Details for: ATP6

Gene ID: 4508

Symbol: ATP6

Ensembl ID: ENSG00000198899

Description: ATP synthase F0 subunit 6

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 2.27
    Cell Significance Index: 2
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.13
    Cell Significance Index: 2
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 2.04
    Cell Significance Index: 2
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.67
    Cell Significance Index: 2
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.66
    Cell Significance Index: 2
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.59
    Cell Significance Index: 2
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.54
    Cell Significance Index: 2
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 1.43
    Cell Significance Index: 1
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.43
    Cell Significance Index: 2
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.35
    Cell Significance Index: 1
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.34
    Cell Significance Index: 1
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.33
    Cell Significance Index: 1
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: 1.29
    Cell Significance Index: 1
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 1.28
    Cell Significance Index: 1
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.27
    Cell Significance Index: 1
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.26
    Cell Significance Index: 1
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 1.18
    Cell Significance Index: 1
  • Cell Name: liver dendritic cell (CL2000055)
    Fold Change: 1.18
    Cell Significance Index: 1
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 1.16
    Cell Significance Index: 1
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.15
    Cell Significance Index: 1
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.15
    Cell Significance Index: 1
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.14
    Cell Significance Index: 1
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.12
    Cell Significance Index: 1
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.12
    Cell Significance Index: 1
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.08
    Cell Significance Index: 1
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.08
    Cell Significance Index: 1
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.08
    Cell Significance Index: 1
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 1.08
    Cell Significance Index: 1
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.08
    Cell Significance Index: 1
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 1.07
    Cell Significance Index: 1
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.06
    Cell Significance Index: 1
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.05
    Cell Significance Index: 1
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 1.05
    Cell Significance Index: 1
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.05
    Cell Significance Index: 1
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 1.04
    Cell Significance Index: 1
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: 1.03
    Cell Significance Index: 1
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 1.03
    Cell Significance Index: 1
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.03
    Cell Significance Index: 1
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.02
    Cell Significance Index: 1
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.01
    Cell Significance Index: 1
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.01
    Cell Significance Index: 1
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1
    Cell Significance Index: 1
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: 0.97
    Cell Significance Index: 1
  • Cell Name: cell (CL0000000)
    Fold Change: 0.97
    Cell Significance Index: 1
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.97
    Cell Significance Index: 1
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.97
    Cell Significance Index: 1
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.96
    Cell Significance Index: 1
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.95
    Cell Significance Index: 1
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.95
    Cell Significance Index: 1
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.94
    Cell Significance Index: 1
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.93
    Cell Significance Index: 1
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 0.93
    Cell Significance Index: 1
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.93
    Cell Significance Index: 1
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 0.92
    Cell Significance Index: 1
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.92
    Cell Significance Index: 1
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.92
    Cell Significance Index: 1
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.92
    Cell Significance Index: 1
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.91
    Cell Significance Index: 1
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.91
    Cell Significance Index: 1
  • Cell Name: glioblast (CL0000030)
    Fold Change: 0.91
    Cell Significance Index: 1
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.91
    Cell Significance Index: 1
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.91
    Cell Significance Index: 1
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: 0.91
    Cell Significance Index: 1
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.9
    Cell Significance Index: 1
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.9
    Cell Significance Index: 1
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.9
    Cell Significance Index: 1
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 0.9
    Cell Significance Index: 1
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 0.9
    Cell Significance Index: 1
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.9
    Cell Significance Index: 1
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.9
    Cell Significance Index: 1
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: 0.9
    Cell Significance Index: 1
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 0.9
    Cell Significance Index: 1
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 0.9
    Cell Significance Index: 1
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.9
    Cell Significance Index: 1
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.9
    Cell Significance Index: 1
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 0.9
    Cell Significance Index: 1
  • Cell Name: salivary gland glandular cell (CL1001596)
    Fold Change: 0.89
    Cell Significance Index: 1
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.89
    Cell Significance Index: 1
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.89
    Cell Significance Index: 1
  • Cell Name: megakaryocyte progenitor cell (CL0000553)
    Fold Change: 0.89
    Cell Significance Index: 1
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.89
    Cell Significance Index: 1
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.89
    Cell Significance Index: 1
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.89
    Cell Significance Index: 1
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.89
    Cell Significance Index: 1
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 0.88
    Cell Significance Index: 1
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.88
    Cell Significance Index: 1
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 0.88
    Cell Significance Index: 1
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 0.88
    Cell Significance Index: 1
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.88
    Cell Significance Index: 1
  • Cell Name: embryonic fibroblast (CL2000042)
    Fold Change: 0.88
    Cell Significance Index: 1
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.88
    Cell Significance Index: 1
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.88
    Cell Significance Index: 1
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.88
    Cell Significance Index: 1
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.88
    Cell Significance Index: 1
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.88
    Cell Significance Index: 1
  • Cell Name: Merkel cell (CL0000242)
    Fold Change: 0.87
    Cell Significance Index: 1

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Subunit of ATP synthase complex**: The ATP6 gene encodes for a subunit of the ATP synthase complex, which is a crucial component in the generation of ATP through chemiosmotic coupling. 2. **Mitochondrial localization**: The ATP6 gene is specifically localized to the mitochondrial inner membrane, where it plays a key role in the functioning of the mitochondria. 3. **High expression levels**: The ATP6 gene is highly expressed in various cell types, including skeletal muscle satellite cells, microglial cells, and pancreatic ductal cells, indicating its importance in maintaining cellular homeostasis. 4. **Conserved across species**: The ATP6 gene is conserved across species, suggesting its evolutionary importance in maintaining mitochondrial function. **Pathways and Functions:** The ATP6 gene is involved in several key pathways, including: 1. **Cristae formation**: The ATP6 gene plays a role in the formation of cristae, the infoldings of the mitochondrial inner membrane that increase the surface area for ATP production. 2. **Chemiosmotic coupling**: The ATP6 gene is essential for the functioning of the chemiosmotic coupling process, where protons flow through the mitochondrial inner membrane, generating a proton motive force that drives ATP synthesis. 3. **Mitochondrial biogenesis**: The ATP6 gene is involved in the regulation of mitochondrial biogenesis, ensuring that the mitochondria are properly formed and functional. 4. **Proton transport**: The ATP6 gene is responsible for the transport of protons across the mitochondrial inner membrane, which is crucial for generating the proton motive force necessary for ATP synthesis. **Clinical Significance:** Dysregulation of the ATP6 gene has been implicated in various diseases, including: 1. **Mitochondrial disorders**: Mutations in the ATP6 gene can lead to mitochondrial disorders, such as MELAS syndrome, which is characterized by a range of symptoms including muscle weakness, seizures, and developmental delays. 2. **Neurodegenerative diseases**: The ATP6 gene has been implicated in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, where mitochondrial dysfunction is a key feature. 3. **Cancer**: The ATP6 gene has been shown to be overexpressed in certain types of cancer, including breast cancer and lung cancer, suggesting its potential role in tumorigenesis. In conclusion, the ATP6 gene plays a critical role in maintaining mitochondrial function and cellular metabolism. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the molecular mechanisms underlying mitochondrial function and the development of therapeutic strategies to target the ATP6 gene.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.