EDN1 | ENSG00000078401 | NCBI 1906

Details for: EDN1

Gene ID: 1906

Symbol: EDN1

Ensembl ID: ENSG00000078401

Description: endothelin 1

Associated with

Class a/1 (rhodopsin-like receptors)
(R-HSA-373076)
Developmental biology
(R-HSA-1266738)
G alpha (q) signalling events
(R-HSA-416476)
Gpcr downstream signalling
(R-HSA-388396)
Gpcr ligand binding
(R-HSA-500792)
Mitf-m-regulated melanocyte development
(R-HSA-9730414)
Peptide ligand-binding receptors
(R-HSA-375276)
Signaling by gpcr
(R-HSA-372790)
Signal transduction
(R-HSA-162582)
Transcriptional and post-translational regulation of mitf-m expression and activity
(R-HSA-9856649)
Adenylate cyclase-inhibiting g protein-coupled receptor signaling pathway
(GO:0007193)
Artery smooth muscle contraction
(GO:0014824)
Body fluid secretion
(GO:0007589)
Branching involved in blood vessel morphogenesis
(GO:0001569)
Calcium-mediated signaling
(GO:0019722)
Cardiac neural crest cell migration involved in outflow tract morphogenesis
(GO:0003253)
Cell-cell signaling
(GO:0007267)
Cell surface receptor signaling pathway
(GO:0007166)
Cellular response to human chorionic gonadotropin stimulus
(GO:0044751)
Cytokine activity
(GO:0005125)
Dorsal/ventral pattern formation
(GO:0009953)
Embryonic heart tube development
(GO:0035050)
Endothelin a receptor binding
(GO:0031707)
Endothelin b receptor binding
(GO:0031708)
Epithelial fluid transport
(GO:0042045)
Glomerular filtration
(GO:0003094)
G protein-coupled receptor signaling pathway
(GO:0007186)
Histamine secretion
(GO:0001821)
Hormone activity
(GO:0005179)
Intracellular calcium ion homeostasis
(GO:0006874)
In utero embryonic development
(GO:0001701)
Leukocyte activation
(GO:0045321)
Middle ear morphogenesis
(GO:0042474)
Mitochondrion organization
(GO:0007005)
Negative regulation of blood coagulation
(GO:0030195)
Negative regulation of gene expression
(GO:0010629)
Negative regulation of hormone secretion
(GO:0046888)
Negative regulation of smooth muscle cell apoptotic process
(GO:0034392)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Neural crest cell fate commitment
(GO:0014034)
Neutrophil chemotaxis
(GO:0030593)
Nitric oxide transport
(GO:0030185)
Noradrenergic neuron differentiation
(GO:0003357)
Peptide hormone secretion
(GO:0030072)
Phosphatidylinositol 3-kinase/protein kinase b signal transduction
(GO:0043491)
Phospholipase c-activating g protein-coupled receptor signaling pathway
(GO:0007200)
Phospholipase d-activating g protein-coupled receptor signaling pathway
(GO:0031583)
Positive regulation of canonical nf-kappab signal transduction
(GO:0043123)
Positive regulation of cardiac muscle hypertrophy
(GO:0010613)
Positive regulation of cell migration
(GO:0030335)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of cell size
(GO:0045793)
Positive regulation of cytosolic calcium ion concentration
(GO:0007204)
Positive regulation of endothelial cell migration
(GO:0010595)
Positive regulation of heart rate
(GO:0010460)
Positive regulation of hormone secretion
(GO:0046887)
Positive regulation of jnk cascade
(GO:0046330)
Positive regulation of mapk cascade
(GO:0043410)
Positive regulation of map kinase activity
(GO:0043406)
Positive regulation of mitotic nuclear division
(GO:0045840)
Positive regulation of nitric oxide biosynthetic process
(GO:0045429)
Positive regulation of odontogenesis
(GO:0042482)
Positive regulation of prostaglandin secretion
(GO:0032308)
Positive regulation of renal sodium excretion
(GO:0035815)
Positive regulation of smooth muscle cell proliferation
(GO:0048661)
Positive regulation of smooth muscle contraction
(GO:0045987)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Positive regulation of urine volume
(GO:0035810)
Prostaglandin biosynthetic process
(GO:0001516)
Protein binding
(GO:0005515)
Protein kinase c deactivation
(GO:0042313)
Regulation of d-glucose transmembrane transport
(GO:0010827)
Regulation of ph
(GO:0006885)
Regulation of systemic arterial blood pressure by endothelin
(GO:0003100)
Regulation of vasoconstriction
(GO:0019229)
Respiratory gaseous exchange by respiratory system
(GO:0007585)
Response to activity
(GO:0014823)
Response to amino acid
(GO:0043200)
Response to amphetamine
(GO:0001975)
Response to leptin
(GO:0044321)
Response to lipopolysaccharide
(GO:0032496)
Response to muscle stretch
(GO:0035994)
Response to nicotine
(GO:0035094)
Response to ozone
(GO:0010193)
Response to prostaglandin f
(GO:0034696)
Response to testosterone
(GO:0033574)
Rhythmic excitation
(GO:0043179)
Superoxide anion generation
(GO:0042554)
Thyroid gland development
(GO:0030878)
Transcription by rna polymerase ii
(GO:0006366)
Vasoconstriction
(GO:0042310)
Vein smooth muscle contraction
(GO:0014826)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 58.4285
Cell Significance Index: -14.8200
Cell Name: embryonic stem cell (CL0002322)
Fold Change: 35.9997
Cell Significance Index: -14.8300
Cell Name: ileal goblet cell (CL1000326)
Fold Change: 21.9367
Cell Significance Index: -14.7200
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 11.9956
Cell Significance Index: -14.7900
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 6.3572
Cell Significance Index: -17.0300
Cell Name: stem cell of epidermis (CL1000428)
Fold Change: 4.3813
Cell Significance Index: 13.0300
Cell Name: epithelial cell of pancreas (CL0000083)
Fold Change: 4.0185
Cell Significance Index: 66.2200
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 3.7557
Cell Significance Index: -14.8200
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 2.8201
Cell Significance Index: 49.8400
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 2.7905
Cell Significance Index: 80.4000
Cell Name: paneth cell of colon (CL0009009)
Fold Change: 2.5701
Cell Significance Index: 38.5100
