Gene EDN1 - ENSG00000078401 | NCBI Gene ID: 1906

Details for: EDN1

Gene ID: 1906

Symbol: EDN1

Ensembl ID: ENSG00000078401

Description: endothelin 1

Associated with

Class a/1 (rhodopsin-like receptors)
(R-HSA-373076)
G alpha (q) signalling events
(R-HSA-416476)
Gpcr downstream signalling
(R-HSA-388396)
Gpcr ligand binding
(R-HSA-500792)
Peptide ligand-binding receptors
(R-HSA-375276)
Signaling by gpcr
(R-HSA-372790)
Signal transduction
(R-HSA-162582)
Adenylate cyclase-inhibiting g protein-coupled receptor signaling pathway
(GO:0007193)
Artery smooth muscle contraction
(GO:0014824)
Axon extension
(GO:0048675)
Body fluid secretion
(GO:0007589)
Branching involved in blood vessel morphogenesis
(GO:0001569)
Calcium-mediated signaling
(GO:0019722)
Cardiac neural crest cell migration involved in outflow tract morphogenesis
(GO:0003253)
Cell-cell signaling
(GO:0007267)
Cell surface receptor signaling pathway
(GO:0007166)
Cellular response to human chorionic gonadotropin stimulus
(GO:0044751)
Cytokine activity
(GO:0005125)
Dorsal/ventral pattern formation
(GO:0009953)
Embryonic heart tube development
(GO:0035050)
Endothelin a receptor binding
(GO:0031707)
Endothelin b receptor binding
(GO:0031708)
Epithelial fluid transport
(GO:0042045)
Glomerular filtration
(GO:0003094)
G protein-coupled receptor signaling pathway
(GO:0007186)
Histamine secretion
(GO:0001821)
Hormone activity
(GO:0005179)
Intracellular calcium ion homeostasis
(GO:0006874)
In utero embryonic development
(GO:0001701)
Leukocyte activation
(GO:0045321)
Middle ear morphogenesis
(GO:0042474)
Mitochondrion organization
(GO:0007005)
Negative regulation of blood coagulation
(GO:0030195)
Negative regulation of gene expression
(GO:0010629)
Negative regulation of hormone secretion
(GO:0046888)
Negative regulation of smooth muscle cell apoptotic process
(GO:0034392)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Neural crest cell fate commitment
(GO:0014034)
Neutrophil chemotaxis
(GO:0030593)
Nitric oxide transport
(GO:0030185)
Noradrenergic neuron differentiation
(GO:0003357)
Peptide hormone secretion
(GO:0030072)
Phosphatidylinositol 3-kinase/protein kinase b signal transduction
(GO:0043491)
Phospholipase c-activating g protein-coupled receptor signaling pathway
(GO:0007200)
Phospholipase d-activating g protein-coupled receptor signaling pathway
(GO:0031583)
Positive regulation of calcium-mediated signaling
(GO:0050850)
Positive regulation of canonical nf-kappab signal transduction
(GO:0043123)
Positive regulation of cardiac muscle hypertrophy
(GO:0010613)
Positive regulation of cell migration
(GO:0030335)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of cell size
(GO:0045793)
Positive regulation of cytosolic calcium ion concentration
(GO:0007204)
Positive regulation of endothelial cell migration
(GO:0010595)
Positive regulation of heart rate
(GO:0010460)
Positive regulation of hormone secretion
(GO:0046887)
Positive regulation of jun kinase activity
(GO:0043507)
Positive regulation of map kinase activity
(GO:0043406)
Positive regulation of mitotic nuclear division
(GO:0045840)
Positive regulation of nitric oxide biosynthetic process
(GO:0045429)
Positive regulation of odontogenesis
(GO:0042482)
Positive regulation of prostaglandin secretion
(GO:0032308)
Positive regulation of renal sodium excretion
(GO:0035815)
Positive regulation of smooth muscle cell proliferation
(GO:0048661)
Positive regulation of smooth muscle contraction
(GO:0045987)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Positive regulation of urine volume
(GO:0035810)
Prostaglandin biosynthetic process
(GO:0001516)
Protein binding
(GO:0005515)
Protein kinase a signaling
(GO:0010737)
Protein kinase c-activating g protein-coupled receptor signaling pathway
(GO:0007205)
Protein kinase c deactivation
(GO:0042313)
Regulation of glucose transmembrane transport
(GO:0010827)
Regulation of ph
(GO:0006885)
Regulation of systemic arterial blood pressure by endothelin
(GO:0003100)
Regulation of vasoconstriction
(GO:0019229)
Respiratory gaseous exchange by respiratory system
(GO:0007585)
Response to activity
(GO:0014823)
Response to amino acid
(GO:0043200)
Response to amphetamine
(GO:0001975)
Response to leptin
