol: ADAM10 (ENSG00000137845)
    Fold Change: 2.33
    Ensembl ID: ENSG00000137845
  • Gene Symbol: CAMK2D (ENSG00000145349)
    Fold Change: 2.32
    Ensembl ID: ENSG00000145349
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 2.32
    Ensembl ID: ENSG00000130402
  • Gene Symbol: PTTG1IP (ENSG00000183255)
    Fold Change: 2.29
    Ensembl ID: ENSG00000183255
  • Gene Symbol: BRAF (ENSG00000157764)
    Fold Change: 2.22
    Ensembl ID: ENSG00000157764
  • Gene Symbol: ACVR1 (ENSG00000115170)
    Fold Change: 2.22
    Ensembl ID: ENSG00000115170
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 2.21
    Ensembl ID: ENSG00000085224
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.05
    Ensembl ID: ENSG00000067560
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.04
    Ensembl ID: ENSG00000184009
  • Gene Symbol: ACTN1 (ENSG00000072110)
    Fold Change: 1.95
    Ensembl ID: ENSG00000072110
  • Gene Symbol: AP2B1 (ENSG00000006125)
    Fold Change: 1.93
    Ensembl ID: ENSG00000006125
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 1.93
    Ensembl ID: ENSG00000143933
  • Gene Symbol: RUNX1T1 (ENSG00000079102)
    Fold Change: 1.91
    Ensembl ID: ENSG00000079102
  • Gene Symbol: BCL2L1 (ENSG00000171552)
    Fold Change: 1.9
    Ensembl ID: ENSG00000171552
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.88
    Ensembl ID: ENSG00000153113
  • Gene Symbol: ABR (ENSG00000159842)
    Fold Change: 1.86
    Ensembl ID: ENSG00000159842
  • Gene Symbol: BICD1 (ENSG00000151746)
    Fold Change: 1.85
    Ensembl ID: ENSG00000151746
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 1.84
    Ensembl ID: ENSG00000185650
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.82
    Ensembl ID: ENSG00000163399
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 1.77
    Ensembl ID: ENSG00000198898
  • Gene Symbol: BST2 (ENSG00000130303)
    Fold Change: 1.76
    Ensembl ID: ENSG00000130303
  • Gene Symbol: ATP7B (ENSG00000123191)
    Fold Change: 1.75
    Ensembl ID: ENSG00000123191
  • Gene Symbol: TMEM50B (ENSG00000142188)
    Fold Change: 1.75
    Ensembl ID: ENSG00000142188
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 1.73
    Ensembl ID: ENSG00000077549
  • Gene Symbol: LDLRAD4 (ENSG00000168675)
    Fold Change: 1.71
    Ensembl ID: ENSG00000168675
  • Gene Symbol: ANGPT2 (ENSG00000091879)
    Fold Change: 1.68
    Ensembl ID: ENSG00000091879
  • Gene Symbol: ADK (ENSG00000156110)
    Fold Change: 1.64
    Ensembl ID: ENSG00000156110
  • Gene Symbol: BACH1 (ENSG00000156273)
    Fold Change: 1.58
    Ensembl ID: ENSG00000156273
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 1.56
    Ensembl ID: ENSG00000133639
  • Gene Symbol: ANK2 (ENSG00000145362)
    Fold Change: 1.56
    Ensembl ID: ENSG00000145362
  • Gene Symbol: SHROOM2 (ENSG00000146950)
    Fold Change: 1.56
    Ensembl ID: ENSG00000146950
  • Gene Symbol: ABL2 (ENSG00000143322)
    Fold Change: 1.53
    Ensembl ID: ENSG00000143322
  • Gene Symbol: ABL1 (ENSG00000097007)
    Fold Change: 1.52
    Ensembl ID: ENSG00000097007
  • Gene Symbol: ACACA (ENSG00000278540)
    Fold Change: 1.5
    Ensembl ID: ENSG00000278540
  • Gene Symbol: ZFHX3 (ENSG00000140836)
    Fold Change: 1.48
    Ensembl ID: ENSG00000140836
  • Gene Symbol: BCR (ENSG00000186716)
    Fold Change: 1.47
    Ensembl ID: ENSG00000186716
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.47
    Ensembl ID: ENSG00000160710
  • Gene Symbol: AP2A2 (ENSG00000183020)
    Fold Change: 1.47
    Ensembl ID: ENSG00000183020
  • Gene Symbol: CACNA1C (ENSG00000151067)
