Details for: CAVIN3

Gene ID: 112464

Gene Type:  Protein-coding  - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: CAVIN3

Ensembl ID: ENSG00000170955

Description: caveolae associated protein 3

Selected Context(s):  Overall

Cell Significance Landscape

Contexts:

Associated with

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • epithelial cell of lung CL0000082
    CSI 18.75
    rCSI 15.54%
    PRS 84.52
  • microcirculation associated smooth muscle cell CL0008035
    CSI 14.56
    rCSI 42.16%
    PRS 82.66
  • melanocyte CL0000148
    CSI 11.46
    rCSI 8.49%
    PRS 77.61
  • skin fibroblast CL0002620
    CSI 10.93
    rCSI 9.42%
    PRS 83.73
  • bronchus fibroblast of lung CL2000093
    CSI 9.67
    rCSI 7.86%
    PRS 82.91
  • smooth muscle cell CL0000192
    CSI 9.3
    rCSI 22.17%
    PRS 79.1
  • pancreatic acinar cell CL0002064
    CSI 8.59
    rCSI 11.41%
    PRS 88.18
  • pancreatic stellate cell CL0002410
    CSI 7.67
    rCSI 44.64%
    PRS 86.62
  • tracheobronchial smooth muscle cell CL0019019
    CSI 6.76
    rCSI 11.93%
    PRS 87.91
  • fallopian tube secretory epithelial cell CL4030006
    CSI 5.99
    rCSI 5.76%
    PRS 82.8
  • myofibroblast cell CL0000186
    CSI 5.53
    rCSI 7.65%
    PRS 80.3
  • type EC enteroendocrine cell CL0000577
    CSI 5.46
    rCSI 19.39%
    PRS 86.41
  • adventitial cell CL0002503
    CSI 5.41
    rCSI 12.92%
    PRS 86.89
  • pancreatic D cell CL0000173
    CSI 5.23
    rCSI 5.14%
    PRS 85.65
  • perivascular cell CL4033054
    CSI 5.11
    rCSI 6.98%
    PRS 87.61
  • fibroblast of lung CL0002553
    CSI 4.89
    rCSI 4.55%
    PRS 84.3
  • mononuclear phagocyte CL0000113
    CSI 4.46
    rCSI 9.82%
    PRS 86.74
  • interstitial cell of Cajal CL0002088
    CSI 4.33
    rCSI 5.51%
    PRS 88.14
  • endothelial cell of artery CL1000413
    CSI 4.32
    rCSI 6.33%
    PRS 88.43
  • fibroblast of breast CL4006000
    CSI 4.28
    rCSI 18%
    PRS 87.18
  • ciliated epithelial cell CL0000067
    CSI 3.95
    rCSI 3.48%
    PRS 73.29
  • blood vessel endothelial cell CL0000071
    CSI 3.89
    rCSI 8.08%
    PRS 80.46
  • enteric smooth muscle cell CL0002504
    CSI 3.88
    rCSI 5.54%
    PRS 84.09
  • intestinal epithelial cell CL0002563
    CSI 3.67
    rCSI 3.83%
    PRS 81
  • neural crest cell CL0011012
    CSI 3.56
    rCSI 2.81%
    PRS 73.47
  • Schwann cell CL0002573
    CSI 3.47
    rCSI 9.85%
    PRS 79.21
  • keratinocyte CL0000312
    CSI 3.44
    rCSI 2.88%
    PRS 85.42
  • bronchiolar smooth muscle cell CL4033017
    CSI 3.39
    rCSI 50.92%
    PRS 90.33
  • pulmonary artery endothelial cell CL1001568
    CSI 3.36
    rCSI 4.57%
    PRS 90.56
  • alveolar type 1 fibroblast cell CL4028004
    CSI 3.23
    rCSI 3.54%
    PRS 85.23
  • extravillous trophoblast CL0008036
    CSI 3.14
    rCSI 3.89%
    PRS 81.7
  • basal cell CL0000646
    CSI 3.13
    rCSI 4.18%
    PRS 81.51
  • keratocyte CL0002363
    CSI 3.12
    rCSI 7.5%
    PRS 85.79
  • alveolar adventitial fibroblast CL4028006
    CSI 3.05
    rCSI 4.82%
    PRS 84.79