(GO:0044321)
Response to lipopolysaccharide
(GO:0032496)
Response to muscle stretch
(GO:0035994)
Response to nicotine
(GO:0035094)
Response to ozone
(GO:0010193)
Response to prostaglandin f
(GO:0034696)
Response to testosterone
(GO:0033574)
Rhythmic excitation
(GO:0043179)
Superoxide anion generation
(GO:0042554)
Thyroid gland development
(GO:0030878)
Transcription by rna polymerase ii
(GO:0006366)
Vasoconstriction
(GO:0042310)
Vein smooth muscle contraction
(GO:0014826)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
Fold Change: 3.05
Marker Score: 7746
Cell Name: pulmonary artery endothelial cell (CL1001568)
Fold Change: 2.44
Marker Score: 2097
Cell Name: glandular epithelial cell (CL0000150)
Fold Change: 2.07
Marker Score: 5078
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 2.03
Marker Score: 4950.5
Cell Name: endothelial cell of vascular tree (CL0002139)
Fold Change: 1.77
Marker Score: 2579
Cell Name: endothelial cell of uterus (CL0009095)
Fold Change: 1.56
Marker Score: 3106
Cell Name: type I pneumocyte (CL0002062)
Fold Change: 1.49
Marker Score: 1796
Cell Name: mucous neck cell (CL0000651)
Fold Change: 1.3
Marker Score: 2950
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 1.27
Marker Score: 1270
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 1.27
Marker Score: 2575
Cell Name: endocardial cell (CL0002350)
Fold Change: 1.27
Marker Score: 715
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 1.25
Marker Score: 744
Cell Name: stem cell of epidermis (CL1000428)
Fold Change: 1.22
Marker Score: 413
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 1.2
Marker Score: 1249
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 1.13
Marker Score: 2576
Cell Name: stem cell (CL0000034)
Fold Change: 1.1
Marker Score: 2616
Cell Name: mammary gland epithelial cell (CL0002327)
Fold Change: 1.1
Marker Score: 390
Cell Name: enterocyte (CL0000584)
Fold Change: 1.03
Marker Score: 4942
Cell Name: eukaryotic cell (CL0000255)
Fold Change: 1.02
Marker Score: 524
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71802
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48027
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30407
Cell Name: epithelial fate stem cell (CL0000036)
Fold Change: 0.98
Marker Score: 281
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.98
Marker Score: 503
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.97
Marker Score: 457
Cell Name: blood vessel endothelial cell (CL0000071)
Fold Change: 0.95
Marker Score: 961
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2411
Cell Name: colon epithelial cell (CL0011108)
Fold Change: 0.94
Marker Score: 2952
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.92
Marker Score: 2741
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.91
Marker Score: 1482
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 0.9
Marker Score: 1526
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.9
Marker Score: 322
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.89
Marker Score: 5082
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.88
Marker Score: 13833
Cell Name: peritubular capillary endothelial cell (CL1001033)
Fold Change: 0.88
Marker Score: 205
Cell Name: duct epithelial cell (CL0000068)
Fold Change: 0.87
Marker Score: 407.5
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5277
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.85
Marker Score: 3260
Cell Name: capillary endothelial cell (CL0002144)
Fold Change: 0.84
Marker Score: 905
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.82
Marker Score: 623
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.8
Marker Score: 541
Cell Name: endothelial cell of sinusoid (CL0002262)
Fold Change: 0.79
Marker Score: 191
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.77
Marker Score: 310
Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: 0.77
Marker Score: 607
Cell Name: enterocyte of colon (CL1000347)
Fold Change: 0.76
Marker Score: 1176
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.76
Marker Score: 803
Cell Name: type EC enteroendocrine cell (CL0000577)
Fold Change: 0.76
Marker Score: 717
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.76
Marker Score: 392
