Details for: TNNC1

Gene ID: 7134

Symbol: TNNC1

Ensembl ID: ENSG00000114854

Description: troponin C1, slow skeletal and cardiac type

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 4.04
    Marker Score: 1329
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 3.86
    Marker Score: 4646
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 3.6
    Marker Score: 47907
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 2.76
    Marker Score: 61691.5
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 2.3
    Marker Score: 6508
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 2.1
    Marker Score: 1061
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 2.07
    Marker Score: 12442
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 1.91
    Marker Score: 1454
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 1.52
    Marker Score: 5408
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.48
    Marker Score: 169391
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 1.41
    Marker Score: 1756
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 1.33
    Marker Score: 2136
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 1.26
    Marker Score: 1816
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.22
    Marker Score: 19118
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.19
    Marker Score: 2428
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.17
    Marker Score: 850
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4810
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 793
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 1.03
    Marker Score: 460
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.02
    Marker Score: 1935
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.01
    Marker Score: 3988
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1
    Marker Score: 1059
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71820
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48046
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 506
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 459
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.95
    Marker Score: 304
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.94
    Marker Score: 639
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5344
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 371
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.93
    Marker Score: 6030
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2737
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 323
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5289
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1268
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 705
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 394
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.71
    Marker Score: 455
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 176
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 0.67
    Marker Score: 204
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.64
    Marker Score: 10327
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.64
    Marker Score: 3342
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.63
    Marker Score: 379
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.62
    Marker Score: 347
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 0.62
    Marker Score: 348
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.59
    Marker Score: 393
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.59
    Marker Score: 326
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.58
    Marker Score: 1433
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.58
    Marker Score: 182.5
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.55
    Marker Score: 147
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 442
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.54
    Marker Score: 171
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.53
    Marker Score: 252
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.49
    Marker Score: 472
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: 0.48
    Marker Score: 157
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.46
    Marker Score: 1936.5
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.46
    Marker Score: 275
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.46
    Marker Score: 597
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.43
    Marker Score: 692
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4
    Marker Score: 595
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.39
    Marker Score: 1039
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.38
    Marker Score: 267
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 369
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.35
    Marker Score: 355
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.33
    Marker Score: 106
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.33
    Marker Score: 150
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.33
    Marker Score: 11282
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.32
    Marker Score: 156
  • Cell Name: ventricular cardiac muscle cell (CL2000046)
    Fold Change: 0.32
    Marker Score: 131
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.31
    Marker Score: 90
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.31
    Marker Score: 297
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.31
    Marker Score: 181
  • Cell Name: epithelial cell of thymus (CL0002293)
    Fold Change: 0.31
    Marker Score: 99
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.3
    Marker Score: 125
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.3
    Marker Score: 132
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.3
    Marker Score: 419
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.29
    Marker Score: 185
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.29
    Marker Score: 983
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: 0.29
    Marker Score: 86
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.28
    Marker Score: 658
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 0.28
    Marker Score: 73
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.27
    Marker Score: 158
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 0.27
    Marker Score: 526
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.27
    Marker Score: 3581
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.25
    Marker Score: 288.5
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.24
    Marker Score: 191
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.24
    Marker Score: 123
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.24
    Marker Score: 71
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.23
    Marker Score: 247
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.23
    Marker Score: 121.5
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.23
    Marker Score: 205
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 64
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.22
    Marker Score: 81
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.22
    Marker Score: 398
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.22
    Marker Score: 105
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.21
    Marker Score: 49
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 0.21
    Marker Score: 114
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.2
    Marker Score: 82