    Fold Change: 1.47
    Ensembl ID: ENSG00000151067
  • Gene Symbol: ARHGAP5 (ENSG00000100852)
    Fold Change: 1.46
    Ensembl ID: ENSG00000100852
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.45
    Ensembl ID: ENSG00000164111
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.43
    Ensembl ID: ENSG00000143761
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.41
    Ensembl ID: ENSG00000182718
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.41
    Ensembl ID: ENSG00000116489
  • Gene Symbol: BMP6 (ENSG00000153162)
    Fold Change: 1.4
    Ensembl ID: ENSG00000153162
  • Gene Symbol: ACVRL1 (ENSG00000139567)
    Fold Change: 1.39
    Ensembl ID: ENSG00000139567
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.38
    Ensembl ID: ENSG00000084234
  • Gene Symbol: BNIP2 (ENSG00000140299)
    Fold Change: 1.36
    Ensembl ID: ENSG00000140299
  • Gene Symbol: RHOC (ENSG00000155366)
    Fold Change: 1.36
    Ensembl ID: ENSG00000155366
  • Gene Symbol: ASPH (ENSG00000198363)
    Fold Change: 1.35
    Ensembl ID: ENSG00000198363
  • Gene Symbol: ATP2A2 (ENSG00000174437)
    Fold Change: 1.34
    Ensembl ID: ENSG00000174437
  • Gene Symbol: PARP4 (ENSG00000102699)
    Fold Change: 1.34
    Ensembl ID: ENSG00000102699
  • Gene Symbol: ATP6V0C (ENSG00000185883)
    Fold Change: 1.32
    Ensembl ID: ENSG00000185883
  • Gene Symbol: DST (ENSG00000151914)
    Fold Change: 1.32
    Ensembl ID: ENSG00000151914
  • Gene Symbol: CASP10 (ENSG00000003400)
    Fold Change: 1.31
    Ensembl ID: ENSG00000003400
  • Gene Symbol: ADARB1 (ENSG00000197381)
    Fold Change: 1.31
    Ensembl ID: ENSG00000197381
  • Gene Symbol: XIAP (ENSG00000101966)
    Fold Change: 1.3
    Ensembl ID: ENSG00000101966
  • Gene Symbol: APC (ENSG00000134982)
    Fold Change: 1.29
    Ensembl ID: ENSG00000134982
  • Gene Symbol: AUH (ENSG00000148090)
    Fold Change: 1.29
    Ensembl ID: ENSG00000148090
  • Gene Symbol: ABCA1 (ENSG00000165029)
    Fold Change: 1.28
    Ensembl ID: ENSG00000165029
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.28
    Ensembl ID: ENSG00000069849
  • Gene Symbol: AP1G1 (ENSG00000166747)
    Fold Change: 1.27
    Ensembl ID: ENSG00000166747
  • Gene Symbol: CASP4 (ENSG00000196954)
    Fold Change: 1.27
    Ensembl ID: ENSG00000196954
  • Gene Symbol: ACYP2 (ENSG00000170634)
    Fold Change: 1.25
    Ensembl ID: ENSG00000170634
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.25
    Ensembl ID: ENSG00000127022
  • Gene Symbol: CALD1 (ENSG00000122786)
    Fold Change: 1.25
    Ensembl ID: ENSG00000122786
  • Gene Symbol: KLF9 (ENSG00000119138)
    Fold Change: 1.23
    Ensembl ID: ENSG00000119138
  • Gene Symbol: CAPN2 (ENSG00000162909)
    Fold Change: 1.22
    Ensembl ID: ENSG00000162909
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 1.22
    Ensembl ID: ENSG00000143878
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 1.21
    Ensembl ID: ENSG00000124172
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.17
    Ensembl ID: ENSG00000070961
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.16
    Ensembl ID: ENSG00000104964
  • Gene Symbol: ACOX1 (ENSG00000161533)
    Fold Change: 1.15
    Ensembl ID: ENSG00000161533
  • Gene Symbol: ACACB (ENSG00000076555)
    Fold Change: 1.13
    Ensembl ID: ENSG00000076555
  • Gene Symbol: JAG1 (ENSG00000101384)
    Fold Change: 1.12
    Ensembl ID: ENSG00000101384
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 1.12
    Ensembl ID: ENSG00000179218
  • Gene Symbol: ATP2B4 (ENSG00000058668)
    Fold Change: 1.11
