Details for: CL0002368

Cell ID: CL0002368

Cell Name: respiratory epithelial cell

Marker Score Threshold: 551
(Derived using integrated single-cell and genomic data)

Description: An endo-epithelial cell of the respiratory tract.

Synonyms: airway epithelial cell

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 2.42
    Ensembl ID: ENSG00000075624
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.37
    Ensembl ID: ENSG00000184009
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 2.26
    Ensembl ID: ENSG00000182718
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 2.25
    Ensembl ID: ENSG00000135390
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 2.24
    Ensembl ID: ENSG00000145741
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 2.22
    Ensembl ID: ENSG00000142192
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 2.2
    Ensembl ID: ENSG00000185650
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 2.19
    Ensembl ID: ENSG00000133639
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 2.17
    Ensembl ID: ENSG00000169100
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 2.17
    Ensembl ID: ENSG00000124172
  • Gene Symbol: ANXA3 (ENSG00000138772)
    Fold Change: 2.12
    Ensembl ID: ENSG00000138772
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 2.11
    Ensembl ID: ENSG00000172270
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 2.08
    Ensembl ID: ENSG00000134825
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 2.06
    Ensembl ID: ENSG00000152518
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.06
    Ensembl ID: ENSG00000067560
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 2.02
    Ensembl ID: ENSG00000004059
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 2.02
    Ensembl ID: ENSG00000110955
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 2.01
    Ensembl ID: ENSG00000154518
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.98
    Ensembl ID: ENSG00000143761
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.98
    Ensembl ID: ENSG00000104763
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 1.98
    Ensembl ID: ENSG00000166710
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.97
    Ensembl ID: ENSG00000100823
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 1.95
    Ensembl ID: ENSG00000099624
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 1.93
    Ensembl ID: ENSG00000154723
  • Gene Symbol: ATP6V0C (ENSG00000185883)
    Fold Change: 1.93
    Ensembl ID: ENSG00000185883
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.92
    Ensembl ID: ENSG00000152234
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.89
    Ensembl ID: ENSG00000084234
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.89
    Ensembl ID: ENSG00000149925
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.88
    Ensembl ID: ENSG00000164111
  • Gene Symbol: ATP1B1 (ENSG00000143153)
    Fold Change: 1.88
    Ensembl ID: ENSG00000143153
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.86
    Ensembl ID: ENSG00000168374
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.83
    Ensembl ID: ENSG00000163399
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.83
    Ensembl ID: ENSG00000104765
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 1.83
    Ensembl ID: ENSG00000169020
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 1.83
    Ensembl ID: ENSG00000005022
  • Gene Symbol: ADH5 (ENSG00000197894)
    Fold Change: 1.82
    Ensembl ID: ENSG00000197894
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.82
    Ensembl ID: ENSG00000165629
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.79
    Ensembl ID: ENSG00000198931
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.78
    Ensembl ID: ENSG00000116459
  • Gene Symbol: ALCAM (ENSG00000170017)
    Fold Change: 1.75
    Ensembl ID: ENSG00000170017
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.75
    Ensembl ID: ENSG00000143727
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.72
    Ensembl ID: ENSG00000085224
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 1.72
    Ensembl ID: ENSG00000143878
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.7
    Ensembl ID: ENSG00000122359
  • Gene Symbol: CALD1 (ENSG00000122786)
    Fold Change: 1.69
    Ensembl ID: ENSG00000122786
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.62
    Ensembl ID: ENSG00000117410
  • Gene Symbol: PTTG1IP (ENSG00000183255)
    Fold Change: 1.61
    Ensembl ID: ENSG00000183255
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.59
    Ensembl ID: ENSG00000128272
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.58
    Ensembl ID: ENSG00000108561
  • Gene Symbol: BMP3 (ENSG00000152785)
