Details for: CL1001131

Cell ID: CL1001131

Cell Name: vasa recta ascending limb cell

Marker Score Threshold: 264
(Derived using integrated single-cell and genomic data)

Description: A cell that is part of some vasa recta ascending limb.

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 3.15
    Ensembl ID: ENSG00000075624
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 2.98
    Ensembl ID: ENSG00000169100
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 2.76
    Ensembl ID: ENSG00000166710
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.66
    Ensembl ID: ENSG00000184009
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 2.5
    Ensembl ID: ENSG00000135390
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 2.38
    Ensembl ID: ENSG00000198668
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 2.37
    Ensembl ID: ENSG00000145741
  • Gene Symbol: CDC42 (ENSG00000070831)
    Fold Change: 2.26
    Ensembl ID: ENSG00000070831
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 2.22
    Ensembl ID: ENSG00000133639
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.17
    Ensembl ID: ENSG00000067560
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 2.16
    Ensembl ID: ENSG00000077549
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 2.14
    Ensembl ID: ENSG00000124172
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 1.96
    Ensembl ID: ENSG00000143933
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 1.94
    Ensembl ID: ENSG00000179218
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 1.9
    Ensembl ID: ENSG00000154518
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 1.88
    Ensembl ID: ENSG00000005022
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.88
    Ensembl ID: ENSG00000152234
  • Gene Symbol: SEPTIN7 (ENSG00000122545)
    Fold Change: 1.88
    Ensembl ID: ENSG00000122545
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.86
    Ensembl ID: ENSG00000143761
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 1.84
    Ensembl ID: ENSG00000099624
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.81
    Ensembl ID: ENSG00000110955
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.78
    Ensembl ID: ENSG00000172270
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 1.75
    Ensembl ID: ENSG00000152518
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.75
    Ensembl ID: ENSG00000116489
  • Gene Symbol: CD74 (ENSG00000019582)
    Fold Change: 1.74
    Ensembl ID: ENSG00000019582
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.74
    Ensembl ID: ENSG00000198931
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 1.74
    Ensembl ID: ENSG00000169020
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.7
    Ensembl ID: ENSG00000127022
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 1.69
    Ensembl ID: ENSG00000134825
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 1.68
    Ensembl ID: ENSG00000154723
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.68
    Ensembl ID: ENSG00000117410
  • Gene Symbol: CD47 (ENSG00000196776)
    Fold Change: 1.64
    Ensembl ID: ENSG00000196776
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.63
    Ensembl ID: ENSG00000165629
  • Gene Symbol: CD63 (ENSG00000135404)
    Fold Change: 1.63
    Ensembl ID: ENSG00000135404
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 1.61
    Ensembl ID: ENSG00000185650
  • Gene Symbol: CD44 (ENSG00000026508)
    Fold Change: 1.61
    Ensembl ID: ENSG00000026508
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.58
    Ensembl ID: ENSG00000085224
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.56
    Ensembl ID: ENSG00000153113
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.54
    Ensembl ID: ENSG00000116459
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 1.52
    Ensembl ID: ENSG00000142192
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.52
    Ensembl ID: ENSG00000160014
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.47
    Ensembl ID: ENSG00000241837
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.46
    Ensembl ID: ENSG00000104964
  • Gene Symbol: CD59 (ENSG00000085063)
    Fold Change: 1.43
    Ensembl ID: ENSG00000085063
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.43
    Ensembl ID: ENSG00000182718
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.43
    Ensembl ID: ENSG00000141522
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.43
    Ensembl ID: ENSG00000128272
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.42
    Ensembl ID: ENSG00000072778
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.4
    Ensembl ID: ENSG00000070961
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.39
    Ensembl ID: ENSG00000163399
  • Gene Symbol: CEBPD (ENSG00000221869)
    Fold Change: 1.38
    Ensembl ID: ENSG00000221869
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.37
    Ensembl ID: ENSG00000100823
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 1.37
    Ensembl ID: ENSG00000198898
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.36
    Ensembl ID: ENSG00000104763
  • Gene Symbol: BST2 (ENSG00000130303)
    Fold Change: 1.35
    Ensembl ID: ENSG00000130303
  • Gene Symbol: CDKN1A (ENSG00000124762)
    Fold Change: 1.35
    Ensembl ID: ENSG00000124762
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.35
    Ensembl ID: ENSG00000122359
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.35
    Ensembl ID: ENSG00000168374
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.35
    Ensembl ID: ENSG00000159199
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 1.33
    Ensembl ID: ENSG00000143878
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.33
    Ensembl ID: ENSG00000108561
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 1.32
    Ensembl ID: ENSG00000135046
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.32
    Ensembl ID: ENSG00000130402
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.31
    Ensembl ID: ENSG00000104765
  • Gene Symbol: CEBPB (ENSG00000172216)
    Fold Change: 1.3
    Ensembl ID: ENSG00000172216
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.3
    Ensembl ID: ENSG00000143727
  • Gene Symbol: CCT6A (ENSG00000146731)
    Fold Change: 1.3
    Ensembl ID: ENSG00000146731
  • Gene Symbol: CD9 (ENSG00000010278)
    Fold Change: 1.29
    Ensembl ID: ENSG00000010278
  • Gene Symbol: CD81 (ENSG00000110651)
    Fold Change: 1.28
    Ensembl ID: ENSG00000110651
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 1.26
    Ensembl ID: ENSG00000100300
  • Gene Symbol: ATF3 (ENSG00000162772)
    Fold Change: 1.25
    Ensembl ID: ENSG00000162772
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.23
    Ensembl ID: ENSG00000138279
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.22
    Ensembl ID: ENSG00000123505
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.21
    Ensembl ID: ENSG00000164111
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.21
    Ensembl ID: ENSG00000069849
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.21
    Ensembl ID: ENSG00000148700
  • Gene Symbol: ATM (ENSG00000149311)
    Fold Change: 1.21
    Ensembl ID: ENSG00000149311
  • Gene Symbol: PARP1 (ENSG00000143799)
    Fold Change: 1.19
    Ensembl ID: ENSG00000143799
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.19
    Ensembl ID: ENSG00000084234
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.17
    Ensembl ID: ENSG00000165527
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.17
    Ensembl ID: ENSG00000115307
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: 1.17
    Ensembl ID: ENSG00000087088
  • Gene Symbol: A2M (ENSG00000175899)
    Fold Change: 1.16
    Ensembl ID: ENSG00000175899
  • Gene Symbol: RHOC (ENSG00000155366)
    Fold Change: 1.15
    Ensembl ID: ENSG00000155366
  • Gene Symbol: CCND3 (ENSG00000112576)
    Fold Change: 1.15
    Ensembl ID: ENSG00000112576
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.15
    Ensembl ID: ENSG00000149925
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.13
    Ensembl ID: ENSG00000004059
  • Gene Symbol: CAMLG (ENSG00000164615)
    Fold Change: 1.12
    Ensembl ID: ENSG00000164615
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.12
    Ensembl ID: ENSG00000160710
  • Gene Symbol: PTTG1IP (ENSG00000183255)
    Fold Change: 1.12
    Ensembl ID: ENSG00000183255
  • Gene Symbol: CALD1 (ENSG00000122786)
    Fold Change: 1.11
    Ensembl ID: ENSG00000122786
  • Gene Symbol: VPS51 (ENSG00000149823)
    Fold Change: 1.11
    Ensembl ID: ENSG00000149823
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 1.1
    Ensembl ID: ENSG00000142599
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 1.08
    Ensembl ID: ENSG00000111348
  • Gene Symbol: KLF9 (ENSG00000119138)
    Fold Change: 1.08
    Ensembl ID: ENSG00000119138
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.07
    Ensembl ID: ENSG00000087274
  • Gene Symbol: ADH5 (ENSG00000197894)
    Fold Change: 1.06
    Ensembl ID: ENSG00000197894
  • Gene Symbol: CCNH (ENSG00000134480)
    Fold Change: 1.06
    Ensembl ID: ENSG00000134480
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.01
    Ensembl ID: ENSG00000177556
  • Gene Symbol: BAG1 (ENSG00000107262)
    Fold Change: N/A
    Ensembl ID: ENSG00000107262
Hovered Details

