Details for: CL0002601

Cell ID: CL0002601

Cell Name: uterine smooth muscle cell

Marker Score Threshold: 1303
(Derived using integrated single-cell and genomic data)

Description: A smooth muscle cell of the uterus.

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ACTA2 (ENSG00000107796)
    Fold Change: 5.84
    Ensembl ID: ENSG00000107796
  • Gene Symbol: CALD1 (ENSG00000122786)
    Fold Change: 5.7
    Ensembl ID: ENSG00000122786
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 5.52
    Ensembl ID: ENSG00000075624
  • Gene Symbol: ACTG2 (ENSG00000163017)
    Fold Change: 5.33
    Ensembl ID: ENSG00000163017
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 5.26
    Ensembl ID: ENSG00000166710
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 5.23
    Ensembl ID: ENSG00000143933
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 4.98
    Ensembl ID: ENSG00000184009
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 4.64
    Ensembl ID: ENSG00000185650
  • Gene Symbol: CD63 (ENSG00000135404)
    Fold Change: 4.6
    Ensembl ID: ENSG00000135404
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 4.51
    Ensembl ID: ENSG00000124172
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 4.33
    Ensembl ID: ENSG00000143878
  • Gene Symbol: CFL1 (ENSG00000172757)
    Fold Change: 4.31
    Ensembl ID: ENSG00000172757
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 4.11
    Ensembl ID: ENSG00000145741
  • Gene Symbol: ATF3 (ENSG00000162772)
    Fold Change: 3.94
    Ensembl ID: ENSG00000162772
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 3.81
    Ensembl ID: ENSG00000133639
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 3.63
    Ensembl ID: ENSG00000169020
  • Gene Symbol: CEBPB (ENSG00000172216)
    Fold Change: 3.53
    Ensembl ID: ENSG00000172216
  • Gene Symbol: ACTN1 (ENSG00000072110)
    Fold Change: 3.28
    Ensembl ID: ENSG00000072110
  • Gene Symbol: CEBPD (ENSG00000221869)
    Fold Change: 3.21
    Ensembl ID: ENSG00000221869
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 3.2
    Ensembl ID: ENSG00000169100
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 3.15
    Ensembl ID: ENSG00000149925
  • Gene Symbol: SEPTIN7 (ENSG00000122545)
    Fold Change: 3.15
    Ensembl ID: ENSG00000122545
  • Gene Symbol: ATP1B1 (ENSG00000143153)
    Fold Change: 3.14
    Ensembl ID: ENSG00000143153
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 3.06
    Ensembl ID: ENSG00000135390
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 3.02
    Ensembl ID: ENSG00000154723
  • Gene Symbol: CD44 (ENSG00000026508)
    Fold Change: 2.94
    Ensembl ID: ENSG00000026508
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 2.88
    Ensembl ID: ENSG00000134825
  • Gene Symbol: CDC42 (ENSG00000070831)
    Fold Change: 2.85
    Ensembl ID: ENSG00000070831
  • Gene Symbol: CD9 (ENSG00000010278)
    Fold Change: 2.61
    Ensembl ID: ENSG00000010278
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 2.5
    Ensembl ID: ENSG00000172270
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 2.33
    Ensembl ID: ENSG00000198898
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 2.3
    Ensembl ID: ENSG00000241837
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 2.3
    Ensembl ID: ENSG00000099624
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 2.29
    Ensembl ID: ENSG00000154518
  • Gene Symbol: CFL2 (ENSG00000165410)
    Fold Change: 2.29
    Ensembl ID: ENSG00000165410
  • Gene Symbol: CD81 (ENSG00000110651)
    Fold Change: 2.27
    Ensembl ID: ENSG00000110651
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 2.23
    Ensembl ID: ENSG00000164111
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 2.19
    Ensembl ID: ENSG00000168374
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 2.15
    Ensembl ID: ENSG00000130402
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 2.14
    Ensembl ID: ENSG00000198668
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 2.13
    Ensembl ID: ENSG00000077549
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 2.1
    Ensembl ID: ENSG00000084234
  • Gene Symbol: CAV1 (ENSG00000105974)
    Fold Change: 2.05
    Ensembl ID: ENSG00000105974
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.02
    Ensembl ID: ENSG00000067560
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 2.02
    Ensembl ID: ENSG00000128272
  • Gene Symbol: CD151 (ENSG00000177697)
    Fold Change: 2
    Ensembl ID: ENSG00000177697
  • Gene Symbol: ATP2B4 (ENSG00000058668)
    Fold Change: 1.94
    Ensembl ID: ENSG00000058668
  • Gene Symbol: ADH5 (ENSG00000197894)
    Fold Change: 1.93
    Ensembl ID: ENSG00000197894
  • Gene Symbol: CD59 (ENSG00000085063)
    Fold Change: 1.9