  • vascular associated smooth muscle cell CL0000359
    CSI 3.03
    rCSI 9.84%
    PRS 81.6
  • smooth muscle cell of the pulmonary artery CL0002591
    CSI 3.01
    rCSI 23.11%
    PRS 84.49
  • cerebral cortex endothelial cell CL1001602
    CSI 2.8
    rCSI 4.85%
    PRS 75.68
  • myeloid leukocyte CL0000766
    CSI 2.78
    rCSI 2.57%
    PRS 84.73
  • blood vessel smooth muscle cell CL0019018
    CSI 2.72
    rCSI 22.09%
    PRS 78.35
  • myoepithelial cell CL0000185
    CSI 2.72
    rCSI 6.87%
    PRS 87.53
  • respiratory hillock cell CL4030023
    CSI 2.71
    rCSI 4.82%
    PRS 90.29
  • peripheral nervous system neuron CL2000032
    CSI 2.68
    rCSI 3.65%
    PRS 75.5
  • lung pericyte CL0009089
    CSI 2.67
    rCSI 7.05%
    PRS 89.16
  • vein endothelial cell of respiratory system CL4033008
    CSI 2.47
    rCSI 16.97%
    PRS 88.77
  • ciliated columnar cell of tracheobronchial tree CL0002145
    CSI 2.45
    rCSI 5.59%
    PRS 77.06
  • mucous neck cell CL0000651
    CSI 2.42
    rCSI 3.48%
    PRS 88.96
  • endothelial cell of uterus CL0009095
    CSI 2.33
    rCSI 17.06%
    PRS 90.03
  • lung ciliated cell CL1000271
    CSI 2.28
    rCSI 2.64%
    PRS 76.32
  • stromal cell CL0000499
    CSI 2.21
    rCSI 6.21%
    PRS 78.74
  • enteroendocrine cell CL0000164
    CSI 2.07
    rCSI 2.83%
    PRS 82.84
  • mesodermal cell CL0000222
    CSI 2.03
    rCSI 2.44%
    PRS 81.6
  • retinal blood vessel endothelial cell CL0002585
    CSI 1.92
    rCSI 3.07%
    PRS 86.7
  • club cell CL0000158
    CSI 1.91
    rCSI 2.8%
    PRS 78.29
  • chondrocyte CL0000138
    CSI 1.88
    rCSI 2.99%
    PRS 76.98
  • multi-ciliated epithelial cell CL0005012
    CSI 1.83
    rCSI 1.83%
    PRS 77.53
  • mesenchymal cell CL0008019
    CSI 1.81
    rCSI 4.59%
    PRS 77.26
  • uterine smooth muscle cell CL0002601
    CSI 1.38
    rCSI 9.08%
    PRS 88.43
  • respiratory basal cell CL0002633
    CSI 1.33
    rCSI 1.38%
    PRS 86.72
  • smooth muscle cell of prostate CL1000487
    CSI 1.26
    rCSI 7.38%
    PRS 88.24
  • stromal cell of ovary CL0002132
    CSI 1.15
    rCSI 3.17%
    PRS 89.16
  • enteroglial cell CL4040002
    CSI 1.08
    rCSI 5.67%
    PRS 84.52
  • bronchial goblet cell CL1000312
    CSI 0.98
    rCSI 3.92%
    PRS 89.69
  • endothelial cell of placenta CL0009092
    CSI 0.95
    rCSI 4.7%
    PRS 89.81
  • vasa recta descending limb cell CL1001285
    CSI 0.91
    rCSI 7.23%
    PRS 90.19
  • follicular dendritic cell CL0000442
    CSI 0.79
    rCSI 12.61%
    PRS 91.22
  • lung microvascular endothelial cell CL2000016
    CSI 0.76
    rCSI 14.66%
    PRS 89.74
  • vasa recta ascending limb cell CL1001131
    CSI 0.68
    rCSI 3.06%
    PRS 89.45
  • kidney interstitial cell CL1000500
    CSI 0.53
    rCSI 8.61%
    PRS 86.38
  • peptic cell CL0000155
    CSI 0.47
    rCSI 4.67%
    PRS 91.47
  • P/D1 enteroendocrine cell CL0002268
    CSI 0.4
    rCSI 2.17%
    PRS 89.41
  • mesenchymal stem cell CL0000134
    CSI 0.28
    rCSI 3.11%
    PRS 87.68
  • pluripotent stem cell CL0002248
    CSI 0.15
    rCSI 4.42%
    PRS 91.59