Hover over a box to see details here...

Hovered Details

Hover over a box to see details here...

**Key Characteristics** * **Cell Type:** Vasa recta ascending limb cell * **Function:** Reabsorbs essential nutrients and ions from the filtrate * **Genes:** + ACTB (actin beta) + SLC25A6 (solute carrier family 25 member 6) + B2M (beta-2 microglobulin) * **Pathways/Ontologies:** + Actin cytoskeleton + Adherens junction + Apoptotic process + Disease + Infectious disease + Immune system + Interferon signaling + Iron ion transport **Clinical Significance** The vasa recta ascending limb cell plays a critical role in maintaining renal function and overall health. Dysregulation of this cell's function can lead to various kidney diseases, including: 1. **Chronic Kidney Disease (CKD):** Impaired reabsorption of essential nutrients and ions can lead to CKD, characterized by progressive damage to the kidneys. 2. **Kidney Failure:** Severe impairment of renal function can result in end-stage kidney disease, requiring dialysis or transplantation. 3. **Hypertension:** Abnormal blood pressure regulation can lead to hypertension, increasing the risk of cardiovascular disease and kidney damage. 4. **Metabolic Disorders:** Impaired nutrient and ion reabsorption can contribute to metabolic disorders, such as diabetes and obesity. Understanding the function and regulation of the vasa recta ascending limb cell is essential for developing effective treatments for kidney diseases and maintaining overall health.