Details for: UBE2D3

Gene ID: 7323

Symbol: UBE2D3

Ensembl ID: ENSG00000109332

Description: ubiquitin conjugating enzyme E2 D3

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 3.94
    Marker Score: 134069
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 3.9
    Marker Score: 9535
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 3.63
    Marker Score: 3095
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 3.6
    Marker Score: 35674
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 3.6
    Marker Score: 3841
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 3.59
    Marker Score: 1608
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 3.39
    Marker Score: 811
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 3.38
    Marker Score: 9349
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 3.37
    Marker Score: 178306
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 3.32
    Marker Score: 185735
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 3.31
    Marker Score: 4000
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 3.26
    Marker Score: 2035
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 3.17
    Marker Score: 1107
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 3.16
    Marker Score: 9958
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 3.15
    Marker Score: 2479
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 3.14
    Marker Score: 2378
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 3.08
    Marker Score: 1281
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 3.06
    Marker Score: 8927
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 3.05
    Marker Score: 13068
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 3.05
    Marker Score: 1856
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 3.03
    Marker Score: 2549
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 3.02
    Marker Score: 1757
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 3.01
    Marker Score: 1219
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 3
    Marker Score: 1221
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 2.99
    Marker Score: 4239
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 2.98
    Marker Score: 5325
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 2.98
    Marker Score: 3237
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 2.97
    Marker Score: 52733
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 2.97
    Marker Score: 8329
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 2.94
    Marker Score: 995.5
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 2.93
    Marker Score: 2618
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 2.91
    Marker Score: 1705.5
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 2.91
    Marker Score: 2862
  • Cell Name: basal cell (CL0000646)
    Fold Change: 2.9
    Marker Score: 3741
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.9
    Marker Score: 11171
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 2.89
    Marker Score: 2270
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 2.88
    Marker Score: 660
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 2.88
    Marker Score: 6036
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 2.88
    Marker Score: 3373
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 2.87
    Marker Score: 6295
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 2.86
    Marker Score: 14063
  • Cell Name: blood cell (CL0000081)
    Fold Change: 2.85
    Marker Score: 33154
  • Cell Name: muscle precursor cell (CL0000680)
    Fold Change: 2.85
    Marker Score: 738
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 2.85
    Marker Score: 988
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.85
    Marker Score: 2995
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 2.84
    Marker Score: 3248.5
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 2.84
    Marker Score: 1725
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 2.82
    Marker Score: 37135
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 2.82
    Marker Score: 37826
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 2.8
    Marker Score: 1262
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 2.79
    Marker Score: 2504
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 2.79
    Marker Score: 2609
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 2.78
    Marker Score: 1743
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 2.77
    Marker Score: 790
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 2.77
    Marker Score: 5055
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: 2.76
    Marker Score: 1255
  • Cell Name: Unknown (CL0000548)
    Fold Change: 2.76
    Marker Score: 2011
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 2.76
    Marker Score: 2158
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 2.75
    Marker Score: 677
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 2.75
    Marker Score: 5353
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 2.75
    Marker Score: 2649
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 2.74
    Marker Score: 6694
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 2.74
    Marker Score: 2949
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 2.74
    Marker Score: 637
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 2.73
    Marker Score: 1839
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 2.73
    Marker Score: 4619.5
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 2.73
    Marker Score: 5449
  • Cell Name: podocyte (CL0000653)
    Fold Change: 2.73
    Marker Score: 1008
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 2.72
    Marker Score: 596
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 2.71
    Marker Score: 2492
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 2.71
    Marker Score: 589
  • Cell Name: type I enteroendocrine cell (CL0002277)
    Fold Change: 2.7
    Marker Score: 673
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 2.7
    Marker Score: 3922
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 2.7
    Marker Score: 1016
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 2.69
    Marker Score: 2366
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 2.69
    Marker Score: 4416.5
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 2.69
    Marker Score: 1246
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 2.69
    Marker Score: 2034.5
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 2.68
    Marker Score: 2683
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 2.68
    Marker Score: 6818
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 2.68
    Marker Score: 5027
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 2.67
    Marker Score: 1821
  • Cell Name: lung neuroendocrine cell (CL1000223)
    Fold Change: 2.67
    Marker Score: 754
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: 2.67
    Marker Score: 708
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 2.66
    Marker Score: 706
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 2.66
    Marker Score: 2349
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 2.66
    Marker Score: 1605
  • Cell Name: glomerular endothelial cell (CL0002188)
    Fold Change: 2.66
    Marker Score: 675
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.66
    Marker Score: 26928
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 2.65
    Marker Score: 4825
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 2.65
    Marker Score: 2170
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 2.65
    Marker Score: 6391
  • Cell Name: Schwann cell precursor (CL0002375)
    Fold Change: 2.65
    Marker Score: 658
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 2.65
    Marker Score: 1919
  • Cell Name: interneuron (CL0000099)
    Fold Change: 2.65
    Marker Score: 1208
  • Cell Name: tendon cell (CL0000388)
    Fold Change: 2.64
    Marker Score: 649
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 2.64
    Marker Score: 699
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 2.64
    Marker Score: 4597
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 2.64
    Marker Score: 11033
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 2.64
    Marker Score: 1799.5