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Comma-separated if multiple.
Comma-separated if multiple.
Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [CAVIN3](/details-gene/112464), also known as Caveolae Associated Protein 3, is a protein-coding gene located on chromosome 11p15.4. It is a member of the cavin family of proteins, which are essential for the formation and function of caveolae, the small invaginations of the plasma membrane involved in signal transduction, endocytosis, and mechanosensing. Functionally, [CAVIN3](/details-gene/112464) acts as a caveolin adapter protein and is implicated in regulating key signaling pathways, including the ERK and PI3K/AKT cascades ([Link](https://doi.org/10.1038/emboj.2009.46)). Expression data reveals its significant role primarily in non-hematopoietic cell types, with particularly high significance in structural, secretory, and mesenchymal cells such as [epithelial cell of lung](/details-cell/CL0000082), [microcirculation associated smooth muscle cell](/details-cell/CL0008035), and [skin fibroblast](/details-cell/CL0002620). Its location within a known tumor suppressor region suggests a potential role in cancer biology ([Link](https://pubmed.ncbi.nlm.nih.gov/11691816)). ## Cellular Roles and Expression Landscape The expression profile of [CAVIN3](/details-gene/112464) highlights its importance in cells that require robust structural integrity, high levels of membrane trafficking, and complex signaling regulation. **Overall**, its most significant expression is observed in a diverse set of structural and mesenchymal cells. * **Structural and Mesenchymal Cells:** The gene shows prominent significance in [microcirculation associated smooth muscle cell](/details-cell/CL0008035) (CSI: 14.56), [skin fibroblast](/details-cell/CL0002620) (CSI: 10.93), [smooth muscle cell](/details-cell/CL0000192) (CSI: 9.30), and [myofibroblast cell](/details-cell/CL0000186) (CSI: 5.53). This is consistent with its functional annotation in [cortical actin cytoskeleton organization](/details-cell/GO:0030866) and its role within [caveola](/details-cell/GO:0005901), which are critical for mechanotransduction and maintaining cellular architecture in these cell types. * **Epithelial and Secretory Cells:** The highest significance score is found in [epithelial cell of lung](/details-cell/CL0000082) (CSI: 18.75), with notable expression in [pancreatic acinar cell](/details-cell/CL0002064) (CSI: 8.59) and [fallopian tube secretory epithelial cell](/details-cell/CL4030006) (CSI: 5.99). This pattern suggests [CAVIN3](/details-gene/112464) is integral to the specialized membrane functions of these cells, which may include regulated secretion and maintenance of apical-basal polarity. * **Other Specialized Cells:** High significance is also noted in [melanocyte](/details-cell/CL0000148) (CSI: 11.46) and various pancreatic cells, including [pancreatic stellate cell](/details-cell/CL0002410) and [pancreatic D cell](/details-cell/CL0000173). The absence of immune cells, neurons, or hematopoietic progenitors from the top-expressed list suggests a specialized function for [CAVIN3](/details-gene/112464) outside of these lineages, reinforcing its role in tissue structure and specialized signaling events. ## Pathways and Molecular Function The functions of [CAVIN3](/details-gene/112464) are tightly linked to its localization and protein interactions. Gene Ontology annotations place it squarely within the [caveola](/details-cell/GO:0005901), as well as the broader [cytoplasm](/details-cell/GO:0005737) and [cytosol](/details-cell/GO:0005829), where it participates in [protein-containing complex](/details-cell/GO:0032991) formation. Its molecular functions include general [protein binding](/details-cell/GO:0005515) and specific [protein kinase c binding](/details-cell/GO:0005080), positioning it as a key scaffolding and adapter protein. This role is critical for its involvement in several biological processes: * **Signal Transduction:** [CAVIN3](/details-gene/112464) is a modulator of critical signaling cascades. It is annotated for the [positive regulation of erk1 and erk2 cascade](/details-cell/GO:0070374) and the [negative regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction](/details-cell/GO:0051898). The dual regulatory role suggests it may act as a context-dependent switch that fine-tunes cellular responses to external stimuli, a function consistent with the signaling hub role of caveolae. * **Cytoskeletal Organization:** Its involvement in [cortical actin cytoskeleton organization](/details-cell/GO:0030866) directly supports its high expression in structural cells like fibroblasts and smooth muscle cells, where the interplay between the plasma membrane and the actin network is crucial for cell shape, motility, and contractility. * **Metabolic and Circadian Regulation:** Annotations for [negative regulation of fermentation](/details-cell/GO:1901003) and [circadian regulation of gene expression](/details-cell/GO:0032922) suggest broader, less characterized roles in cellular metabolism and rhythmic biological processes. ## Research Directions The established role of [CAVIN3](/details-gene/112464) as a caveolae-associated signaling modulator, combined with its high expression in specific tissues and its location in a tumor suppressor region, opens several avenues for future investigation. **Proposed Hypotheses:** 1. **Tumor Suppression in Lung Epithelium:** Given that [CAVIN3](/details-gene/112464) is highly expressed in [epithelial cell of lung](/details-cell/CL0000082) and has been implicated as a tumor suppressor ([Link](https://pubmed.ncbi.nlm.nih.gov/11691816)), it is hypothesized that the loss or downregulation of [CAVIN3](/details-gene/112464) in these cells disrupts caveolae integrity, leading to aberrant PI3K/AKT signaling and promoting oncogenic transformation and proliferation in non-small cell lung cancer. 2. **Regulation of Fibrosis:** Based on its high significance in [skin fibroblast](/details-cell/CL0002620), [bronchus fibroblast of lung](/details-cell/CL2000093), and [myofibroblast cell](/details-cell/CL0000186), we hypothesize that [CAVIN3](/details-gene/112464) is a key regulator of fibroblast-to-myofibroblast differentiation. Dysregulation of [CAVIN3](/details-gene/112464) may contribute to pathological fibrosis by altering cellular responses to pro-fibrotic stimuli like TGF-beta, mediated through its modulation of cytoskeletal organization and ERK signaling. **Experimental Approach:** To test the first hypothesis regarding tumor suppression, one could employ a CRISPR-Cas9 system to knock out [CAVIN3](/details-gene/112464) in a non-malignant human lung epithelial cell line (e.g., BEAS-2B). The functional consequences would be assessed by comparing knockout cells to isogenic wild-type controls. Key assays would include: (i) Western blotting to confirm loss of [CAVIN3](/details-gene/112464) and measure the phosphorylation status of AKT and ERK; (ii) proliferation assays (e.g., cell counting, Ki-67 staining) and migration/invasion assays (e.g., transwell assay); and (iii) anchorage-independent growth assays (soft agar) to assess transformation potential. **Therapeutic Potential:** As [CAVIN3](/details-gene/112464) is implicated as a tumor suppressor, therapeutic strategies would likely focus on restoring its function or expression rather than inhibition. This makes it a challenging direct drug target for small molecules. However, its potential loss in certain cancers could serve as a valuable prognostic biomarker. Future therapeutic avenues might involve gene therapies aimed at re-introducing [CAVIN3](/details-gene/112464) into tumor cells or developing strategies to stabilize its expression or the protein complexes it forms.

