Details for: CL0002144

Cell ID: CL0002144

Cell Name: capillary endothelial cell

Marker Score Threshold: 1076
(Derived using integrated single-cell and genomic data)

Description: An endothelial cell found in capillaries.

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 4.14
    Ensembl ID: ENSG00000075624
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 4.08
    Ensembl ID: ENSG00000166710
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 3.7
    Ensembl ID: ENSG00000184009
  • Gene Symbol: APOC1 (ENSG00000130208)
    Fold Change: 3.59
    Ensembl ID: ENSG00000130208
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 3.51
    Ensembl ID: ENSG00000198668
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 3.34
    Ensembl ID: ENSG00000145741
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 3.21
    Ensembl ID: ENSG00000067560
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 3.02
    Ensembl ID: ENSG00000143933
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 2.96
    Ensembl ID: ENSG00000169100
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 2.83
    Ensembl ID: ENSG00000185650
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 2.79
    Ensembl ID: ENSG00000182718
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 2.77
    Ensembl ID: ENSG00000142192
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 2.76
    Ensembl ID: ENSG00000133639
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 2.74
    Ensembl ID: ENSG00000179218
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 2.67
    Ensembl ID: ENSG00000135390
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 2.63
    Ensembl ID: ENSG00000143761
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 2.61
    Ensembl ID: ENSG00000154723
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 2.38
    Ensembl ID: ENSG00000143878
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 2.34
    Ensembl ID: ENSG00000169020
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 2.33
    Ensembl ID: ENSG00000110955
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 2.28
    Ensembl ID: ENSG00000134825
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 2.27
    Ensembl ID: ENSG00000172270
  • Gene Symbol: RHOC (ENSG00000155366)
    Fold Change: 2.24
    Ensembl ID: ENSG00000155366
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 2.24
    Ensembl ID: ENSG00000130402
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 2.24
    Ensembl ID: ENSG00000005022
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 2.21
    Ensembl ID: ENSG00000152518
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 2.16
    Ensembl ID: ENSG00000135046
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 2.14
    Ensembl ID: ENSG00000154518
  • Gene Symbol: C1QB (ENSG00000173369)
    Fold Change: 2.14
    Ensembl ID: ENSG00000173369
  • Gene Symbol: CALD1 (ENSG00000122786)
    Fold Change: 2.11
    Ensembl ID: ENSG00000122786
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 2.03
    Ensembl ID: ENSG00000164111
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 2.01
    Ensembl ID: ENSG00000104964
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 2
    Ensembl ID: ENSG00000127022
  • Gene Symbol: PTTG1IP (ENSG00000183255)
    Fold Change: 1.98
    Ensembl ID: ENSG00000183255
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.95
    Ensembl ID: ENSG00000165629
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 1.95
    Ensembl ID: ENSG00000099624
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.93
    Ensembl ID: ENSG00000177556
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 1.93
    Ensembl ID: ENSG00000100300
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.88
    Ensembl ID: ENSG00000085224
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.87
    Ensembl ID: ENSG00000084234
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.86
    Ensembl ID: ENSG00000128272
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.86
    Ensembl ID: ENSG00000141522
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 1.84
    Ensembl ID: ENSG00000111348
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.82
    Ensembl ID: ENSG00000117410
  • Gene Symbol: A2M (ENSG00000175899)
    Fold Change: 1.81
    Ensembl ID: ENSG00000175899
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.8
    Ensembl ID: ENSG00000152234
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.78
    Ensembl ID: ENSG00000168374
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.76
    Ensembl ID: ENSG00000163399
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.76
    Ensembl ID: ENSG00000069849
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.76
    Ensembl ID: ENSG00000149925
  • Gene Symbol: BST2 (ENSG00000130303)
    Fold Change: 1.7
    Ensembl ID: ENSG00000130303
  • Gene Symbol: BMPR2 (ENSG00000204217)
    Fold Change: 1.68
    Ensembl ID: ENSG00000204217
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.65
    Ensembl ID: ENSG00000116459
  • Gene Symbol: CAPN2 (ENSG00000162909)
    Fold Change: 1.64
    Ensembl ID: ENSG00000162909
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.61
    Ensembl ID: ENSG00000241837
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.58
    Ensembl ID: ENSG00000198931
  • Gene Symbol: CAPNS1 (ENSG00000126247)
    Fold Change: 1.52
    Ensembl ID: ENSG00000126247
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.52
    Ensembl ID: ENSG00000087274
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.49
    Ensembl ID: ENSG00000116489
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 1.47
    Ensembl ID: ENSG00000124172
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.46
    Ensembl ID: ENSG00000160710
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.43
    Ensembl ID: ENSG00000122359
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.42
    Ensembl ID: ENSG00000160014
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.4
    Ensembl ID: ENSG00000115307
  • Gene Symbol: ALOX5AP (ENSG00000132965)
    Fold Change: 1.38
    Ensembl ID: ENSG00000132965
  • Gene Symbol: ATP6V0C (ENSG00000185883)
    Fold Change: 1.37
    Ensembl ID: ENSG00000185883
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.37
    Ensembl ID: ENSG00000159199
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.36
    Ensembl ID: ENSG00000104763
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.35
    Ensembl ID: ENSG00000004059
  • Gene Symbol: SERPING1 (ENSG00000149131)
    Fold Change: 1.33
    Ensembl ID: ENSG00000149131
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.33
    Ensembl ID: ENSG00000108561
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.32
    Ensembl ID: ENSG00000072778
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: 1.32
    Ensembl ID: ENSG00000087088
  • Gene Symbol: ARL2 (ENSG00000213465)
    Fold Change: 1.3
    Ensembl ID: ENSG00000213465
  • Gene Symbol: BNIP2 (ENSG00000140299)
    Fold Change: 1.28
    Ensembl ID: ENSG00000140299
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.27
    Ensembl ID: ENSG00000104765
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.26
    Ensembl ID: ENSG00000138279
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.26
    Ensembl ID: ENSG00000165527
  • Gene Symbol: ATP6V1E1 (ENSG00000131100)
    Fold Change: 1.24
    Ensembl ID: ENSG00000131100
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.24
    Ensembl ID: ENSG00000148700
  • Gene Symbol: C1QA (ENSG00000173372)
    Fold Change: 1.24
    Ensembl ID: ENSG00000173372
  • Gene Symbol: ADH5 (ENSG00000197894)
    Fold Change: 1.23
    Ensembl ID: ENSG00000197894
  • Gene Symbol: CCND1 (ENSG00000110092)
    Fold Change: 1.22
    Ensembl ID: ENSG00000110092
  • Gene Symbol: BAG1 (ENSG00000107262)
    Fold Change: 1.21
    Ensembl ID: ENSG00000107262
  • Gene Symbol: ADAM10 (ENSG00000137845)
    Fold Change: 1.2
    Ensembl ID: ENSG00000137845
  • Gene Symbol: AP2B1 (ENSG00000006125)
    Fold Change: 1.19
    Ensembl ID: ENSG00000006125
  • Gene Symbol: C1QC (ENSG00000159189)
    Fold Change: 1.17
    Ensembl ID: ENSG00000159189
  • Gene Symbol: ATP6AP1 (ENSG00000071553)
    Fold Change: 1.15
    Ensembl ID: ENSG00000071553
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 1.12
    Ensembl ID: ENSG00000142599
  • Gene Symbol: ALDH2 (ENSG00000111275)
    Fold Change: 1.11
    Ensembl ID: ENSG00000111275
  • Gene Symbol: BNIP3 (ENSG00000176171)
    Fold Change: 1.11
    Ensembl ID: ENSG00000176171
  • Gene Symbol: CAMLG (ENSG00000164615)
    Fold Change: 1.1
    Ensembl ID: ENSG00000164615
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.09
    Ensembl ID: ENSG00000143727
  • Gene Symbol: ATF3 (ENSG00000162772)
    Fold Change: 1.07
    Ensembl ID: ENSG00000162772
  • Gene Symbol: TMEM50B (ENSG00000142188)
    Fold Change: 1.06
    Ensembl ID: ENSG00000142188
  • Gene Symbol: CALU (ENSG00000128595)
    Fold Change: 1.05
    Ensembl ID: ENSG00000128595
  • Gene Symbol: RHOG (ENSG00000177105)
    Fold Change: 1.04
    Ensembl ID: ENSG00000177105
  • Gene Symbol: DST (ENSG00000151914)
    Fold Change: 1.03
    Ensembl ID: ENSG00000151914
  • Gene Symbol: AK2 (ENSG00000004455)
    Fold Change: 1.02
    Ensembl ID: ENSG00000004455
  • Gene Symbol: PLIN2 (ENSG00000147872)
    Fold Change: 1.01
    Ensembl ID: ENSG00000147872
Hovered Details