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Other Information

**Key Characteristics:** UBE2D3 is a small protein (~12 kDa) with a high degree of sequence similarity to other E2 enzymes. It is primarily expressed in cells of the immune system, including T cells, macrophages, and dendritic cells. UBE2D3 exhibits a high degree of specificity, targeting a range of substrates involved in protein degradation, immune response, and cell signaling. **Pathways and Functions:** UBE2D3 is involved in various cellular processes, including: 1. **Protein Degradation:** UBE2D3 mediates the ubiquitination of proteins involved in protein degradation, such as the 26S proteasome and other E3 ubiquitin ligases. 2. **Immune Response:** UBE2D3 plays a critical role in regulating immune responses, including the activation of T cells, the induction of interferon-alpha/beta, and the regulation of cytokine signaling. 3. **Apoptosis:** UBE2D3 is involved in the regulation of apoptosis, with its substrates including pro-apoptotic proteins and anti-apoptotic proteins. 4. **Cell Signaling:** UBE2D3 modulates cell signaling pathways, including the regulation of BMP, TGF-β, and CSF3 (G-CSF) signaling. 5. **DNA Repair:** UBE2D3 is involved in the regulation of DNA repair pathways, including the repair of DNA damage and the maintenance of genome stability. **Clinical Significance:** Dysregulation of UBE2D3 has been implicated in various diseases, including: 1. **Cancer:** UBE2D3 overexpression has been linked to cancer progression, with its substrates including tumor suppressor proteins and oncogenes. 2. **Autoimmune Diseases:** UBE2D3 is involved in the regulation of immune responses, and its dysregulation has been implicated in autoimmune diseases such as multiple sclerosis and rheumatoid arthritis. 3. **Infectious Diseases:** UBE2D3 plays a critical role in the regulation of immune responses, and its dysregulation has been implicated in infectious diseases such as HIV and tuberculosis. In conclusion, UBE2D3 is a crucial regulator of protein degradation and immune response, with its dysregulation implicated in various diseases. Further research is needed to fully elucidate the mechanisms by which UBE2D3 regulates protein degradation and immune responses, and to explore its therapeutic potential in disease treatment.

Genular Protein ID: 3410515189

Symbol: UB2D3_HUMAN

Name: Ubiquitin-conjugating enzyme E2 D3

UniProtKB Accession Codes:

P61077 A6NJ93 A6NJB1 A6NM99 P47986 Q6IB88 Q6NXS4 Q8N924

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 BRENDA 2 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CORUM 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EC 2 EMBL 11 EMDB 3 EPD 1 Ensembl 9 EvolutionaryTrace 1 ExpressionAtlas 1 GO 27 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MoonDB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 20 PDBsum 15 PRO 1 PROSITE 2 PROSITE-ProRule 2 PathwayCommons 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 12 RefSeq 9 SIGNOR 1 SMART 1 SMR 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 2 TreeFam 1 UCSC 1 UniPathway 1 UniProtKB 1 VEuPathDB 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8530467

Title: Identification of a family of closely related human ubiquitin conjugating enzymes.

PubMed ID: 8530467

DOI: 10.1074/jbc.270.51.30408

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10329681

Title: Identification of the ubiquitin carrier proteins, E2s, involved in signal-induced conjugation and subsequent degradation of IkappaBalpha.

PubMed ID: 10329681

DOI: 10.1074/jbc.274.21.14823

PubMed ID: 11743028

Title: CHIP is a chaperone-dependent E3 ligase that ubiquitylates unfolded protein.

PubMed ID: 11743028

DOI: 10.1093/embo-reports/kve246

PubMed ID: 12646252

Title: Mammalian Numb is a target protein of Mdm2, ubiquitin ligase.

PubMed ID: 12646252

DOI: 10.1016/s0006-291x(03)00282-1

PubMed ID: 15247280

Title: Topors functions as an E3 ubiquitin ligase with specific E2 enzymes and ubiquitinates p53.

PubMed ID: 15247280

DOI: 10.1074/jbc.c400300200

PubMed ID: 15280377

Title: Regulation of p53 by the ubiquitin-conjugating enzymes UbcH5B/C in vivo.

PubMed ID: 15280377

DOI: 10.1074/jbc.m403362200

PubMed ID: 15496420

Title: The poxvirus p28 virulence factor is an E3 ubiquitin ligase.