    Ensembl ID: ENSG00000085063
  • Gene Symbol: CETN2 (ENSG00000147400)
    Fold Change: 1.87
    Ensembl ID: ENSG00000147400
  • Gene Symbol: CALU (ENSG00000128595)
    Fold Change: 1.83
    Ensembl ID: ENSG00000128595
  • Gene Symbol: RHOC (ENSG00000155366)
    Fold Change: 1.78
    Ensembl ID: ENSG00000155366
  • Gene Symbol: DST (ENSG00000151914)
    Fold Change: 1.78
    Ensembl ID: ENSG00000151914
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 1.76
    Ensembl ID: ENSG00000005022
  • Gene Symbol: CDH13 (ENSG00000140945)
    Fold Change: 1.76
    Ensembl ID: ENSG00000140945
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.72
    Ensembl ID: ENSG00000165629
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.72
    Ensembl ID: ENSG00000143761
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.7
    Ensembl ID: ENSG00000152234
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.69
    Ensembl ID: ENSG00000127022
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.68
    Ensembl ID: ENSG00000110955
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.6
    Ensembl ID: ENSG00000159199
  • Gene Symbol: SERPING1 (ENSG00000149131)
    Fold Change: 1.59
    Ensembl ID: ENSG00000149131
  • Gene Symbol: ARL2 (ENSG00000213465)
    Fold Change: 1.58
    Ensembl ID: ENSG00000213465
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.56
    Ensembl ID: ENSG00000153113
  • Gene Symbol: CAMLG (ENSG00000164615)
    Fold Change: 1.56
    Ensembl ID: ENSG00000164615
  • Gene Symbol: SERPINH1 (ENSG00000149257)
    Fold Change: 1.54
    Ensembl ID: ENSG00000149257
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 1.52
    Ensembl ID: ENSG00000152518
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.46
    Ensembl ID: ENSG00000177556
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.44
    Ensembl ID: ENSG00000104964
  • Gene Symbol: KLF9 (ENSG00000119138)
    Fold Change: 1.44
    Ensembl ID: ENSG00000119138
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 1.39
    Ensembl ID: ENSG00000179218
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.39
    Ensembl ID: ENSG00000165527
  • Gene Symbol: AEBP1 (ENSG00000106624)
    Fold Change: 1.38
    Ensembl ID: ENSG00000106624
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.37
    Ensembl ID: ENSG00000085224
  • Gene Symbol: CDKN1A (ENSG00000124762)
    Fold Change: 1.35
    Ensembl ID: ENSG00000124762
  • Gene Symbol: ADGRE5 (ENSG00000123146)
    Fold Change: 1.32
    Ensembl ID: ENSG00000123146
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 1.29
    Ensembl ID: ENSG00000142192
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.26
    Ensembl ID: ENSG00000116459
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.24
    Ensembl ID: ENSG00000117410
  • Gene Symbol: CCND2 (ENSG00000118971)
    Fold Change: 1.21
    Ensembl ID: ENSG00000118971
  • Gene Symbol: ANXA6 (ENSG00000197043)
    Fold Change: 1.18
    Ensembl ID: ENSG00000197043
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.17
    Ensembl ID: ENSG00000123505
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.17
    Ensembl ID: ENSG00000069849
  • Gene Symbol: C1R (ENSG00000159403)
    Fold Change: 1.15
    Ensembl ID: ENSG00000159403
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.12
    Ensembl ID: ENSG00000104763
  • Gene Symbol: RND3 (ENSG00000115963)
    Fold Change: 1.1
    Ensembl ID: ENSG00000115963
  • Gene Symbol: C1S (ENSG00000182326)
    Fold Change: 1.1
    Ensembl ID: ENSG00000182326
  • Gene Symbol: ATP6V1E1 (ENSG00000131100)
    Fold Change: 1.09
    Ensembl ID: ENSG00000131100
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.08
    Ensembl ID: ENSG00000108561
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.07
    Ensembl ID: ENSG00000100823
  • Gene Symbol: ARL3 (ENSG00000138175)
    Fold Change: 1.07
    Ensembl ID: ENSG00000138175
  • Gene Symbol: BAD (ENSG00000002330)
    Fold Change: 1.07
    Ensembl ID: ENSG00000002330
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.07
    Ensembl ID: ENSG00000104765
  • Gene Symbol: AXL (ENSG00000167601)
    Fold Change: 1.06
    Ensembl ID: ENSG00000167601
  • Gene Symbol: A2M (ENSG00000175899)
    Fold Change: 1.05
    Ensembl ID: ENSG00000175899
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 1.05
    Ensembl ID: ENSG00000142599
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.05
    Ensembl ID: ENSG00000072778
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.04
    Ensembl ID: ENSG00000004059
  • Gene Symbol: PTTG1IP (ENSG00000183255)
    Fold Change: 1.03
    Ensembl ID: ENSG00000183255
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.01
    Ensembl ID: ENSG00000116489
Hovered Details