    Ensembl ID: ENSG00000058668
  • Gene Symbol: ALPL (ENSG00000162551)
    Fold Change: 1.09
    Ensembl ID: ENSG00000162551
  • Gene Symbol: ANK3 (ENSG00000151150)
    Fold Change: 1.09
    Ensembl ID: ENSG00000151150
  • Gene Symbol: ATR (ENSG00000175054)
    Fold Change: 1.07
    Ensembl ID: ENSG00000175054
  • Gene Symbol: ACVR2A (ENSG00000121989)
    Fold Change: 1.06
    Ensembl ID: ENSG00000121989
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.05
    Ensembl ID: ENSG00000104765
  • Gene Symbol: ATM (ENSG00000149311)
    Fold Change: 1.04
    Ensembl ID: ENSG00000149311
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 1.04
    Ensembl ID: ENSG00000145741
  • Gene Symbol: PLIN2 (ENSG00000147872)
    Fold Change: 1.01
    Ensembl ID: ENSG00000147872
  • Gene Symbol: CAV2 (ENSG00000105971)
    Fold Change: 1.01
    Ensembl ID: ENSG00000105971
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: N/A
    Ensembl ID: ENSG00000122359
  • Gene Symbol: ARNT (ENSG00000143437)
    Fold Change: N/A
    Ensembl ID: ENSG00000143437
Hovered Details

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Hovered Details

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**Key Characteristics** The cerebral cortex endothelial cell is characterized by its: 1. **Location**: The cerebral cortex endothelial cell is located within the cerebral cortex, the outer layer of the brain responsible for processing sensory information. 2. **Cellular structure**: These cells form the walls of capillaries, which are small blood vessels that supply the brain with oxygen and nutrients. 3. **Gene expression**: The cerebral cortex endothelial cell expresses specific genes, including BMPR2, which is involved in signaling pathways that regulate cell growth and differentiation. 4. **Signaling pathways**: These cells are involved in various signaling pathways, including the activin receptor signaling pathway, which regulates cell growth and differentiation. 5. **Function**: The cerebral cortex endothelial cell plays a crucial role in maintaining the blood-brain barrier, regulating the exchange of nutrients and waste products between the brain and the bloodstream. **Clinical Significance** The cerebral cortex endothelial cell has significant clinical implications, particularly in the context of neurological disorders. Some of the key clinical significance of these cells includes: 1. **Blood-brain barrier dysfunction**: Disruption of the blood-brain barrier, which is maintained by the cerebral cortex endothelial cell, can lead to various neurological disorders, including multiple sclerosis, Alzheimer's disease, and Parkinson's disease. 2. **Neurodegenerative diseases**: The cerebral cortex endothelial cell has been implicated in the pathogenesis of neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS). 3. **Stroke and cerebral ischemia**: The cerebral cortex endothelial cell plays a critical role in maintaining the integrity of the blood-brain barrier, and disruption of this barrier can lead to cerebral ischemia and stroke. 4. **Neuroinflammation**: The cerebral cortex endothelial cell is involved in the regulation of neuroinflammation, which is a key feature of various neurological disorders. In summary, the cerebral cortex endothelial cell is a unique type of endothelial cell that plays a crucial role in maintaining the blood-brain barrier and regulating the exchange of nutrients and waste products between the brain and the bloodstream. Its dysfunction has significant clinical implications, particularly in the context of neurological disorders.