Cell Name: glandular cell of esophagus (CL0002657)
Fold Change: 0.74
Marker Score: 233
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.73
Marker Score: 469
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.73
Marker Score: 181.5
Cell Name: brush cell (CL0002204)
Fold Change: 0.72
Marker Score: 661
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 0.72
Marker Score: 1691
Cell Name: epithelial cell of alveolus of lung (CL0010003)
Fold Change: 0.72
Marker Score: 322
Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
Fold Change: 0.7
Marker Score: 153
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.69
Marker Score: 176
Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: 0.68
Marker Score: 395
Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
Fold Change: 0.68
Marker Score: 979
Cell Name: endothelial cell (CL0000115)
Fold Change: 0.67
Marker Score: 604.5
Cell Name: intestinal crypt stem cell (CL0002250)
Fold Change: 0.66
Marker Score: 249
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.65
Marker Score: 958
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.65
Marker Score: 388
Cell Name: epithelial cell (CL0000066)
Fold Change: 0.63
Marker Score: 997
Cell Name: myoepithelial cell of mammary gland (CL0002324)
Fold Change: 0.62
Marker Score: 3030
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.62
Marker Score: 2587
Cell Name: lung microvascular endothelial cell (CL2000016)
Fold Change: 0.58
Marker Score: 124
Cell Name: retinal blood vessel endothelial cell (CL0002585)
Fold Change: 0.57
Marker Score: 138
Cell Name: paneth cell of colon (CL0009009)
Fold Change: 0.57
Marker Score: 164
Cell Name: basal cell (CL0000646)
Fold Change: 0.57
Marker Score: 730
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.56
Marker Score: 447
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.55
Marker Score: 146
Cell Name: mucus secreting cell (CL0000319)
Fold Change: 0.55
Marker Score: 139
Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.54
Marker Score: 258
Cell Name: vein endothelial cell (CL0002543)
Fold Change: 0.5
Marker Score: 456
Cell Name: epithelial cell of lung (CL0000082)
Fold Change: 0.5
Marker Score: 2641
Cell Name: luminal epithelial cell of mammary gland (CL0002326)
Fold Change: 0.5
Marker Score: 881
Cell Name: epithelial cell of uterus (CL0002149)
Fold Change: 0.48
Marker Score: 111
Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
Fold Change: 0.48
Marker Score: 144
Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 0.46
Marker Score: 143
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.45
Marker Score: 186
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.43
Marker Score: 14957
Cell Name: kidney loop of Henle epithelial cell (CL1000909)
Fold Change: 0.43
Marker Score: 270
Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: 0.42
Marker Score: 688
Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: 0.41
Marker Score: 2629
Cell Name: secretory cell (CL0000151)
Fold Change: 0.41
Marker Score: 749
Cell Name: endothelial cell of artery (CL1000413)
Fold Change: 0.41
Marker Score: 170
Cell Name: pro-B cell (CL0000826)
Fold Change: 0.4
Marker Score: 387
Cell Name: eurydendroid cell (CL0000253)
Fold Change: 0.4
Marker Score: 162
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 0.39
Marker Score: 250
Cell Name: vasa recta descending limb cell (CL1001285)
Fold Change: 0.39
Marker Score: 108
Cell Name: club cell (CL0000158)
Fold Change: 0.36
Marker Score: 421
Cell Name: respiratory epithelial cell (CL0002368)
Fold Change: 0.36
Marker Score: 196
Cell Name: kidney collecting duct principal cell (CL1001431)
Fold Change: 0.35
Marker Score: 885
Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
Fold Change: 0.35
Marker Score: 96
Cell Name: lactocyte (CL0002325)
Fold Change: 0.35
Marker Score: 5590
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 0.35
Marker Score: 2978.5
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.34
Marker Score: 143
Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
Fold Change: 0.34
Marker Score: 363.5
Cell Name: paneth cell (CL0000510)
Fold Change: 0.33
Marker Score: 232
Cell Name: M cell of gut (CL0000682)
Fold Change: 0.33
Marker Score: 85

