Details for: ATP6
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 875.6199
Cell Significance Index: -413.4000 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 853.0863
Cell Significance Index: -438.8200 - Cell Name: ileal goblet cell (CL1000326)
Fold Change: 618.4297
Cell Significance Index: -414.9800 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 112.6748
Cell Significance Index: -301.8400 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: 65.3309
Cell Significance Index: 5174.2100 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: 52.8711
Cell Significance Index: 1940.8600 - Cell Name: glandular epithelial cell (CL0000150)
Fold Change: 51.3970
Cell Significance Index: 408.9400 - Cell Name: Sertoli cell (CL0000216)
Fold Change: 48.0178
Cell Significance Index: 673.5200 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 43.7288
Cell Significance Index: 32061.8100 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: 43.0759
Cell Significance Index: 635.8000 - Cell Name: abnormal cell (CL0001061)
Fold Change: 15.1981
Cell Significance Index: 1552.4900 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: 14.7323
Cell Significance Index: 773.5000 - Cell Name: seromucus secreting cell (CL0000159)
Fold Change: 13.2328
Cell Significance Index: 275.9800 - Cell Name: cell in vitro (CL0001034)
Fold Change: 11.4699
Cell Significance Index: 6263.9700 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 11.4631
Cell Significance Index: 105.5600 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 11.3001
Cell Significance Index: 307.5800 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 10.8814
Cell Significance Index: 291.0700 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 10.7570
Cell Significance Index: 487.5800 - Cell Name: cone retinal bipolar cell (CL0000752)
Fold Change: 9.5707
Cell Significance Index: 73.7700 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 9.4902
Cell Significance Index: 1303.2700 - Cell Name: peg cell (CL4033014)
Fold Change: 9.2361
Cell Significance Index: 213.3900 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 8.8805
Cell Significance Index: 965.9300 - Cell Name: pro-T cell (CL0000827)
Fold Change: 8.4128
Cell Significance Index: 214.9200 - Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: 8.2816
Cell Significance Index: 124.8000 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 8.2028
Cell Significance Index: 236.3400 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 7.9854
Cell Significance Index: 981.8800 - Cell Name: hepatic pit cell (CL2000054)
Fold Change: 7.9268
Cell Significance Index: 21.2400 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 7.3072
Cell Significance Index: 123.0900 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 7.2975
Cell Significance Index: 470.8000 - Cell Name: odontoblast (CL0000060)
Fold Change: 6.7831
Cell Significance Index: 869.5500 - Cell Name: granulosa cell (CL0000501)
Fold Change: 6.6366
Cell Significance Index: 174.5100 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 6.4491
Cell Significance Index: 300.6900 - Cell Name: lactocyte (CL0002325)
Fold Change: 6.4141
Cell Significance Index: 828.6500 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 5.9665
Cell Significance Index: 1075.5700 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 5.3931
Cell Significance Index: 4869.5500 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 5.3639
Cell Significance Index: 252.1000 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 5.1977
Cell Significance Index: 387.3800 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 4.7264
Cell Significance Index: 135.4900 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 4.7165
Cell Significance Index: 3569.9900 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 4.3333
Cell Significance Index: 80.0900 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 3.2007
Cell Significance Index: 520.5700 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 3.1787
Cell Significance Index: 110.4600 - Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 3.1108
Cell Significance Index: 35.3400 - Cell Name: enterocyte (CL0000584)
Fold Change: 2.5339
Cell Significance Index: 15.7200 - Cell Name: preadipocyte (CL0002334)
Fold Change: 2.4655
Cell Significance Index: 48.1200 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 2.3429
Cell Significance Index: 840.3400 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 2.2599
Cell Significance Index: 223.5500 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 1.7798
Cell Significance Index: 52.2700 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.7663
Cell Significance Index: 350.5300 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.1624
Cell Significance Index: 233.1800 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 1.1500
Cell Significance Index: 69.0400 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 1.1431
Cell Significance Index: 217.5400 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 1.0062
Cell Significance Index: 35.3600 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.4004
Cell Significance Index: 10.6900 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.1415
Cell Significance Index: 7.3500 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 0.1169
Cell Significance Index: 7.8600 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.0755
Cell Significance Index: 4.2300 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.1929
Cell Significance Index: -363.2100 - Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: -0.2136
Cell Significance Index: -2.7400 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.3104