Cell Name: endocardial cell (CL0002350)
Fold Change: 2.5084
Cell Significance Index: 14.8100
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 2.4178
Cell Significance Index: 65.8100
Cell Name: lactocyte (CL0002325)
Fold Change: 2.0301
Cell Significance Index: 262.2800
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 1.6551
Cell Significance Index: 75.0200
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 1.5139
Cell Significance Index: 288.1000
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 1.4969
Cell Significance Index: 32.4300
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 1.3415
Cell Significance Index: 15.2400
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.8588
Cell Significance Index: 44.6100
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.8513
Cell Significance Index: 63.4500
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.8250
Cell Significance Index: 49.5300
Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
Fold Change: 0.8019
Cell Significance Index: 4.9400
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.7149
Cell Significance Index: 15.2300
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.7126
Cell Significance Index: 70.5000
Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: 0.7085
Cell Significance Index: 4.3900
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.6031
Cell Significance Index: 544.5700
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.5749
Cell Significance Index: 62.5400
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.4742
Cell Significance Index: 22.2900
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 0.4573
Cell Significance Index: 52.4000
Cell Name: endothelial cell of uterus (CL0009095)
Fold Change: 0.4025
Cell Significance Index: 2.5200
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.3912
Cell Significance Index: 48.1000
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.3765
Cell Significance Index: 61.2400
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.3276
Cell Significance Index: 178.9000
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.3142
Cell Significance Index: 21.7300
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.3141
Cell Significance Index: 138.8600
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: 0.2880
Cell Significance Index: 1.7400
Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
Fold Change: 0.2874
Cell Significance Index: 1.0000
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 0.2606
Cell Significance Index: 2.4000
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.2485
Cell Significance Index: 3.3900
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.2031
Cell Significance Index: 6.5100
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 0.2000
Cell Significance Index: 3.1000
Cell Name: basal cell of epidermis (CL0002187)
Fold Change: 0.1774
Cell Significance Index: 2.7000
Cell Name: epithelial cell of uterus (CL0002149)
Fold Change: 0.1521
Cell Significance Index: 2.1100
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.1388
Cell Significance Index: 9.8200
Cell Name: peg cell (CL4033014)
Fold Change: 0.0844
Cell Significance Index: 1.9500
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0817
Cell Significance Index: 2.8700
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.0761
Cell Significance Index: 13.7200
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.0731
Cell Significance Index: 3.4100
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.0339
Cell Significance Index: 6.8000
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.0338
Cell Significance Index: 0.3500
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.0336
Cell Significance Index: 0.8400
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.0178
Cell Significance Index: 12.3100
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.0014
Cell Significance Index: 0.2400
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0015
Cell Significance Index: -1.1700
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0069
Cell Significance Index: -12.9000
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0070
Cell Significance Index: -5.2100
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0075
Cell Significance Index: -4.7100
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0092
Cell Significance Index: -6.7200
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0108
Cell Significance Index: -19.9600
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0112
Cell Significance Index: -4.0100
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0132
Cell Significance Index: -20.3300
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0142
Cell Significance Index: -8.9900
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0142
Cell Significance Index: -8.0100
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0151
Cell Significance Index: -20.4800
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0342
Cell Significance Index: -7.2000
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0349
Cell Significance Index: -15.8400
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0378
Cell Significance Index: -5.1900
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0492
Cell Significance Index: -14.1700
Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.0516
Cell Significance Index: -10.2500
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.0559
Cell Significance Index: -6.3800
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.0567
Cell Significance Index: -6.6100
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0775
Cell Significance Index: -11.2700
Cell Name: odontoblast (CL0000060)
Fold Change: -0.0791
Cell Significance Index: -10.1400