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Hovered Details

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**Key Characteristics** * **Cell Type:** Uterine Smooth Muscle Cell * **Gene Expression:** + ACTA2: Involved in muscle contraction + CALD1: Involved in actin filament bundle assembly and muscle contraction + ACTB: Involved in actin cytoskeleton organization and muscle contraction * **Pathways and Ontology:** + Atp binding + Basement membrane + Cell body + Cellular response to transforming growth factor beta stimulus + Cytoplasm + Cytosol + Extracellular exosome + Extracellular space + Filopodium + Glomerular mesangial cell development + Hydrolase activity + Juxtaglomerular apparatus development + Lamellipodium + Mesenchyme migration + Motile cilium + Muscle contraction + Notch4 intracellular domain regulates transcription + Positive regulation of erk1 and erk2 cascade + Positive regulation of gene expression + Positive regulation of hepatic stellate cell activation + Positive regulation of hepatic stellate cell contraction + Positive regulation of hepatic stellate cell migration + Protein-containing complex + Protein kinase binding + Regulation of blood pressure + Response to virus + Signaling by notch + Signaling by notch4 + Signal transduction + Smooth muscle contractile fiber + Smooth muscle contraction + Stress fiber + Vascular associated smooth muscle contraction * **Clinical Significance:** The uterine smooth muscle cell plays a crucial role in maintaining uterine tone and supporting pregnancy. Abnormalities in this cell type have been implicated in various reproductive disorders, including uterine fibroids and pregnancy complications. **Clinical Significance** The uterine smooth muscle cell is a critical component of the female reproductive system, and its dysfunction can have significant clinical implications. The cell's ability to contract and relax is essential for maintaining uterine tone, which is necessary for supporting pregnancy. Abnormalities in this cell type have been implicated in various reproductive disorders, including: 1. **Uterine Fibroids:** Uterine fibroids are benign tumors that arise from the smooth muscle cells of the uterus. They can cause symptoms such as heavy menstrual bleeding, pelvic pain, and infertility. 2. **Pregnancy Complications:** Abnormalities in the uterine smooth muscle cell can increase the risk of pregnancy complications, including preterm labor, postpartum hemorrhage, and placenta previa. 3. **Infertility:** Dysfunction in the uterine smooth muscle cell can affect fertility, as it can disrupt the normal functioning of the reproductive system. 4. **Hypertension:** Abnormalities in the uterine smooth muscle cell have been linked to hypertension, which can increase the risk of cardiovascular disease. Understanding the role of the uterine smooth muscle cell in maintaining uterine tone and supporting pregnancy is essential for developing effective treatments for reproductive disorders. Further research is needed to elucidate the mechanisms underlying uterine smooth muscle cell dysfunction and to develop novel therapeutic strategies for addressing these conditions.