Cell Significance Index: -572.4200 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.3251
Cell Significance Index: -55.5200 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.3729
Cell Significance Index: -574.0800 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.4255
Cell Significance Index: -578.5400 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.5288
Cell Significance Index: -391.6900 - Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: -0.5908
Cell Significance Index: -10.4400 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.6341
Cell Significance Index: -402.7300 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.7229
Cell Significance Index: -407.6900 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.8113
Cell Significance Index: -506.6500 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.8632
Cell Significance Index: -391.7900 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -1.2818
Cell Significance Index: -368.8100 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: -1.3737
Cell Significance Index: -95.0000 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -1.6007
Cell Significance Index: -183.3900 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -2.2408
Cell Significance Index: -471.9700 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -2.5027
Cell Significance Index: -62.5600 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -3.0601
Cell Significance Index: -154.6500 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -3.1009
Cell Significance Index: -450.7500 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -3.2977
Cell Significance Index: -105.6200 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -3.4605
Cell Significance Index: -74.9700 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -3.4865
Cell Significance Index: -58.3500 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -3.7219
Cell Significance Index: -387.5400 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -4.0060
Cell Significance Index: -114.3200 - Cell Name: neuron associated cell (CL0000095)
Fold Change: -4.1241
Cell Significance Index: -168.9900 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -4.2913
Cell Significance Index: -270.4700 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -4.4445
Cell Significance Index: -341.0700 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -4.9061
Cell Significance Index: -301.5500 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -5.2576
Cell Significance Index: -110.0500 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -5.6933
Cell Significance Index: -349.0500 - Cell Name: paneth cell of colon (CL0009009)
Fold Change: -6.1832
Cell Significance Index: -92.6500 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -7.2601
Cell Significance Index: -154.6200 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: -8.0275
Cell Significance Index: -83.1000 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -8.0450
Cell Significance Index: -355.8500 - Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: -8.1682
Cell Significance Index: -140.8100 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -9.4373
Cell Significance Index: -277.9700 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -10.0267
Cell Significance Index: -379.6900 - Cell Name: retinal rod cell (CL0000604)
Fold Change: -10.5913
Cell Significance Index: -126.2600 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -10.8479
Cell Significance Index: -225.0300 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -11.1535
Cell Significance Index: -390.7300 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -11.3592
Cell Significance Index: -291.9900 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -11.7515
Cell Significance Index: -384.7500 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -11.9738
Cell Significance Index: -381.3500
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 3174650439
Symbol: ATP6_HUMAN
Name: ATP synthase subunit a
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 7219534
Title: Sequence and organization of the human mitochondrial genome.
PubMed ID: 7219534
DOI: 10.1038/290457a0
PubMed ID: 7530363
Title: Recent African origin of modern humans revealed by complete sequences of hominoid mitochondrial DNAs.
PubMed ID: 7530363
PubMed ID: 11130070
Title: Mitochondrial genome variation and the origin of modern humans.
PubMed ID: 11130070
DOI: 10.1038/35047064
PubMed ID: 11553319
Title: Major genomic mitochondrial lineages delineate early human expansions.
PubMed ID: 11553319
PubMed ID: 12022039
Title: Mitochondrial genome diversity of native Americans supports a single early entry of founder populations into America.
PubMed ID: 12022039
DOI: 10.1086/341358
PubMed ID: 14563219
Title: Mitochondrial DNA transit between West Asia and North Africa inferred from U6 phylogeography.
PubMed ID: 14563219
PubMed ID: 12840039
Title: Mitochondrial genome variation and evolutionary history of Australian and New Guinean aborigines.
PubMed ID: 12840039
DOI: 10.1101/gr.686603
PubMed ID: 12949126
Title: Lineage-specific selection in human mtDNA: lack of polymorphisms in a segment of MTND5 gene in haplogroup J.
PubMed ID: 12949126
PubMed ID: 12509511
Title: Natural selection shaped regional mtDNA variation in humans.
PubMed ID: 12509511
PubMed ID: 12870132
Title: Phylogeny of east Asian mitochondrial DNA lineages inferred from complete sequences.
PubMed ID: 12870132
DOI: 10.1086/377718
PubMed ID: 15382008
Title: The molecular dissection of mtDNA haplogroup H confirms that the Franco-Cantabrian glacial refuge was a major source for the European gene pool.