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0804
Cell Significance Index: -8.2100
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.0899
Cell Significance Index: -4.5400
Cell Name: mucous neck cell (CL0000651)
Fold Change: -0.1365
Cell Significance Index: -0.6500
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.1401
Cell Significance Index: -14.5900
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.1460
Cell Significance Index: -8.9500
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.1464
Cell Significance Index: -17.2600
Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.1595
Cell Significance Index: -6.5400
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.1801
Cell Significance Index: -14.2600
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.1959
Cell Significance Index: -15.0300
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.2061
Cell Significance Index: -13.8600
Cell Name: stem cell (CL0000034)
Fold Change: -0.2325
Cell Significance Index: -1.6900
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.2515
Cell Significance Index: -15.4600
Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.2528
Cell Significance Index: -16.3100
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.2594
Cell Significance Index: -7.2500
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.2675
Cell Significance Index: -15.0100
Cell Name: enterocyte (CL0000584)
Fold Change: -0.3014
Cell Significance Index: -1.8700
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.3217
Cell Significance Index: -14.2300
Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: -0.3225
Cell Significance Index: -4.8600
Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.3275
Cell Significance Index: -14.2400
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.3309
Cell Significance Index: -17.3800
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.3342
Cell Significance Index: -12.2700
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.3475
Cell Significance Index: -9.3000
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.3517
Cell Significance Index: -11.5200
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.3580
Cell Significance Index: -9.5600
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.3664
Cell Significance Index: -12.8400
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.3768
Cell Significance Index: -14.2700
Cell Name: keratinocyte (CL0000312)
Fold Change: -0.3792
Cell Significance Index: -9.4700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** EDN1 is characterized by its high affinity for endothelin receptors, which are divided into two main subtypes: ETA and ETB. ETA receptors are primarily found in vascular smooth muscle cells and mediate vasoconstriction, while ETB receptors are found in endothelial cells and mediate vasodilation. EDN1 is also known for its ability to induce vasoconstriction, which can lead to increased blood pressure and cardiac workload. Additionally, EDN1 has been shown to have pro-inflammatory and pro-apoptotic effects, particularly in the context of cardiovascular disease. **Pathways and Functions** EDN1 activates a variety of signaling pathways, including: 1. Calcium-mediated signaling: EDN1 binds to ETA receptors on vascular smooth muscle cells, leading to an increase in intracellular calcium concentrations and subsequent contraction. 2. Phospholipase C activation: EDN1 binds to ETB receptors on endothelial cells, leading to the activation of phospholipase C and the production of inositol trisphosphate (IP3) and diacylglycerol (DAG). 3. Mitogen-activated protein kinase (MAPK) signaling: EDN1 activates MAPK pathways, leading to increased cell proliferation and migration. 4. NF-κB signaling: EDN1 activates NF-κB pathways, leading to increased inflammation and oxidative stress. EDN1 has been implicated in a wide range of biological processes, including: 1. Cardiovascular regulation: EDN1 plays a key role in regulating blood pressure and cardiac workload. 2. Smooth muscle contraction: EDN1 induces vasoconstriction in vascular smooth muscle cells. 3. Cell migration: EDN1 promotes cell migration and invasion in various cell types. 4. Inflammation: EDN1 has pro-inflammatory effects, particularly in the context of cardiovascular disease. **Clinical Significance** EDN1 has significant clinical implications, particularly in the context of cardiovascular disease. Elevated levels of EDN1 have been associated with: 1. Hypertension: EDN1 has been shown to contribute to the development of hypertension. 2. Atherosclerosis: EDN1 has been implicated in the development of atherosclerosis. 3. Heart failure: EDN1 has been shown to contribute to the development of heart failure. 4. Cancer: EDN1 has been implicated in the progression of various cancers, including breast and lung cancer. In addition to its role in cardiovascular disease, EDN1 has also been implicated in other diseases, including: 1. Neurological disorders: EDN1 has been implicated in the development of neurological disorders, including Parkinson's disease and Alzheimer's disease. 2. Respiratory diseases: EDN1 has been implicated in the development of respiratory diseases, including chronic obstructive pulmonary disease (COPD). 3. Gastrointestinal diseases: EDN1 has been implicated in the development of gastrointestinal diseases, including inflammatory bowel disease. Overall, EDN1 is a complex peptide that plays a critical role in various physiological and pathological processes. Further research is needed to fully understand the mechanisms by which EDN1 regulates biological processes and to develop therapeutic strategies to target EDN1 in the treatment of various diseases.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Endothelin-1