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Hovered Details

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**Key Characteristics** 1. **Cell Morphology**: Capillary endothelial cells have a characteristic thin, fenestrated structure that allows for the passage of small molecules and cells. 2. **Adhesion Molecules**: These cells express a range of adhesion molecules, including integrins, selectins, and cadherins, which facilitate cell-cell interactions and tissue organization. 3. **Apical-Basal Polarization**: Capillary endothelial cells exhibit apical-basal polarization, with distinct apical and basal domains that regulate the expression of specific genes and proteins. 4. **Cytoskeletal Organization**: The cytoskeleton of these cells is organized into actin filaments, microtubules, and intermediate filaments, which provide structural support and regulate cellular movements. 5. **Endothelial Barrier Function**: Capillary endothelial cells maintain the integrity of the endothelial barrier by regulating the expression of tight junction proteins and tight junction assembly. **Clinical Significance** 1. **Disease Association**: Alterations in the function and morphology of capillary endothelial cells have been implicated in various diseases, including cardiovascular disease, cancer, and inflammatory disorders. 2. **Angiogenesis**: Capillary endothelial cells play a critical role in angiogenesis, the process of new blood vessel formation, which is essential for tissue repair and growth. 3. **Immune Response**: These cells are involved in the regulation of immune responses, including the presentation of antigens to T-cells and the production of cytokines. 4. **Thrombosis**: Abnormalities in the function of capillary endothelial cells can lead to thrombosis, a condition characterized by the formation of blood clots in blood vessels. 5. **Cancer Metastasis**: The ability of capillary endothelial cells to facilitate the spread of cancer cells to distant organs is a critical aspect of cancer metastasis. **Pathways and Ontology** 1. **Actin Cytoskeleton**: Capillary endothelial cells regulate the expression of actin-binding proteins and actin-modulating enzymes to maintain cytoskeletal organization. 2. **Adherens Junction**: These cells express a range of adherens junction proteins, including E-cadherin and N-cadherin, which regulate cell-cell interactions. 3. **Apical-Basal Polarization**: The apical-basal polarization of capillary endothelial cells is regulated by the expression of specific genes and proteins, including the Wnt/β-catenin pathway. 4. **Blood-Brain Barrier**: These cells play a critical role in maintaining the integrity of the blood-brain barrier, which regulates the passage of molecules and cells between the bloodstream and the central nervous system. 5. **Cytokine Signaling**: Capillary endothelial cells regulate cytokine signaling, including the production of cytokines and the presentation of antigens to T-cells.