Details for: SLC5A4

Gene ID: 6527

Symbol: SLC5A4

Ensembl ID: ENSG00000100191

Description: solute carrier family 5 member 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: endothelial stalk cell (CL0002671)
    Fold Change: 0.6060
    Cell Significance Index: 6.7900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.5741
    Cell Significance Index: 35.2000
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.5194
    Cell Significance Index: 5.3800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3748
    Cell Significance Index: 75.1900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3710
    Cell Significance Index: 10.6900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2686
    Cell Significance Index: 12.1800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2380
    Cell Significance Index: 45.3000
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.1984
    Cell Significance Index: 2.9900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1816
    Cell Significance Index: 6.3800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1416
    Cell Significance Index: 3.5400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.1286
    Cell Significance Index: 3.0900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1268
    Cell Significance Index: 7.6100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1110
    Cell Significance Index: 6.8200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1006
    Cell Significance Index: 36.0800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0953
    Cell Significance Index: 3.6100
  • Cell Name: Langerhans cell (CL0000453)
    Fold Change: 0.0944
    Cell Significance Index: 0.9000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0921
    Cell Significance Index: 6.1900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0809
    Cell Significance Index: 3.5800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0734
    Cell Significance Index: 1.5900
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.0610
    Cell Significance Index: 0.9000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0605
    Cell Significance Index: 12.0000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0573
    Cell Significance Index: 0.8200
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.0553
    Cell Significance Index: 1.3800
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.0528
    Cell Significance Index: 0.7600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0474
    Cell Significance Index: 13.6300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0435
    Cell Significance Index: 39.3100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.0322
    Cell Significance Index: 3.5000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0236
    Cell Significance Index: 1.6300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0183
    Cell Significance Index: 0.3900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0132
    Cell Significance Index: 9.1300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0047
    Cell Significance Index: 0.0800
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.0035
    Cell Significance Index: 0.1100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0031
    Cell Significance Index: 4.7900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0014
    Cell Significance Index: 1.9700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0010
    Cell Significance Index: 1.8000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0008
    Cell Significance Index: 1.4200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0035
    Cell Significance Index: -2.5600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0044
    Cell Significance Index: -2.7600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0046
    Cell Significance Index: -2.5800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0063
    Cell Significance Index: -3.9800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0072
    Cell Significance Index: -0.1500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0073
    Cell Significance Index: -3.3000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0073
    Cell Significance Index: -3.9900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0080
    Cell Significance Index: -0.2000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.0083
    Cell Significance Index: -1.3500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.0128
    Cell Significance Index: -1.2700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0162
    Cell Significance Index: -2.3600
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0185
    Cell Significance Index: -0.4000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0198
    Cell Significance Index: -4.1800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0204
    Cell Significance Index: -0.6500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0225
    Cell Significance Index: -3.8400
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0244
    Cell Significance Index: -0.4900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0254
    Cell Significance Index: -0.5400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0261
    Cell Significance Index: -4.7000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0299
    Cell Significance Index: -4.1100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0308
    Cell Significance Index: -1.0100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0337
    Cell Significance Index: -2.5900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0350
    Cell Significance Index: -0.9000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0394
    Cell Significance Index: -4.1000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0405
    Cell Significance Index: -4.9800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0428
    Cell Significance Index: -4.9000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0431
    Cell Significance Index: -1.5100
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0443
    Cell Significance Index: -0.4200
  • Cell Name: surface ectodermal cell (CL0000114)
    Fold Change: -0.0469
    Cell Significance Index: -0.3700
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.0493
    Cell Significance Index: -0.5100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0514
    Cell Significance Index: -5.2500
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0531
    Cell Significance Index: -1.0500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0577
    Cell Significance Index: -3.0300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0629
    Cell Significance Index: -3.5300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0683
    Cell Significance Index: -1.9500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0791
    Cell Significance Index: -2.2100
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0815
    Cell Significance Index: -1.7000
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0894
    Cell Significance Index: -1.7600
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0945
    Cell Significance Index: -1.2600
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.0952
    Cell Significance Index: -1.2700
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0953
    Cell Significance Index: -2.3800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0960
    Cell Significance Index: -2.0100
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0977
    Cell Significance Index: -1.1400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1053
    Cell Significance Index: -4.9500
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.1111
    Cell Significance Index: -2.2600
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.1160
    Cell Significance Index: -2.8300
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.1163
    Cell Significance Index: -1.5700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1199
    Cell Significance Index: -2.3400
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.1234
    Cell Significance Index: -2.4600
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.1251
    Cell Significance Index: -1.5600
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.1281
    Cell Significance Index: -1.5100
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1311
    Cell Significance Index: -3.0300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1384
    Cell Significance Index: -3.0300
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.1430
    Cell Significance Index: -1.7400
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.1435
    Cell Significance Index: -1.9900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1526
    Cell Significance Index: -4.0900
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: -0.1556
    Cell Significance Index: -1.4900
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.1569
    Cell Significance Index: -2.2300
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.1579
    Cell Significance Index: -1.7200
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.1579
    Cell Significance Index: -2.7300
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.1623
    Cell Significance Index: -2.3100
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: -0.1626
    Cell Significance Index: -1.6400
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.1647
    Cell Significance Index: -1.9700
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.1664
    Cell Significance Index: -2.1000
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.1670
    Cell Significance Index: -2.6800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Glucose Transporter:** SLC5A4 is a glucose transporter that facilitates the transport of glucose across cell membranes, playing a crucial role in maintaining glucose homeostasis in various tissues. 2. **Sodium Symporter:** This gene also functions as a sodium symporter, transporting sodium ions in conjunction with glucose, which is essential for maintaining cellular sodium balance. 3. **Cellular Expression:** SLC5A4 is expressed in multiple cell types, including OFF-bipolar cells, retinal bipolar neurons, and goblet cells in the colon, highlighting its widespread importance in cellular regulation. 4. **Tissue-Specific Expression:** The gene's expression pattern varies across different tissues, suggesting its involvement in distinct cellular processes and signaling pathways. **Pathways and Functions:** 1. **Cellular Hexose Transport:** SLC5A4 is involved in the transport of glucose across cell membranes, regulating glucose uptake and metabolism in various tissues. 2. **Glucose Transmembrane Transport:** This gene facilitates the transport of glucose across cell membranes, influencing glucose homeostasis and cellular differentiation. 3. **Sodium Ion Transmembrane Transport:** SLC5A4 also transports sodium ions, maintaining cellular sodium balance and influencing cellular signaling pathways. 4. **Protein Binding:** The gene interacts with various proteins, modulating its activity and regulating glucose and sodium transport. **Clinical Significance:** 1. **Diabetes and Metabolic Disorders:** Abnormalities in SLC5A4 expression or function may contribute to the development of diabetes and metabolic disorders, highlighting the importance of this gene in glucose homeostasis. 2. **Neurological Disorders:** The gene's expression in the cerebral cortex and other neural tissues suggests its involvement in neurological disorders, such as epilepsy and Alzheimer's disease. 3. **Cancer and Gastrointestinal Diseases:** Alterations in SLC5A4 expression or function may contribute to cancer and gastrointestinal diseases, such as colon cancer and irritable bowel syndrome. 4. **Neurodevelopmental Disorders:** The gene's expression in retinal bipolar cells and other neural tissues suggests its involvement in neurodevelopmental disorders, such as retinitis pigmentosa and autism spectrum disorder. In conclusion, the SLC5A4 gene plays a vital role in regulating glucose and sodium transport across cell membranes, influencing cellular metabolism, differentiation, and signaling pathways. Further research is necessary to fully elucidate the gene's functions and its involvement in various diseases, ultimately leading to the development of novel therapeutic strategies.