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Other Information

**Key Characteristics:** 1. **Troponin Complex Component:** TNNC1 is a subunit of the troponin complex, which is essential for regulating muscle contraction. 2. **Slow Skeletal and Cardiac Type:** The specific expression of TNNC1 in slow skeletal and cardiac muscle cells highlights its unique characteristics. 3. **Calcium Ion Binding:** TNNC1 interacts with calcium ions to modulate muscle contraction, making it a critical regulator of muscle function. 4. **Muscle Contraction Regulation:** TNNC1 plays a key role in regulating muscle contraction, including both skeletal and cardiac muscle. 5. **Expression in Multiple Cell Types:** The expression of TNNC1 is observed in various cell types, including cardiac, skeletal muscle, and other cell types, indicating its broader physiological significance. **Pathways and Functions:** 1. **Actin Filament Binding:** TNNC1 interacts with actin filaments to regulate muscle contraction. 2. **Calcium-Dependent Protein Binding:** TNNC1 binds to calcium ions, which in turn regulates muscle contraction. 3. **Cardiac Muscle Contraction:** TNNC1 plays a crucial role in regulating cardiac muscle contraction, including ventricular cardiac muscle tissue morphogenesis. 4. **Skeletal Muscle Contraction:** TNNC1 is also involved in regulating skeletal muscle contraction, including diaphragm contraction and muscle contraction. 5. **Regulation of ATP-Dependent Activity:** TNNC1 regulates ATP-dependent activity, which is essential for muscle contraction. **Clinical Significance:** 1. **Muscular Dystrophy:** Mutations in the TNNC1 gene have been associated with muscular dystrophy, highlighting its importance in muscle function. 2. **Cardiac Arrhythmias:** Abnormalities in TNNC1 expression or function may contribute to cardiac arrhythmias, emphasizing the need for further research. 3. **Muscle Weakness:** TNNC1 dysfunction may lead to muscle weakness, particularly in slow-twitch muscle fibers, underscoring the importance of maintaining proper muscle function. 4. **Therapeutic Applications:** Understanding the role of TNNC1 in muscle contraction may lead to the development of novel therapeutic strategies for muscle-related disorders. In conclusion, TNNC1 is a critical component of the troponin complex, playing a pivotal role in regulating muscle contraction in both cardiac and skeletal muscle cells. Its unique characteristics, interactions with calcium ions, and expression in multiple cell types highlight its importance in various physiological processes. Further research is necessary to fully understand the clinical significance of TNNC1 and its potential applications in the treatment of muscle-related disorders.

Genular Protein ID: 199186478

Symbol: TNNC1_HUMAN

Name: Troponin C, slow skeletal and cardiac muscles

UniProtKB Accession Codes:

P63316 O14800 P02590 P04463

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 15 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 8 DrugCentral 1 EMBL 4 EMDB 2 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 18 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 5 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 60 PDBsum 53 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3951483

Title: The amino acid sequence of human cardiac troponin-C.

PubMed ID: 3951483

DOI: 10.1002/mus.880090112

PubMed ID: 3166492

Title: Differential expression of slow and fast skeletal muscle troponin C. Slow skeletal muscle troponin C is expressed in human fibroblasts.

PubMed ID: 3166492

DOI: 10.1016/0022-2836(88)90145-3

PubMed ID: 2250022

Title: Cloning, structural analysis, and expression of the human slow twitch skeletal muscle/cardiac troponin C gene.

PubMed ID: 2250022

DOI: 10.1016/s0021-9258(17)45353-1

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9315850

Title: Calcium-induced structural transition in the regulatory domain of human cardiac troponin C.

PubMed ID: 9315850

DOI: 10.1021/bi971223d

PubMed ID: 9219516

Title: Structural and functional domains of the troponin complex revealed by limited digestion.

PubMed ID: 9219516

DOI: 10.1111/j.1432-1033.1997.00611.x

PubMed ID: 12732641

Title: Structure and dynamics of the C-domain of human cardiac troponin C in complex with the inhibitory region of human cardiac troponin I.

PubMed ID: 12732641

DOI: 10.1074/jbc.m302497200

PubMed ID: 11385718

Title: First mutation in cardiac troponin C, L29Q, in a patient with hypertrophic cardiomyopathy.

PubMed ID: 11385718

DOI: 10.1002/humu.1143

PubMed ID: 15542288

Title: Severe disease expression of cardiac troponin C and T mutations in patients with idiopathic dilated cardiomyopathy.

PubMed ID: 15542288

DOI: 10.1016/j.jacc.2004.08.027

PubMed ID: 16302972

Title: Cardiac troponin C-L29Q, related to hypertrophic cardiomyopathy, hinders the transduction of the protein kinase A dependent phosphorylation signal from cardiac troponin I to C.

PubMed ID: 16302972

DOI: 10.1111/j.1742-4658.2005.05001.x

PubMed ID: 18572189

Title: Molecular and functional characterization of novel hypertrophic cardiomyopathy susceptibility mutations in TNNC1-encoded troponin C.

PubMed ID: 18572189

DOI: 10.1016/j.yjmcc.2008.05.003

PubMed ID: 19439414

Title: A functional and structural study of troponin C mutations related to hypertrophic cardiomyopathy.

PubMed ID: 19439414

DOI: 10.1074/jbc.m109.007021

Sequence Information:

  • Length: 161
  • Mass: 18403
  • Checksum: 34DCCC46D503A312
  • Sequence:
    • MDDIYKAAVE QLTEEQKNEF KAAFDIFVLG AEDGCISTKE LGKVMRMLGQ NPTPEELQEM 
IDEVDEDGSG TVDFDEFLVM MVRCMKDDSK GKSEEELSDL FRMFDKNADG YIDLDELKIM 
LQATGETITE DDIEELMKDG DKNNDGRIDY DEFLEFMKGV E

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.