Hover over a box to see details here...

**Key characteristics:** - EDN1 is a secreted protein that is expressed in various cell types, including endothelial cells, fibroblasts, and immune cells. - It is a glycoprotein with a molecular weight of approximately 140 kDa. - EDN1 is a key regulator of blood vessel morphogenesis and function. **Pathways and functions:** - EDN1 is involved in several important pathways, including: - Branching involved in blood vessel morphogenesis. - Regulation of endothelial cell migration and adhesion. - Activation of various signaling pathways, including those involving GPCRs and G proteins. - Regulation of angiogenesis and vasodilation. **Clinical significance:** - Mutations in the EDN1 gene have been linked to several human diseases, including: - Pulmonary hypertension and heart failure. - Diabetes. - Cancer. **Additional notes:** - EDN1 is a highly conserved protein, with a similar gene found in humans, mice, and rats. - It is a well-known target for therapeutic interventions in vascular diseases. - Further research is needed to fully understand the role of EDN1 in human health and disease.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Endothelin-1

Genular Protein ID: 2227273900

Symbol: EDN1_HUMAN

Name: Endothelin-1

UniProtKB Accession Codes:

P05305 Q96DA1

Database IDs:

Citations:

PubMed ID: 3282927

Title: Cloning and sequence analysis of cDNA encoding the precursor of a human endothelium-derived vasoconstrictor peptide, endothelin: identity of human and porcine endothelin.

PubMed ID: 3282927

DOI: 10.1016/0014-5793(88)80867-6

PubMed ID: 2670930

Title: The human preproendothelin-1 gene. Complete nucleotide sequence and regulation of expression.

PubMed ID: 2670930

DOI: 10.1016/s0021-9258(18)63795-0

PubMed ID: 2659594

Title: Structural organization and chromosomal assignment of the gene encoding endothelin.

PubMed ID: 2659594

DOI: 10.1016/s0021-9258(18)81698-2

PubMed ID: 8450044

Title: Two preproendothelin 1 mRNAs transcribed by alternative promoters.

PubMed ID: 8450044

DOI: 10.1172/jci116274

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2649896

Title: The human endothelin family: three structurally and pharmacologically distinct isopeptides predicted by three separate genes.

PubMed ID: 2649896

DOI: 10.1073/pnas.86.8.2863

PubMed ID: 10438732

Title: Proteolytic processing of big endothelin-3 by the kell blood group protein.

PubMed ID: 10438732

PubMed ID: 1864385

Title: The signal peptide of human preproendothelin-1.

PubMed ID: 1864385

DOI: 10.1016/0014-5793(91)80948-3

PubMed ID: 9284755

Title: Endothelin-1 and ETA receptor expression in vascular smooth muscle cells from human placenta: a new ETA receptor messenger ribonucleic acid is generated by alternative splicing of exon 3.

PubMed ID: 9284755

DOI: 10.1210/jcem.82.9.4209

PubMed ID: 17446437

Title: Association of ATP1A1 and dear single-nucleotide polymorphism haplotypes with essential hypertension: sex-specific and haplotype-specific effects.

PubMed ID: 17446437

DOI: 10.1161/01.res.0000267716.96196.60

PubMed ID: 17357073

Title: Genetic analysis of 103 candidate genes for coronary artery disease and associated phenotypes in a founder population reveals a new association between endothelin-1 and high-density lipoprotein cholesterol.

PubMed ID: 17357073

DOI: 10.1086/513286

PubMed ID: 18288492

Title: Investigating the association between K198N coding polymorphism in EDN1 and hypertension, lipoprotein levels, the metabolic syndrome and cardiovascular disease.

PubMed ID: 18288492

DOI: 10.1007/s00439-008-0481-0

PubMed ID: 19086031

Title: Pyk2 mediates endothelin-1 signaling via p130Cas/BCAR3 cascade and regulates human glomerular mesangial cell adhesion and spreading.

PubMed ID: 19086031

DOI: 10.1002/jcp.21649

PubMed ID: 1515112

Title: Crystallization and preliminary X-ray analysis of human endothelin.

PubMed ID: 1515112

DOI: 10.1107/s0108768191010625

PubMed ID: 7664037

Title: The crystal structure of human endothelin.

PubMed ID: 7664037

DOI: 10.1038/nsb0594-311

PubMed ID: 1859417

Title: The conformation of endothelin-1 in aqueous solution: NMR-derived constraints combined with distance geometry and molecular dynamics calculations.

PubMed ID: 1859417

DOI: 10.1016/0006-291x(91)90146-x

PubMed ID: 1736987

Title: Conformational isomerism of endothelin in acidic aqueous media: a quantitative NOESY analysis.

PubMed ID: 1736987

DOI: 10.1021/bi00120a003

PubMed ID: 1422154

Title: Solution conformation of human big endothelin-1.

PubMed ID: 1422154

DOI: 10.1007/bf02192805

PubMed ID: 7773179

Title: A comparison of X-ray and NMR structures for human endothelin-1.

PubMed ID: 7773179

DOI: 10.1002/pro.5560040110

PubMed ID: 10231710

Title: Solution structure of a novel ETB receptor selective agonist ET1-21 [Cys(Acm)1,15, Aib3,11, Leu7] by nuclear magnetic resonance spectroscopy and molecular modelling.