Genular Protein ID: 2227273900

Symbol: EDN1_HUMAN

Name: Endothelin-1

UniProtKB Accession Codes:

P05305 Q96DA1

Database IDs:

Citations:

PubMed ID: 3282927

Title: Cloning and sequence analysis of cDNA encoding the precursor of a human endothelium-derived vasoconstrictor peptide, endothelin: identity of human and porcine endothelin.

PubMed ID: 3282927

DOI: 10.1016/0014-5793(88)80867-6

PubMed ID: 2670930

Title: The human preproendothelin-1 gene. Complete nucleotide sequence and regulation of expression.

PubMed ID: 2670930

DOI: 10.1016/s0021-9258(18)63795-0

PubMed ID: 2659594

Title: Structural organization and chromosomal assignment of the gene encoding endothelin.

PubMed ID: 2659594

DOI: 10.1016/s0021-9258(18)81698-2

PubMed ID: 8450044

Title: Two preproendothelin 1 mRNAs transcribed by alternative promoters.

PubMed ID: 8450044

DOI: 10.1172/jci116274

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2649896

Title: The human endothelin family: three structurally and pharmacologically distinct isopeptides predicted by three separate genes.

PubMed ID: 2649896

DOI: 10.1073/pnas.86.8.2863

PubMed ID: 10438732

Title: Proteolytic processing of big endothelin-3 by the kell blood group protein.

PubMed ID: 10438732

PubMed ID: 1864385

Title: The signal peptide of human preproendothelin-1.

PubMed ID: 1864385

DOI: 10.1016/0014-5793(91)80948-3

PubMed ID: 9284755

Title: Endothelin-1 and ETA receptor expression in vascular smooth muscle cells from human placenta: a new ETA receptor messenger ribonucleic acid is generated by alternative splicing of exon 3.

PubMed ID: 9284755

DOI: 10.1210/jcem.82.9.4209

PubMed ID: 17446437

Title: Association of ATP1A1 and dear single-nucleotide polymorphism haplotypes with essential hypertension: sex-specific and haplotype-specific effects.

PubMed ID: 17446437

DOI: 10.1161/01.res.0000267716.96196.60

PubMed ID: 17357073

Title: Genetic analysis of 103 candidate genes for coronary artery disease and associated phenotypes in a founder population reveals a new association between endothelin-1 and high-density lipoprotein cholesterol.

PubMed ID: 17357073

DOI: 10.1086/513286

PubMed ID: 18288492

Title: Investigating the association between K198N coding polymorphism in EDN1 and hypertension, lipoprotein levels, the metabolic syndrome and cardiovascular disease.

PubMed ID: 18288492

DOI: 10.1007/s00439-008-0481-0

PubMed ID: 19086031

Title: Pyk2 mediates endothelin-1 signaling via p130Cas/BCAR3 cascade and regulates human glomerular mesangial cell adhesion and spreading.

PubMed ID: 19086031

DOI: 10.1002/jcp.21649

PubMed ID: 1515112

Title: Crystallization and preliminary X-ray analysis of human endothelin.

PubMed ID: 1515112

DOI: 10.1107/s0108768191010625

PubMed ID: 7664037

Title: The crystal structure of human endothelin.

PubMed ID: 7664037

DOI: 10.1038/nsb0594-311

PubMed ID: 1859417

Title: The conformation of endothelin-1 in aqueous solution: NMR-derived constraints combined with distance geometry and molecular dynamics calculations.

PubMed ID: 1859417

DOI: 10.1016/0006-291x(91)90146-x

PubMed ID: 1736987

Title: Conformational isomerism of endothelin in acidic aqueous media: a quantitative NOESY analysis.

PubMed ID: 1736987

DOI: 10.1021/bi00120a003

PubMed ID: 1422154

Title: Solution conformation of human big endothelin-1.

PubMed ID: 1422154

DOI: 10.1007/bf02192805

PubMed ID: 7773179

Title: A comparison of X-ray and NMR structures for human endothelin-1.