PubMed ID: 15496420

DOI: 10.1074/jbc.m410583200

PubMed ID: 16628214

Title: A conserved pathway to activate BRCA1-dependent ubiquitylation at DNA damage sites.

PubMed ID: 16628214

DOI: 10.1038/sj.emboj.7601102

PubMed ID: 17588522

Title: E3-independent monoubiquitination of ubiquitin-binding proteins.

PubMed ID: 17588522

DOI: 10.1016/j.molcel.2007.05.014

PubMed ID: 18515077

Title: Physical and functional interactions between ZIP kinase and UbcH5.

PubMed ID: 18515077

DOI: 10.1016/j.bbrc.2008.05.113

PubMed ID: 18948756

Title: PCNA is ubiquitinated by RNF8.

PubMed ID: 18948756

DOI: 10.4161/cc.7.21.6949

PubMed ID: 18508924

Title: Ubc4/5 and c-Cbl continue to ubiquitinate EGF receptor after internalization to facilitate polyubiquitination and degradation.

PubMed ID: 18508924

DOI: 10.1091/mbc.e07-10-0988

PubMed ID: 18851830

Title: Multimodal activation of the ubiquitin ligase SCF by Nedd8 conjugation.

PubMed ID: 18851830

DOI: 10.1016/j.molcel.2008.08.021

PubMed ID: 18284575

Title: Legionella translocates an E3 ubiquitin ligase that has multiple U-boxes with distinct functions.

PubMed ID: 18284575

DOI: 10.1111/j.1365-2958.2008.06124.x

PubMed ID: 20061386

Title: The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines.

PubMed ID: 20061386

DOI: 10.1074/jbc.m109.089003

PubMed ID: 20525694

Title: The N terminus of Cbl-c regulates ubiquitin ligase activity by modulating affinity for the ubiquitin-conjugating enzyme.

PubMed ID: 20525694

DOI: 10.1074/jbc.m109.091157

PubMed ID: 20347421

Title: Priming and extending: a UbcH5/Cdc34 E2 handoff mechanism for polyubiquitination on a SCF substrate.

PubMed ID: 20347421

DOI: 10.1016/j.molcel.2010.02.025

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21532592

Title: UBCH7 reactivity profile reveals parkin and HHARI to be RING/HECT hybrids.

PubMed ID: 21532592

DOI: 10.1038/nature09966

PubMed ID: 24211586

Title: The UbL protein UBTD1 stably interacts with the UBE2D family of E2 ubiquitin conjugating enzymes.

PubMed ID: 24211586

DOI: 10.1016/j.bbrc.2013.10.137

PubMed ID: 28469175

Title: Ube2D3 and Ube2N are essential for RIG-I-mediated MAVS aggregation in antiviral innate immunity.

PubMed ID: 28469175

DOI: 10.1038/ncomms15138

PubMed ID: 28685749

Title: The E3 ubiquitin ligase and RNA-binding protein ZNF598 orchestrates ribosome quality control of premature polyadenylated mRNAs.

PubMed ID: 28685749

DOI: 10.1038/ncomms16056

PubMed ID: 36528027

Title: Ring domains are essential for GATOR2-dependent mTORC1 activation.

PubMed ID: 36528027

DOI: 10.1016/j.molcel.2022.11.021

PubMed ID: 16543155

Title: A UbcH5/ubiquitin noncovalent complex is required for processive BRCA1-directed ubiquitination.

PubMed ID: 16543155

DOI: 10.1016/j.molcel.2006.02.008

Sequence Information:

  • Length: 147
  • Mass: 16687
  • Checksum: ADD74A8A708EFEE3
  • Sequence:
    • MALKRINKEL SDLARDPPAQ CSAGPVGDDM FHWQATIMGP NDSPYQGGVF FLTIHFPTDY 
PFKPPKVAFT TRIYHPNINS NGSICLDILR SQWSPALTIS KVLLSICSLL CDPNPDDPLV 
PEIARIYKTD RDKYNRISRE WTQKYAM

Genular Protein ID: 194889726

Symbol: D6RAH7_HUMAN

Name: N/A

UniProtKB Accession Codes:

D6RAH7

Database IDs:

ARBA 11 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 ChiTaRS 1 DNASU 1 EC 2 EMBL 1 EPD 1 Ensembl 5 GO 3 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 InterPro 3 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 3 PROSITE-ProRule 1 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 2 RuleBase 1 SMART 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

Sequence Information:

  • Length: 118
  • Mass: 13637
  • Checksum: A74F8C7199FE8085
  • Sequence:
    • MFHWQATIMG PNDSPYQGGV FFLTIHFPTD YPFKPPKVAF TTRIYHPNIN SNGSICLDIL 
RSQWSPALTI SKVLLSICSL LCDPNPDDPL VPEIARIYKT DRDKYNRISR EWTQKYAM

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.