PubMed ID: 10231710

DOI: 10.1034/j.1399-3011.1999.00001.x

PubMed ID: 10334806

Title: The Lys198Asn polymorphism in the endothelin-1 gene is associated with blood pressure in overweight people.

PubMed ID: 10334806

DOI: 10.1161/01.hyp.33.5.1169

PubMed ID: 10391210

Title: Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis.

PubMed ID: 10391210

DOI: 10.1038/10297

PubMed ID: 24268655

Title: Mutations in endothelin 1 cause recessive auriculocondylar syndrome and dominant isolated question-mark ears.

PubMed ID: 24268655

DOI: 10.1016/j.ajhg.2013.10.023

Sequence Information:

Length: 212
Mass: 24425
Checksum: E2DA0EB86755BC3D
Sequence:

MDYLLMIFSL LFVACQGAPE TAVLGAELSA VGENGGEKPT PSPPWRLRRS KRCSCSSLMD 
KECVYFCHLD IIWVNTPEHV VPYGLGSPRS KRALENLLPT KATDRENRCQ CASQKDKKCW 
NFCQAGKELR AEDIMEKDWN NHKKGKDCSK LGKKCIYQQL VRGRKIRRSS EEHLRQTRSE 
TMRNSVKSSF HDPKLKGKPS RERYVTHNRA HW

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: EDN1

Associated with

Cells (max top 100)

Other Information

Cloning and sequence analysis of cDNA encoding the precursor of a human endothelium-derived vasoconstrictor peptide, endothelin: identity of human and porcine endothelin. PubMed ID: 3282927

The human preproendothelin-1 gene. Complete nucleotide sequence and regulation of expression. PubMed ID: 2670930

Structural organization and chromosomal assignment of the gene encoding endothelin. PubMed ID: 2659594

Two preproendothelin 1 mRNAs transcribed by alternative promoters. PubMed ID: 8450044

The DNA sequence and analysis of human chromosome 6. PubMed ID: 14574404

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The human endothelin family: three structurally and pharmacologically distinct isopeptides predicted by three separate genes. PubMed ID: 2649896

Proteolytic processing of big endothelin-3 by the kell blood group protein. PubMed ID: 10438732

The signal peptide of human preproendothelin-1. PubMed ID: 1864385

Endothelin-1 and ETA receptor expression in vascular smooth muscle cells from human placenta: a new ETA receptor messenger ribonucleic acid is generated by alternative splicing of exon 3. PubMed ID: 9284755

Association of ATP1A1 and dear single-nucleotide polymorphism haplotypes with essential hypertension: sex-specific and haplotype-specific effects. PubMed ID: 17446437

Genetic analysis of 103 candidate genes for coronary artery disease and associated phenotypes in a founder population reveals a new association between endothelin-1 and high-density lipoprotein cholesterol. PubMed ID: 17357073

Investigating the association between K198N coding polymorphism in EDN1 and hypertension, lipoprotein levels, the metabolic syndrome and cardiovascular disease. PubMed ID: 18288492

Pyk2 mediates endothelin-1 signaling via p130Cas/BCAR3 cascade and regulates human glomerular mesangial cell adhesion and spreading. PubMed ID: 19086031

Crystallization and preliminary X-ray analysis of human endothelin. PubMed ID: 1515112

The crystal structure of human endothelin. PubMed ID: 7664037

The conformation of endothelin-1 in aqueous solution: NMR-derived constraints combined with distance geometry and molecular dynamics calculations. PubMed ID: 1859417

Conformational isomerism of endothelin in acidic aqueous media: a quantitative NOESY analysis. PubMed ID: 1736987

Solution conformation of human big endothelin-1. PubMed ID: 1422154

A comparison of X-ray and NMR structures for human endothelin-1. PubMed ID: 7773179

Solution structure of a novel ETB receptor selective agonist ET1-21 [Cys(Acm)1,15, Aib3,11, Leu7] by nuclear magnetic resonance spectroscopy and molecular modelling. PubMed ID: 10231710

The Lys198Asn polymorphism in the endothelin-1 gene is associated with blood pressure in overweight people. PubMed ID: 10334806

Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis. PubMed ID: 10391210

Mutations in endothelin 1 cause recessive auriculocondylar syndrome and dominant isolated question-mark ears. PubMed ID: 24268655