    Fold Change: 1.58
    Ensembl ID: ENSG00000152785
  • Gene Symbol: ATP6AP1 (ENSG00000071553)
    Fold Change: 1.56
    Ensembl ID: ENSG00000071553
  • Gene Symbol: AHCY (ENSG00000101444)
    Fold Change: 1.54
    Ensembl ID: ENSG00000101444
  • Gene Symbol: AAMP (ENSG00000127837)
    Fold Change: 1.51
    Ensembl ID: ENSG00000127837
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.51
    Ensembl ID: ENSG00000104964
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.51
    Ensembl ID: ENSG00000115307
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.5
    Ensembl ID: ENSG00000130402
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.48
    Ensembl ID: ENSG00000159199
  • Gene Symbol: AK2 (ENSG00000004455)
    Fold Change: 1.47
    Ensembl ID: ENSG00000004455
  • Gene Symbol: ADK (ENSG00000156110)
    Fold Change: 1.46
    Ensembl ID: ENSG00000156110
  • Gene Symbol: PARP1 (ENSG00000143799)
    Fold Change: 1.46
    Ensembl ID: ENSG00000143799
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.45
    Ensembl ID: ENSG00000072778
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.45
    Ensembl ID: ENSG00000177556
  • Gene Symbol: SERPING1 (ENSG00000149131)
    Fold Change: 1.45
    Ensembl ID: ENSG00000149131
  • Gene Symbol: ALDH7A1 (ENSG00000164904)
    Fold Change: 1.44
    Ensembl ID: ENSG00000164904
  • Gene Symbol: KLF5 (ENSG00000102554)
    Fold Change: 1.44
    Ensembl ID: ENSG00000102554
  • Gene Symbol: ATF3 (ENSG00000162772)
    Fold Change: 1.43
    Ensembl ID: ENSG00000162772
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.42
    Ensembl ID: ENSG00000087274
  • Gene Symbol: BNIP3 (ENSG00000176171)
    Fold Change: 1.41
    Ensembl ID: ENSG00000176171
  • Gene Symbol: DDR1 (ENSG00000204580)
    Fold Change: 1.39
    Ensembl ID: ENSG00000204580
  • Gene Symbol: BAG1 (ENSG00000107262)
    Fold Change: 1.36
    Ensembl ID: ENSG00000107262
  • Gene Symbol: BCAT2 (ENSG00000105552)
    Fold Change: 1.35
    Ensembl ID: ENSG00000105552
  • Gene Symbol: ARL3 (ENSG00000138175)
    Fold Change: 1.33
    Ensembl ID: ENSG00000138175
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.33
    Ensembl ID: ENSG00000141522
  • Gene Symbol: ANXA4 (ENSG00000196975)
    Fold Change: 1.33
    Ensembl ID: ENSG00000196975
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 1.3
    Ensembl ID: ENSG00000142599
  • Gene Symbol: ARL1 (ENSG00000120805)
    Fold Change: 1.28
    Ensembl ID: ENSG00000120805
  • Gene Symbol: BAD (ENSG00000002330)
    Fold Change: 1.28
    Ensembl ID: ENSG00000002330
  • Gene Symbol: CCND1 (ENSG00000110092)
    Fold Change: 1.26
    Ensembl ID: ENSG00000110092
  • Gene Symbol: VPS51 (ENSG00000149823)
    Fold Change: 1.26
    Ensembl ID: ENSG00000149823
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.25
    Ensembl ID: ENSG00000148700
  • Gene Symbol: BLVRB (ENSG00000090013)
    Fold Change: 1.24
    Ensembl ID: ENSG00000090013
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: 1.24
    Ensembl ID: ENSG00000087088
  • Gene Symbol: ZFHX3 (ENSG00000140836)
    Fold Change: 1.23
    Ensembl ID: ENSG00000140836
  • Gene Symbol: GET3 (ENSG00000198356)
    Fold Change: 1.2
    Ensembl ID: ENSG00000198356
  • Gene Symbol: TMEM50B (ENSG00000142188)
    Fold Change: 1.2
    Ensembl ID: ENSG00000142188
  • Gene Symbol: AQP4 (ENSG00000171885)
    Fold Change: 1.18
    Ensembl ID: ENSG00000171885
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.15
    Ensembl ID: ENSG00000123505
  • Gene Symbol: ACTL6A (ENSG00000136518)
    Fold Change: 1.14
    Ensembl ID: ENSG00000136518
  • Gene Symbol: ARHGAP5 (ENSG00000100852)
    Fold Change: 1.14
    Ensembl ID: ENSG00000100852
  • Gene Symbol: AKT1 (ENSG00000142208)
    Fold Change: 1.14
    Ensembl ID: ENSG00000142208
  • Gene Symbol: ACADM (ENSG00000117054)
    Fold Change: 1.13
    Ensembl ID: ENSG00000117054
  • Gene Symbol: ADSS2 (ENSG00000035687)
    Fold Change: 1.12
    Ensembl ID: ENSG00000035687
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.12
    Ensembl ID: ENSG00000160710
  • Gene Symbol: ACAA1 (ENSG00000060971)
    Fold Change: 1.08
    Ensembl ID: ENSG00000060971
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 1.06
    Ensembl ID: ENSG00000100300
  • Gene Symbol: APEH (ENSG00000164062)
    Fold Change: 1.04
    Ensembl ID: ENSG00000164062
  • Gene Symbol: SLC25A4 (ENSG00000151729)
    Fold Change: 1.02
    Ensembl ID: ENSG00000151729
  • Gene Symbol: ADSL (ENSG00000239900)
    Fold Change: 1.02
    Ensembl ID: ENSG00000239900
  • Gene Symbol: ACTN1 (ENSG00000072110)
    Fold Change: 1.01
    Ensembl ID: ENSG00000072110
  • Gene Symbol: APOE (ENSG00000130203)
    Fold Change: N/A
    Ensembl ID: ENSG00000130203
Hovered Details