Genular Protein ID: 2352227018

Symbol: SC5A4_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9NY91 O15279

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugCentral 1 EMBL 3 Ensembl 1 GO 4 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SMR 1 STRING 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 13130073

Title: A glucose sensor hiding in a family of transporters.

PubMed ID: 13130073

DOI: 10.1073/pnas.1733027100

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 17110502

Title: Imino sugars are potent agonists of the human glucose sensor SGLT3.

PubMed ID: 17110502

DOI: 10.1124/mol.106.030288

PubMed ID: 20421923

Title: A single amino acid change converts the sugar sensor SGLT3 into a sugar transporter.

PubMed ID: 20421923

DOI: 10.1371/journal.pone.0010241

PubMed ID: 22766068

Title: A novel SGLT is expressed in the human kidney.

PubMed ID: 22766068

DOI: 10.1016/j.ejphar.2012.06.033

Sequence Information:

  • Length: 659
  • Mass: 72456
  • Checksum: F8A34AED648B523A
  • Sequence:
    • MASTVSPSTI AETPEPPPLS DHIRNAADIS VIVIYFLVVM AVGLWAMLKT NRGTIGGFFL 
AGRDMAWWPM GASLFASNIG SNHYVGLAGT GAASGVATVT FEWTSSVMLL ILGWIFVPIY 
IKSGVMTMPE YLKKRFGGER LQVYLSILSL FICVVLLISA DIFAGAIFIK LALGLDLYLA 
IFILLAMTAV YTTTGGLASV IYTDTLQTII MLIGSFILMG FAFNEVGGYE SFTEKYVNAT 
PSVVEGDNLT ISASCYTPRA DSFHIFRDAV TGDIPWPGII FGMPITALWY WCTNQVIVQR 
CLCGKDMSHV KAACIMCAYL KLLPMFLMVM PGMISRILYT DMVACVVPSE CVKHCGVDVG 
CTNYAYPTMV LELMPQGLRG LMLSVMLASL MSSLTSIFNS ASTLFTIDLY TKMRKQASEK 
ELLIAGRIFV LLLTVVSIVW VPLVQVSQNG QLIHYTESIS SYLGPPIAAV FVLAIFCKRV 
NEQGAFWGLM VGLAMGLIRM ITEFAYGTGS CLAPSNCPKI ICGVHYLYFS IVLFFGSMLV 
TLGISLLTKP IPDVHLYRLC WVLRNSTEER IDIDAEEKSQ EETDDGVEED YPEKSRGCLK 
KAYDLFCGLQ KGPKLTKEEE EALSKKLTDT SERPSWRTIV NINAILLLAV VVFIHGYYA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.