Genular Protein ID: 1813209784

Symbol: CAVN3_HUMAN

Name: Cavin-3

UniProtKB Accession Codes:

Q969G5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 1 ExpressionAtlas 1 GO 10 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11691816

Title: Inactivation of human SRBC, located within the 11p15.5-p15.4 tumor suppressor region, in breast and lung cancers.

PubMed ID: 11691816

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19262564

Title: SRBC/cavin-3 is a caveolin adapter protein that regulates caveolae function.

PubMed ID: 19262564

DOI: 10.1038/emboj.2009.46

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26614875

Title: Cavin family: new players in the biology of caveolae.

PubMed ID: 26614875

DOI: 10.1016/bs.ircmb.2015.07.009

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

  • Length: 261
  • Mass: 27701
  • Checksum: E806A01DA992C53B
  • Sequence:
    • MRESALERGP VPEAPAGGPV HAVTVVTLLE KLASMLETLR ERQGGLARRQ GGLAGSVRRI 
QSGLGALSRS HDTTSNTLAQ LLAKAERVSS HANAAQERAV RRAAQVQRLE ANHGLLVARG 
KLHVLLFKEE GEVPASAFQK APEPLGPADQ SELGPEQLEA EVGESSDEEP VESRAQRLRR 
TGLQKVQSLR RALSGRKGPA APPPTPVKPP RLGPGRSAEA QPEAQPALEP TLEPEPPQDT 
EEDPGRPGAA EEALLQMESV A