PubMed ID: 15382008
DOI: 10.1086/425590
PubMed ID: 15467980
Title: Phylogeny of mitochondrial DNA macrohaplogroup N in India, based on complete sequencing: implications for the peopling of South Asia.
PubMed ID: 15467980
DOI: 10.1086/425871
PubMed ID: 14760490
Title: Single nucleotide polymorphisms over the entire mtDNA genome that increase the power of forensic testing in Caucasians.
PubMed ID: 14760490
PubMed ID: 15638829
Title: Mitochondrial DNA diversity in indigenous populations of the southern extent of Siberia, and the origins of native american haplogroups.
PubMed ID: 15638829
PubMed ID: 17352390
Title: Late onset Leigh syndrome and ataxia due to a T to C mutation at bp 9,185 of mitochondrial DNA.
PubMed ID: 17352390
DOI: 10.1002/ajmg.a.31637
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 25037980
Title: Mitochondrial myopathy, lactic acidosis, and sideroblastic anemia (MLASA) plus associated with a novel de novo mutation (m.8969G>A) in the mitochondrial encoded ATP6 gene.
PubMed ID: 25037980
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 30318146
Title: The 7q11.23 protein DNAJC30 interacts with ATP synthase and links mitochondria to brain development.
PubMed ID: 30318146
PubMed ID: 3201231
Title: Mitochondrial DNA mutation associated with Leber's hereditary optic neuropathy.
PubMed ID: 3201231
PubMed ID: 2137962
Title: A new mitochondrial disease associated with mitochondrial DNA heteroplasmy.
PubMed ID: 2137962
PubMed ID: 1757091
Title: Normal variants of human mitochondrial DNA and translation products: the building of a reference data base.
PubMed ID: 1757091
DOI: 10.1007/bf00206061
PubMed ID: 8395787
Title: A second missense mutation in the mitochondrial ATPase 6 gene in Leigh's syndrome.
PubMed ID: 8395787
PubMed ID: 7726182
Title: A mitochondrial mutation at nt 9101 in the ATP synthase 6 gene associated with deficient oxidative phosphorylation in a family with Leber hereditary optic neuroretinopathy.
PubMed ID: 7726182
PubMed ID: 7668837
Title: A novel mitochondrial ATPase 6 point mutation in familial bilateral striatal necrosis.
PubMed ID: 7668837
PubMed ID: 9270604
Title: Leigh syndrome associated with the T9176C mutation in the ATPase 6 gene of mitochondrial DNA.
PubMed ID: 9270604
DOI: 10.1212/wnl.49.2.595
PubMed ID: 9556461
Title: De novo mtDNA nt 8993 (T-G) mutation resulting in Leigh syndrome.
PubMed ID: 9556461
DOI: 10.1086/301751
PubMed ID: 9501263
Title: Fulminant Leigh syndrome and sudden unexpected death in a family with the T9176C mutation of the mitochondrial ATPase 6 gene.
PubMed ID: 9501263
PubMed ID: 9461455
Title: Automating the identification of DNA variations using quality-based fluorescence re-sequencing: analysis of the human mitochondrial genome.
PubMed ID: 9461455
DOI: 10.1093/nar/26.4.967
PubMed ID: 16049925
Title: Adult-onset ataxia and polyneuropathy caused by mitochondrial 8993T-->C mutation.
PubMed ID: 16049925
DOI: 10.1002/ana.20555
PubMed ID: 18055910
Title: Episodic ataxia and hemiplegia caused by the 8993T->C mitochondrial DNA mutation.
PubMed ID: 18055910
PubMed ID: 19188198
Title: Infantile cardiomyopathy caused by a mutation in the overlapping region of mitochondrial ATPase 6 and 8 genes.
PubMed ID: 19188198
Sequence Information:
- Length: 226
- Mass: 24817
- Checksum: 7DB0F0BE86F55207
- Sequence:
MNENLFASFI APTILGLPAA VLIILFPPLL IPTSKYLINN RLITTQQWLI KLTSKQMMTM HNTKGRTWSL MLVSLIIFIA TTNLLGLLPH SFTPTTQLSM NLAMAIPLWA GTVIMGFRSK IKNALAHFLP QGTPTPLIPM LVIIETISLL IQPMALAVRL TANITAGHLL MHLIGSATLA MSTINLPSTL IIFTILILLT ILEIAVALIQ AYVFTLLVSL YLHDNT
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.