PubMed ID: 7773179

DOI: 10.1002/pro.5560040110

PubMed ID: 10231710

Title: Solution structure of a novel ETB receptor selective agonist ET1-21 [Cys(Acm)1,15, Aib3,11, Leu7] by nuclear magnetic resonance spectroscopy and molecular modelling.

PubMed ID: 10231710

DOI: 10.1034/j.1399-3011.1999.00001.x

PubMed ID: 10334806

Title: The Lys198Asn polymorphism in the endothelin-1 gene is associated with blood pressure in overweight people.

PubMed ID: 10334806

DOI: 10.1161/01.hyp.33.5.1169

PubMed ID: 10391210

Title: Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis.

PubMed ID: 10391210

DOI: 10.1038/10297

PubMed ID: 24268655

Title: Mutations in endothelin 1 cause recessive auriculocondylar syndrome and dominant isolated question-mark ears.

PubMed ID: 24268655

DOI: 10.1016/j.ajhg.2013.10.023

Sequence Information:

Length: 212
Mass: 24425
Checksum: E2DA0EB86755BC3D
Sequence:

MDYLLMIFSL LFVACQGAPE TAVLGAELSA VGENGGEKPT PSPPWRLRRS KRCSCSSLMD 
KECVYFCHLD IIWVNTPEHV VPYGLGSPRS KRALENLLPT KATDRENRCQ CASQKDKKCW 
NFCQAGKELR AEDIMEKDWN NHKKGKDCSK LGKKCIYQQL VRGRKIRRSS EEHLRQTRSE 
TMRNSVKSSF HDPKLKGKPS RERYVTHNRA HW

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: EDN1

Associated with

Cells (max top 100)

Other Information

Cloning and sequence analysis of cDNA encoding the precursor of a human endothelium-derived vasoconstrictor peptide, endothelin: identity of human and porcine endothelin. PubMed ID: 3282927

The human preproendothelin-1 gene. Complete nucleotide sequence and regulation of expression. PubMed ID: 2670930

Structural organization and chromosomal assignment of the gene encoding endothelin. PubMed ID: 2659594

Two preproendothelin 1 mRNAs transcribed by alternative promoters. PubMed ID: 8450044

The DNA sequence and analysis of human chromosome 6. PubMed ID: 14574404

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The human endothelin family: three structurally and pharmacologically distinct isopeptides predicted by three separate genes. PubMed ID: 2649896

Proteolytic processing of big endothelin-3 by the kell blood group protein. PubMed ID: 10438732

The signal peptide of human preproendothelin-1. PubMed ID: 1864385

Endothelin-1 and ETA receptor expression in vascular smooth muscle cells from human placenta: a new ETA receptor messenger ribonucleic acid is generated by alternative splicing of exon 3. PubMed ID: 9284755

Association of ATP1A1 and dear single-nucleotide polymorphism haplotypes with essential hypertension: sex-specific and haplotype-specific effects. PubMed ID: 17446437

Genetic analysis of 103 candidate genes for coronary artery disease and associated phenotypes in a founder population reveals a new association between endothelin-1 and high-density lipoprotein cholesterol. PubMed ID: 17357073

Investigating the association between K198N coding polymorphism in EDN1 and hypertension, lipoprotein levels, the metabolic syndrome and cardiovascular disease. PubMed ID: 18288492

Pyk2 mediates endothelin-1 signaling via p130Cas/BCAR3 cascade and regulates human glomerular mesangial cell adhesion and spreading. PubMed ID: 19086031

Crystallization and preliminary X-ray analysis of human endothelin. PubMed ID: 1515112

The crystal structure of human endothelin. PubMed ID: 7664037

The conformation of endothelin-1 in aqueous solution: NMR-derived constraints combined with distance geometry and molecular dynamics calculations. PubMed ID: 1859417

Conformational isomerism of endothelin in acidic aqueous media: a quantitative NOESY analysis. PubMed ID: 1736987

Solution conformation of human big endothelin-1. PubMed ID: 1422154

A comparison of X-ray and NMR structures for human endothelin-1. PubMed ID: 7773179

Solution structure of a novel ETB receptor selective agonist ET1-21 [Cys(Acm)1,15, Aib3,11, Leu7] by nuclear magnetic resonance spectroscopy and molecular modelling. PubMed ID: 10231710

The Lys198Asn polymorphism in the endothelin-1 gene is associated with blood pressure in overweight people. PubMed ID: 10334806

Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis. PubMed ID: 10391210

Mutations in endothelin 1 cause recessive auriculocondylar syndrome and dominant isolated question-mark ears. PubMed ID: 24268655