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Hovered Details

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**Key Characteristics** 1. **Location**: RECs are found in the respiratory tract, including the trachea, bronchi, and lungs. 2. **Cell Type**: RECs are a type of endo-epithelial cell. 3. **Function**: RECs are involved in maintaining the integrity of the respiratory epithelium, gas exchange, mucus production, and immune responses. 4. **Gene Expression**: RECs express genes involved in actin cytoskeleton regulation, cell-cell junction formation, and signaling pathways, including ACTB and ACTG1. 5. **Cytoskeleton**: The actin cytoskeleton, particularly the actin filaments, is dynamic and plays a key role in maintaining cell shape, motility, and intracellular transport. 6. **Cell-Cell Junctions**: RECs form adherens junctions and tight junctions, which are essential for maintaining the integrity of the epithelial barrier. 7. **Immune Responses**: RECs are involved in immune responses, including the production of cytokines and chemokines, and the phagocytosis of pathogens. **Clinical Significance** 1. **Respiratory Diseases**: Alterations in REC function and gene expression have been implicated in various respiratory diseases, including chronic obstructive pulmonary disease (COPD), asthma, and cystic fibrosis. 2. **Cancer**: Abnormalities in REC gene expression and function have been linked to lung cancer and other cancers of the respiratory tract. 3. **Infections**: RECs play a crucial role in the innate immune response to respiratory infections, and alterations in REC function and gene expression can influence the severity of infections. 4. **Pharmacotoxicity**: RECs are sensitive to environmental toxins and pollutants, and alterations in REC function and gene expression can influence the toxicity of these substances. 5. **Therapeutic Applications**: Targeting REC function and gene expression has potential therapeutic applications in the treatment of respiratory diseases, including the development of novel therapeutic agents to modulate REC function and gene expression. In conclusion, RECs are dynamic cells that play a crucial role in maintaining the integrity of the respiratory epithelium and are involved in various physiological processes. Understanding the key characteristics and clinical significance of RECs is essential for the development of novel therapeutic agents and the treatment of respiratory diseases.